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Diagnostic Mycobacteriology

Dr. med. Inna Friesen, MSc
Dr. med. Inna Friesen, MSc
+49 4537 / 188-2110
+49 4537 / 188-3110
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Dr. med. Martin Kuhns
Dr. med. Martin Kuhns
+49 4537 / 188-2075
+49 4537 / 188-3110
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As part of the worldwide laboratory network of the WHO, the German National Reference Laboratory for mycobacteria (NRL) acts as a Supranational Reference Laboratory since 1995. Since 2008, the NRL coordinates and provides samples for external quality assurance in the field of mycobacterial diagnostics, organized by INSTAND e-V. Düsseldorf. On a daily basis consultancy is provided for laboratories and clinics concerning diagnostics and therapy of mycobacterial diseases. The research of the NRL focusses on the topics “evaluation of new techniques for the improvement of diagnostics”, “resistance of tuberculosis”, and “variability of clinical mycobacterial isolates”.

 

Diagnostic procedures:

  • Susceptibility testing of second line drugs
  • Evaluation of line probe assays
  • Evaluation of a immunochromatographic test for identification of TB-bacteria
  • Evaluation and precision study of a direct test for detection of TB-bacteria and RMP resistance
  • Effectiveness of Mycobacteria Growth Indicator Tube (MGIT) for Detection of Pulmonary Tuberculosis and Drug Susceptibility Testing (DST) in High PDR/MDR TB Burden Countries
  • Research on new mechanisms responsible for resistance against EMB

 

Epidemiological studies:

  • on all drug resistant M. tuberculosis isolates from Germany
  • on all culture positive TB cases from Hamburg, Hannover, Frankfurt, Schleswig-Holstein, and Baden-Württemberg

 

Surveillance in ‚high-incidence’ countries:

  • Study on the development of resistances and the spread of MDR strains in Uzbekistan
  • TB-Surveillance in Armenia and Azerbaijan

 

Further projects:

  • Establishment of a network for external quality control for second line drug testing (Baltic Nordic TB-Laboratory Network; EU)
  • Analysis of the effectivity of disinfectants against mycobacteria
  • Analysis of the activity of new drugs against mycobacteria
  • Research network on susceptibility and resistance against infection with non tuberculous mycobacteria

 

Federal Ministry of Health

  • National Reference Laboratory for Mycobacteria
  • MetaCorDia: Metagenomics laboratory for the detection of corona viruses in respiratory patient materials & Structured medical initial assessment (SmE), rapid diagnosis in the context of a corona virus outbreak and new antiviral substances at the FZB, 2020 - 2022
  • CoroDia: Expansion of corona testing capacity in southern Schleswig-Holstein, 2020-2021
  • PHIMS-TB: Public Health contribution of a nationwide integrated molecular surveillance using the example of tuberculosis, 2020 - 2022

Robert-Koch-Institute

  • MIRU-VNTR Re-Typing of strains from a longitudinal epidemiological study and performance of a study for data linkage with the RKI

European Union

  • Pan-European network for the study and clinical management of drug resistant tuberculosis
  • ETBRA: European tuberculosis regimen accelerator, 2020-

Foundation for Innovative New Diagnostics (FIND)

  • Effectiveness of Mycobacteria Growth Indicator Tube (MGIT) for Detection of Pulmonary Tuberculosis and Drug Susceptibility Testing (DST) in High PDR/MDR TB Burden Countries
  • Precision study of an assay for direct detection of MTB and RMP resistance
  • Preparation of slides for evaluation of a new technique for microscopy

Foundations

  • Society of Schleswig-Holstein for prevention and combat of tuberculosis and lung diseases: Population structure and diversity of M. tuberculosis isolates from Schleswig-Holstein
  • Mukoviszidose e.V.: CronoClone: Clinical relevance of nontuberculous mycobacteria recovered from cystic fibrosis patients and genome changes in highly virulent clones, 2020-2023

 

  • Microscopy: 
    Rapid detection of acid fast bacilli by means of Ziehl-Neelsen-, Kinyoun-, and Auramin-staining
  • Primary isolation:
    Culture for mycobacteria is performed from all biological specimens by using liquid (MGIT 960, BACTEC 9050, BACTEC 460) and solid media (Löwenstein-Jensen, Stonebrink, Middlebrook)
  • Identification and differentiation:
    Identification of mycobacteria grown in culture media is performed with the aid of molecular techniques (line probe assays, sequencing of specific genes (16S rDNA, ITS, hsp65), spoligotyping)
  • Susceptibilty testing of first- and second line drugs:
    Susceptibility testing is performed using the MGIT 960 system and on Löwenstein-Jensen slants.
    Rapid detection of mutations associated with resistance against INH and RMP by using molecular techniques.
  • Epidemiological techniques:
    Fingerprint techniques are performed on TB strains for the confirmation of transmission or in cases suspect of laboratory cross contamination (IS6110-fingerprinting, Spoligotyping, and MIRU-VNTR-analysis).

 

2024

Blankson, HNA, Kamara, RF, Barilar, I, Andres, S, Conteh, OS, Dallenga, T, Foray, L, Maurer, F, Kranzer, K & Utpatel, C et al. 2024, 'Molecular determinants of multidrug-resistant tuberculosis in Sierra Leone', Microbiology spectrum, Jg. 12, Nr. 3, S. e0240523. https://doi.org/10.1128/spectrum.02405-23

de Vos, M, David, A, Duraisamy, K, Nadarajan, D, Noroc, E, Penn-Nicholson, A, Crudu, V, Giri, S, Maurer, FP & Pati, S et al. 2024, 'Accuracy of cobas MTB and MTB-RIF/INH for Detection of Mycobacterium tuberculosis and Drug Resistance', Journal of Molecular Diagnostics, Jg. 26, Nr. 8, S. 708-718. https://doi.org/10.1016/j.jmoldx.2024.05.004

Friesen, I, Dreyer, V, Klingmüller, A, Zuber, S, Hoffmann, AM, Suárez, I, Schütz, B, Preßel, T, Andres, S & Niemann, S et al. 2024, 'First detection of a Mycobacterium tuberculosis XDR clinical isolate harbouring an RpoB I491F mutation in a Ukrainian patient treated in Germany, October 2023', Eurosurveillance, Jg. 29, Nr. 28. https://doi.org/10.2807/1560-7917.ES.2024.29.28.2400420

Friesen, I, Saluzzo, F, Groenheit, R, Aubry, A, Anthony, R, Niemann, S, Mathys, V, Cirillo, DM & TB European Reference Laboratory Network (ERLTB-Net-3) 2024, 'Re: 'Availability of drugs and resistance testing for BPaLM regimen for rifampicin-resistant tuberculosis in Europe' by Lange et al', CLINICAL MICROBIOLOGY AND INFECTION , Jg. 30, Nr. 9, S. 1204-1206. https://doi.org/10.1016/j.cmi.2024.06.001

Froböse, NJ, Theiler, T, Horn, D, Sußiek, J, Böing, C, Kuhns, M, Schuler, F, Raschke, M, Schaumburg, F & Roßlenbroich, SB 2024, 'Fracture-associated infection with Mycobacterium smegmatis in a 16-year old patient', Diagnostic microbiology and infectious disease, Jg. 110, Nr. 1, S. 116379. https://doi.org/10.1016/j.diagmicrobio.2024.116379

Gröschel, MI, Pérez-Llanos, FJ, Diel, R, Vargas, R, Escuyer, V, Musser, K, Trieu, L, Meissner, JS, Knorr, J & Klinkenberg, D et al. 2024, 'Differential rates of Mycobacterium tuberculosis transmission associate with host-pathogen sympatry', Nature Microbiology, Jg. 9, Nr. 8, S. 2113-2127. https://doi.org/10.1038/s41564-024-01758-y

Meiwes, L, Kontsevaya, I, Chesov, D, Kulciţkaia, S, Dreyer, V, Hillemann, D, Dlamini, Q, Williams, C, Barer, M & Brinkmann, F et al. 2024, 'Whispers in the wind: Face mask sampling for Mycobacterium tuberculosis detection in children with pulmonary tuberculosis', JOURNAL OF INFECTIOUS DISEASES. https://doi.org/10.1093/infdis/jiae282

Otto-Knapp, R, Bauer, T, Brinkmann, F, Feiterna-Sperling, C, Friesen, I, Geerdes-Fenge, H, Hartmann, P, Häcker, B, Heyckendorf, J & Kuhns, M et al. 2024, 'Treatment of MDR, Pre-XDR, XDR, and Rifampicin-Resistant Tuberculosis or in Case of Intolerance to at Least Rifampicin in Austria, Germany, and Switzerland', RESPIRATION, Jg. 103, Nr. 9, S. 593-600. https://doi.org/10.1159/000539410

Paulowski, L, Filip, R, Jankovic Makek, M, Guglielmetti, L, Goletti, D, van Ingen, J, Kranzer, K, Maurer, FP & ESGMYC 2024, 'Impact of the COVID-19 pandemic on the real-world diagnostic infrastructure for tuberculosis-An ESGMYC collaborative study', PLOS ONE, Jg. 19, Nr. 4, S. e0291404. https://doi.org/10.1371/journal.pone.0291404

Svensson, E, Ketelsen, H, Andres, S, Folkvardsen, DB, Hillemann, D, Conteh, O, Norman, A, Niemann, S, Lillebaek, T & Kuhns, M 2024, 'Dual-centre evaluation of the FluoroType MTBDR version 2 assay for detection of Mycobacterium tuberculosis complex and resistance-conferring mutations in pulmonary and extrapulmonary samples from Denmark, Germany and Sierra Leone', CLINICAL MICROBIOLOGY AND INFECTION , Jg. 30, Nr. 8, S. 1055-1060. https://doi.org/10.1016/j.cmi.2024.04.006

Trauth, J, Kantelhardt, V, Usenko, B, Knipper, M, Kuhns, M, Friesen, I & Herold, S 2024, 'Bedaquiline, pretomanid and linezolid in multidrug-resistant and pre-extensively drug-resistant tuberculosis in refugees from Ukraine and Somalia in Germany', The European respiratory journal, Jg. 63, Nr. 5. https://doi.org/10.1183/13993003.00303-2024

Wetzstein, N, Diricks, M, Andres, S, Kuhns, M, Marschall, L, Biciusca, T, Smaczny, C, Friesen, I, Niemann, S & Wichelhaus, TA 2024, 'Genomic diversity and clinical relevance of Mycobacterium simiae', ERJ Open Research, Jg. 10, Nr. 2, 00773-2023. https://doi.org/10.1183/23120541.00773-2023

Wetzstein, N, Diricks, M, Anton, TB, Andres, S, Kuhns, M, Kohl, TA, Schwarz, C, Lewin, A, Kehrmann, J & Kahl, BC et al. 2024, 'Clinical and genomic features of Mycobacterium avium complex: a multi-national European study', Genome medicine, Jg. 16, Nr. 1, S. 86. https://doi.org/10.1186/s13073-024-01359-8

 

2023

Brehm, TT, Köhler, N, Schmiedel, S, Terhalle, E, Martensen, J, Kalsdorf, B, Kandulla, J, Heyckendorf, J, Kuhns, M, Friesen, I & Lange, C 2023, 'Therapie der Tuberkulose: Was gibt es Neues?', Innere Medizin (Heidelberg, Germany), Jg. 64, Nr. 7, S. 701-707. https://doi.org/10.1007/s00108-023-01523-z

EUCAST AMST and ESCMYC study groups, Fröberg, G, Maurer, FP, Chryssanthou, E, Fernström, L, Benmansour, H, Boarbi, S, Mengshoel, AT, Keller, PM, Viveiros, M, Machado, D, Fitzgibbon, MM, Mok, S, Werngren, J, Cirillo, DM, Alcaide, F, Hyyryläinen, H-L, Aubry, A, Andres, S, Nadarajan, D, Svensson, E, Turnidge, J, Giske, CG, Kahlmeter, G, Cambau, E, van Ingen, J & Schön, T 2023, 'Towards clinical breakpoints for non-tuberculous mycobacteria - Determination of epidemiological cut off values for the Mycobacterium avium complex and Mycobacterium abscessus using broth microdilution', CLINICAL MICROBIOLOGY AND INFECTION , Jg. 29, Nr. 6, S. 758-764. https://doi.org/10.1016/j.cmi.2023.02.007

Koehler, N, Andres, S, Merker, M, Dreyer, V, John, A, Kuhns, M, Krieger, D, Choong, E, Verougstraete, N, Zur Wiesch, PA, Wicha, SG, König, C, Kalsdorf, B, Sanchez Carballo, PM, Schaub, D, Werngren, J, Schön, T, Peloquin, CA, Schönfeld, N, Verstraete, AG, Decosterd, LA, Aarnoutse, R, Niemann, S, Maurer, FP & Lange, C 2023, 'Pretomanid-Resistant Tuberculosis', Journal of infection, Jg. 86, Nr. 5, S. 520-524. https://doi.org/10.1016/j.jinf.2023.01.039

Maier, C, Chesov, D, Schaub, D, Kalsdorf, B, Andres, S, Friesen, I, Reimann, M & Lange, C 2023, 'Long-term treatment outcomes in patients with multidrug-resistant tuberculosis', CLINICAL MICROBIOLOGY AND INFECTION , Jg. 29, Nr. 6, S. 751-757. https://doi.org/10.1016/j.cmi.2023.02.013

Pérez-Llanos, FJ, Dreyer, V, Barilar, I, Utpatel, C, Kohl, TA, Murcia, MI, Homolka, S, Merker, M & Niemann, S 2023, 'Transmission Dynamics of a Mycobacterium tuberculosis Complex Outbreak in an Indigenous Population in the Colombian Amazon Region', Microbiology spectrum, S. e0501322. https://doi.org/10.1128/spectrum.05013-22

Rollo, RF, Mori, G, Hill, TA, Hillemann, D, Niemann, S, Homolka, S, Fairlie, DP & Blumenthal, A 2023, 'Wollamide Cyclic Hexapeptides Synergize with Established and New Tuberculosis Antibiotics in Targeting Mycobacterium tuberculosis', Microbiology spectrum, Jg. 11, Nr. 4, S. e0046523. https://doi.org/10.1128/spectrum.00465-23

TBNET and RESIST-TB networks, Domínguez, J, Boeree, MJ, Cambau, E, Chesov, D, Conradie, F, Cox, V, Dheda, K, Dudnyk, A, Farhat, MR, Gagneux, S, Grobusch, MP, Gröschel, MI, Guglielmetti, L, Kontsevaya, I, Lange, B, van Leth, F, Lienhardt, C, Mandalakas, AM, Maurer, FP, Merker, M, Miotto, P, Molina-Moya, B, Morel, F, Niemann, S, Veziris, N, Whitelaw, A, Horsburgh, CR & Lange, C 2023, 'Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: a 2023 TBnet/RESIST-TB consensus statement', Lancet Infectious Diseases, Jg. 23, Nr. 4, S. e122-e137. https://doi.org/10.1016/S1473-3099(22)00875-1

Van, N, Degefu, YN, Leus, PA, Larkins-Ford, J, Klickstein, J, Maurer, FP, Stone, D, Poonawala, H, Thorpe, CM, Smith, TC & Aldridge, BB 2023, 'Novel Synergies and Isolate Specificities in the Drug Interaction Landscape of Mycobacterium abscessus', ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Jg. 67, Nr. 7, S. e0009023. https://doi.org/10.1128/aac.00090-23

 

2022

Akwani, WC, van Vliet, AHM, Joel, JO, Andres, S, Diricks, M, Maurer, FP, Chambers, MA & Hingley-Wilson, SM 2022, 'The Use of Comparative Genomic Analysis for the Development of Subspecies-Specific PCR Assays for Mycobacterium abscessus', Frontiers in Cellular and Infection Microbiology, Jg. 12, S. 816615. https://doi.org/10.3389/fcimb.2022.816615

Antimycobacterial Susceptibility Testing Group 2022, 'Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment', The European respiratory journal, Jg. 59, Nr. 4, 2200166. https://doi.org/10.1183/13993003.00166-2022

Bateson, A, Ortiz Canseco, J, McHugh, TD, Witney, AA, Feuerriegel, S, Merker, M, Kohl, TA, Utpatel, C, Niemann, S, Andres, S, Kranzer, K, Maurer, FP, Ghodousi, A, Borroni, E, Cirillo, DM, Wijkander, M, Toro, JC, Groenheit, R, Werngren, J, Machado, D, Viveiros, M, Warren, RM, Sirgel, F, Dippenaar, A, Köser, CU, Sun, E & Timm, J 2022, 'Ancient and recent differences in the intrinsic susceptibility of Mycobacterium tuberculosis complex to pretomanid', JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Jg. 77, Nr. 6, S. 1685-1693. https://doi.org/10.1093/jac/dkac070

Brandenburg, J, Heyckendorf, J, Marwitz, F, Zehethofer, N, Linnemann, L, Gisch, N, Karaköse, H, Reimann, M, Kranzer, K, Kalsdorf, B, Sanchez-Carballo, P, Weinkauf, M, Scholz, V, Malm, S, Homolka, S, Gaede, KI, Herzmann, C, Schaible, UE, Hölscher, C, Reiling, N & Schwudke, D 2022, 'Tuberculostearic Acid-Containing Phosphatidylinositols as Markers of Bacterial Burden in Tuberculosis', ACS infectious diseases, Jg. 8, Nr. 7, S. 1303-1315. https://doi.org/10.1021/acsinfecdis.2c00075

Chesov, E, Chesov, D, Maurer, FP, Andres, S, Utpatel, C, Barilar, I, Donica, A, Reimann, M, Niemann, S, Lange, C, Crudu, V, Heyckendorf, J & Merker, M 2022, 'Emergence of bedaquiline resistance in a high tuberculosis burden country', The European respiratory journal, Jg. 59, Nr. 3, 2100621. https://doi.org/10.1183/13993003.00621-2021

Diricks, M, Merker, M, Wetzstein, N, Kohl, TA, Niemann, S & Maurer, FP 2022, 'Delineating Mycobacterium abscessus population structure and transmission employing high-resolution core genome multilocus sequence typing', Nature communications, Jg. 13, Nr. 1, S. 4936. https://doi.org/10.1038/s41467-022-32122-5

European Laboratory Initiative on TB, HIV and viral hepatitis core group members 2022, 'Integrated use of laboratory services for multiple infectious diseases in the WHO European Region during the COVID-19 pandemic and beyond', Eurosurveillance, Jg. 27, Nr. 29, 2100930. https://doi.org/10.2807/1560-7917.ES.2022.27.29.2100930

European Laboratory Initiative on TB, HIV and Viral Hepatitis(3) & Niemann, S 2022, 'Diagnostic Capacities for Multidrug-Resistant Tuberculosis in the World Health Organization European Region: Action is Needed by all Member States', Journal of Molecular Diagnostics, Jg. 24, Nr. 11, S. 1189-1194. https://doi.org/10.1016/j.jmoldx.2022.07.005

Finci, I, Albertini, A, Merker, M, Andres, S, Bablishvili, N, Barilar, I, Cáceres, T, Crudu, V, Gotuzzo, E, Hapeela, N, Hoffmann, H, Hoogland, C, Kohl, TA, Kranzer, K, Mantsoki, A, Maurer, FP, Nicol, MP, Noroc, E, Plesnik, S, Rodwell, T, Ruhwald, M, Savidge, T, Salfinger, M, Streicher, E, Tukvadze, N, Warren, R, Zemanay, W, Zurek, A, Niemann, S & Denkinger, CM 2022, 'Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multicentre observational study', The Lancet. Microbe, Jg. 3, Nr. 9, S. e672-e682. https://doi.org/10.1016/S2666-5247(22)00116-1

Gisch, N, Utpatel, C, Gronbach, LM, Kohl, TA, Schombel, U, Malm, S, Dobos, KM, Hesser, DC, Diel, R, Götsch, U, Gerdes, S, Shuaib, YA, Ntinginya, NE, Khosa, C, Viegas, S, Kerubo, G, Ali, S, Al-Hajoj, SA, Ndung’u, PW, Rachow, A, Hoelscher, M, Maurer, FP, Schwudke, D, Niemann, S, Reiling, N & Homolka, S 2022, 'Sub-Lineage Specific Phenolic Glycolipid Patterns in the Mycobacterium tuberculosis Complex Lineage 1', Frontiers in Microbiology, Jg. 13, S. 832054. https://www.frontiersin.org/article/10.3389/fmicb.2022.832054

Hansen, J, Kolbe, K, König, IR, Scherließ, R, Hellfritzsch, M, Malm, S, Müller-Loennies, S, Zallet, J, Hillemann, D, Wiesmüller, K-H, Herzmann, C, Brandenburg, J & Reiling, N 2022, 'Lipobiotin-capture magnetic bead assay for isolation, enrichment and detection of Mycobacterium tuberculosis from saliva', PLOS ONE, Jg. 17, Nr. 7, S. e0265554. https://doi.org/10.1371/journal.pone.0265554

Kanyala, E, Shuaib, YA, Schwarz, NG, Andres, S, Richter, E, Sawadogo, B, Sawadogo, M, Germaine, M, Lassina, O, Poppert, S & Frickmann, H 2022, 'Prevalence and Molecular Characterization of Mycobacterium bovis in Slaughtered Cattle Carcasses in Burkina Faso; West Africa', Microorganisms, Jg. 10, Nr. 7, 1378. https://doi.org/10.3390/microorganisms10071378

Klein, C, Borsche, M, Balck, A, Föh, B, Rahmöller, J, Peters, E, Knickmann, J, Lane, M, Vollstedt, E-J, Elsner, SA, Käding, N, Hauswaldt, S, Lange, T, Hundt, JE, Lehrian, S, Giese, J, Mischnik, A, Niemann, S, Maurer, F, Homolka, S, Paulowski, L, Kramer, J, Twesten, C, Sina, C, Gillessen-Kaesbach, G, Busch, H, Ehlers, M, Taube, S, Rupp, J & Katalinic, A 2022, 'One-year surveillance of SARS-CoV-2 transmission of the ELISA cohort: A model for population-based monitoring of infection risk', Science advances, Jg. 8, Nr. 15, S. eabm5016. https://doi.org/10.1126/sciadv.abm5016

Lagune, M, Le Moigne, V, Johansen, MD, Vásquez Sotomayor, F, Daher, W, Petit, C, Cosentino, G, Paulowski, L, Gutsmann, T, Wilmanns, M, Maurer, FP, Herrmann, J-L, Girard-Misguich, F & Kremer, L 2022, 'The ESX-4 substrates, EsxU and EsxT, modulate Mycobacterium abscessus fitness', PLOS PATHOGENS, Jg. 18, Nr. 8, S. e1010771. https://doi.org/10.1371/journal.ppat.1010771

Merker, M, Rasigade, J-P, Barbier, M, Cox, H, Feuerriegel, S, Kohl, TA, Shitikov, E, Klaos, K, Gaudin, C, Antoine, R, Diel, R, Borrell, S, Gagneux, S, Nikolayevskyy, V, Andres, S, Crudu, V, Supply, P, Niemann, S & Wirth, T 2022, 'Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis', Nature communications, Jg. 13, Nr. 1, S. 5105. https://doi.org/10.1038/s41467-022-32455-1

Paulowski, L, Beckham, KSH, Johansen, MD, Berneking, L, Van, N, Degefu, Y, Staack, S, Sotomayor, FV, Asar, L, Rohde, H, Aldridge, BB, Aepfelbacher, M, Parret, A, Wilmanns, M, Kremer, L, Combrink, K & Maurer, FP 2022, 'C25-modified rifamycin derivatives with improved activity against Mycobacterium abscessus', PNAS nexus, Jg. 1, Nr. 4, S. pgac130. https://doi.org/10.1093/pnasnexus/pgac130

Schaberg, T, Brinkmann, F, Feiterna-Sperling, C, Geerdes-Fenge, H, Hartmann, P, Häcker, B, Hauer, B, Haas, W, Heyckendorf, J, Lange, C, Maurer, FP, Nienhaus, A, Otto-Knapp, R, Priwitzer, M, Richter, E, Salzer, HJF, Schoch, O, Schönfeld, N, Stahlmann, R & Bauer, T 2022, 'Tuberkulose im Erwachsenenalter', Pneumologie (Stuttgart, Germany), Jg. 76, Nr. 11, S. 727-819. https://doi.org/10.1055/a-1934-8303

Shuaib, YA, Utpatel, C, Kohl, TA, Barilar, I, Diricks, M, Ashraf, N, Wieler, LH, Kerubo, G, Mesfin, EA, Diallo, AB, Al-Hajoj, S, Ndung'u, P, Fitzgibbon, MM, Vaziri, F, Sintchenko, V, Martinez, E, Viegas, SO, Zhou, Y, Azmy, A, Al-Amry, K, Godreuil, S, Varma-Basil, M, Narang, A, Ali, S, Beckert, P, Dreyer, V, Kabwe, M, Bates, M, Hoelscher, M, Rachow, A, Gori, A, Tekwu, EM, Sidze, LK, Jean-Paul, AA, Beng, VP, Ntoumi, F, Frank, M, Diallo, AG, Mboup, S, Tessema, B, Beyene, D, Khan, SN, Diel, R, Supply, P, Maurer, FP, Hoffmann, H, Niemann, S & Merker, M 2022, 'Origin and Global Expansion of Mycobacterium tuberculosis Complex Lineage 3', Genes, Jg. 13, Nr. 6, 990. https://doi.org/10.3390/genes13060990

Sibandze, DB, Kay, A, Dreyer, V, Sikhondze, W, Dlamini, Q, DiNardo, A, Mtetwa, G, Lukhele, B, Vambe, D, Lange, C, Glenn Dlamini, M, Ness, T, Mejia, R, Kalsdorf, B, Heyckendorf, J, Kuhns, M, Maurer, FP, Dlamini, S, Maphalala, G, Niemann, S & Mandalakas, A 2022, 'Rapid molecular diagnostics of tuberculosis resistance by targeted stool sequencing', Genome medicine, Jg. 14, Nr. 1, S. 52. https://doi.org/10.1186/s13073-022-01054-6

Study Group on Mycobacteria of the European Society of Microbiology and Infectious Diseases (ESGMYC), European Society of Mycobacteriology (ESM), European Respiratory Society (ERS) and 2022, 'Rifapentine access in Europe: growing concerns over key tuberculosis treatment component', The European respiratory journal, Jg. 59, Nr. 5, S. 2200388. https://doi.org/10.1183/13993003.00388-2022

Walter, K, Kokesch-Himmelreich, J, Treu, A, Waldow, F, Hillemann, D, Jakobs, N, Lemm, A-K, Schwudke, D, Römpp, A & Hölscher, C 2022, 'Interleukin-13 overexpressing mice represent an advanced pre-clinical model for detecting the distribution of anti-mycobacterial drugs within centrally necrotizing granulomas', ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Jg. 66, Nr. 6, S. e0158821. https://doi.org/10.1128/AAC.01588-21

Welte, T, Dinkel, J, Maurer, F, Richter, E, Rohde, G, Schwarz, C, Taube, C & Diel, R 2022, 'Versorgung von Patienten/innen mit einer durch nichttuberkulöse Mykobakterien verursachten Lungenerkrankung in Deutschland – ein transsektorales patientenorientiertes Versorgungskonzept', Pneumologie (Stuttgart, Germany), Jg. 76, Nr. 8, S. 534-546. https://doi.org/10.1055/a-1855-0858

Wetzstein, N, Diricks, M, Kohl, TA, Wichelhaus, TA, Andres, S, Paulowski, L, Schwarz, C, Lewin, A, Kehrmann, J, Kahl, BC, Dichtl, K, Hügel, C, Eickmeier, O, Smaczny, C, Schmidt, A, Zimmermann, S, Nährlich, L, Hafkemeyer, S, Niemann, S, Maurer, FP & Hogardt, M 2022, 'Molecular Epidemiology of Mycobacterium abscessus Isolates Recovered from German Cystic Fibrosis Patients', Microbiology spectrum, Jg. 10, Nr. 4, S. e0171422. https://doi.org/10.1128/spectrum.01714-22

 

Head

Dr. med. Inna Friesen, MSc
Dr. med. Inna Friesen, MSc
+49 4537 / 188-2110
+49 4537 / 188-3110
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Dr. med. Martin Kuhns
Dr. med. Martin Kuhns
+49 4537 / 188-2075
+49 4537 / 188-3110
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Office / Requests for test results

Birgit Voß
Birgit Voß
+49 4537 / 188-2110
+49 4537 / 188-3110
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Laboratory manager / Accounting

Anne-Kathrin Slevogt
Anne-Kathrin Slevogt
+49 4537 / 188-2050
+49 4537 / 188-3110
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Staff scientists / external quality assessments

Dr. Sönke Andres
Dr. Sönke Andres
+49 4537 / 188-6480
+49 4537 / 188-3110
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Dr. Doris Hillemann
Dr. Doris Hillemann
+49 4537 / 188-7610
+49 4537 / 188-3110
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Dr. Susanne Homolka
Dr. Susanne Homolka
+49 4537 / 188-2840
+49 4537 / 188-3110
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Darsha Nadarajan
Darsha Nadarajan
Doktorandin
+49 4537 / 188-6460
+49 4537 / 188-3110
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Technical staff

 
Melanie Albrecht
+49 4537 / 188-2100
+49 4537 / 188-3110
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Lea Behrens
+49 4537 / 188-2100
+49 4537 / 188-3110
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Kristine Beuck
+49 4537 / 188-2100
+49 4537 / 188-3110
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Fenja Boysen
+49 4537 / 188-2100
+49 4537 / 188-3110
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Carina Hahn
+49 4537 / 188-2100
+49 4537 / 188-3110
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Silvia Höllger
+49 4537 / 188-2100
+49 4537 / 188-3110
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Kirsten Ott
+49 4537 / 188-2100
+49 4537 / 188-3110
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Ilse Radzio
+49 4537 / 188-2100
+49 4537 / 188-3110
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Birte Schlüter
+49 4537 / 188-2100
+49 4537 / 188-3110
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Last Update: 27.11.2023