Priority Research Area Infections

2022

Brandenburg, J, Heyckendorf, J, Marwitz, F, Zehethofer, N, Linnemann, L, Gisch, N, Karaköse, H, Reimann, M, Kranzer, K, Kalsdorf, B, Sanchez-Carballo, P, Weinkauf, M, Scholz, V, Malm, S, Homolka, S, Gaede, KI, Herzmann, C, Schaible, UE, Hölscher, C, Reiling, N & Schwudke, D 2022, 'Tuberculostearic Acid-Containing Phosphatidylinositols as Markers of Bacterial Burden in Tuberculosis', ACS infectious diseases, Jg. 8, Nr. 7, S. 1303-1315. https://doi.org/10.1021/acsinfecdis.2c00075

Kokesch-Himmelreich, J, Treu, A, Race, AM, Walter, K, Hölscher, C & Römpp, A 2022, 'Do Anti-tuberculosis Drugs Reach Their Target?─High-Resolution Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Provides Information on Drug Penetration into Necrotic Granulomas', ANALYTICAL CHEMISTRY , Jg. 94, Nr. 14, S. 5483-5492. https://doi.org/10.1021/acs.analchem.1c03462

Osterloh, A 2022, 'Vaccination against Bacterial Infections: Challenges, Progress, and New Approaches with a Focus on Intracellular Bacteria', Vaccines, Jg. 10, Nr. 5, 751. https://doi.org/10.3390/vaccines10050751

Ritter, K, Behrends, J, Rückerl, D, Hölscher, A, Volz, J, Prinz, I & Hölscher, C 2022, 'High-Dose Mycobacterium tuberculosis H37rv Infection in IL-17A- and IL-17A/F-Deficient Mice', Cells, Jg. 11, Nr. 18, 2875. https://doi.org/10.3390/cells11182875

Ritter, K, Rousseau, J & Hölscher, C 2022, 'Interleukin-27 in Tuberculosis: A Sheep in Wolf's Clothing?', FRONTIERS IN IMMUNOLOGY, Jg. 12, S. 810602. https://doi.org/10.3389/fimmu.2021.810602

Walter, K, Kokesch-Himmelreich, J, Treu, A, Waldow, F, Hillemann, D, Jakobs, N, Lemm, A-K, Schwudke, D, Römpp, A & Hölscher, C 2022, 'Interleukin-13 overexpressing mice represent an advanced pre-clinical model for detecting the distribution of anti-mycobacterial drugs within centrally necrotizing granulomas', ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Jg. 66, Nr. 6, S. e0158821. https://doi.org/10.1128/AAC.01588-21

 

2021

Brandenburg, J, Marwitz, S, Tazoll, SC, Waldow, F, Kalsdorf, B, Vierbuchen, T, Scholzen, T, Gross, A, Goldenbaum, S, Hölscher, A, Hein, M, Linnemann, L, Reimann, M, Kispert, A, Leitges, M, Rupp, J, Lange, C, Niemann, S, Behrends, J, Goldmann, T, Heine, H, Schaible, UE, Hölscher, C, Schwudke, D & Reiling, N 2021, 'WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis', Journal of Clinical Investigation, Jg. 131, Nr. 16, e141833. https://doi.org/10.1172/JCI141833

Killy, B, Bodendorfer, B, Mages, J, Ritter, K, Schreiber, J, Hölscher, C, Pracht, K, Ekici, A, Jäck, H-M & Lang, R 2021, 'DGCR8 deficiency impairs macrophage growth and unleashes the interferon response to mycobacteria', Life Science Alliance, Jg. 4, Nr. 6. https://doi.org/10.26508/lsa.202000810

Lösslein, AK, Lohrmann, F, Scheuermann, L, Gharun, K, Neuber, J, Kolter, J, Forde, AJ, Kleimeyer, C, Poh, YY, Mack, M, Triantafyllopoulou, A, Dunlap, MD, Khader, SA, Seidl, M, Hölscher, A, Hölscher, C, Guan, XL, Dorhoi, A & Henneke, P 2021, 'Monocyte progenitors give rise to multinucleated giant cells', Nature communications, Jg. 12, Nr. 1, S. 2027. https://doi.org/10.1038/s41467-021-22103-5

Osterloh, A 2021, 'Vaccine design and vaccination strategies against rickettsiae', Vaccines, Jg. 9, Nr. 8, S. 896. https://doi.org/10.3390/vaccines9080896

Osterloh, A, Rauch, J, Barton, J, Kwiatkowski, M, Wunderlich, M, Steffen, P, Moderzynski, K, Papp, S, Höhn, K, Schwanke, H, Witt, S, Richardt, U, Mehlhoop, U, Schlüter, H, Pianka, V, Fleischer, B & Tappe, D 2021, 'GroEL is an immunodominant surface-exposed antigen of Rickettsia typhi', PLOS ONE, Jg. 16, Nr. 6. https://doi.org/10.1371/journal.pone.0253084

Ritter, K, Behrends, J, Erdmann, H, Rousseau, J, Hölscher, A, Volz, J, Prinz, I, Lindenstrøm, T & Hölscher, C 2021, 'Interleukin-23 instructs protective multifunctional CD4 T cell responses after immunization with the Mycobacterium tuberculosis subunit vaccine H1 DDA/TDB independently of interleukin-17A', JOURNAL OF MOLECULAR MEDICINE-JMM , Jg. 99, Nr. 11, S. 1585-1602. https://doi.org/10.1007/s00109-021-02100-3

Schumacher, N, Yan, K, Gandraß, M, Müller, M, Krisp, C, Häsler, R, Carambia, A, Nofer, J-R, Bernardes, JP, Khouja, M, Thomsen, I, Chalupsky, K, Bolik, J, Hölscher, C, Wunderlich, T, Herkel, J, Rosenstiel, P, Schramm, C, Schlüter, H, Renné, T, Mittrücker, H-W, Rose-John, S & Schmidt-Arras, D 2021, 'Cell-autonomous hepatocyte-specific GP130 signaling is sufficient to trigger a robust innate immune response in mice', Journal of hepatology, Jg. 74, Nr. 2, S. 407-418. https://doi.org/10.1016/j.jhep.2020.09.021

Theobald, SJ, Gräb, J, Fritsch, M, Suárez, I, Eisfeld, HS, Winter, S, Koch, M, Hölscher, C, Pasparakis, M, Kashkar, H & Rybniker, J 2021, 'Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages', Cell death discovery, Jg. 7, Nr. 1, 327. https://doi.org/10.1038/s41420-021-00716-5

Walter, K, Kokesch-Himmelreich, J, Treu, A, Waldow, F, Hillemann, D, Jakobs, N, Lemm, A-K, Schwudke, D, Römpp, A & Hölscher, C 2021, 'Interleukin-13 overexpressing mice represent an advanced pre-clinical model for detecting the distribution of anti-mycobacterial drugs within centrally necrotizing granulomas', ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, S. AAC0158821. https://doi.org/10.1128/AAC.01588-21

 

2020

Almanan, M, Raynor, J, Ogunsulire, I, Malyshkina, A, Mukherjee, S, Hummel, SA, Ingram, JT, Saini, A, Xie, MM, Alenghat, T, Way, SS, Deepe, GS, Divanovic, S, Singh, H, Miraldi, E, Zajac, AJ, Dent, AL, Hölscher, C, Chougnet, C & Hildeman, DA 2020, 'IL-10-producing Tfh cells accumulate with age and link inflammation with age-related immune suppression', Science advances, Jg. 6, Nr. 31, S. eabb0806. https://doi.org/10.1126/sciadv.abb0806

Bartsch, YC, Eschweiler, S, Leliavski, A, Lunding, HB, Wagt, S, Petry, J, Lilienthal, G-M, Rahmöller, J, de Haan, N, Hölscher, A, Erapaneedi, R, Giannou, AD, Aly, L, Sato, R, de Neef, LA, Winkler, A, Braumann, D, Hobusch, J, Kuhnigk, K, Krémer, V, Steinhaus, M, Blanchard, V, Gemoll, T, Habermann, JK, Collin, M, Salinas, G, Manz, RA, Fukuyama, H, Korn, T, Waisman, A, Yogev, N, Huber, S, Rabe, B, Rose-John, S, Busch, H, Berberich-Siebelt, F, Hölscher, C, Wuhrer, M & Ehlers, M 2020, 'IgG Fc sialylation is regulated during the germinal center reaction following immunization with different adjuvants', The Journal of allergy and clinical immunology. https://doi.org/10.1016/j.jaci.2020.04.059

Hölscher, C, Gräb, J, Hölscher, A, Müller, AL, Schäfer, SC & Rybniker, J 2020, 'Chemical p38 MAP kinase inhibition constrains tissue inflammation and improves antibiotic activity in Mycobacterium tuberculosis-infected mice', Scientific Reports, Jg. 10, Nr. 1, S. 13629. https://doi.org/10.1038/s41598-020-70184-x

Osterloh, A 2020, 'The neglected challenge: Vaccination against rickettsiae', PLoS Neglected Tropical Diseases, Jg. 14, Nr. 10, S. e0008704. https://doi.org/10.1371/journal.pntd.0008704

Ritter, K, Sodenkamp, JC, Hoelscher, A, Behrends, J & Hölscher, C 2020, 'IL-6 is not Absolutely Essential for the Development of a TH17 Immune Response after an Aerosol Infection with Mycobacterium Tuberculosis H37rv', Cells, Jg. 10, Nr. 1. https://doi.org/10.3390/cells10010009

Ritter, K, Rousseau, J & Hölscher, C 2020, 'The Role of gp130 Cytokines in Tuberculosis', Cells, Jg. 9, Nr. 12. https://doi.org/10.3390/cells9122695

Treu, A, Kokesch-Himmelreich, J, Walter, K, Hölscher, C & Römpp, A 2020, 'Integrating High-Resolution MALDI Imaging into the Development Pipeline of Anti-Tuberculosis Drugs', Journal of the American Society for Mass Spectrometry, Jg. 31, Nr. 11, S. 2277-2286. https://doi.org/10.1021/jasms.0c00235

 

2019

Chakievska, L, Holtsche, MM, Künstner, A, Goletz, S, Petersen, B-S, Thaci, D, Ibrahim, SM, Ludwig, RJ, Franke, A, Sadik, CD, Zillikens, D, Hölscher, C, Busch, H & Schmidt, E 2019, 'IL-17A is functionally relevant and a potential therapeutic target in bullous pemphigoid', Journal of autoimmunity, Jg. 2019, Nr. 96, S. 104-112. https://doi.org/10.1016/j.jaut.2018.09.003

Gräb, J, Suárez, I, van Gumpel, E, Winter, S, Schreiber, F, Esser, A, Hölscher, C, Fritsch, M, Herb, M, Schramm, M, Wachsmuth, L, Pallasch, C, Pasparakis, M, Kashkar, H & Rybniker, J 2019, 'Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition', Nature communications, Jg. 10, Nr. 1, S. 688. https://doi.org/10.1038/s41467-019-08405-9

Ring, S, Eggers, L, Behrends, J, Wutkowski, A, Schwudke, D, Kröger, A, Hierweger, AM, Hölscher, C, Gabriel, G & Schneider, B 2019, 'Blocking IL-10 receptor signaling ameliorates Mycobacterium tuberculosis infection during influenza-induced exacerbation', JCI Insight, Jg. 5. https://doi.org/10.1172/jci.insight.126533

 

2018

Chakievska, L, Holtsche, MM, Künstner, A, Goletz, S, Petersen, BS, Thaci, D, Ibrahim, SM, Ludwig, RJ, Franke, A, Sadik, CD, Zillikens, D, Hölscher, C, Busch, H & Schmidt, E 2018, „IL-17A is functionally relevant and a potential therapeutic target in bullous pemphigoid“, J AUTOIMMUN. doi: 10.1016/j.jaut.2018.09.003.

Erdmann, H, Behrends, J, Ritter, K, Hölscher, A, Volz, J, Rosenkrands, I & Hölscher, C 2018, 'The increased protection and pathology in Mycobacterium tuberculosis-infected IL-27R-alpha-deficient mice is supported by IL-17A and is associated with the IL-17A-induced expansion of multifunctional T cells' Mucosal immunology. DOI: 10.1038/s41385-018-0026-3

Holz, K, Prinz, M, Brendecke, SM, Hölscher, A, Deng, F, Mitrücker, H-W, Rose-John, S & Hölscher, C 2018, 'Differing Outcome of Experimental Autoimmune Encephalitis in Macrophage/Neutrophil- and T Cell-Specific gp130-Deficient Mice' FRONTIERS IN IMMUNOLOGY, Bd 9, S. 836. DOI: 10.3389/fimmu.2018.00836

Mahin Abad Dar and Christoph Hölscher. Arginase-1 Is Responsible for IL-13-Mediated Susceptibility to Trypanosoma cruzi Infection. Front Immunol 2018; Volume 9: 2790; doi: 10.3389/fimmu.2018.02790

Stüve, P, Minarrieta, L, Erdmann, H, Arnold-Schrauf, C, Swallow, M, Guderian, M, Krull, F, Hölscher, A, Ghorbani, P, Behrends, J, Abraham, W-R, Hölscher, C, Sparwasser, TD & Berod, L 2018, 'Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages' FRONTIERS IN IMMUNOLOGY, Bd 9, S. 495. DOI: 10.3389/fimmu.2018.00495

Uwe Müller, Günter A. Schaub, Horst Mossmann, Gabriele Köhler, Rita Carsetti and Christoph Hölscher. Immunosuppression in Experimental Chagas Disease Is Mediated by an Alteration of Bone Marrow Stromal Cell Function During the Acute Phase of Infection. Front Immunol 2018; Volume 9: 2794; doi: 10.3389/fimmu.2018.02794

 

2017

Deng, F, Chen, Y, Zheng, J, Huang, Q, Cao, X, Zillikens, D, Petersen, F & Yu, X 2017, 'CD11b-deficient mice exhibit an increased severity in the late phase of antibody transfer-induced experimental epidermolysis bullosa acquisita' EXPERIMENTAL DERMATOLOGY , Bd 26, Nr. 12, 12, S. 1175-1178. DOI: 10.1111/exd.13434

Schmok, E, Abad Dar, M, Behrends, J, Erdmann, H, Rückerl, D, Endermann, T, Heitmann, L, Hessmann, M, Yoshimura, A, Rose-John, S, Scheller, J, Schaible, UE, Ehlers, S, Lang, R & Hölscher C 2017 „Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis“ FRONT IMMUNOL Bd 8, S 1537. doi: 10.3389/fimmu.2017.01537. eCollection 2017.

Zheng, J, Huang, Q, Huang, R, Deng, F, Yue, X, Yin, J, Zhao, W, Chen, Y, Wen, L, Zhou, J, Huang, R, Riemekasten, G, Liu, Z, Petersen, F & Yu, X 2017, 'B Cells Are Indispensable for a Novel Mouse Model of Primary Sjögren's Syndrome' Frontiers in Immunology, Bd 8, S. 1384. DOI: 10.3389/fimmu.2017.01384