Press Releases 2023

We stand with Israel!

The FZB stands in solidarity with our long-lasting scientific partners in Israel. Our thoughts are with our academic colleagues, their families & friends and all those affected.

Prof. Christoph Lange new Clinical Lead of the consortium UNITE4TB

With 30 international partners and 20 study sites in Africa, Asia, Europe and South America, the UNITE4TB consortium is building the largest study platform for clinical evaluation of anti-tuberculosis drugs in history.

After 2 ½ years, Professor Christoph Lange, Medical Director at the Research Center Borstel, followed Professor Guy Thwaites from the University of Oxford on October 01. 2023 as Clinical Lead of the consortium. He is now part of the four-member board that oversees UNITE4TB's activities. UNITE4TB is funded jointly as an EU-IMI project with 185 million Euros from the European Commission and the pharmaceutical industry.

Apart from the consortium leadership, the Research Center Borstel is also involved in biomarker evaluation and molecular prediction of antibiotic resistance in UNITE4TB. In total, approximately 3000 patients are expected to be enrolled in clinical trials by 2028, with the first ones starting as early as November 2023.

 

Further Information:

Contact:

Prof. Dr. med. Dr. h.c. Christoph Lange
Medizinischer Direktor
Forschungszentrum Borstel, Leibniz Lungenzentrum 
Parkallee 35, 23845 Borstel
T +49 4537 188 3010
F +49 4537 188 6030
This email address is being protected from spambots. You need JavaScript enabled to view it.

Chronic fungal infections of the lungs

Chronic pulmonary infections with molds (Aspergillus) occur more frequently in patients with a history of tuberculosis. The diagnosis of "Chronic Pulmonary Aspergillosis (CPA)" is often based on an immunological footprint of the infection, the detection of Aspergillus specific antibodies in the blood. How well the detection of this test corresponds to the actual presence of CPA has not been known until now.

The Clinical Infectious Diseases team at the Research Center Borstel, in collaboration with the CPAnet study network, has now investigated the correlation between the detection of Aspergillus specific antibodies in the blood and the actual presence of CPA.

For this purpose, blood samples from 47 patients with confirmed CPA (evidence of fungal growth or visualization of fungi under the microscope from tissue samples) were examined for the presence of Aspergillus-specific antibodies (N=47). In addition, blood samples from 303 control subjects at the Medical Clinic of the Research Center Borstel were examined. Detection of Aspergillus-specific antibodies was successful in 85% of patients with confirmed CPA. However, false-positive test results occurred in one third of the healthy control subjects.

"The results of our study confirm a high sensitivity of the Aspergillus-specific antibody test for the diagnosis of CPA," said Professor Christoph Lange, head of the clinical study at the Research Center Borstel. "However, positive test results should always be consistent with radiological findings, as false-positive test results limit the interpretation of the test."

Reference:

Salzer HJF, Reimann M, Oertel C, Davidsen JR, Laursen CB, Van Braeckel E, Agarwal R, Avsar K, Munteanu O, Irfan M, Lange C for the CPAnet. Aspergillus-specific IgG antibodies for diagnosing chronic pulmonary aspergillosis compared to the reference gold standard. Clin Microbiol Infect. 2023 Sep 7:S1198-743X(23)00416-0. doi: 10.1016/j.cmi.2023.08.032. Epub ahead of print. PMID: 37689265.

Contact:

Prof. Dr. med. Dr. h.c. Christoph Lange 
Medical Director, Research Center Borstel, Leibniz Lungcenter 
Professor for Respiratory Medicine & International Health, Lübeck University
Parkallee 35, 23845 Borstel, Germany

T +49 4537 188 3321/0
F +49 4537 188 6030
This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Weiterentwicklung im und mit dem Wandel: Forschungszentrum Borstel, Leibniz Lungenzentrum erneut für systematische Vereinbarkeitspolitik ausgezeichnet

Das Forschungszentrum Borstel, Leibniz Lungenzentrum wurde in diesem Jahr bereits zum 5. Mal für seine familien- und lebensphasenbewusste Personalpolitik mit dem Zertifikat zum audit berufundfamilie ausgezeichnet.

Seit der ersten Auszeichnung im Jahre 2010 sind Themen, wie Vereinbarkeit von Beruf und Familie, Gleichstellung und Diversität essentielle Bestandteile der Unternehmenskultur des Forschungszentrums geworden. Von diesen familienbewussten Maßnahmen profitieren die Beschäftigten auf vielen Ebenen: Neben einer flexible Gestaltung der Arbeitszeit, der Möglichkeit zur Heimarbeit oder die Nutzung des Eltern-Kind-Büros, steht den Mitarbeiterinnen und Mitarbeitern ein Angebot an Sportkursen und gesundheitsfördernden Maßnahmen zur Verfügung. Das FZB hat zudem eine betriebseigene Kita, legt großen Wert auf familienfreundliche Veranstaltungszeiten und bietet soziale Beratung an.

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Visionäre High-End Technologie potenziert Spitzenforschung am FZB

Das Forschungszentrum Borstel, Leibniz Lungenzentrum, investiert in die Zukunft und hat insgesamt vier Analysegeräte der neuesten Generation angeschafft, um die Forschung am Zentrum auf allerhöchstem Niveau weiter zu stärken und international konkurrenzfähig zu bleiben.

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