Priority Research Area Asthma and Allergy

Biofunctional Metabolites and Structures

Mission   Projects   Funding   Techniques   Publications    Staff



Marchetti, R, Fabregat, FN, Pallach, M, Gully, D, Giraud, E, Molinaro, A, Duda, KA & Silipo, A 2021, 'The peculiar structure of Acetobacter pasteurianus CIP103108 LPS core oligosaccharide', Chembiochem : a European journal of chemical biology, Jg. 22, Nr. 1, S. 147-150.



Dudeck, A., Köberle, M., Goldmann, O., Meyer, N.,  Dudeck, J., Lemmens, S., Rohde, M., González Roldán, N., Dietze-Schwonberg, K., Orinska, Z., Medina, E., Hendrix, S., Metz, M., Zenclussen, A.C., von Stebut, E., Biedermann, T. 2019. Mast cells as protectors of health. J Allergy Clin Immunol. 144(4S):S4-S18. doi: 10.1016/j.jaci.2018.10.054

González Roldán, N., Engel, R., Düpow, S., Jakob, K., Koops, F., Orinska, F., Vigor, C., Oger, C., Galano, J-M., Durand, T., Jappe, U., Duda, K.A. 2019. Lipid mediators from Timothy grass pollen contribute to the effector phase of allergy and prime dendritic cells for glycolipid presentation. Front Immunol. ;10:974. doi: 10.3389/fimmu.2019.00974. eCollection 2019

Jappe, U, Schwager, C, Schromm, A, González Roldán, N, Stein, K, Heine, H & Duda, K 2019, 'Lipophilic allergens, different modes of allergen-lipid interaction and their impact on asthma and allergy' Front Immunol. 10:122. doi: 10.3389/fimmu.2019.00122. eCollection 2019.

Li, C., Duda, K.A., Elverdal, P.L., Skovsted, I.C., Kjeldsen, C., Duus, JØ. 2019 Structural, biosynthetic and serological cross-reactive elucidation of capsular polysaccharides from Streptococcus pneumoniae serogroup 16. J Bacteriol. 201(20). pii: e00453-19. doi: 10.1128/JB.00453-19

Pallach, M., Di Lorenzo, F., Duda, K.A., Molinaro, A., Silipo, A. 2019. The Lipid A structure from the marine sponge symbiont Endozoicomonas sp. HEX 311. Chembiochem. 20(2):230-236. doi: 10.1002/cbic.201800441



Bönisch, E., Oh, Y.J., Anzengruber, J., Hager, F.F., López-Guzmán, A., Zayni, S., Hinterdorfer, P., Kosma, P., Messner, P., Duda, K.A.*, Schäffer, C*. 2018. Lipoteichoic acid mediates binding of a Lactobacillus S-layer protein. Glycobiology. 1;28(3):148-158. doi: 10.1093/glycob/cwx102.

Dudeck, A., Köberle, M., Goldmann, O., Meyer, N.,  Dudeck, J., Lemmens, S., Rohde, M., González Roldán, N., Dietze-Schwonberg, K., Orinska, Z., Medina, E., Hendrix, S., Metz, M., Zenclussen, A.C., von Stebut, E., Biedermann, T. 2018. Mast cells as protectors of health. JACI. Accepted.

Pallach, M., Di Lorenzo, F., Duda, K.A., Molinaro, A., Silipo, A. 2018. The Lipid A structure from the marine sponge symbiont Endozoicomonas sp. HEX 311. ChemBioChem. [Epub ahead of print]

Pallach, M., Di Lorenzo, F., Facchini, F.A., Gully, D., Giraud, E., Peri, F., Duda, K.A., Molinaro, A., Silipo, A. 2018. Structure and inflammatory activity of the LPS isolated from Acetobacter pasteurianus CIP103108. Int J Biol Macromol. 8;119:1027-1035. doi: 10.1016/j.ijbiomac.2018.08.035. [Epub ahead of print]

* corresponding authors 



Ling Choy, S., Bernin, H., Aiba, T.,  Bifeld, E.,  Lender, S.C.,  Mühlenpfordt, M., Noll, J.,  Eick, J., Marggraff, C., Niss, H., González Roldán, N., Tanaka, S., Kitamura, M., Fukase, K., Clos, J., Tannich, E., Fujimoto, Y. & Lotter, H. 2017. Synthetic analogs of an Entamoeba histolytica glycolipid designed to
combat intracellular Leishmania infection. Scientific Reports, DOI:10.1038/s41598-017-09894-8

Di Lorenzo, F., Palmigiano, A., Duda, K.A., Pallach, M., Busset, N., Sturiale, L., Giraud, E., Garozzo, D., Molinaro, A., Silipo, A. 2017. Structure of the Lipopolysaccharide from the Bradyrhizobium sp. ORS285 rfaL Mutant Strain. ChemistryOpen. 6(4):541-553

Di Lorenzo F., Palmigiano A., Al Bitar-Nehme S., Sturiale L., Duda K.A., Gully D., Lanzetta R., Giraud E., Garozzo D., Bernardini M.L., Molinaro A., Silipo A. 2017. The Lipid A from Rhodopseudomonas palustris Strain BisA53 LPS Possesses a Unique Structure and Low Immunostimulant Properties. Chemistry. 23(15):3637-3647.



Steffens T.*, Duda K. *, Lindner B., Vorhölter F.J., Bednarz H., Niehaus K., Holst O. 2016. The lipopolysaccharide of the crop pathogen Xanthomonas translucens pv. translucens: chemical characterization and determination of signaling events in plant cells. Glycobiology. 27(3):264-274

* Contributed equally

Gonzalez Roldan N, Orinska Z, Ewers H, Bulfone-Paus S. CD252 regulates mast cell mediated, CD1d-restricted NKT-cell activation in mice. Eur J Immunol. 2016 Feb; 46(2):432-9.

Duda K.A., Petersen S., Holst O. 2016. Structural characterization of the lipoteichoic acid isolated from Staphylococcus sciuri W620. Carbohydr Res. 430:44-47.

Kenyon* J. J., Duda* K. A., De Felice A., Cunneen M. M., Molinaro A., Laitinen J., Skurnik M., Holst O., Reeves P. R. and De Castro C. 2016. Serotype O:8 isolates in the Yersinia pseudotuberculosis complex have different O-antigen gene clusters and produce various forms of rough LPS. Innate Immunity. 22(3):2015-217. * contributed equally

Diederich A. K., Duda K. A., Romero-Saavedra F., Engel R., Holst O., Huebner J. 2016. Deletion of fabN in Enterococcus faecalis results in unsaturated fatty acid auxotrophy and decreased release of inflammatory cytokines. Innate Immunity. pii: 1753425916639669. [Epub ahead of print]



Diercks H, Semeniuk A, Gisch N, Moll H, Duda K.A., Hölzl G. 2015. Accumulation of novel Glycolipids and Ornithine Lipids in Mesorhizobium loti under Phosphate Deprivation. J Bacteriol. 197(3):497. IF 2.8

Turska-Szewczuk A, Pietras H, Duda K.A., Kozińska A, Pękala A, Holst O. 2015. Structure of the O-specific polysaccharide from the lipopolysaccharide of Aeromonas sobria strain Pt312. Carbohydr Res. 403:142. IF 1.93

Lind M., Sipka A.S., Schuberth H.-J, Blutke A., Wanke R., Sauter-Louis C., Duda K.A., Holst O., Rainard P., Germon P., Zerbe H. and Petzl W. 2015. Location specific expression of chemokines, TNF-a and S100 proteins in a teat explant model. Innate Immunity. 21(3):322. IF 3.27

Noszczyńska M., Kasperkiewicz K., Duda K.A., Podhorodecka J., Rabsztyn K., Gwizdała K., Swierzko A.S., Radziejewska-Lebrecht J., Holst O., Skurnik M. 2015. Serological characterization of the enterobacterial common antigen substitution of the lipopolysaccharide of Yersinia enterocolitica O:3. Microbiology. 161:219 IF 2.56

Danis-Wlodarczyk K., Olszak T., Arabski M., Wasik S., Majkowska-Skrobek G., Augustyniak D., Gula G., Briers Y., Jang H.B., Vandenheuvel D., Duda K. A., Lavigne R., Drulis-Kawa Z. 2015. Characterization of the Newly Isolated Lytic Bacteriophages KTN6 and KT28 and Their Efficacy against Pseudomonas aeruginosa Biofilm. PLoS One. 10(5): e0127603. doi:10.1371/journal.pone.0127603  IF 3.23

Kasperkiewicz K., Swierzko A.S., Bartlomiejczyk M.A., Cedzynski M., Noszczynska M., Duda K.A., Michalski M., Skurnik M. 2015. Interaction of human mannose-binding lectin (MBL) with Yersinia enterocolitica lipopolysaccharide. Int J Med Microbiol. 305(6):544. IF 3.6

Megson Z. A., Pittenauer E., Duda K. A., Engel R., Ortmayr K., Koellensperger G., Mach L., Allmaier G., Holst O., Messner P. & Schäffer C. 2015. Inositol-phosphodihydroceramides in the periodontal pathogen Tannerella forsythia: Structural analysis and incorporation of exogenous myo-inositol. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1851(11):1417. IF 5.16



Komaniecka I., Choma A., Mazur A., Duda K.A., Lindner B., Schwudke D., Holst O. 2014. Occurrence of an unusual hopanoid-containing lipid A among lipopolysaccharides from Bradyrhizobium species. J Biol Chem. 289: 35644. IF 4.6

Turska-Szewczuk A., Duda K.A., Schwudke D., Pekala A., Kozinska A., Holst O. 2014. Structural Studies of the Lipopolysaccharide from the Fish Pathogen Aeromonas veronii Strain Bs19, Serotype O16. Mar. Drugs.12:1298. IF 2.85

Neiwert O., Holst O., Duda K.A. 2014. Structural investigation of rhamnose-rich polysaccharides from Streptococcus dysgalactiae bovine mastitis isolate. Carbohydr Res. 389:192. IF 1.93

Semeniuk A., Sohlenkamp Ch., Duda K., Hölzl G. 2014. A bifunctional glycosyltransferase from Agrobacterium tumefaciens synthesizes monoglucosyl and glucuronosyl diacylglycerol under phosphate deprivation. J Biol Chem. 289:10104. IF 4.57



Lotter H, Helk E, Bernin H, Jacobs T, Prehn C, Adamski J, González-Roldán N, Holst O, Tannich E. 2013. Testosterone increases susceptibility to amebic liver abscess in mice and mediates inhibition of IFNγ secretion in natural killer T cells. PLoS One. 8(2):e55694.

Sandig H, Jobbings CE, Roldan NG, Whittingham-Dowd JK, Orinska Z, Takeuchi O, Akira S, Bulfone-Paus S. 2013. IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation. Eur J Immunol. 43(4):979-88.

Duda K.A., Fruth A., Holst O. 2013. Structural studies of the O-antigenic polysaccharide of the bovine mastitis isolate Escherichia coli serotype O174. Carbohydr Res. 373:18. IF 1.93

Czabańska A., Holst O., Duda K.A. 2013. Chemical structures of the secondary cell wall polymers (SCWPs) isolated from bovine mastitis Streptococcus uberis. Carbohydr Res. 377:58. IF 1.93

Muszyński A., Rabsztyn K., Knapska K., Duda K.A., Duda-Grychtoł K., Kasperkiewicz K., Radziejewska-Lebrecht J., Holst O., Skurnik M. 2013. Enterobacterial common antigen and O-specific polysaccharide coexist in the lipopolysaccharide of Yersinia enterocolitica serotype O:3. Microbiology. 8:1782. IF 2.56

Hong Y., Duda K.A., Cunneen M.M., Holst O., Reeves P.R. 2013. The WbaK acetyltransferase of Salmonella enteric group E gives insights into O antigen evolution. Microbiology. 11:2316. IF 2.56



Czabanska A.*, Neiwert O.*, Lindner B., Leigh J., Holst O., Duda K.A. 2012. Structural analysis of the lipoteichoic acids isolated from bovine mastitis Streptococcus uberis 233, S. dysgalactiae 2023 and S. agalactiae 0250. Carbohydr Res. 361:200. IF 1.96 *  equal contribution

Beczała A., Duda K.A., Skurnik M., Holst O. 2012. The structure of the O-specific polysaccharide of the lipopolysaccharide from Yersinia enterocolitica serotype O:50 strain 3229. Carbohydr Res. 359:97.



Rabsztyn K., Kasperkiewicz K., Duda K.A., Li C-M., Łukasik M., Radziejewska-Lebrecht J., Skurnik M. 2011. Characterization of the anti-ECA antibodies in rabbit antiserum against rough Yersinia enterocolitica O:3. Biochemistry (Mosc). 76(7):832-839.

Duda K.A., Lindner B., Brade H., Leimbach A., Brzuszkiewicz E., Dobrindt U., Holst O. 2011. The lipopolysaccharide of the mastitis isolate Escherichia coli strain 1303 comprises a novel O-antigen and the rare K-12 core type. Microbiology. 157(6):1750-1760.



Duda K.A., Duda K.T., Beczała A., Kasperkiewicz K., Radziejewska-Lebrecht J., Skurnik M. 2009. ECA-immunogenicity of Proteus mirabilis strains. Arch Immunol Ther Exp. 57(2):147.

Hannelore Lotter *, Nestor Gonzalez-Roldan *, Buko Lindner, Florian Winau, Armando Isibasi, Martha Moreno-Lafont, Otto Holst, Egbert Tannich and Thomas Jacobs. 2009. Natural Killer T cells activated by a lipopeptidophosphoglycan from Entamoeba histolytica are critically important to control liver abscess. PLoS Pathog. 5(5):e1000434.

* Contributed equally



Borowski S., Michalik D., Reinke H., Vogel C., Hanuszkiewicz A., Duda K.A., Holst O. 2008. Synthesis of methyl 2-acetamido-2,6-dideoxy-alpha- and beta-d-xylo-hexopyranosid-4-ulose, a keto sugar which misled the analytical chemists. Carbohydr Res. 343(6):1004-11.



Wong-Baeza I *, Gonzalez-Roldan N *, Ferat-Osorio E, Esquivel-Callejas N, Aduna-Vicente R, Arriaga-Pizano L, Astudillo-de la Vega H, Villasis-Keever MA, Torres-Gonzalez R, Estrada-Garcia I, Lopez-Macias C, Isibasi A. 2006. Triggering receptor expressed on myeloid cells (TREM-1) is regulated post-transcriptionally and its ligand is present in the sera of some septic patients. Clin Exp Immunol. 145(3):448-55.



Gonzalez-Roldan N, Ferat-Osorio E, Aduna-Vicente R, Wong-Baeza I, Esquivel-Callejas N, Astudillo-de la Vega H, Sanchez-Fernandez P, Arriaga-Pizano L, Villasis-Keever MA, Lopez-Macias C, Isibasi A. 2005. Expression of triggering receptor on myeloid cell 1 and histocompatibility complex molecules in sepsis and major abdominal surgery. World J Gastroenterol. 11(47):7473-9.