Programmbereich Infektionen


Mission    Projekte    Drittmittel    Methoden    Publikationen    Mitarbeiter/innen



Brandenburg, K, Schromm, AB, Weindl, G, Heinbockel, L, Correa, W, Mauss, K, Martinez de Tejada, G & Garidel, P 2021, 'An update on endotoxin neutralization strategies in Gram-negative bacterial infections', Expert Review of Anti-Infective Therapy , Jg. 19, Nr. 4, S. 495-517.

Heinbockel, L, Weindl, G, Correa, W, Brandenburg, J, Reiling, N, Wiesmüller, K-H, Schürholz, T, Gutsmann, T, Martinez de Tejada, G, Mauss, K & Brandenburg, K 2021, 'Anti-Infective and Anti-Inflammatory Mode of Action of Peptide 19-2.5', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , Jg. 22, Nr. 3.

Jumde, RP, Guardigni, M, Gierse, RM, Alhayek, A, Zhu, D, Hamid, Z, Johannsen, S, Elgaher, WAM, Neusens, PJ, Nehls, C, Haupenthal, J, Reiling, N & Hirsch, AKH 2021, 'Hit-optimization using target-directed dynamic combinatorial chemistry: development of inhibitors of the anti-infective target 1-deoxy-d-xylulose-5-phosphate synthase', Chemical Science, Jg. 12, Nr. 22, S. 7775-7785.

Kuhlmann, N, Nehls, C, Heinbockel, L, Correa, W, Moll, R, Gutsmann, T, Hübner, C, Englisch, U & Brandenburg, K 2021, 'Encapsulation and release of As pidasept peptides in polysaccharide formulation for oral application', European journal of pharmaceutical sciences, Jg. 158, S. 105687.

Mohammad, S, Al Zoubi, S, Collotta, D, Krieg, N, Wissuwa, B, Ferreira Alves, G, Purvis, GSD, Norata, GD, Baragetti, A, Catapano, AL, Solito, E, Zechendorf, E, Schürholz, T, Correa-Vargas, W, Brandenburg, K, Coldewey, SM, Collino, M, Yaqoob, MM, Martin, L & Thiemermann, C 2021, 'A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice', FRONTIERS IN IMMUNOLOGY, Jg. 12, S. 701275.

Schromm, AB, Paulowski, L, Kaconis, Y, Kopp, F, Koistinen, M, Donoghue, A, Keese, S, Nehls, C, Wernecke, J, Garidel, P, Sevcsik, E, Lohner, K, Sanchez-Gomez, S, Martinez-de-Tejada, G, Brandenburg, K, Brameshuber, M, Schütz, GJ, Andrä, J & Gutsmann, T 2021, 'Cathelicidin and PMB neutralize endotoxins by multifactorial mechanisms including LPS interaction and targeting of host cell membranes', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jg. 118, Nr. 27.

Wang, C, Nehls, C, Baabe, D, Burghaus, O, Hurwitz, R, Gutsmann, T, Bröring, M & Kolbe, M 2021, 'Flagellin lysine methyltransferase FliB catalyzes a [4Fe-4S] mediated methyl transfer reaction', PLOS PATHOGENS, Jg. 17, Nr. 11, S. e1010052.

Wohlfart, S, Kilian, M, Storck, P, Gutsmann, T, Brandenburg, K & Mier, W 2021, 'Mass Spectrometric Quantification of the Antimicrobial Peptide Pep19-2.5 with Stable Isotope Labeling and Acidic Hydrolysis', Pharmaceutics, Jg. 13, Nr. 9.



Lubiana, P, Bouws, P, Roth, LK, Dörpinghaus, M, Rehn, T, Brehmer, J, Wichers, JS, Bachmann, A, Höhn, K, Roeder, T, Thye, T, Gutsmann, T, Burmester, T, Bruchhaus, I & Metwally, NG 2020, 'Adhesion between P. falciparum infected erythrocytes and human endothelial receptors follows alternative binding dynamics under flow and febrile conditions', Scientific Reports, Jg. 10, Nr. 1, S. 4548.

Nehls, C, Böhling, A, Podschun, R, Schubert, S, Grötzinger, J, Schromm, A, Fedders, H, Leippe, M, Harder, J, Kaconis, Y, Gronow, S & Gutsmann, T 2020, 'Influence of disulfide bonds in human beta defensin-3 on its strain specific activity against Gram-negative bacteria', BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Jg. 1862, Nr. 8, S. 183273.

Paulowski, L, Donoghue, A, Nehls, C, Groth, S, Koistinen, M, Hagge, SO, Böhling, A, Winterhalter, M & Gutsmann, T 2020, 'The Beauty of Asymmetric Membranes: Reconstitution of the Outer Membrane of Gram-Negative Bacteria', Frontiers in cell and developmental biology, Jg. 8, S. 586.

Pfrommer, E, Dreier, C, Gabriel, G, Dallenga, T, Reimer, R, Schepanski, K, Scherließ, R, Schaible, UE & Gutsmann, T 2020, 'Enhanced tenacity of mycobacterial aerosols from necrotic neutrophils', Scientific Reports, Jg. 10, Nr. 1, S. 9159.

Subh, L, Correa, W, Pinkvos, T-J, Behrens, P, Brandenburg, K, Gutsmann, T, Stiesch, M, Doll, K & Winkel, A 2020, 'Synthetic anti-endotoxin peptides interfere with Gram-positive and Gram-negative bacteria, their adhesion and biofilm formation on titanium', Journal of applied microbiology.

Thoma, J, Abuillan, W, Furikado, I, Habe, T, Yamamoto, A, Gierlich, S, Kaufmann, S, Brandenburg, K, Gutsmann, T, Konovalov, O, Inoue, S & Tanaka, M 2020, 'Specific localisation of ions in bacterial membranes unravels physical mechanism of effective bacteria killing by sanitiser', Scientific Reports, Jg. 10, Nr. 1, S. 12302.



Bleibaum, F, Sommer, A, Veit, M, Rabe, B, Andrä, J, Kunzelmann, K, Nehls, C, Correa, W, Gutsmann, T, Grötzinger, J, Bhakdi, S & Reiss, K 2019, 'ADAM10 sheddase activation is controlled by cell membrane asymmetry', Journal of molecular cell biology, Jg. 11, Nr. 11, S. 979-993.

Byrd-Leotis, L, Jia, N, Dutta, S, Trost, JF, Gao, C, Cummings, SF, Braulke, T, Müller-Loennies, S, Heimburg-Molinaro, J, Steinhauer, DA & Cummings, RD 2019, 'Influenza binds phosphorylated glycans from human lung', Science advances, Jg. 5, Nr. 2, S. eaav2554.

Correa, W, Brandenburg, J, Behrends, J, Heinbockel, L, Reiling, N, Paulowski, L, Schwudke, D, Stephan, K, Martinez-de-Tejada, G, Brandenburg, K & Gutsmann, T 2019, 'Inactivation of Bacteria by γ-Irradiation to Investigate the Interaction with Antimicrobial Peptides', Biophysical journal, Jg. 117, Nr. 10, S. 1805-1819.

Correa, W, Heinbockel, L, Behrends, J, Kaconis, Y, Barcena-Varela, S, Gutsmann, T, Mauss, K, Schürholz, T, Schromm, AB, Martinez de Tejada, G & Brandenburg, K 2019, 'Antibacterial action of synthetic antilipopolysaccharide peptides (SALP) involves neutralization of both membrane-bound and free toxins', The FEBS journal, Jg. 286, Nr. 8, S. 1576-1593.

de Miguel Catalina, A, Forbrig, E, Kozuch, J, Nehls, C, Paulowski, L, Gutsmann, T, Hildebrandt, P & Mroginski, MA 2019, 'The C-Terminal VPRTES Tail of LL-37 Influences the Mode of Attachment to a Lipid Bilayer and Antimicrobial Activity', BIOCHEMISTRY, Jg. 58, Nr. 19, S. 2447-2462.

Haji-Ghassemi, O, Müller-Loennies, S, Brooks, CL, MacKenzie, CR, Caveney, N, Van Petegem, F, Brade, L, Kosma, P, Brade, H & Evans, SV 2019, 'Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody-Carbohydrate Binding Affinity by an Order of Magnitude', BIOCHEMISTRY, Jg. 58, Nr. 6, S. 714-726.

Jannadi, H, Correa, W, Zhang, Z, Brandenburg, K, Oueslati, R & Rouabhia, M 2019, 'Antimicrobial peptides Pep19-2.5 and Pep19-4LF inhibit Streptococcus mutans growth and biofilm formation', MICROBIAL PATHOGENESIS , Jg. 133, S. 103546.

Pfalzgraff, A, Correa, W, Heinbockel, L, Schromm, AB, Lübow, C, Gisch, N, Martinez-de-Tejada, G, Brandenburg, K & Weindl, G 2019, 'LPS-neutralizing peptides reduce outer membrane vesicle-induced inflammatory responses', BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, Jg. 1864, Nr. 10, S. 1503-1513.

von Bargen, K, Scraba, M, Krämer, I, Ketterer, M, Nehls, C, Krokowski, S, Repnik, U, Wittlich, M, Maaser, A, Zapka, P, Bunge, M, Schlesinger, M, Huth, G, Klees, A, Hansen, P, Jeschke, A, Bendas, G, Utermöhlen, O, Griffiths, G, Gutsmann, T, Wohlmann, J & Haas, A 2019, 'Virulence-associated protein A from Rhodococcus equi is an intercompartmental pH-neutralising virulence factor', CELLULAR MICROBIOLOGY, Jg. 21, Nr. 1, S. e12958.



Pfalzgraff, A, Bárcena-Varela, S, Heinbockel, L, Gutsmann, T, Brandenburg, K, Martinez-de-Tejada, G & Weindl, G 2018, 'Antimicrobial endotoxin-neutralizing peptides promote keratinocyte migration via P2X7 receptor activation and accelerate wound healing in vivo' BRITISH JOURNAL OF PHARMACOLOGY, Jg. 175, Nr. 17, S. 3581-3593. DOI: 10.1111/bph.14425

Pfalzgraff, A, Brandenburg, K & Weindl, G 2018, 'Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds' Frontiers in pharmacology, Jg. 9, S. 281. DOI: 10.3389/fphar.2018.00281

Di Lorenzo, G, Voltolini Velho, R, Winter, D, Thelen, M, Ahmadi, S, Schweizer, M, De Pace, R, Cornils, K, Yorgan, TA, Grüb, S, Hermans-Borgmeyer, I, Schinke, T, Müller-Loennies, S, Braulke, T & Pohl, S 2018, 'Lysosomal proteome and secretome analysis identifies missorted enzymes and their non-degraded substrates in mucolipidosis III mouse cells' MOLECULAR & CELLULAR PROTEOMICS , Jg. 17, Nr. 8, S. 1612-1626. DOI: 10.1074/mcp.RA118.000720

Yamada, N, Martin, LB, Zechendorf, E, Purvis, GSD, Chiazza, F, Varrone, B, Collino, M, Shepherd, J, Heinbockel, L, Gutsmann, T, Correa Vargas, WA, Brandenburg, K, Marx, G, Schuerholz, T, Brohi, K & Thiemermann, C 2018, 'Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock' American journal of surgical pathology, Jg. 268, Nr. 2, S. 348-356. DOI: 10.1097/SLA.0000000000002186

Kuhlmann, N, Heinbockel, L, Correa, W, Gutsmann, T, Goldmann, T, Englisch, U & Brandenburg, K 2018, 'Peptide drug stability: The anti-inflammatory drugs Pep19-2.5 and Pep19-4LF in cream formulation' European journal of pharmaceutical sciences, Jg. 115, S. 240-247. DOI: 10.1016/j.ejps.2018.01.022

Kos, O, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Heumann, D, Khatri, I, Mach, JP, Rietschel, ET, Tersikh, A, Ulmer, AJ, Waelli, T, Yu, K, Zähringer, U & Gorczynski, RM 2018, 'Regulation of fetal hemoglobin expression during hematopoietic stem cell development and its importance in bone metabolism and osteoporosis' INTERNATIONAL IMMUNOPHARMACOLOGY , Jg. 57, S. 112-120. DOI: 10.1016/j.intimp.2018.02.010



Gorczynski, RM, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Heumann, D, Mach, J-P, Rietschel, ET, Ulmer, AJ, Zähringer, U, Yu, K & Khatri, I 2017, 'An altered REDOX environment, assisted by over-expression of fetal hemoglobins, protects from inflammatory colitis and reduces inflammatory cytokine expression' INTERNATIONAL IMMUNOPHARMACOLOGY , Bd 50, Nr. (2017), S. 69-76.

Metwally, NG, Tilly, A-K, Lubiana, P, Roth, LK, Dörpinghaus, M, Lorenzen, S, Schuldt, K, Witt, S, Bachmann, A, Tidow, H, Gutsmann, T, Burmester, T, Roeder, T, Tannich, E & Bruchhaus, I 2017, 'Characterisation of Plasmodium falciparum populations selected on the human endothelial receptors P-selectin, E-selectin, CD9 and CD151' Scientific Reports, Bd 7, Nr. 1, S. 4069. DOI: 10.1038/s41598-017-04241-3

Blodkamp, S, Kadlec, K, Gutsmann, T, Quiblier, C, Naim, HY, Schwarz, S & von Köckritz-Blickwede, M 2017, 'Effects of SecDF on the antimicrobial functions of cathelicidins against Staphylococcus aureus' Veterinary Microbiology, Nr. 200, S. 52-58. DOI: 10.1016/j.vetmic.2016.03.021

Bang, C, Vierbuchen, T, Gutsmann, T, Heine, H & Schmitz, RA 2017, 'Immunogenic properties of the human gut-associated archaeon Methanomassiliicoccus luminyensis and its susceptibility to antimicrobial peptides' PLOS ONE, Bd 12, Nr. 10, S. e0185919. DOI: 10.1371/journal.pone.0185919

Ito, H, Murakami, R, Sakuma, S, Tsai, C-HD, Gutsmann, T, Brandenburg, K, Pöschl, JMB, Arai, F, Kaneko, M & Tanaka, M 2017, 'Mechanical diagnosis of human erythrocytes by ultra-high speed manipulation unraveled critical time window for global cytoskeletal remodeling' Scientific Reports, Bd 7, S. 43134. DOI: 10.1038/srep43134

de Buhr, N, Reuner, F, Neumann, A, Stump-Guthier, C, Tenenbaum, T, Schroten, H, Ishikawa, H, Müller, K, Beineke, A, Hennig-Pauka, I, Gutsmann, T, Valentin-Weigand, P, Baums, CG & von Köckritz-Blickwede, M 2017, 'Neutrophil extracellular trap formation in the Streptococcus suis-infected cerebrospinal fluid compartment' CELLULAR MICROBIOLOGY, Bd 19, Nr. 2. DOI: 10.1111/cmi.12649

Yamada, N, Martin, LB, Zechendorf, E, Purvis, GSD, Chiazza, F, Varrone, B, Collino, M, Shepherd, J, Heinbockel, L, Gutsmann, T, Correa Vargas, WA, Brandenburg, K, Marx, G, Schuerholz, T, Brohi, K & Thiemermann, C 2017, 'Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock' American journal of surgical pathology. DOI: 10.1097/SLA.0000000000002186

Haji-Ghassemi, O, Gagnon, SML, Müller-Loennies, S & Evans, SV 2017, 'Polyspecificity of Anti-lipid A Antibodies and Its Relevance to the Development of Autoimmunity'  Advances in Experimental Medicine and Biology , Bd 966, S. 181-202. DOI: 10.1007/5584_2017_94

Pfalzgraff, A, Heinbockel, L, Su, Q, Brandenburg, K & Weindl, G 2017, 'Synthetic anti-endotoxin peptides inhibit cytoplasmic LPS-mediated responses' BIOCHEMICAL PHARMACOLOGY , Bd 140, S. 64-72. DOI: 10.1016/j.bcp.2017.05.015

Langer, MN, Blodkamp, S, Bayerbach, M, Feßler, AT, de Buhr, N, Gutsmann, T, Kreienbrock, L, Schwarz, S & von Köckritz-Blickwede, M 2017, 'Testing cathelicidin susceptibility of bacterial mastitis isolates: Technical challenges and data output for clinical isolates' Veterinary Microbiology, Bd 210, S. 107-115. DOI: 10.1016/j.vetmic.2017.08.022