Press Releases 2023

Targeted test for antibiotic resistance in clinical Enterobacter species

Bacteria of the genus Enterobacter are among the most dangerous bacteria associated with hospital infections worldwide. Some of their representatives are highly resistant to commonly used antibiotics, so that the reserve antibiotic colistin is increasingly used as a last resort therapy option. To avoid unnecessary reliance on colistin and risk increasing resistance, bacteria are tested for sensitivity or resistance to colistin before recommending treatment. However, commonly used tests for Enterobacter are not reliable. In a comprehensive study with broad participation within the German Center for Infection Research (DZIF), scientists have now resolved this problem. Based on these findings, they developed a simple, sensitive and robust test for the genus Enterobacter, which now enables targeted antibiotic therapy for the various Enterobacter species. 

The currently used microbiological tests for colistin resistance and other antibiotic resistances did not allow accurate conclusions regarding the spread of resistance in different Enterobacter species. This was partly because the taxonomic classification of clinical Enterobacter isolates was imprecise, and partly because the error rate in determining resistance was high. The large-scale DZIF study has now achieved a breakthrough and clarified the relationships between the numerous Enterobacter species as well as optimised resistance testing. To this end, researchers at the Institute of Medical Microbiology of Justus Liebig University Giessen (Deep-iAMR project), together with DZIF scientists at the Research Center Borstel, Leibniz Lung Center, analysed Enterobacter isolates collected at German university hospitals over a period of three years.

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Zellkompartimente als Nischen zum Überleben von Infektionserregern im Körper

Hamburg. Die vielfältigen Strategien von Infektionserregern, im Wirt zu überleben und sich zu vermehren, und wie wir diese raffinierten Strategien nutzen könnten, um die Erreger besser zu bekämpfen, stehen im Mittelpunkt des diesjährigen Symposiums „Compartments in Infection“ des Leibniz Center Infection (LCI). Am 26. und 27. Januar 2023 werden internationale Forscherinnen und Forscher am Bernhard-Nocht-Institut für Tropenmedizin zusammenkommen und hierzu diskutieren.

Pressemitteilung des Leibniz Center Infection vom 20.01.2023

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Prevention of tuberculosis: Diagnostic tests put to the test

An international team of researchers with the participation of the Research Center Borstel, Leibniz Lung Center, has compared established diagnostic methods that predict the future occurrence of tuberculosis. The results have now been published in the journal EClinicalMedicine.

The tuberculin skin test (TST) and the interferon-gamma release assay (IGRA) are both tests for predicting the future risk of tuberculosis in risk groups. However, they work in slightly different ways.

The TST involves injecting a small amount of a substance called tuberculin into the skin on the forearm. If a person has had contact with the tuberculosis bacteria, the immune system reacts to the tuberculin and causes a hard, raised area (induration) at the injection site. The size of the induration is measured 48 to 72 hours after the injection to determine the likelihood of contact with tuberculosis bacteria.

IGRAs, on the other hand, are blood tests that measure the level of interferon-gamma, a substance produced by the immune system in response to antigens from the tuberculosis bacteria.

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Winteracademy of Pneumology:  Education again at a high level

From 08-13 January 2023, the Winteracademy of Pneumology took place for the 13th time St. Leonard in Pitztal (Austria) at almost 1800 meters above sea level. Physicians from all parts of Germany met in a pleasant workshop atmosphere to discuss the major topics of pulmonary medicine: asthma/COPD, tumor diseases, infectious diseases, intensive care, interstitial lung diseases and cardiopulmonary diseases with leading experts. Theoretical lectures were complemented by interactive case discussions and practical exercises (bronchoscopy course, pulmonary function course, ventilation course and radiology course).

The Winteracademy of Pneumology is supported by the German Society of Pneumology (DGP) and is aimed at advanced physicians in internal medicine training. In view of the increasing shortage of specialists, the event helps to recruit new colleagues for the pneumological specialty. Most of the >300 participants so far find their way into pneumology.

"Time for career discussions, an excellent "up-to-date" of pulmonary medicine and "hand-on courses" characterize the atmosphere at the Winteracademy," says Professor Christoph Lange of the Borstel Research Center, who co-chairs the event together with Professor Felix Herth of the University Thorax Clinic in Heidelberg.

Contact:

Prof. Dr. med. Dr. h.c. Christoph Lange 
Medical Director, Research Center Borstel, Leibniz Lung Center 
Professor of Respiratory Medicine & International Health, University of Lübeck
Parkallee 35
D-23845 Borstel
Germany

T +49 4537 188 3321/0
F +49 4537 188 6030
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Schon jetzt Rekordjahr: Früher Pollenflug durch milden Winter

Aufgrund der milden Temperaturen hat der Pollenflug in diesem Jahr bereits sehr früh begonnen, darüber berichtete der Norddeutsche Rundfunk (NDR) am Freitag in den Nachrichten aus Schleswig-Holstein. Das belegen die Daten der Pollenfalle am Forschungszentrum Borstel, Leibniz Lungenzentrum. Dr. Nestor Gonzalez Roldan, Leiter der Pollenmessstation am FZB, hat bereits im Januar eine hohe Anzahl an Pollenkörnern feststellen können.


Hier können Sie den gesamten Artikel hören und lesen:

Schleswig-Holstein aktuell: Nachrichten im Überblick

Schon jetzt Rekordjahr: Früher Pollenflug durch milden Winter | NDR.de - Nachrichten - Schleswig-Holstein

Erscheinungsdatum: 13.01.2023


Weitere Informationen

Kontakt:

Dr. Nestor Gonzalez Roldan
Dr. Nestor Gonzalez Roldan
 
 
 

 

 

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