Priority Research Area Chronic Lung Diseases

2023

Borio, A, Holgado, A, Passegger, C, Strobl, H, Beyaert, R, Heine, H & Zamyatina, A 2023, 'Exploring Species-Specificity in TLR4/MD-2 Inhibition with Amphiphilic Lipid A Mimicking Glycolipids', Molecules (Basel, Switzerland), Jg. 28, Nr. 16. https://doi.org/10.3390/molecules28165948

Vierbuchen, T, Agarwal, S, Johnson, JL, Galia, L, Lei, X, Stein, K, Olagnier, D, Gaede, KI, Herzmann, C, Holm, CK, Heine, H, Pai, A, O'Hara Hall, A, Hoebe, K & Fitzgerald, KA 2023, 'The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jg. 120, Nr. 1, S. e2213715120. https://doi.org/10.1073/pnas.2213715120

Volkmar, K, Jaedtka, M, Baars, I, Walber, B, Philipp, M-S, Bagola, K, Müller, AJ, Heine, H & van Zandbergen, G 2023, 'Investigating pyroptosis as a mechanism of L. major cell-to-cell spread in the human BLaER1 infection model', MOLECULAR MICROBIOLOGY. https://doi.org/10.1111/mmi.15142

 

2022

Heine, H & Zamyatina, A 2022, 'Therapeutic Targeting of TLR4 for Inflammation, Infection, and Cancer: A Perspective for Disaccharide Lipid A Mimetics', Pharmaceuticals (Basel, Switzerland), Jg. 16, Nr. 1, 23. https://doi.org/10.3390/ph16010023

Köllisch, G, Solis, FV, Obermann, H-L, Eckert, J, Müller, T, Vierbuchen, T, Rickmeyer, T, Muche, S, Przyborski, JM, Heine, H, Kaufmann, A, Baumeister, S, Lingelbach, K & Bauer, S 2022, 'TLR8 is activated by 5'-methylthioinosine, a Plasmodium falciparum-derived intermediate of the purine salvage pathway', Cell reports, Jg. 39, Nr. 2, S. 110691. https://doi.org/10.1016/j.celrep.2022.110691

Sirocko, K-T, Angstmann, H, Papenmeier, S, Wagner, C, Spohn, M, Indenbirken, D, Ehrhardt, B, Kovacevic, D, Hammer, B, Svanes, C, Rabe, KF, Roeder, T, Uliczka, K & Krauss-Etschmann, S 2022, 'Early-life exposure to tobacco smoke alters airway signaling pathways and later mortality in D. melanogaster', Environmental pollution (Barking, Essex : 1987), Jg. 309, S. 119696. https://doi.org/10.1016/j.envpol.2022.119696

Strobl, S, Hofbauer, K, Heine, H & Zamyatina, A 2022, 'Lipid A mimetics based on unnatural disaccharide scaffold as potent TLR4 agonists for prospective immunotherapeutics and adjuvants', Chemistry (Weinheim an der Bergstrasse, Germany), Jg. 28, Nr. 35, e202200547, S. e202200547. https://doi.org/10.1002/chem.202200547

 

2021

Bossen, J, Uliczka, K, Steen, L, Neugebauer, P, Mai, MM-Q, Fink, C, Stracke, F, Heine, H & Roeder, T 2021, 'Driver mutations in major lung cancer oncogenes can be analyzed in Drosophila models', ALTEX, Jg. 38, Nr. 2. https://doi.org/10.14573/altex.1912131

Brandenburg, J, Marwitz, S, Tazoll, SC, Waldow, F, Kalsdorf, B, Vierbuchen, T, Scholzen, T, Gross, A, Goldenbaum, S, Hölscher, A, Hein, M, Linnemann, L, Reimann, M, Kispert, A, Leitges, M, Rupp, J, Lange, C, Niemann, S, Behrends, J, Goldmann, T, Heine, H, Schaible, UE, Hölscher, C, Schwudke, D & Reiling, N 2021, 'WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis', Journal of Clinical Investigation, Jg. 131, Nr. 16, e141833. https://doi.org/10.1172/JCI141833

Heine, H, Adanitsch, F, Peternelj, TT, Haegman, M, Kasper, C, Ittig, S, Beyaert, R, Jerala, R & Zamyatina, A 2021, 'Tailored Modulation of Cellular Pro-inflammatory Responses With Disaccharide Lipid A Mimetics', FRONTIERS IN IMMUNOLOGY, Jg. 12, S. 631797. https://doi.org/10.3389/fimmu.2021.631797

Wagner, C, Uliczka, K, Bossen, J, Niu, X, Fink, C, Thiedmann, M, Knop, M, Vock, C, Abdelsadik, A, Zissler, UM, Isermann, K, Garn, H, Pieper, M, Wegmann, M, Koczulla, AR, Vogelmeier, CF, Schmidt-Weber, CB, Fehrenbach, H, König, P, Silverman, N, Renz, H, Pfefferle, P, Heine, H & Roeder, T 2021, 'Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways', Cell reports, Jg. 35, Nr. 1, S. 108956. https://doi.org/10.1016/j.celrep.2021.108956

 

2020

Herster, F, Bittner, Z, Archer, NK, Dickhöfer, S, Eisel, D, Eigenbrod, T, Knorpp, T, Schneiderhan-Marra, N, Löffler, MW, Kalbacher, H, Vierbuchen, T, Heine, H, Miller, LS, Hartl, D, Freund, L, Schäkel, K, Heister, M, Ghoreschi, K & Weber, ANR 2020, 'Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis', Nature communications, Jg. 11, Nr. 1, S. 1-13. https://doi.org/10.1038/s41467-019-13756-4

Komaniecka, I, Susniak, K, Chroma, A, Heine, H & Holst, O 2020, 'The Lipid A from the Lipopolysaccharide of the Phototrophic Bacterium Rhodomicrobium vannielii ATCC 17100 Revisited', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , Jg. 22, Nr. 1. https://doi.org/10.3390/ijms22010258

Wang, Z, Minarsch, E-ML, Kublik, S, Heine, H, Schloter, M & Foesel, BU 2020, 'Complete Genome Sequence of Lactococcus lactis subsp. lactis G121, an Isolate with Allergy-Protective Features Derived from a Farming Environment', Microbiology resource announcements, Jg. 9, Nr. 41. https://doi.org/10.1128/MRA.00777-20

Zamyatina, A & Heine, H 2020, 'Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways', FRONTIERS IN IMMUNOLOGY, Jg. 11, S. 585146. https://doi.org/10.3389/fimmu.2020.585146

 

2019

Bossen J, Uliczka K, Steen L, Pfefferkorn R, Mai MM, Burkhardt L, Spohn M, Bruchhaus I, Fink C, Heine H, Roeder T: An EGFR-Induced Drosophila Lung Tumor Model Identifies Alternative Combination Treatments. Mol Cancer Ther 2019, 18(9):1659-1668.

Freund I, Buhl DK, Boutin S, Kotter A, Pichot F, Marchand V, Vierbuchen T, Heine H, Motorin Y, Helm M, Dalpke AH, Eigenbrod T: 2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms. Rna 2019, 25(7):869-880.

Jappe U, Schwager C, Schromm AB, Gonzalez Roldan N, Stein K, Heine H, Duda KA: Lipophilic Allergens, Different Modes of Allergen-Lipid Interaction and Their Impact on Asthma and Allergy. Front Immunol 2019, 10:122.

Vierbuchen T, Stein K, Heine H: RNA is taking its Toll: Impact of RNA-specific Toll-like receptors on health and disease. Allergy 2019, 74(2):223-235.

 

2018

Adanitsch, F, Shi, J, Shao, F, Beyaert, R, Heine, H & Zamyatina, A 2018, 'Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics' Journal of Physical Chemistry B, Bd 9, Nr. 16, S. 3957-3963. DOI: 10.1039/c7sc05323a

Borio A, Holgado A, Garate JA, Beyaert R, Heine H, Zamyatina A, ‘Disaccharide-Based Anionic Amphiphiles as Potent Inhibitors of Lipopolysaccharide-Induced Inflammation’. ChemMedChem 2018, 13(21):2317-2331.

Vierbuchen, T., Stein, K., Hein, H., ‘RNA is taking its Toll - Impact of RNA-specific Toll-like receptors on health and disease’. Allergy 2018 Nov 26. doi: 10.1111/all.13680. [Epub ahead of print].

 

2017

Gorczynski, RM, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Heumann, D, Mach, J-P, Rietschel, ET, Ulmer, AJ, Zähringer, U, Yu, K & Khatri, I 2017, 'An altered REDOX environment, assisted by over-expression of fetal hemoglobins, protects from inflammatory colitis and reduces inflammatory cytokine expression' INTERNATIONAL IMMUNOPHARMACOLOGY , Bd 50, Nr. (2017), S. 69-76.

Lindner, K, Ströbele, M, Schlick, S, Webering, S, Jenckel, A, Kopf, J, Danov, O, Sewald, K, Buj, C, Creutzenberg, O, Tillmann, T, Pohlmann, G, Ernst, H, Ziemann, C, Hüttmann, G, Heine, H, Bockhorn, H, Hansen, T, König, P & Fehrenbach, H 2017, 'Biological effects of carbon black nanoparticles are changed by surface coating with polycyclic aromatic hydrocarbons' Particle and Fibre Toxicology, Bd 14, Nr. 1, S. 8. DOI: 10.1186/s12989-017-0189-1

Stein, K, Brand, S, Jenckel, A, Sigmund, A, Chen, ZJ, Kirschning, CJ, Kauth, M & Heine, H 2017, 'Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects' The Journal of allergy and clinical immunology, Bd 139, Nr. 2, S. 667-678. DOI: 10.1016/j.jaci.2016.06.018

Bang, C, Vierbuchen, T, Gutsmann, T, Heine, H & Schmitz, RA 2017, 'Immunogenic properties of the human gut-associated archaeon Methanomassiliicoccus luminyensis and its susceptibility to antimicrobial peptides' PLOS ONE, Bd 12, Nr. 10, S. e0185919. DOI: 10.1371/journal.pone.0185919

Jatzlauk, G, Bartel, S, Heine, H, Schloter, M & Krauss-Etschmann, S 2017, 'Influences of environmental bacteria and their metabolites on allergies, asthma and host microbiota' ALLERGY, Bd 72, Nr. 12, S. 1859-1867. DOI: 10.1111/all.13220

Pooe, OJ, Köllisch, G, Heine, H & Shonhai, A 2017, 'Plasmodium falciparum heat shock protein 70 lacks immune modulatory activity' PROTEIN AND PEPTIDE LETTERS, Bd 24, Nr. 6, S. 503-510. DOI: 10.2174/0929866524666170214141909