Priority Research Area Infections

Evolution of the Resistome

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We are particularly interested in the changes of the microbiome composition in patients treated for tuberculosis, or other lung infections as well as bronchial carcinoma. Therefore, we analyze within the Schleswig-Holstein Excellence Cluster "Precision Medicine in chronic Inflammation" (PMI) the microbiome of stool and bronchoscopy specimens. Furthermore, we sought to identify and isolate key bacterial species which potentially influence therapy outcomes.

In the near future we plan evolutionary experiments to analyze the adaptation of lung pathogens especially under therapy conditions. Are there possibly therapeutic interventions which can stall or reverse antibiotic resistance evolution?