Programmbereich Infektionen

Zelluläre Mikrobiologie

Mission    Projekte    Drittmittel    Methoden    Publikationen    Mitarbeiter/innen



Dal, N-JK, Schäfer, G, Thompson, AM, Schmitt, S, Redinger, N, Alonso-Rodriguez, N, Johann, K, Ojong, J, Wohlmann, J, Best, A, Koynov, K, Zentel, R, Schaible, UE, Griffiths, G, Barz, M & Fenaroli, F 2023, 'Π-Π interactions stabilize PeptoMicelle-based formulations of Pretomanid derivatives leading to promising therapy against tuberculosis in zebrafish and mouse models', JOURNAL OF CONTROLLED RELEASE , Jg. 354, S. 851-868.

Schick, J, Altunay, M, Lacorcia, M, Marschner, N, Westermann, S, Schluckebier, J, Schubart, C, Bodendorfer, B, Christensen, D, Alexander, C, Wirtz, S, Voehringer, D, da Costa, CP & Lang, R 2023, 'IL-4 and helminth infection downregulate MINCLE-dependent macrophage response to mycobacteria and Th17 adjuvanticity', eLife, Jg. 12, e72923.




Behera, A, Jain, P, Ganguli, G, Biswas, M, Padhi, A, Pattanaik, KP, Nayak, B, Ergün, S, Hagens, K, Redinger, N, Saqib, M, Mishra, BB, Schaible, UE, Karnati, S & Sonawane, A 2022, 'Mycobacterium tuberculosis Acetyltransferase Suppresses Oxidative Stress by Inducing Peroxisome Formation in Macrophages', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , Jg. 23, Nr. 5, 2584.

Brandenburg, J, Heyckendorf, J, Marwitz, F, Zehethofer, N, Linnemann, L, Gisch, N, Karaköse, H, Reimann, M, Kranzer, K, Kalsdorf, B, Sanchez-Carballo, P, Weinkauf, M, Scholz, V, Malm, S, Homolka, S, Gaede, KI, Herzmann, C, Schaible, UE, Hölscher, C, Reiling, N & Schwudke, D 2022, 'Tuberculostearic Acid-Containing Phosphatidylinositols as Markers of Bacterial Burden in Tuberculosis', ACS infectious diseases, Jg. 8, Nr. 7, S. 1303-1315.

Dallenga, T, Linnemann, L & Schaible, UE 2022, 'Evaluation of Myeloperoxidase as Target for Host-Directed Therapy in Tuberculosis In Vivo', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , Jg. 23, Nr. 5, S. 2554.

Gómez, A-C, Lyons, T, Mamat, U, Yero, D, Bravo, M, Daura, X, Elshafee, O, Brunke, S, Gahan, CGM, O'Driscoll, M, Gibert, I & O'Sullivan, TP 2022, 'Synthesis and evaluation of novel furanones as biofilm inhibitors in opportunistic human pathogens', EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , Jg. 242, S. 114678.

Mrochen, DM, Miebach, L, Skowski, H, Bansemer, R, Drechsler, CA, Hofmanna, U, Hein, M, Mamat, U, Gerling, T, Schaible, U, von Woedtke, T & Bekeschus, S 2022, 'Toxicity and virucidal activity of a neon-driven micro plasma jet on eukaryotic cells and a coronavirus', Free radical biology & medicine, Jg. 191, S. 105-118.

Scior, T., Garcia-Hernandez, J.C., Abdallah H.H., Christian Alexander, C. 2022, 'QSAR Applied to 4-Chloro-3-formylcoumarin Derivatives Targeting Human Thymidine Phosphorylase: -', Clinical Complementary Medicine and Pharmacology, Jg. 2, Nr. 2, DOI:, S. 1-11.

von Woedtke, T, Gabriel, G, Schaible, UE & Bekeschus, S 2022, 'Oral SARS-CoV-2 reduction by local treatment: A plasma technology application?', Plasma processes and polymers (Print), S. e2200196.



Boom, WH, Schaible, UE & Achkar, JM 2021, 'The knowns and unknowns of latent Mycobacterium tuberculosis infection', Journal of Clinical Investigation, Jg. 131, Nr. 3, S. e136222.

Brandenburg, J, Marwitz, S, Tazoll, SC, Waldow, F, Kalsdorf, B, Vierbuchen, T, Scholzen, T, Gross, A, Goldenbaum, S, Hölscher, A, Hein, M, Linnemann, L, Reimann, M, Kispert, A, Leitges, M, Rupp, J, Lange, C, Niemann, S, Behrends, J, Goldmann, T, Heine, H, Schaible, UE, Hölscher, C, Schwudke, D & Reiling, N 2021, 'WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis', Journal of Clinical Investigation, Jg. 131, Nr. 16, e141833.

Gradtke, A-C, Mentrup, T, Lehmann, CHK, Cabrera-Cabrera, F, Desel, C, Okakpu, D, Assmann, M, Dalpke, A, Schaible, UE, Dudziak, D & Schröder, B 2021, 'Deficiency of the Intramembrane Protease SPPL2a Alters Antimycobacterial Cytokine Responses of Dendritic Cells', JOURNAL OF IMMUNOLOGY, Jg. 206, Nr. 1, S. 164-180.

Klionsky, DJ, Abdel-Aziz, AK, Abdelfatah, S, Abdellatif, M, Abdoli, A, Abel, S, Abeliovich, H, Abildgaard, MH, Abudu, YP, Acevedo-Arozena, A, Adamopoulos, IE, Adeli, K, Adolph, TE, Adornetto, A, Aflaki, E, Agam, G, Agarwal, A, Aggarwal, BB, Agnello, M, Agostinis, P, Agrewala, JN, Agrotis, A, Aguilar, PV, Ahmad, ST, Ahmed, ZM, Ahumada-Castro, U, Aits, S, Aizawa, S, Akkoc, Y, Akoumianaki, T, Akpinar, HA, Al-Abd, AM, Al-Akra, L, Al-Gharaibeh, A, Alaoui-Jamali, MA, Alberti, S, Alcocer-Gómez, E, Alessandri, C, Ali, M, Alim Al-Bari, MA, Aliwaini, S, Alizadeh, J, Almacellas, E, Almasan, A, Alonso, A, Dallenga, T, Leschczyk, C, Schaible, UE, Schneider, BE & Sonawane, A 2021, 'Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1', Autophagy, Jg. 17, Nr. 1, S. 1-382.

Kontsevaya, I, Lange, C, Comella-Del-Barrio, P, Coarfa, C, DiNardo, AR, Gillespie, SH, Hauptmann, M, Leschczyk, C, Mandalakas, AM, Martinecz, A, Merker, M, Niemann, S, Reimann, M, Rzhepishevska, O, Schaible, UE, Scheu, KM, Schurr, E, Abel Zur Wiesch, P & Heyckendorf, J 2021, 'Perspectives for systems biology in the management of tuberculosis', European Respiratory Review, Jg. 30, Nr. 160.

Salillas, S, Galano-Frutos, JJ, Mahía, A, Maity, R, Conde-Giménez, M, Anoz-Carbonell, E, Berlamont, H, Velazquez-Campoy, A, Touati, E, Mamat, U, Schaible, UE, Gálvez, JA, Díaz-de-Villegas, MD, Haesebrouck, F, Aínsa, JA & Sancho, J 2021, 'Selective Targeting of Human and Animal Pathogens of the Helicobacter Genus by Flavodoxin Inhibitors: Efficacy, Synergy, Resistance and Mechanistic Studies', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , Jg. 22, Nr. 18.

Tizzano, B, Dallenga, T, Utpatel, C, Behrends, J, Homolka, S, Kohl, T & Niemann, S 2021, 'Survival of hypoxia-induced dormancy is not a common feature of all strains of the Mycobacterium tuberculosis complex', Scientific Reports, Jg. 11, Nr. 1, S. 2628.



Alio, I, Gudzuhn, M, Pérez García, P, Danso, D, Schoelmerich, M, Mamat, U, Schaible, UE, Steinmann, J, Yero, D, Gibert, I, Kohl, TA, Niemann, S, Gröschel, MI, Haerdter, J, Hackl, T, Vollstedt, C, Bömeke, M, Egelkamp, R, Daniel, R, Poehlein, A & Streit, WR 2020, 'Phenotypic and Transcriptomic Analyses of Seven Clinical Stenotrophomonas maltophilia Isolates Identify a Small Set of Shared and Commonly Regulated Genes Involved in the Biofilm Lifestyle', APPLIED AND ENVIRONMENTAL MICROBIOLOGY , Jg. 86, Nr. 24.

Dorhoi, A, Kotzé, LA, Berzofsky, JA, Sui, Y, Gabrilovich, DI, Garg, A, Hafner, R, Khader, SA, Schaible, UE, Kaufmann, SH, Walzl, G, Lutz, MB, Mahon, RN, Ostrand-Rosenberg, S, Bishai, W & du Plessis, N 2020, 'Therapies for tuberculosis and AIDS: myeloid-derived suppressor cells in focus', Journal of Clinical Investigation, Jg. 130, Nr. 6, S. 2789-2799.

Gröschel, MI, Meehan, CJ, Barilar, I, Diricks, M, Gonzaga, A, Steglich, M, Conchillo-Solé, O, Scherer, I-C, Mamat, U, Luz, CF, De Bruyne, K, Utpatel, C, Yero, D, Gibert, I, Daura, X, Kampmeier, S, Rahman, NA, Kresken, M, van der Werf, TS, Alio, I, Streit, WR, Zhou, K, Schwartz, T, Rossen, JWA, Farhat, MR, Schaible, UE, Nübel, U, Rupp, J, Steinmann, J, Niemann, S & Kohl, TA 2020, 'The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia', Nature communications, Jg. 11, Nr. 1, S. 2044.

Lozano-Aponte, J, Scior, T, Ambrosio, FNM, González-Melchor, M & Alexander, C 2020, 'Exploring electrostatic patterns of human, murine, equine and canine TLR4/MD-2 receptors', INNATE IMMUNITY, Jg. 26, Nr. 5, S. 364-380.

Mackiewicz, M, Seitzer, U, Ahmed, JS & Reiling, N 2020, 'Theileria annulata surface protein (TaSP) is a target of cyclin‐dependent kinase 1 phosphorylation in Theileria annulata‐infected cells', Transboundary and Emerging Diseases, Jg. 67, Nr. S1, S. 40-55.

Naik, SK, Pattanaik, K, Eich, J, Sparr, V, Hauptmann, M, Kalsdorf, B, Reiling, N, Liedtke, W, Kuebler, WM, Schaible, UE & Sonawane, A 2020, 'Differential Roles of the Calcium Ion Channel TRPV4 in Host Responses to Mycobacterium tuberculosis Early and Late in Infection', iScience, Jg. 23, Nr. 6, S. 101206.

Patel, A, Redinger, N, Richter, A, Woods, A, Neumann, PR, Keegan, G, Childerhouse, N, Imming, P, Schaible, UE, Forbes, B & Dailey, LA 2020, 'In vitro and in vivo antitubercular activity of benzothiazinone-loaded human serum albumin nanocarriers designed for inhalation', JOURNAL OF CONTROLLED RELEASE , Jg. 328, S. 339-349.

Pfrommer, E, Dreier, C, Gabriel, G, Dallenga, T, Reimer, R, Schepanski, K, Scherließ, R, Schaible, UE & Gutsmann, T 2020, 'Enhanced tenacity of mycobacterial aerosols from necrotic neutrophils', Scientific Reports, Jg. 10, Nr. 1, S. 9159.

Schick, J, Schäfer, J, Alexander, C, Dichtl, S, Murray, PJ, Christensen, D, Sorg, U, Pfeffer, K, Schleicher, U & Lang, R 2020, 'Cutting Edge: TNF Is Essential for Mycobacteria-Induced MINCLE Expression, Macrophage Activation, and Th17 Adjuvanticity', JOURNAL OF IMMUNOLOGY, Jg. 205, Nr. 2, S. 323-328.

Shuaib, YA, Khalil, EAG, Wieler, LH, Schaible, UE, Bakheit, MA, Mohamed-Noor, SE, Abdalla, MA, Kerubo, G, Andres, S, Hillemann, D, Richter, E, Kranzer, K, Niemann, S & Merker, M 2020, 'Mycobacterium tuberculosis Complex Lineage 3 as Causative Agent of Pulmonary Tuberculosis, Eastern Sudan', EMERGING INFECTIOUS DISEASES, Jg. 26, Nr. 3, S. 427-436.

Stachnik, K, Warmer, M, Mohacsi, I, Hennicke, V, Fischer, P, Meyer, J, Spitzbart, T, Barthelmess, M, Eich, J, David, C, Feldmann, C, Busse, B, Jähn, K, Schaible, UE & Meents, A 2020, 'Multimodal X-ray imaging of nanocontainer-treated macrophages and calcium distribution in the perilacunar bone matrix', Scientific Reports, Jg. 10, Nr. 1, S. 1784.

Yero, D, Huedo, P, Conchillo-Solé, O, Martínez-Servat, S, Mamat, U, Coves, X, Llanas, F, Roca, I, Vila, J, Schaible, UE, Daura, X & Gibert, I 2020, 'Genetic Variants of the DSF Quorum Sensing System in Stenotrophomonas maltophilia Influence Virulence and Resistance Phenotypes Among Genotypically Diverse Clinical Isolates', Frontiers in Microbiology, Jg. 11, S. 1160.



Lozano-Aponte, J, Scior, T, Ambrosio, FNM, González-Melchor, M & Alexander, C 2019, 'Exploring electrostatic patterns of human, murine, equine and canine TLR4/MD-2 receptors', INNATE IMMUNITY, S. 1753425919894628.

Komazin, G, Maybin, M, Woodard, RW, Scior, T, Schwudke, D, Schombel, U, Gisch, N, Mamat, U & Meredith, TC 2019, 'Substrate structure-activity relationship reveals a limited lipopolysaccharide chemotype range for intestinal alkaline phosphatase', The Journal of biological chemistry, Jg. 294, Nr. 50, S. 19405-19423.

Paschke, A, Schaible, UE & Hein, W 2019, 'Legionella transmission through cooling towers: towards better control and research of a neglected pathogen', Lancet Respiratory Medicine, Jg. 7, Nr. 5, S. 378-380.

Rein, V, Meschkov, A, Hagens, K, Redinger, N, Schepers, U, Mehlhorn, H, Schaible, UE & Feldmann, C 2019, 'Zirconyl Hydrogenphosphate Nanocontainers for Flexible Transport and Release of Lipophilic Cytostatics, Insecticides, and Antibiotics', Advanced Functional Materials, Jg. 2019, Nr. 29, 10.1002/adfm.201900543.



Binsker, U, Palankar, R, Wesche, J, Kohler, TP, Prucha, J, Burchhardt, G, Rohde, M, Schmidt, F, Bröker, BM, Mamat, U, Pané-Farré, J, Graf, A, Ebner, P, Greinacher, A & Hammerschmidt, S 2018, 'Secreted Immunomodulatory Proteins of Staphylococcus aureus Activate Platelets and Induce Platelet Aggregation' Thrombosis and Haemostasis, Jg. 118, Nr. 4, S. 745-757. DOI: 10.1055/s-0038-1637735

Dallenga, T, Linnemann, L, Paudyal, B, Repnik, U, Griffiths, G & Schaible, UE 2018, 'Targeting neutrophils for host-directed therapy to treat tuberculosis' INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, Jg. 308, Nr. 1, S. 142-147. DOI: 10.1016/j.ijmm.2017.10.001

Herzmann, C, Dallenga, T & Kalinke, U 2018, 'Pulmonale Immunität bei Tuberkulose' PNEUMOLOGIE, Jg. 72, S. 1-10. DOI: 10.1055/s-0043-122961 

Khatri, I, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Heumann, D, Mach, J-P, Mazzoli, V, Rietschel, E, Terskikh, A, Ulmer, A, Yu, K, Zähringer, U & Gorczynski, R 2018, 'Analysis of cytokine immune response profile in response to inflammatory stimuli in mice with genetic defects in fetal and adult hemoglobin chain expression' Pharmacogenomics J., Jg. 18, Nr. 4, S. 546-555. DOI: 10.1038/s41397-017-0008-y

Kos, O, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Heumann, D, Khatri, I, Mach, JP, Rietschel, ET, Tersikh, A, Ulmer, AJ, Waelli, T, Yu, K, Zähringer, U & Gorczynski, RM 2018, 'Regulation of fetal hemoglobin expression during hematopoietic stem cell development and its importance in bone metabolism and osteoporosis' INTERNATIONAL IMMUNOPHARMACOLOGY , Jg. 57, S. 112-120. DOI: 10.1016/j.intimp.2018.02.010

Lange, C, Alghamdi, WA, Al-Shaer, MH, Brighenti, S, Diacon, AH, DiNardo, AR, Grobbel, HP, Gröschel, MI, von Groote-Bidlingmaier, F, Hauptmann, M, Heyckendorf, J, Köhler, N, Kohl, TA, Merker, M, Niemann, S, Peloquin, CA, Reimann, M, Schaible, UE, Schaub, D, Schleusener, V, Thye, T & Schön, T 2018, 'Perspectives for personalized therapy for patients with multidrug-resistant tuberculosis' JOURNAL OF INTERNAL MEDICINE . DOI: 10.1111/joim.12780

Malm, S, Maaß, S, Schaible, UE, Ehlers, S & Niemann, S 2018, 'In vivo virulence of Mycobacterium tuberculosis depends on a single homologue of the LytR-CpsA-Psr proteins' Scientific Reports, Jg. 8, Nr. 1, S. 3936. DOI: 10.1038/s41598-018-22012-6

Shuaib YA, Khalil EAG, Schaible UE, Wieler LH, Bakheit MAM, Mohamed-Noor SE, Abdalla MA, Homolka S, Andres S, Hillemann D, Lonnroth K, Richter E, Niemann S, Kranzer K. Smear Microscopy for Diagnosis of Pulmonary Tuberculosis in Eastern Sudan. Tuberc Res Treat. 2018 Jun 14;2018:8038137. doi: 10.1155/2018/8038137. eCollection 2018.

Steinmann, J, Mamat, U, Abda, EM, Kirchhoff, L, Streit, WR, Schaible, UE, Niemann, S & Kohl, TA 2018, 'Analysis of Phylogenetic Variation of Reveals Human-Specific Branches' Frontiers in Microbiology, Jg. 9, S. 806. DOI: 10.3389/fmicb.2018.00806

Surmann K, Depke M, Dhople VM, Pané-Farré J, Hildebrandt P, Gumz J, Schaible UE, Völker U, Schmidt F. Analysis of Staphylococcus aureus proteins secreted inside infected human epithelial cells. Int J Med Microbiol. 2018 Aug;308(6):664-674. doi: 10.1016/j.ijmm.2018.06.002. Epub 2018

Wutkowski A, Krajewski M, Bagwan N, Schäfer M, Paudyal BR, Schaible UE, Schwudke D. Software-aided quality control of parallel reaction monitoring based quantitation of lipid mediators. Anal Chim Acta. 2018 Dec 11;1037:168-176. doi: 10.1016/j.aca.2018.01.044. Epub 2018



Gorczynski, RM, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Heumann, D, Mach, J-P, Rietschel, ET, Ulmer, AJ, Zähringer, U, Yu, K & Khatri, I 2017, 'An altered REDOX environment, assisted by over-expression of fetal hemoglobins, protects from inflammatory colitis and reduces inflammatory cytokine expression' INTERNATIONAL IMMUNOPHARMACOLOGY , Bd 50, Nr. (2017), S. 69-76.

Groeger, S, Jarzina, F, Mamat, U & Meyle, J 2017, 'Induction of B7-H1 receptor by bacterial cells fractions of Porphyromonas gingivalis on human oral epithelial cells: B7-H1 induction by Porphyromonas gingivalis fractions' IMMUNOBIOLOGY, Bd 222, Nr. 2, S. 137-147. DOI: 10.1016/j.imbio.2016.10.011

Dallenga, T, Repnik, U, Corleis, B, Eich, J, Reimer, R, Griffiths, GW & Schaible, UE 2017, 'M. tuberculosis-Induced Necrosis of Infected Neutrophils Promotes Bacterial Growth Following Phagocytosis by Macrophages' Cell Host & Microbe, Bd 22, Nr. 4, S. 519-530.e3. DOI: 10.1016/j.chom.2017.09.003

Dallenga, T, Linnemann, L, Paudyal, B, Repnik, U, Griffiths, G & Schaible, UE 2017, 'Targeting neutrophils for host-directed therapy to treat tuberculosis' INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY. DOI: 10.1016/j.ijmm.2017.10.001

Haas, A, Hensel, M, Lührmann, A, Rudel, T, Saftig, P & Schaible, UE 2017, 'Intracellular compartments of pathogens: Highways to hell or stairways to heaven?' INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY. DOI: 10.1016/j.ijmm.2017.10.009

Patin, EC, Orr, SJ & Schaible, UE 2017, 'Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity' Frontiers in Immunology, Bd 8, S. 861. DOI: 10.3389/fimmu.2017.00861

Jeschke, A, Zehethofer, N, Schwudke, D & Haas, A 2017, 'Quantification of Phosphatidylinositol Phosphate Species in Purified Membranes' Methods in Enzymology, Bd 587, S. 271-291. DOI: 10.1016/bs.mie.2016.10.037

Singh, S, Dallenga, T, Winkler, A, Roemer, S, Maruschak, B, Siebert, H, Brück, W & Stadelmann, C 2017, 'Relationship of acute axonal damage, Wallerian degeneration, and clinical disability in multiple sclerosis' Journal of Neuroinflammation, Bd 14, Nr. 1, S. 57. DOI: 10.1186/s12974-017-0831-8

Schaible, UE, Linnemann, L, Redinger, N, Patin, E & Dallenga, T 2017, 'Strategies to improve vaccine efficacy againts tuberculosis by targeting innate immunity' Frontiers in Immunology, Bd 8, Nr. 1755, 1755. DOI: 10.3389/fimmu.2017.01755

Patin, EC, Geffken, AC, Willcocks, S, Leschczyk, C, Haas, A, Nimmerjahn, F, Lang, R, Ward, TH & Schaible, UE 2017, 'Trehalose dimycolate interferes with FcγR-mediated phagosome maturation through Mincle, SHP-1 and FcγRIIB signalling' PLOS ONE, Bd 12, Nr. 4, S. e0174973. DOI: 10.1371/journal.pone.0174973, 10.1371/journal.pone.0174973