Priority Research Area Infections
Evolution of the Resistome
Mission Projects Funding Techniques Staff
The global rise of antimicrobial resistance (AMR) is a public health crisis. The human microbiome and all associated resistance genes ("the resistome") are under constant evolutionary pressure. Disease, treatment, microbiome cross-talk, and the host immune system can change the composition of host microbes ("dysbiosis") or select for antimicrobial resistances. We employ laboratory evolution experiments and microbial genomics, such as whole (meta)genome sequencing, to understand bacterial evolutionary pathways that influence disease progression or treatment outcomes. In the long run, we seek to identify improved therapies which reduce or prevent pathogen adaptation, e.g. resistance evolution, and preserve a healthy microbiome.