Programmbereich Infektionen

Zelluläre Pneumologie

Mission    Projekte    Drittmittel    Methoden    Publikationen    Mitarbeiter/innen



Minutti CM, Jackson-Jones LH, García-Fojeda B, Knipper JA, Sutherland TE, Logan N, Rinqvist E, Guillamat-Prats R, Ferenbach DA, Artigas A, Stamme C, Chroneos ZC, Zaiss DM, Casals C, Allen JE. Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver. Science. 2017 Jun 9;356(6342):1076-1080. doi: 10.1126/science.aaj2067. Epub 2017 May 11.

Wagner NM, Van Aken C, Butschkau A, Bierhansl L, Kellner P, Schleusener V, Seggewiss J, Vollmar B, Nöldge-Schomburg G, Roesner JP. Procalcitonin Impairs Endothelial Cell Function and Viability. Anesth Analg. 2017 Mar;124(3):836-845.

Kellner P, Müller M, Piegeler T, Eugster P, Booy C, Schläpfer M, Beck-Schimmer B. Sevoflurane Abolishes Oxygenation Impairment in a Long-Term Rat Model of Acute Lung Injury. Anesth Analg. 2017 Jan;124(1):194-203.



Stelzner M, Lau FL, Freundt K, Büther F, Nguyen ML, Stamme C, Ebers S. Precise detection and treatment of human diseases based on nano networking. BodyNets '16 Proceedings of the 11th EAI International Conference on Body Area Networks, Pages 58-64, Turin, Italy-December 15-16,2016, ICST (Institute for Computer Sciences, Social-Informatics and Telecommunications Engineering) ICST, Brussels, Belgium 2016, ISBN: 978-1-63190-132-4.

Karnati S, Palaniswamy S, Alam MR, Oruqaj G, Stamme C, Baumgart-Vogt E. C22-bronchial and T7-alveolar epithelial cell lines of the immortomouse are excellent murine cell culture model systems to study pulmonary peroxisome biology and metabolism. Histochem Cell Biol. 2016 Mar;145(3):287-304. doi: 10.1007/s00418-015-1385-4.

Kellner P, Schleusener V, Bauerfeind F, Soukup J. Influence of different infracardial positions of central venous catheters in hemodynamic monitoring using the transpulmonal thermodilution method. J Clin Monit Comput. 2016 Oct;30(5):629-40. doi: 10.1007/s10877-015-9762-z.

Kellner P, Herzog B, Plößl S, Rohrmeier C, Kühnel T, Wanzek R, Plontke S, Herzog M. Depth-dependent changes of obstruction patterns under increasing sedation during drug-induced sedation endoscopy: results of a German monocentric clinical trial. Sleep Breath. 2016 Sep;20(3):1035-43. doi: 10.1007/s11325-016-1348-6.

Moulakakis C, Steinhäuser C, Biedziak D, Freundt K, Reiling N, Stamme C. Surfactant Protein A Enhances Constitutive Immune Functions of Clathrin Heavy Chain and Clathrin Adaptor Protein 2. Am J Respir Cell Mol Biol. 2016 Jul;55(1):92-104. doi: 10.1165/rcmb.2015-0219OC.

Karnati S, Graulich T, Oruqaj G, Pfreimer S, Seimetz M, Stamme C, Mariani TJ, Weissmann N, Mühlfeld C, Baumgart-Vogt E. Postnatal development of the bronchiolar club cells of distal airways in the mouse lung: stereological and molecular biological studies. Cell Tissue Res. 2016 Jun;364(3):543-57. doi: 10.1007/s00441-015-2354-x.

Wagner NM, Van Aken C, Butschkau A, Bierhansl L, Kellner P, Schleusener V, Seggewiss J, Vollmar B, Nöldge-Schomburg G, Roesner JP. Procalcitonin Impairs Endothelial Cell Function and Viability. Anesth Analg. 2016 Sep 20. [Epub ahead of print]


Herzog M, Kellner P, Plößl S, Glien A, Rohrmeier C, Kühnel T, Plontke S, Herzog B. Drug-induced sleep endoscopy and simulated snoring in patients with sleep-disordered breathing: agreement of anatomic changes in the upper airway. Eur Arch Otorhinolaryngol. 2015 Sep;272(9):2541-50. doi: 10.1007/s00405-015-3559-z.

Herzog M, Plößl S, Glien A, Herzog B, Rohrmeier C, Kühnel T, Plontke S, Kellner P. Evaluation of acoustic characteristics of snoring sounds obtained during drug-induced sleep endoscopy. Sleep Breath. 2015 Sep;19(3):1011-9. doi: 10.1007/s11325-014-1085-7.



Sender V, Stamme C.  Lung cell-specific modulation of LPS-induced TLR4 receptor and adaptor localization. Commun Integr Biol. 2014 May 16;7:e29053. doi: 10.4161/cib.29053

Kellner P, Nestler F, Leimert A, Bucher M, Czeslick E, Sablotzki A, Raspè C. Antithrombin III, but not C1 esterase inhibitor reduces inflammatory response in lipopolysaccharide-stimulated human monocytes in an ex-vivo whole blood setting. Cytokine. 2014 Dec;70(2):173-8.



Sender V, Lang L, Stamme C. Surfactant Protein-A Modulates LPS-Induced TLR4 Localization and Signaling via ß-Arrestin 2. PLoS ONE. 2013;8(3):e59896. Open Access



Sender V, Moulakakis C, Stamme C. Pulmonary Surfactant Protein A Enhances Endolysosomal Trafficking in Alveolar Macrophages through Regulation of Rab7. JOURNAL OF IMMUNOLOGY 2011 Feb;186(4):2397-2411.

Rades D, Freundt K, Meyners T, Bajrovic A, Basic H, Karstens JH, Adamietz IA, Wildfang I, Rudat V, Schild SE, Dunst J. Dose escalation for metastatic spinal cord compression in patients with relatively radioresistant tumors. Int J Radiat Oncol Biol Phys. 2011 Aug 1;80(5):1492-7.



Sender V, Hofmeister-Mielke N, Sievert K, Teifke JP, Vogel H, Baumgart J, Pichlmeier U, Freund M, Casper J, Wolff D. Preclinical analysis of treosulfan in combination with total body irradiation as conditioning regimen prior to bone marrow transplantation in rats. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY 2009 Dec;31(4):595-600.

Moulakakis C, Stamme C. Role of clathrin-mediated endocytosis of surfactant protein A by alveolar macrophages in intracellular signaling. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 2009 Mar;296(3):L430-L441.


Meier T, Lange A, Papenberg H, Ziemann M, Fentrop C, Uhlig U, Schmucker P, Uhlig S, Stamme C. Pulmonary cytokine responses during mechanical ventilation of noninjured lungs with and without end-expiratory pressure. ANESTHESIA AND ANALGESIA 2008 Oct;107(4):1265-1275.


Moulakakis C, Adam S, Seitzer U, Schromm A, Leitges M, Stamme C. Surfactant protein A activation of atypical protein kinase C zeta in I kappa B-alpha-dependent anti-inflammatory immune regulation. JOURNAL OF IMMUNOLOGY 2007 Oct;179(7):4480-4491.

2002-2006 (Selection)

Mueller M, Stamme C, Draing C, Hartung T, Seydel U, Schromm A. Cell activation of human macrophages by lipoteichoic acid is strongly attenuated by lipopolysaccharide-binding protein. JOURNAL OF BIOLOGICAL CHEMISTRY 2006 Oct;281(42):31448-31456.

Papavlassopoulos M, Stamme C, Thon L, Adam D, Hillemann D, Seydel U, Schromm A. MaxiK blockade selectively inhibits the lipopolysaccharide-induced I kappa B-alpha/NF-kappa B signaling pathway in macrophages. JOURNAL OF IMMUNOLOGY 2006 Sep;177(6):4086-4093.

Hamann L, Gomma A, Schroder N, Stamme C, Glaeser C, Schulz S, Gross M, Anker S, Fox K, Schumann R. A frequent toll-like receptor (TLR)-2 polymorphism is a risk factor for coronary restenosis. JOURNAL OF MOLECULAR MEDICINE-JMM 2005 Jun;83(6):478-485.

Hamann L, Alexander C, Stamme C, Zahringer U, Schumann R. Acute-phase concentrations of lipopolysaccharide (LPS)-binding protein inhibit innate immune cell activation by different LPS chemotypes via different mechanisms. INFECTION AND IMMUNITY 2005 Jan;73(1):193-200.

Wu Y, Adam S, Hamann L, Heine H, Ulmer A, Buwitt-Beckmann U, Stamme C. Accumulation of inhibitory kappa B-alpha as a mechanism contributing to the anti-inflammatory effects of surfactant protein-A. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 2004 Dec;31(6):587-594.

Stamme C, Muller M, Hamann L, Gutsmann T, Seydel U. Surfactant protein A inhibits lipopolysaccharide-induced immune cell activation by preventing the interaction of lipopolysaccharide with lipopolysaccharide-binding protein. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 2002 Sep;27(3):353-360.

Hamann L, Stamme C, Ulmer A, Schumann R. Inhibition of LPS-induced activation of alveolar macrophages by high concentrations of LPS-binding protein. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2002 Jul;295(2):553-560.

Pechkovsky D, Zissel G, Stamme C, Goldmann T, Jaffe H, Einhaus M, Taube C, Magnussen H, Schlaak M, Muller-Quernheim J. Human alveolar epithelial cells induce nitric oxide synthase-2 expression in alveolar macrophages. EUROPEAN RESPIRATORY JOURNAL 2002 Apr;19(4):672-683.

Stamme C, Brasch F, von Bethmann A, Uhlig S. Effect of surfactant on ventilation-induced mediator release in isolated perfused mouse lungs. PULMONARY PHARMACOLOGY & THERAPEUTICS 2002;15(5):455-461.

Book Chapters

Schromm AB, Alexander C, Gutsmann T, Stamme C. Pathogens in Sepsis: Gram-negative Bacterial PAMPs and PRRs.  In: Cavaillon, Jean-Marc (Ed.): Sepsis and non-infectious systemic inflammation : from biology to critical care.  Weinheim: Wiley-VCH; 2009 p. 75-104.