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Clinical and Molecular Allergology

Prof. Dr. Uta Jappe
Prof. Dr. Uta Jappe
Head of the Research Group, senior physician/consultant,
Head of the Interdisciplinary Allergy Outpatient Clinic, Medical Clinic III (Pneumology), UKSH Lübeck, and Chair of the Comprehensive Allergy Center "KLIMA".
Patient registration: Tel.: 0451-500-44165; -44195; -44196 and by email at ambulanz.innere.luebeck@uksh.de or ambulanz.gastro.luebeck@uksh.de)
+49 4537 / 188-7406
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The Division of Clinical and Molecular Allergology is working on the elucidation of sensitization routes and the pathomechanisms of allergy and asthma. In order to achieve these goals we identify allergenic (glyco-/lipo-) proteins and epitopes in allergen sources (inhalant allergens, foods, and biological drugs), isolate and structurally characterize them. These well-characterized molecules are used to improve allergy diagnostic tests, a prerequisite for patient-tailored diagnostics. They are also used for investigating the influence of allergen structures on allergy / asthma development and on the severity and organ-manifestations of allergic symptoms. Because of the close association of the research group with the Interdisciplinary Allergy Outpatient Clinic at the University Hospital Schleswig-Holstein, UKSH, University of Lübeck, (A) the patients are provided with the latest research results (translation of basic science), and (B) basic science is performed with primary material from well-characterized patients in studies with ethical approval.

In the course of the projects, marker allergens will be identified that will allow to determine the individual risk of patients a.) to develop allergy and/or asthma, and b) in the case of already existing allergy to predict the severity of a reaction, the exacerbation of a pre-existing bronchial asthma, and (c) to choose the most beneficial treatment option for the individual patient in the future. Our recent findings regarding structure and function additionally are the basis for the development of novel treatment options.

 

 
Notification

We offer master students with degrees in biology, biochemistry, food chemistry, nutritional sciences or related courses the possibility to perform their master project and thesis in our group. You can find further information in the "project" section. We also offer PhD projects – please check for calls for doctoral theses.

 

General Introduction

Allergies are complex, multi-organ diseases. In Germany, 20-30 M people are affected by allergies (asthma not included), and the prevalence is still increasing. Therefore, allergies nowadays are a widespread disease. Some allergies are life-threatening and/or pave the way for chronic diseases, for example allergic rhinitis (e.g. hay fever) may transition into bronchial asthma. Similar to the allergic rhinoconjunctivitis, these respiratory diseases are chronic recurrent and lower the quality of life and overall performance. As a consequence, they are a major socio-economic burden (Weißbuch Allergologie in Deutschland 2025).

Allergy is a hypersensitivity response type I towards harmless substances in nature. Allergies are partly driven by both, a genetic predisposition and environmental factors.

 

The research group (RG) Clinical and Molecular Allergology investigates these key topics (Figure 1):

  • The influence of allergens on sensitization/sensitization routes.
  • The development of allergy and asthma (e.g. via trained immunity).
  • The trajectory and transition of allergic diseases (e.g. rhinitis to asthma).
  • The grade of symptom severity assessment of symptom localization (lung, gastrointestinal tract, skin, etc.) with the so-called “Molecular Phenotyping”.

 

We have the following aims based on single allergens and individual sensitization profiles in our study cohorts:

  • To improve the understanding of allergy and asthma
  • To enhance the knowledge on allergic disease trajectories.
  • To predict allergy severity.
  • To simplify discrimination between the different asthma phenotypes.
  • To facilitate a beneficial treatment decision by identifying the “theratype”.
  • To predict therapeutic success via improvement of diagnostic measures.

Figure 1: Aims and objectives of the research group Clinical and Molecular Allergology.


 

Projects of the RG Clinical and Molecular Allergology

1. Identification and Characterization of Novel Allergens (CARE)

The identification of new allergens is a main focus of our research in order to establish biomarkers for clinical diagnostics and organ manifestation. Characterization of proteins in terms of structure, molecular weight, hydrophilic/lipophilic characteristics, function (e.g. protease activity) and serum IgE-binding shall help to answer the question: What makes an allergen an allergen? What are the relevant adjuvant factors?

To date, our RG has identified and isolated single allergens from different plant-based food sources. These allergen biomarkers seem to be associated with the severity of allergic symptoms. The identified allergens are the lipid transfer proteins of hazelnut, Cor a 8, of the blue Lupine (Lup an 3), the lupine profilin (Lup a 5), Ara h 6 (storage protein of peanut), Ara h 9 (lipid transfer protein of peanut), Ara h 12 and Ara h 13 (peanut defensins), and Ara h 14 and Ara h 15 (peanut oleosins). Investigations of blood from patients with mild and severe peanut allergy revealed that only those suffering from severe peanut allergy had IgE-antibodies against the oleosins.

The isolated and characterized allergens are important tools for the

  • assessment of sensitization routes (CONTROL)
  • understanding of disease development and dynamics (CONTROL)
  • identification of biomarkers to improve diagnostic tests and patient therapy (CARE)

 

2. Investigation of Sensitization Routes (CONTROL)

The origin of sensitization to specific proteins and the development of symptoms / allergic diseases are not fully understood. Peanut allergy is a good model to understand these processes as even small amounts can trigger severe allergic reactions.

Sensitization to different foods can occur via different routes:  a) The gastrointestinal tract (food ingestion including breast feeding), b) the skin (favored as primary sensitization route for peanut allergy), c) the respiratory tract, or already d) in utero before birth.

We previously demonstrated that the biomarker peanut allergens Ara h 2 and 6 (storage proteins) are present in breast milk after peanut consumption. This raises the important question in allergology whether peanut exposure during breast feeding may act as a sensitization route or as an inducer of tolerance to peanuts very early in life.

Several peanut allergens have been identified and isolated in the RG over the years.
Some peanut allergens are very stable molecules and can travel through the air, which can induce bronchospasm after opening a bag with a peanut snack some distance apart from the patient. We want to use these specific allergens to elucidate the initiation of sensitization and pathomechanisms of allergy and asthma in projects funded by the German Center for Lung Research (DZL).

A special focus of our research lies on the interaction of lipophilic allergens (e.g. oleosins, lipid transfer proteins from plants, galactose-alpha-1-3 galactose (alpha-Gal) from mammalian meat) and the lipids of the respective allergen source and its effect on allergenicity. In addition, we investigate if lipophilic allergens can be responsible for severe allergic reactions and asthma development, and if so, by which underlying mechanisms (Flagship Project Basic Science of the DZL, coordinator: Prof. Uta Jappe).

Apart from peanut as one of the most severe food allergies we recombinantly produce allergens from house dust mites in order to determine individual sensitization profiles. We recently succeeded in the development of a serum-saving array for the detection of IgE-antibodies against several house dust mite allergens.

These assays will enable us to identify “initiator allergens” triggering the primary hyperreactivity response in very young children from families with a history of atopy, and from which only a small volume of blood can be drawn (DZL-ALLIANCE-cohort). This will help to understand allergic disease and asthma development, and may help to predict therapeutic outcomes and/or may be the basis for potential new therapeutic interventions (Figure 1, image 2 and 4).

 

3. Determination of Pathomechanisms (CONTROL)

For the determination of the pathomechanisms of immediate-type (type I) allergy it is crucial to elucidate how individual allergens initiate the production of allergy-mediating IgE antibodies. Therefore, the specific interaction of allergens with different body surfaces (e.g. the mucosal epithelium of the respiratory and gastrointestinal tracts) is examined. Our aims are to understand how allergens are processed and metabolized by epithelial cells, and whether there are differences between allergic and non-allergic individuals. In addition, we want to examine how the immune system is dysregulated towards harmless molecules, thereby initiating sensitization and subsequent clinically relevant allergic reactions. Determining the pathomechanisms in allergic disease, including determination of the relevant adjuvant factors, is the rational way to battle and/or to prevent them (Figure 1, image 3).

Our group was able to show that sensitization profiles differed between patients with different phenotypes of house dust mite allergy (Figure 2). The corresponding allergens were recombinantly produced in Eschericha coli and purified. IgE-reactivity towards specific allergens was analyzed using a multiplex assay. Different patterns of sensitization to these allergens were observed depending on the phenotype (rhinitis, allergic asthma, and atopic dermatitis). In contrast to patients with rhinitis, asthma patients were sensitized towards more allergens. Based on our results, we can assume that Der p 5 and p 21 are marker allergens for house dust mite-associated asthma. In contrast, significantly more house dust mite allergens were recognized by atopic dermatitis patients, including Der p 5, Der p 21, as well as Der 10, Der p 13 and Der p 20.
Based on these results, the organ specific reaction to house dust mite allergens is currently investigated in collaboration with the Hannover Medical School (MHH) as part of the DFG project JA 1007/4-1.

Clinical and Molecular Allergology fig2Figure 2: Individual HDM sensitization patterns to nine HDM allergens were investigated in 384 patients with different allergic diseases. Sensitization to more than three HDM allergens was associated with the simultaneous occurrence of multiple allergic diseases. Der p 5 and Der p 21 were associated with allergic asthma and atopic dermatitis. High Der p 20-IgE was strongly associated with severe atopic dermatitis (graphical abstract [Walsemann, T, Böttger, M, Traidl, S, Schwager, C, Gülsen, A, Freimooser, S, Rösner, LM, Werfel, T & Jappe, U 2023, 'Specific IgE against the house dust mite allergens Der p 5, 20 and 21 influences the phenotype and severity of atopic diseases', ALLERGY, Jg. 78, Nr. 3, S. 731-742. https://doi.org/10.1111/all.15553]).

 

Trained Immunity 

Over the past three years, our research has focused on uncovering the mechanisms of trained immunity within epithelial tissues. We have explored how epithelial cells—long considered passive physical barriers—can acquire memory‑like properties following infectious. Supported by DZL funding, this project demonstrated that repeated viral infections can induce durable epithelial reprogramming, reshaping how epithelial cells respond to subsequent challenges (Figure 3). Building on this foundation, our next objective is to define the mechanistic bridge between microbial infection and epithelial reprogramming in the context of chronic inflammatory diseases. This line of investigation will clarify how early‑life or first‑encounter microbial exposures influence epithelial behavior during later “second‑hit” events, such as allergen exposure or asthma‑related triggers. Through this work, we aim to advance a deeper understanding of how epithelial memory contributes to disease susceptibility and progression.

Clinical and Molecular Allergology fig3Figure 3: Trained immunity aspect. Upon stimulation with a viral infection, the epithelial cells produce an initial response which increased upon repeated infections based on the epigenetic reprogramming (such as histone modification and DNA methylation).

 

4. Identification and Characterization of Biomarkers for Diagnosis and Therapy (CARE)

The identification of biomarkers in sera of allergic patients is another important research field of our group. Examples of these biomarkers include a) metabolized and/or immunologically altered allergens, b) allergen-coupled carrier molecules, c) antibodies of the IgE isotype, but also d) other antibody isotypes like allergen-specific IgG and IgA, which may have anti-allergic effects. Certain IgE-binding motifs may serve as risk factors for the severity of allergic symptoms. Also, a certain allergen-specific IgE-antibody pattern (sensitization profile) may present a risk factor, e.g. a peanut-allergic patient with IgE against the storage proteins Ara h 1, 2 and 3 (see Figure 1, image 4) as well as the oleosins Ara h 14 and Ara h 15.
Determination of IgE antibodies against single allergens is a molecule-specific diagnosis, and its significance is strongly dependent on the allergen source and the clinical characterization of the single allergens. This is only possible due to the close connection of the Research Group to the Interdisciplinary Allergy Outpatient Clinic at the University Hospital Schleswig-Holstein (UKSH), University of Lübeck (UzL), both headed by Prof. Dr. med. Uta Jappe.

The basophil activation test (BAT), which enables the differentiation between sensitized and allergic individuals, was optimized in cooperation with the Flow Cytometry Core Facility of the Research Center Borstel. Both the gating strategy (EP4200610A1 und US20230349890A1) and the BAT-based algorithm (WO2025/003040) were submitted for patent. We are currently running a study on peanut-allergic children in cooperation with the Department of Dermatology of the Elbe Klinikum Buxtehude.

 

Optimization of individualised Diagnostics

The identification and characterization of clinically relevant individual allergens, cloning and production of recombinant allergens as well as synthesis of peptides which are part of IgE epitopes puts us in the position to perform component-resolved diagnostics. Therefore, IgE antibodies specific for an allergenic protein or a specific linear epitope can be identified and analyzed. Thus, individual sensitization patterns (“allergograms”) against different a) proteins, e.g. food allergens like peanut and lupine, house dust mite allergens, pollen, drugs like novel biological drugs, b) homologous (structurally related) proteins in different food and c) different antibody-binding motifs (IgE binding regions) of a single allergen are determined (precision diagnostics). We successfully isolated and characterized peanut oleosins, which we identified as markers for allergy severity. Since these allergens are not soluble in aqueous solutions, they are most probably not part of the solutions available for routine allergy diagnostic tests or treatments. We are currently working on the transfer of these lipophilic allergens into routine allergy diagnostic tests (transfer), and investigate their potential in therapeutics.

Clinical and Molecular Allergology fig4Figure 4: Schematic visualization of the interaction between improved diagnostic measures (individual sensitization profiles and marker allergens for the severity of the allergic reactions) and their beneficial influence on treatment decisions (choice of immunotherapies).

 

Additionally, we have developed a multianalyte assay for the detection of delayed anaphylaxis to meat, the so-called alpha-GAL syndrome, which is already in use for the patients in the RG-associated allergy outpatient clinics. This assay was superior compared to routine tests in detecting the alpha-GAL-syndrome in some patient cases. These patients were then able to re-evaluate their diet which minimized their risk of anaphylaxis (precision diagnostics).

In a proof-of-principle project on immune reactions to target treatments (biologicals), we identified epitopes on therapeutic antibodies which are likely responsible for the loss of efficacy during treatment due to anti-drug-antibodies in patients’ sera. This discovery will benefit patient care as safe and effective alternative biologicals, that do not cross-react with other biological allergens, could be prescribed in a timely manner (Figure 1, image 4).

 

ImproviNg DIagnostiCs And ThErapy of Food Hypersensitivity (INDICATE-FH): A BMBF-financed consortium

Since 2021, we have worked on "ImproviNg DIagnostiCs And ThErapy of Food Hypersensitivity" (INDICATE-FH) in a consortium with the Institute of Nutritional Medicine of the University of Lübeck and the University of Hohenheim to improve diagnostics regarding allergic and non-allergic wheat-related diseases. Food intolerances to wheat flour is a common problem in medical practice. In many cases, the non-specific gastrointestinal symptoms are misinterpreted as irritable bowel syndrome. The main reason for this is the lack of specific biomarkers and practical diagnostic procedures. The main goal of the project is to optimize existing diagnostics for non-celiac wheat sensitivity (NCWS) in differentiation to celiac disease (CD), wheat allergy (WA) and irritable bowel syndrome. The RG Clinical and Molecular Allergology examines the pathogenesis of wheat intolerance and aims to improve the diagnostics for wheat allergy by identifying, purifying and characterizing wheat allergens. They are subsequently recombinantly produced to enhance the sensitivity and specificity of allergy tests, and to use them in future antibody- and cell-based assays. Our goal is to better distinguish between WA, CD, NCWS and other intestinal diseases in the future. In addition, we will assess whether the individual allergens can be associated with the severity of an allergic reaction and may therefore serve as a biomarker or not. Furthermore, transcriptome and methylome analyses will be used to screen for genes with biomarker potential that would allow discrimination between allergic and non-allergic reactions to wheat using a simple blood test (Prof. T. Goldmann, Borstel). The recombinant wheat allergens will be used to examine pathomechanisms in a cell culture model. This will optimize the diagnostics and – eventually - the treatment of patients with symptoms to wheat products. This would be a relief for many patients as they would be able to change their diet accordingly to get through their daily life as symptom-free as possible.

 

Future Perspectives

During the next years, our lipophilic allergens will be incorporated into routine allergy diagnostic platforms.

We will know more about the organ specificity of certain individual allergens and the mechanisms by which they act directly on the epithelium and also in the immune cells.

In the near future, we will have additional allergens available for the diagnosis of wheat allergy, but the diagnosis of other wheat-associated diseases will also be improved by means of non-allergen-, but -omics-based tests.

Elucidating the interaction of microbial components with individual allergens and their role in the development of allergies in the context of trained immunity will open up new avenues for primary prevention.

In this context, we will include microbial allergens into our research that directly trigger asthma and allergies, but which may also represent a bridge between post-infectious and allergic inflammation.

 

5. Setup of Registries and Data Bases

Data, which was acquired in registries and data bases (Figure 1, image 5), is used for epidemiologic studies and serves as a tool to detect new allergies (German and European Anaphylaxis Registry, NORA). We participate in registries and build own cohorts. Furthermore, the RG cooperates intensely with the BioMaterialBank (BMB) Nord and contributes to their biomaterial collection.

 

 

German Research Foundation

  • DFG JA 1007/4-1: The role of house dust mite single allergens - structural and functional features in the context of atopic diseases 2023-2027.
  • DFG JA 1007/2-3: Investigation of peanut oil bodies and the new lipophilic allergens like oleosins regarding promotion of sensitization and elicitation processes in food allergy (2019-2022)
  • DFG JA1007/2-1: Structural- and functional investigations of lipophilic peanut allergens with special emphasis on oleosins (2013-2015)
  • DFG Scho 828/2-1: Investigation of peanut antigen /peanut allergens in breast milk after having been processed at mucosal interfaces and their interaction with the immune system

 

Exzellenz Cluster: 2019 - 2032 Precision Medicine in Chronic Infammation (PMI)

 

Federal Ministry of Education and Science

  • FKZ:01EA2109B Verbundprojekt ImproviNg DIagnostiCs And ThErapy of Food Hypersensitivity; INDICATE-FH (PI: U. Jappe) (2021-2024)
  • DZL: Disease Area Asthma & Allergy (DA-AA), German Center for Lung Research (DZL) (PI U. Jappe); AA-FPB: Co-ordinator of the Flagship Project Basic Science: U. Jappe) (2010-2027)
  • DZL - Flexible Funds; Single Cell Analysis (SCA): Cell Circuits in Predictive and Personalized Pulmonary Medicine. PI Prof. Uta Jappe, cooperation with Prof. Marc Ehlers, UzL (2024-2027)
  • FK 01KG 0911 Verbundprojekt Birch Associated Soy Allergy and Immuno-Therapy (BASALIT) (PI. U. Jappe) (2009-2015)

 

Federal Ministry of Economy and Technology

  • ZIM-KF2784702SB4: Förderprogramm Zentrales Innovationsprogramm Mittelstand (ZIM), Fördermodul Kooperationsprojekte: Development of an innovative test to prevent secondary treatment failure due to hypersensitivity reaction to a target treatment with biologicals (PI: Uta Jappe) (2015-2018)
  • ZIM-KF2784701AJ0: Förderprogramm Zentrales Innovationsprogramm Mittelstand (ZIM), Fördermodul Kooperationsprojekte: Development of tests for the detection of specific IgE-antibodies directed against therapeutic monoclonal antibodies (biologicals) (PI: Uta Jappe) (2011-2015)

 

Federal Ministry of Food and Agriculture (BMEL)

  • Federal Ministry of Food and Agriculture (BMEL) via the Federal Office for Agriculture and Food (BLE) under the innovation support programme "Development of an aptamer-based biosensor for the detection and investigation of allergens and their allergenic potential in foods; AptaSens" (2020-2023)

 

Foundations

  • Kanert-Foundation: Investigation of peanut oilbodies for allergen transport with subsequent analysis of reconstituted oil bodies as vehicles for therapeutic allergen transport (epicutaneous immunotherapy (EPIT)) for peanut allergy (PI. U. Jappe) (2018-2019)

 

EU - 7. FP

  • FP7 RegPot 2010-5_256756FCUB Er Scientific Support of the West Balkan states; cooperation with the Dept. of Biochemistry, University of Belgrade, Serbia

 

Member of the German Center for Lung Research (DZL) and Airway Research Center North (ARCN)

Member of Companion Diagnostics Network

Member of Network of Severe Allergic Reactions (NORA)


 

Genetic Methods

  • Cloning and recombinant expression of allergens
    • E. coli, "Clear coli"
    • Pichia pastoris
    • Insect cells (Sf9 cells)
  • RNA-silencing of specific genes
  • (real-time) PCR

 

Allergen/Protein Purification

  • Aqueous and organic extraction methods
  • Chromatography
    • Affinity chromatography
    • Ion exchange
    • Hydrophobic interaction
    • Reversed phase
  • (Preparative) gel electrophoresis
  • purification of lipophilic allergens

 

Allergen/Protein Analysis

  • Electrophoresis
    • Isoelectric focusing (IEF)
    • Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE)
    • 2D-SDS-PAGE
    • Difference gel electrophoresis (DIGE)
  • Immunoblotting
    • Detection of IgE, IgG und IgG subclasses
    • Colorimetric readout
    • Readout by chemiluminescence
  • ELISA Techniques and ELISA establishment
  • N-terminal sequencing
  • Zymography
  • Enzyme kinetics
  • Epitope mapping of allergens

Design of peptide arrays

 

Mapping of b cells epitopes: IgE / IgG

 

Allergen/Protein engineering

  • Protein fragmentation by protease digestion
    • simulation of human digestion (Enzynorm/Kreon)  
  • Protein analysis: reduction / native analysis
  • Controlled deglycosylation of proteins
    • Enzymatic: Glycosidases
    • Chemical: Periodate

 

Cell analysis / cell culture

  • Cultivation of human / mammalian cells
  • Cell analysis by flow cytometry (FCM, FACS)
  • Analysis of cell activation by allergens (BAT, basophile activation test)
  • Fluorescence microscopy, FRET techniques

 

Further techniques

  • Generation of monoclonal antibodies and antisera (MAB technique)
  • Immunohistochemistry (IHC)
  • In silico protein-ligand docking studies (Autodock)

 

Allergie-Kolloquium Borstel

Lübecker Allergie-Symposium

 

Internationaler Kongress
7th International Symposium on Molecular Allergology (ISMA), Luxembourg 2017  (see details)

International Workshop on Molecular Allergology
Joint workshop of the WHO/IUIS Allergen Nomenclature Subcommittee and the EAACI Task Force BACALL, Borstel 2023

DGAKI-Symposium
Allergieakademie der DGAKI 2019 (see details)

44th Symposium of the North German Immunologists
NDI3 - New Developments in Immunology, Inflammation and Infection, 2021 (see details)

 

2006: Award of the German Contact Allergy Research Group (DKG) (Uta Jappe and co-authors)

2006: Deutsche Gesellschaft für Ultraschall in der Medizin (DEGUM) Scientific Award (Uta Jappe and co-authors)

2007: Kanert Price for Allergy Research (Wolf-Meinhard Becker und Arnd Petersen)

2010: Poster Prize of the European Academy of Allergy and Clinical Immunology (EAACI) Congress in London, Great Britain (Uta Jappe and co-authors)

2011: Abstract Prize „Best of Mainz“, Scientific Symposium of the DGAKI in Mainz („Mainzer Allergie-Workshop”) (Uta Jappe)

2011: Best Master-Thesis-Award of the Research Center Borstel in 2011 to Saskia Hellmig; Title of the Thesis: “Lupine as cause of food allergy: Allergen-identification and characterization”.

2012: Poster Award, XX. North-German Society of Dermatology in Berlin (Uta Jappe and co-authors)

2012: Award for the Best Talk, European Academy of Allergy and Clinical Immunology (EAACI) Congress in Geneva, Switzerland (Uta Jappe)

2013: Award for the Best Talk, European Academy of Allergy and Clinical Immunology (EAACI) and the World Allergy Organization (WAO) in Milano, Italy (Uta Jappe)

2015: Best Master-Thesis-Award of the Research Center Borstel in 2015 to Alexandra Scharf; Title of the Thesis: “Development and validation of an ELISA for the quantification of the peanut allergen Ara h 2 in breast milk.”

2015: Award for the Best Talk, 38th Symposium of North German Immunologists, 2015 in Borstel, Germany (Christian Schwager)

2016: Best contribution (Talk and Poster) on the Retreat of the Cluster of Excellence „Inflammation at Interfaces“ (Arne Homann and co-authors)

2016: Travel Grant and Biolegend Best Talk Award, X. World Immune Regulation Meeting (WIRM), Davos, Switzerland (Arne Homann).

2016: Best Master-Thesis-Award of the Research Center Borstel in 2016 to Arabella Karstedt; Title of the Thesis: "Isolation and characterization of new lupine allergens".

2017: Young Talent Award of the German Society for Allergy and Clinical Immunology (DGAKI) for the most valuable Publication (Christian Schwager for all authors)

2018: Kanert Price for Allergy Research (Uta Jappe and Christian Schwager)

2018: District-Segeberg-Award for the best PhD thesis of the Research Center Borstel (Christian Schwager) Title of the thesis: Peanut oleosins: isolation, characterization and demonstration of their clinical relevance”

2020: Best Master-Thesis-Award of the Research Center Borstel in 2020 to Vivian Valeska Lelleck; Title of the Thesis: "Lipophilic peanut allergens for allergy diagnostic tests".

2022: 2nd Abstract Prize of the DGAKI on the Mainzer Allergie-Workshop 2022 for the cooperative project between Research Center Borstel and the Max-Rubner-Institutes Kiel and Karlsruhe to the authors Roggensack T, Rodriguez Gomez M, Hui-Zhi-Low, Kappel K, Uta Jappe, Clawin-Rädecker I.

2022: Best Master-Thesis-Award of the Research Center Borstel (RCB) in 2022: Title: "Optimization and validation of the heterologous expression of a food allergen belonging to the group of lipid transfer proteins" (Elisabeth Marie Albert)

2023: Award for the Best Talk (Flash Talk),Congress of the European Academy of Allergy and Clinical Immunology (EAACI) in Hamburg (Theresa Walsemann)

2023: Award for the Best Poster Presentation (Thematic Poster Session), Congress of the European Academy of Allergy and Clinical Immunology (EAACI) in Hamburg (Marua Abu Risha)

2023: District-Segeberg-Award for the best PhD thesis of the Research Center Borstel (Theresa Walsemann) Title of the thesis: "Identification and characterization of house dust mite allergens influencing the allergic phenotype and improvement of allergy diagnosis in clinical routine."

2024: Travel Grant of the European Academy of Allergy and Clinical Immunology (EAACI), EAACI Congress in Valencia, Spain (Marua Abu Risha)

2024: Travel Grant Award to Marua Abu Risha for the Congress of the European Academy of Allergy and Clinical Immunology (EAACI) in Valencia, Spain

2024: Best Master-Thesis-Award of the Research Center Borstel (RCB) in 2024: Title: "Untersuchung der Toll-Like-Rezeptor-Aktivierung von Markerallergenen der Hausstaubmilbe Dermatophagoides pteronyssinus" (Celina Sachs)


 

Press

2022: Prof. Dr. Uta Jappe has been continuously listed in Focus-Gesundheit among Germany's top physicians from 122 specialties since 2017

2023, 2024 and 2025: Prof Dr. Uta Jappe is one of the excellent specialists in the STERN list of Germany`s top physicians 2025 in the area of food intolerances.


 

2025

Jappe, U, Kleine-Tebbe, J & Brans, R 2025, 'Allergene', ALLERGOLOGIE, Nr. 5, S. 699-716. https://doi.org/10.5414/ALP48699

Jappe, U, Kolaly, T, de Vries, MS, Gülsen, A & Homann, A 2025, 'Connecting Diagnostics and Clinical Relevance of the α-Gal Syndrome-Individual Sensitization Patterns of Patients with Suspected α-Gal-Associated Allergy', Nutrients, Jg. 17, Nr. 9. https://doi.org/10.3390/nu17091541

Pascal, M, Chauhan, J, Knol, E, Bianchini, R, Castells, M, De Las Vecillas, L, Hartmann, K, Izquierdo, E, Jappe, U, Jimenez-Rodriguez, T-W, Levi-Schaffer, F, Mayorga, C, Poli, A, Redegeld, F, Santos, AF, Jensen-Jarolim, E, Bergmann, C, Karagiannis, SN & Bax, HJ 2025, 'Basophil Activation Test: Bridging Allergy and Oncology for Diagnostic, Therapeutic and Prognostic Applications in AllergoOncology: An EAACI Position Paper', ALLERGY. https://doi.org/10.1111/all.16607

Radauer, C, Gadermaier, G, Goodman, RE, Jacquet, A, Jappe, U, Lopata, AL, Pomés, A, Raulf, M, Santos, KS, Zakzuk, J, Zhang, Y, Vitte, J & WHO/IUIS Allergen Nomenclature Sub‐Committee 2025, 'New Allergens Approved by the WHO/IUIS Allergen Nomenclature Sub-Committee in 2021-2024 and Their Significance for Future Diagnostics, Regulation, and Research. An EAACI Task Force Report', ALLERGY. https://doi.org/10.1111/all.70166

Reese, I, Schäfer, C, Ballmer-Weber, B, Beyer, K, Dölle-Bierke, S, van Dullemen, S, Jappe, U, Schnadt, S & Treudler, R 2025, 'Response to Letter to the Editor from Christian Koeder
', Allergologie select, Jg. 9, S. 18-20. https://doi.org/10.5414/ALX02573E


Treudler, R, Worm, M, Bauer , A, Dickel , H, Heine, G, Jappe, U, Klimek, L, Raulf, M, Wedi, B, Wieczorek, D, Francuzik, W, Jakob , T, Pfaar, O, Ring, F, Ruëff, F, Schnadt, S, Werfel, T, Wurpts, G, Zarnowski, J, Zuberbier , T & Brockow, K 2025, 'Berufsbedingte Anaphylaxie – Positionspapier der Deutschen Gesellschaft für Allergologie und Klinische Immunologie (DGAKI)', ALLERGOLOGIE, Jg. 2025, Nr. 48, S. 416-435. https://doi.org/10.5414/ALX02543

 

Buchbeitrag / Book contribution

Klimek, L, Vogelberg, C &Werfel, T 2025 Weißbuch Allergie in Deutschland. 5 Aufl.

 

2024

Abu Risha, M, Reddy, KD, Nemani, SSP, Jakwerth, C, Schmidt-Weber, C, Bahmer, T, Hansen, G, von Mutius, E, Rabe, KF, Dittrich, A-M, Grychtol, R, Maison, N, Schaub, B, Kopp, MV, Brinkmann, F, Meiners, S, Jappe, U, Weckmann, M & ALLIANCE Study Group 2024, 'Epigenetic training of human bronchial epithelium cells by repeated rhinovirus infections', ALLERGY, Jg. 79, Nr. 12, S. 3385-3400. https://doi.org/10.1111/all.16388

Abu Risha, M, Rick, E-M, Plum, M & Jappe, U 2024, 'Legume Allergens Pea, Chickpea, Lentil, Lupine and Beyond', Current Allergy and Asthma Reports, Jg. 24, Nr. 9, S. 527-548. https://doi.org/10.1007/s11882-024-01165-7

Darsow, U, Gelincik, A, Jappe, U, Platts-Mills, TA, Ünal, D & Biedermann, T 2024, 'Algorithms in allergy: An algorithm for alpha-Gal syndrome diagnosis and treatment, 2024 update', ALLERGY, Jg. 79, Nr. 11, S. 3169-3172. https://doi.org/10.1111/all.16291

Jappe, U, Bergmann, K-C, Brinkmann, F, Faihs, V, Gülsen, A, Klimek, L, Renz, H, Seurig, S, Taube, C, Traidl, S, Treudler, R, Wagenmann, M, Werfel, T, Worm, M & Zuberbier, T 2024, 'Biologics in allergology and clinical immunology: Update on therapies for atopic diseases, urticaria, and angioedema and on safety aspects focusing on hypersensitivity reactions', Allergologie select, Jg. 8, S. 365-406. https://doi.org/10.5414/ALX02533E

Pascal, M, Bax, HJ, Bergmann, C, Bianchini, R, Castells, M, Chauhan, J, De Las Vecillas, L, Hartmann, K, Álvarez, EI, Jappe, U, Jimenez-Rodriguez, T-W, Knol, E, Levi-Schaffer, F, Mayorga, C, Poli, A, Redegeld, F, Santos, AF, Jensen-Jarolim, E & Karagiannis, SN 2024, 'Granulocytes and mast cells in AllergoOncology-Bridging allergy to cancer: An EAACI position paper', ALLERGY, Jg. 79, Nr. 9, S. 2319-2345. https://doi.org/10.1111/all.16246

Rick, E-M, Woolnough, K, Richardson, M, Monteiro, W, Craner, M, Bourne, M, Cousins, DJ, Swoboda, I, Wardlaw, AJ & Pashley, CH 2024, 'Identification of allergens from Aspergillus fumigatus-Potential association with lung damage in asthma', ALLERGY, Jg. 79, Nr. 5, S. 1208-1218. https://doi.org/10.1111/all.16032

Treudler, R, Worm, M, Bauer, A, Dickel, H, Heine, G, Jappe, U, Klimek, L, Raulf, M, Wedi, B, Wieczorek, D, Francuzik, W, Jakob, T, Pfaar, O, Ring, J, Rueff, F, Schnadt, S, Werfel, T, Wurpts, G, Zarnowski, J, Zuberbier, T & Brockow, K 2024, 'Occupational anaphylaxis: A Position Paper of the German Society of Allergology and Clinical Immunology (DGAKI)', Allergologie select, Jg. 8, S. 407-424. https://doi.org/10.5414/ALX02543E

Turner, MC, Radzikowska, U, Ferastraoaru, DE, Pascal, M, Wesseling, P, McCraw, A, Backes, C, Bax, HJ, Bergmann, C, Bianchini, R, Cari, L, de Las Vecillas, L, Izquierdo, E, Lind-Holm Mogensen, F, Michelucci, A, Nazarov, PV, Niclou, SP, Nocentini, G, Ollert, M, Preusser, M, Rohr-Udilova, N, Scafidi, A, Toth, R, Van Hemelrijck, M, Weller, M, Jappe, U, Escribese, MM, Jensen-Jarolim, E, Karagiannis, SN & Poli, A 2024, 'AllergoOncology: Biomarkers and refined classification for research in the allergy and glioma nexus-A joint EAACI-EANO position paper', ALLERGY, Jg. 79, Nr. 6, S. 1419-1439. https://doi.org/10.1111/all.15994

 

Buchbeitrag / Book contribution

Dramburg S, Hilger C, Santos AF, de Las Vecillas L, Aalberse RC, Acevedo N, Aglas L, Altmann F, Arruda KL, Asero R, Ballmer-Weber B, Barber D, Beyer K, Biedermann T, Bilo MB, Blank S, Bosshard PP, Breiteneder H, Brough HA, Bublin M, Campbell D, Caraballo L, Caubet JC, Celi G, Chapman MD, Chruszcz M, Custovic A, Czolk R, Davies J, Douladiris N, Eberlein B, Ebisawa M, Ehlers A, Eigenmann P, Gadermaier G, Giovannini M, Gomez F, Grohman R, Guillet C, Hafner C, Hamilton RG, Hauser M, Hawranek T, Hoffmann HJ, Holzhauser T, Iizuka T, Jacquet A, Jakob T, Janssen-Weets B, Jappe U, Jutel M, Kalic T, Kamath S, Kespohl S, Kleine-Tebbe J, Knol E, Knulst A, Konradsen JR, Korošec P, Kuehn A, Lack G, Le TM, Lopata A, Luengo O, Mäkelä M, Marra AM, Mills C, Morisset M, Muraro A, Nowak-Wegrzyn A, Nugraha R, Ollert M, Palosuo K, Pastorello EA, Patil SU, Platts-Mills T, Pomés A, Poncet P, Potapova E, Poulsen LK, Radauer C, Radulovic S, Raulf M, Rougé P, Sastre J, Sato S, Scala E, Schmid JM, Schmid-Grendelmeier P, Schrama D, Sénéchal H, Traidl-Hoffmann C, Valverde-Monge M, van Hage M, van Ree R, Verhoeckx K, Vieths S, Wickman M, Zakzuk J, Matricardi PM, Hoffmann-Sommergruber K. Molecular Allergology Pocket Guide. European Academy of Allergy and Clinical Immunology & John Wiley and sons Ltd. 2024

 

2023

Albert E, Walsemann T, Behrends J, Jappe U. Lipid transfer protein syndrome in a Northern European patient: An unusual case report. Front Med (Lausanne). 2023 Feb 7;10:1049477. doi: 10.3389/fmed.2023.1049477. eCollection 2023.

Dölle-Bierke S, Höfer V, Francuzik W, Näher F, Bilo M.B., Cichocka-Jarosz E, Felipe Ensina L, Fernandez-Rivas M, García Figueroa B, Hartmann K, Jappe U, Köhli A, Lange L, Maris I, Mustakov T, Nemat K, Ott H, Papadopoulos NG, Pföhler C, Ruëff F, Spindler T, Stock P, Treudler R, Vogelberg C, Wagner N, Worm M. Food-induced anaphylaxis: Data from the European Anaphylaxis Registry. J Allergy Clin Immunol Pract. 2023 Mar 27:S2213-2198(23)00312-4. doi: 10.1016/j.jaip.2023.03.026. Online ahead of print.

Dramburg S, Hilger C, Santos AF, de las Vecillas L, Aalberse RC, Acevedo N, Aglas L, Altmann F, Arruda KL, Asero R, Ballmer-Weber B, Barber D, Beyer K, Biedermann T, Bilo MB, Blank S, Bosshard PP, Breiteneder H, Brough HA, Bublin M, Campbell D, Caraballo L, Caubet JC, Celi G, Chapman MD, Chruszcz M, Custovic A, Czolk R, Davies J, Douladiris N, Eberlein B, Ebisawa M, Ehlers A, Eigenmann P, Gadermaier G, Giovannini M, Gomez F, Grohman R, Guillet C, Hafner C, Hamilton RG, Hauser M, Hawranek T, Hoffmann HJ, Holzhauser T, Iizuka T, Jacquet A, Jakob T, Janssen-Weets B, Jappe U, Jutel M, Kalic T, Kamath S, Kespohl S, Kleine-Tebbe J, Knol E, Knulst A, Konradsen JR, Korošec P, Kuehn A, Lack G, Thuy-My Le, Lopata A, Luengo O, Mäkelä M, Marra AM, Mills C, Morisset M, Muraro A, Nowak-Wegrzyn A, Nugraha R, Ollert M, Palosuo K, Pastorello EA, Patil SU, Platts-Mills TA, Pomés A, Poncet P, Potapova E, Poulsen LK, Radauer C, Radulovic S, Raulf M, Rougé P, Sastre J, Sato S, Scala E, Schmid JM, Schmid-Grendelmeier P, Schrama D, Sénéchal H, Traidl-Hoffmann C, Valverde-Monge M, van Hage M, van Ree R, Verhoeckx K, Vieths S, Wickman M, Zakzuk J, Matricardi PM, Hoffmann-Sommergruber K. EAACI Molecular Allergology User's Guide 2.0. First published: 26 April 2023 https://doi.org/10.1111/pai.13854

Dühring, L, Petry, J, Lilienthal, G-M, Bartsch, YC, Kubiak, M, Pfeufer, C, Lehrian, S, Buhre, JS, Lunding, HB, Kern, C, Behrends, J, Walsemann, T, Gädert, L, Sommer, C, Krüger, L, Blanchard, V, Dehmel, S, Jappe, U, Rahmöller, J & Ehlers, M 2023, 'Sialylation of IgE reduces FcεRIα interaction and mast cell and basophil activation in vitro and increases IgE half-life in vivo', ALLERGY, Jg. 78, Nr. 8, S. 2301-2305. https://doi.org/10.1111/all.15665

Đurašinović, T, Lopandić, Z, Protić-Rosić, I, Nešić, A, Trbojević-Ivić, J, Jappe, U & Gavrović-Jankulović, M 2024, 'Identification of S-adenosyl-l-homocysteine hydrolase from banana fruit as a novel plant panallergen', Food chemistry, Jg. 437, Nr. Pt 1, S. 137782. https://doi.org/10.1016/j.foodchem.2023.137782

Heßler N, Kordowski A, Sasse J, Ahlemann G, Schulz F, Schröder T, Exner A, Jablonski L, Jappe U, Bischoff SC, Grzegorzek M, König IR, Sina C. Study protocol to investigate the efficacy of confocal laser endomicroscopy-based selective single-elimination diet over standard fivefold elimination diet in patients with endomicroscopically proven food intolerance: app-assisted, monocentric, double-blind, randomised and controlled trial in Germany.BMJ Open. 2023 Nov 2;13(11):e072024. doi: 10.1136/bmjopen-2023-072024.

Jappe U. Vegan diet - alternative protein sources as potential allergy risk. Allergo J Int 2023; 32:251-257 doi.org/10.1007/s40629-023-00248-7

Jappe, U. Das Alpha-Gal-Syndrom – eine komplexe Allergie im interdisziplinären Kontext. Aktuelle Ernährungsmedizin 2023; 48(03): 195-208. DOI: 10.1055/a-1870-7328

Plum M, Tjerrild L, Raiber T, Bantleon F, Bantleon S, Miehe M, Jabs F, Seismann H, Möbs C, Pfützner W, Jakob T, Andersen GR, Spillner E. Structural and functional analyses of antibodies specific for modified core N-glycans suggest a role in TH 2 responses. Allergy. 2023;78(1):121-130. doi: 10.1111/all.15417.

Reese I, Schäfer C, Ballmer-Weber B, Beyer K, Dölle-Bierke S, van Dullemen S, Jappe U, Müller S, Schnadt S, Treudler R, Worm M. Vegan diets from an allergy point of view - Position paper of the DGAKI working group on food allergy. Allergol Select. 2023 Mar 31;7:57-83. doi: 10.5414/ALX02400E. eCollection 2023

 

2022

Jappe, U 2022, Oral Allergy Syndrome. in E Schmidt (Hrsg.), Diseases of the Oral Mucosa. Springer International Publishing Switzerland, S. 427-434. https://doi.org/10.1007/978-3-030-82804-2_40

Kasper, B, Yue, X, Goldmann, T, Gülsen, A, Kugler, C, Yu, X & Petersen, F 2022, 'Air exposure and cell differentiation are essential for investigation of SARS-CoV-2 entry genes in human primary airway epithelial cells in vitro', Frontiers in Medicine, Jg. 9, S. 897695. https://doi.org/10.3389/fmed.2022.897695

Kleine-Tebbe, J, Brans, R & Jappe, U 2022, 'Allergene - Auslöser der verschiedenen Allergievarianten', Allergo Journal, Jg. 31, Nr. 2, S. 16-31. https://doi.org/10.1007/s15007-022-4980-4

Plum, M, Tjerrild, L, Raiber, T, Bantleon, F, Bantleon, S, Miehe, M, Jabs, F, Seismann, H, Möbs, C, Pfützner, W, Jakob, T, Andersen, GR & Spillner, E 2023, 'Structural and functional analyses of antibodies specific for modified core N-glycans suggest a role in TH 2 responses', ALLERGY, Jg. 78, Nr. 1, S. 121-130. https://doi.org/10.1111/all.15417

Schocker F, Jappe U. Breastfeeding: Maternally transferred allergens in breast milk: Protective or sensitizing? Mol Nutr Food Res. 2022 May 26:e2200066. doi: 10.1002/mnfr.202200066. https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202200066

Walsemann, T, Böttger, M, Traidl, S, Schwager, C, Gülsen, A, Freimooser, S, Rösner, LM, Werfel, T & Jappe, U 2023, 'Specific IgE against the house dust mite allergens Der p 5, 20 and 21 influences the phenotype and severity of atopic diseases', ALLERGY, Jg. 78, Nr. 3, S. 731-742. https://doi.org/10.1111/all.15553

Buchbeitrag (Originalartikel 2021) / Book contribution (original article 2021)

Jappe U, Karstedt A, Warneke D, Hellmig S, Böttger M, Riffelmann FW, Treudler R, Lange L, Abraham S, Dölle-Bierke S, Worm M, Wagner N, Rueff F, Reese G, Knulst AC, Becker WM. Identification and Purification of Novel Low-Molecular-Weight Lupine Allergens as Components for Personalized Diagnostics. In:  Food Allergies in Modern Life; eds: Sara Manti, Gian Luigi Marseglia and Salvatore Leonardi. MDPI 2022: 63-83 (www.mdpi.com/journal/nutrients)

 

2021

Behrends, J, Schwager, C, Hein, M, Scholzen, T, Kull, S & Jappe, U 2021, 'Innovative robust basophil activation test using a novel gating strategy reliably diagnosing allergy with full automation', ALLERGY, Jg. 76, Nr. 12, S. 3776-3788. https://doi.org/10.1111/all.14900

Gülsen, A, König, IR, Jappe, U & Drömann, D 2021, 'Effect of comorbid pulmonary disease on the severity of COVID-19: A systematic review and meta-analysis', Respirology (Carlton, Vic.), Jg. 26, Nr. 6, S. 552-565. https://doi.org/10.1111/resp.14049

Gülsen, A, Ruëff, F & Jappe, U 2021, 'Omalizumab ensures compatibility to bee venom immunotherapy (VIT) after VIT-induced anaphylaxis in a patient with systemic mastocytosis', Allergologie select, Jg. 5, S. 128-132. https://doi.org/10.5414/ALX02196E

Jappe, U, Beckert, H, Bergmann, K-C, Gülsen, A, Klimek, L, Philipp, S, Pickert, J, Rauber-Ellinghaus, MM, Renz, H, Taube, C, Treudler, R, Wagenmann, M, Werfel, T, Worm, M & Zuberbier , T 2021, 'Biologika bei atopischen Erkrankungen: Indikationsstellung, Nebenwirkungsmanagement und neue Entwicklungen', ALLERGOLOGIE, S. 54-80. https://doi.org/10.5414/ALX02197

Jappe, U, Beckert, H, Bergmann, K-C, Gülsen, A, Klimek, L, Philipp, S, Pickert, J, Rauber-Ellinghaus, MM, Renz, H, Taube, C, Treudler, R, Wagenmann, M, Werfel, T, Worm, M & Zuberbier, T 2021, 'Biologics for atopic diseases:Indication, side effect management, and new developments', Allergologie select, Jg. 5, S. 1-25. https://doi.org/10.5414/ALX02197E

Jappe, U, Karstedt, A, Warneke , D, Hellmig, S, Böttger, M, Riffelmann , FW, Treudler, R, Lange, L, Abraham, S, Dölle-Bierke, S, Worm, M, Wagner, N, Ruëff, F, Reese, G, Knulst, AC & Becker, W-M 2021, 'Identification and Purification of Novel Low-Molecular-Weight Lupine Allergens as Components for Personalized Diagnostics', Nutrients, Jg. 13, Nr. 2. https://doi.org/10.3390/nu13020409

Jappe, U, Schwager, C & Gadermaier, G 2021, 'Neue Allergene in der Erdnuss als Ursache einer Anaphylaxie', ALLERGOLOGIE, Jg. 44, Nr. 4, S. 271-276. https://doi.org/10.5414/ALX02179

Kraft, M, Dölle-Bierke, S, Renaudin, J-M, Ruëff, F, Hofmeier, KS, Treudler, R, Pföhler, C, Hawranek, T, Poziomkowska-Gęsicka, I, Jappe, U, Christoff, G, Müller, S, Fernandez-Rivas, M, García, BE, De Vicente Jiménez, TM, Cardona, V, Kleinheinz, A, Kreft, B, Bauer, A, Wagner, N, Wedi, B, Wenzel, M, Bilò, MB & Worm, M 2021, 'Wheat anaphylaxis in adults differs from reactions to other types of food', Journal of Allergy and Clinical Immunology in Clinical Practice, Jg. 9, Nr. 7, S. 2844-2852.e5. https://doi.org/10.1016/j.jaip.2021.03.037

Platts-Mills, TA, Hilger, C, Jappe, U, van Hage, M, Gadermaier, G, Spillner, E, Lidholm, J, Keshavarz, B, Aalberse, RC, van Ree, R, Goodman, RE & Pomés, A 2021, 'Carbohydrate Epitopes Currently Recognized as Targets for IgE Antibodies', ALLERGY, Jg. 76, Nr. 8, S. 2383-2394. https://doi.org/10.1111/all.14802

Recke, A, Becker, W-M & Jappe, U 2021, 'Neu erworbene Milchallergie im Erwachsenenalter', ALLERGOLOGIE, Jg. 44, Nr. 8, S. 592-595.

Schocker, F, Fehrenbach, H & Schromm, AB 2021, 'Mission impossible? A cultural change to support scientific integrity', EMBO REPORTS , Jg. 22, Nr. 7, S. e52334. https://doi.org/10.15252/embr.202052334

Worm, M, Reese, I, Ballmer-Weber, B, Beyer, K, Bischoff, SC, Bohle, B, Brockow, K, Claßen, M, Fischer, PJ, Hamelmann, E, Jappe, U, Kleine-Tebbe, J, Klimek, L, Koletzko, B, Lange, L, Lau, S, Lepp, U, Mahler, V, Nemat, K, Raithel, M, Saloga, J, Schäfer, C, Schnadt, S, Schreiber, J, Szépfalusi, Z, Treudler, R, Wagenmann, M, Werfel, T & Zuberbier, T 2021, 'Update of the S2k guideline on the management of IgE-mediated food allergies', Allergologie select, Jg. 5, S. 195-243. https://doi.org/10.5414/ALX02257E

 

2020

 Dölle-Bierke, S, Plank-Habibi, S, Schäfer , C, Ballmer-Weber, B, Beyer , K, Blümchen, K, Huttegger , I, Jappe, U, Kleine-Tebbe, J, Lange , L, Lau, S, Lepp, U, Mahler , V, Müller, S, Saloga, J, Schnaddt, S, Szépfalusi, Z, Treudler, R, Wassmann-Otto, A, Werfel, T, Zuberbier, T & Reese , I 2020, 'Diätische Implikationen bei ASS-Unverträglickeiten: Stellungnahme der AG Nahrungsmittelallergie der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI)', Allergo Journal International.

Ferastraoaru, D, Bax, HJ, Bergmann, C, Capron, M, Castells, M, Dombrowicz, D, Fiebiger, E, Gould, HJ, Hartmann, K, Jappe, U, Jordakieva, G, Josephs, DH, Levi-Schaffer, F, Mahler, V, Poli, A, Rosenstreich, D, Roth-Walter, F, Shamji, M, Steveling-Klein, EH, Turner, MC, Untersmayr, E, Karagiannis, SN & Jensen-Jarolim, E 2020, 'AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer-a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)', Clinical and Translational Allergy, Jg. 10. https://doi.org/10.1186/s13601-020-00335-w

Gülsen, A, Wedi, B & Jappe, U 2020, 'Hypersensitivity reactions to biologics (part I) allergy as an important differential diagnosis in complex immune-derived adverse events', Allergo Journal, Jg. 29, Nr. 4, S. 32-61. https://doi.org/10.1007/s15007-020-2550-1

Gülsen, A, Wedi, B & Jappe, U 2020, 'Hypersensitivity reactions to Biologics (Part II): classifications and current diagnostic and treatment approaches', Allergo Journal International, Jg. 29, S. 139-154. https://doi.org/10.1007/s40629-020-00127-5

Klimek, L, Pfaar, O, Worm, M, Eiwegger, T, Hagemann, J, Ollert, M, Untersmayr, E, Hoffmann-Sommergruber, K, Vultaggio, A, Agache, I, Bavbek, S, Bossios, A, Casper, I, Chan, S, Chatzipetrou, A, Vogelberg, C, Firinu, D, Kauppi, P, Kolios, A, Kothari, A, Matucci, A, Palomares, O, Szépfalusi, Z, Pohl, W, Hötzenecker, W, Rosenkranz, A, Bergmann, K-C, Bieber, T, Buhl, R, Buters, J, Darsow, U, Keil, T, Kleine-Tebbe, J, Lau, S, Maurer, M, Merk, H, Mösges, R, Saloga, J, Staubach, P, Jappe, U, Rabe, C, Rabe, U, Vogelmeier, C, Biedermann, T, Jung, K, Schlenter, W, Ring, J, Chaker, A, Wehrmann, W, Becker, S, Freudelsperger, L, Mülleneisen, N, Nemat, K, Czech, W, Wrede, H, Brehler, R, Fuchs, T, Tomazic, P-V, Aberer, W, Fink Wagner, A, Horak, F, Wöhrl, S, Niederberger-Leppin, V, Pali-Schöll, I, Roller-Wirnsberger, R, Spranger, O, Valenta, R, Akdis, M, Matricardi, PM, Spertini, F, Khaltaev, N, Michel, J-P, Nicod, L, Schmid-Grendelmeier, P, Idzko, M, Hamelmann, E, Jakob, T, Werfel, T, Wagenmann, M, Taube, C, Jensen-Jarolim, E, Korn, S, Hentges, F, Schwarze, J, O Mahony, L, Knol, E, Del Giacco, S, Chivato, T, Bousquet, J, Zuberbier, T, Akdis, C & Jutel, M 2020, 'Anwendung von Biologika bei allergischen und Typ-2-entzündlichen Erkrankungen in der aktuellen Covid-19-Pandemie: Positionspapier des Ärzteverbands Deutscher Allergologen (AeDA)A, der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI)B, der Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA)C, der Österreichischen Gesellschaft für Allergologie und Immunologie (ÖGAI)D, der Luxemburgischen Gesellschaft für Allergologie und Immunologie (LGAI)E, der Österreichischen Gesellschaft für Pneumologie (ÖGP)F in Kooperation mit der deutschen, österreichischen, und schweizerischen ARIA-GruppeG und der Europäischen Akademie für Allergologie und Klinische Immunologie (EAACI)H', Allergo Journal, Jg. 29, Nr. 4, S. 14-27. https://doi.org/10.1007/s15007-020-2553-y

Klimek, L, Pfaar, O, Worm, M, Eiwegger, T, Hagemann, J, Ollert, M, Untersmayr, E, Hoffmann-Sommergruber, K, Vultaggio, A, Agache, I, Bavbek, S, Bossios, A, Casper, I, Chan, S, Chatzipetrou, A, Vogelberg, C, Firinu, D, Kauppi, P, Kolios, A, Kothari, A, Matucci, A, Palomares, O, Szépfalusi, Z, Pohl, W, Hötzenecker, W, Rosenkranz, AR, Bergmann, K-C, Bieber, T, Buhl, R, Buters, J, Darsow, U, Keil, T, Kleine-Tebbe, J, Lau, S, Maurer, M, Merk, H, Mösges, R, Saloga, J, Staubach, P, Jappe, U, Rabe, KF, Rabe, U, Vogelmeier, C, Biedermann, T, Jung, K, Schlenter, W, Ring, J, Chaker, A, Wehrmann, W, Becker, S, Freudelsperger, L, Mülleneisen, N, Nemat, K, Czech, W, Wrede, H, Brehler, R, Fuchs, T, Tomazic, P-V, Aberer, W, Fink-Wagner, A-H, Horak, F, Wöhrl, S, Niederberger-Leppin, V, Pali-Schöll, I, Pohl, W, Roller-Wirnsberger, R, Spranger, O, Valenta, R, Akdis, M, Matricardi, PM, Spertini, F, Khaltaev, N, Michel, J-P, Nicod, L, Schmid-Grendelmeier, P, Idzko, M, Hamelmann, E, Jakob, T, Werfel, T, Wagenmann, M, Taube, C, Jensen-Jarolim, E, Korn, S, Hentges, F, Schwarze, J, O Mahony, L, Knol, EF, Del Giacco, S, Chivato Pérez, T, Bousquet, J, Bedbrook, A, Zuberbier, T, Akdis, C & Jutel, M 2020, 'Use of biologicals in allergic and type-2 inflammatory diseases during the current COVID-19 pandemic: Position paper of Ärzteverband Deutscher Allergologen (AeDA)A, Deutsche Gesellschaft für Allergologie und Klinische Immunologie (DGAKI)B, Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA)C, Österreichische Gesellschaft für Allergologie und Immunologie (ÖGAI)D, Luxemburgische Gesellschaft für Allergologie und Immunologie (LGAI)E, Österreichische Gesellschaft für Pneumologie (ÖGP)F in co-operation with the German, Austrian, and Swiss ARIA groupsG, and the European Academy of Allergy and Clinical Immunology (EAACI)H', Allergologie select, Jg. 4, S. 53-68. https://doi.org/10.5414/ALX02166E

Kraft, M, Hofmeier, KS, Ruëff, F, Pföhler, C, Renaudin, J-M, Bilò, MB, Treudler, R, Lang, R, Cichoka-Jarosz, E, Fernandez-Rivas, M, Christoff, G, Papadopoulus, NG, Ensina, LF, O'B Hourihane, J, Maris, I, Köhli, A, García, BE, Jappe, U, Vogelberg, C, Ott, H, Lange, L, Spindler, T, Dölle-Bierke, S & Worm, M 2020, 'Risk factors and characteristics of biphasic anaphylaxis', Journal of Allergy and Clinical Immunology in Clinical Practice, Jg. 8, Nr. 10, S. 3388-3395.e6. https://doi.org/10.1016/j.jaip.2020.07.036

Krause, T, Röckendorf, N, Frey, B, Sinnecker, H, Schwager, C, Möckel, S, Jappe, U & Frey, A 2020, 'IgE Epitope Profiling for Allergy Diagnosis and Therapy – Parallel Analysis of a Multitude of Potential Linear Epitopes Using a High Throughput Screening Platform', FRONTIERS IN IMMUNOLOGY, Jg. 11, Nr. 11, 565243, S. 565243. https://doi.org/10.3389/fimmu.2020.565243, https://doi.org/10.3389/fimmu.2020.565243

Platts-Mills, TAE, Commins, SP, Biedermann, T, van Hage, M, Levin, M, Beck, LA, Diuk-Wasser, M, Jappe, U, Apostolovic, D, Minnicozzi, M, Plaut, M & Wilson, JM 2020, 'On the cause and consequences of IgE to galactose-α-1,3-galactose: A report from the National Institute of Allergy and Infectious Diseases Workshop on Understanding IgE-Mediated Mammalian Meat Allergy', The Journal of allergy and clinical immunology, Jg. 145, Nr. 4, S. 1061-1071. https://doi.org/10.1016/j.jaci.2020.01.047

Ramírez Caballero, L, Kny, C, Treudler, R, Simon, JC, Kern, K, Jappe, U & Szardenings, M 2020, 'Identification of Seasonal Variations of Antibodies against PR-10-Specific Epitopes Can Be Improved Using Peptide-Phage Display', INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY , Jg. 181, Nr. 12, S. 919–925 . https://doi.org/10.1159/000509995

Schocker, F, Kull, S, Schwager, C, Behrends, J & Jappe, U 2020, 'Individual Sensitization Pattern Recognition to Cow’s Milk and Human Milk Differs for Various Clinical Manifestations of Milk Allergy', Nutrients, Jg. 11, Nr. 6, S. 95-105. https://doi.org/10.3390/books978-3-03928-029-2

Wanka, L & Jappe, U 2021, 'Trained Immunity and Allergy: State of the Art and Future Perspectives', ALLERGY, Jg. 76, Nr. 4, S. 1265-1267. https://doi.org/10.1111/all.14617

 

2019

González Roldán, N, Engel, R, Düpow, S, Jakob, K, Koops, F, Orinska, Z, Vigor, C, Oger, C, Galano, J-M, Durand, T, Jappe, U & Duda, KA 2019, 'Lipid Mediators From Timothy Grass Pollen Contribute to the Effector Phase of Allergy and Prime Dendritic Cells for Glycolipid Presentation', FRONTIERS IN IMMUNOLOGY, Jg. 10, S. 974. https://doi.org/10.3389/fimmu.2019.00974

Gülsen, A, Wallis, S & Jappe, U 2021, 'Combination of immunotherapies for severe allergic asthma', Journal of Asthma, Jg. 58, Nr. 1, S. 75-78. https://doi.org/10.1080/02770903.2019.1658204

Jappe, U, Schwager, C, Schromm, A, Gonzalez Roldan, N, Stein, K, Heine, H & Duda, K 2019, 'Lipophilic allergens, different modes of allergen-lipid interaction and their impact on asthma and allergy', FRONTIERS IN IMMUNOLOGY, Jg. 10, S. 122. https://doi.org/10.3389/fimmu.2019.00122

Recke, A, Massalme, EG, Jappe, U, Steinmüller-Magin , L, Schmidt, J, Hellenbroich, Y, Gillessen-Kaesbach , G, Zillikens, D & Hartmann, K 2019, 'Identification of the recently described plasminogen gene mutation p.Lys330Glu in a family from Northern Germany with hereditary angioedema', Clinical and Translational Allergy, Jg. 9, Nr. 9, S. 9. https://doi.org/10.1186/s13601-019-0247-x

Schocker, F 2019, 'Allergieprophylaxe: Erdnüsse in der Stillzeit?', DEUTSCHE HEBAMMENZEITSCHRIFT, Jg. 71, S. 22-28. https://www.dhz-online.de/no_cache/archiv/archiv-inhalt-heft/archiv-detail-abo/artikel/erdnuesse-in-der-stillzeit/

Schocker, F, Kull, S, Schwager, C, Behrends, J & Jappe, U 2019, 'Individual Sensitization Pattern Recognition to Cow’s Milk and Human Milk Differs for Various Clinical Manifestations of Milk Allergy', Nutrients, Jg. 11, Nr. 6, S. 1331. https://doi.org/10.3390/nu11061331

 

2018

Anemüller, W, Mohrs, M, Brans, R, Homann, A & Jappe, U 2018, 'Alpha-Gal-assoziierte verzögerte Anaphylaxie gegen rotes Fleisch als Berufskrankheit.', Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete, Jg. 69, Nr. 10, S. 848-852. https://doi.org/10.1007/s00105-018-4224-4

Gülsen, A & Jappe, U 2019, 'Lipid transfer protein sensitization in an apple-allergic patient: a case report from northern Europe', European Annals of Allergy and Clinical Immunology, Jg. 51, Nr. 2, S. 80-83. https://doi.org/10.23822/EurAnnACI.1764-1489.63

Jappe, U & Breiteneder, H 2019, 'Peanut allergy - Individual molecules as a key to precision medicine', ALLERGY, Jg. 74, Nr. 2, S. 216-219. https://doi.org/10.1111/all.13625

Jappe, U 2018, 'Die Nomenklatur der Allergene: Allergen nomenclature', HAUTARZT, Jg. 69, Nr. 1, S. 90-91. https://link.springer.com/article/10.1007/s00105-017-4103-4

Jappe, U 2018, 'Nahrungsmittelallergie: Theorie und Praxis.', DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, Jg. 143, S. 713-721. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-121014

McIntyre, M 2018, 'Ohrmuschel und Gehörgang: wann ist es eine Allergie?', ALLERGOLOGIE, Jg. 41, Nr. 3, S. 105-110. https://doi.org/10.5414/ALX1983

Nikolic, J, Kull, S, Schocker, F, Nesic, A & Gavrovic-Jankulovic, M 2018, 'Employment of proteomic and immunological based methods for the identification of catalase as novel allergen from banana', Journal of Proteomics, Jg. 175, S. 87-94. https://doi.org/10.1016/j.prot.2018.01.007

Pomés, A, Davies, JM, Gadermaier, G, Hilger, C, Holzhauser, T, Lidholm, J, Lopata, AL, Mueller, GA, Nandy, A, Radauer, C, Chan, SK, Jappe, U, Kleine-Tebbe, J, Thomas, WR, Chapman, MD, van Hage, M, van Ree, R, Vieths, S, Raulf, M, Goodman, RE & WHO IUIS Allergen Nomenclature Sub-Committee 2018, 'WHO/IUIS Allergen Nomenclature: Providing a common language', MOLECULAR IMMUNOLOGY, Jg. 100, S. 3-13. https://doi.org/10.1016/j.molimm.2018.03.003

Schocker, F, Recke, A, Kull, S, Worm, M, Behrends, J & Jappe, U 2018, 'Reply to Chirumbolo et al', Pediatric Allergy and Immunology, Jg. 29, Nr. 4, S. 461-462. https://doi.org/10.1111/pai.12892

Schocker, F, Recke, A, Kull, S, Worm, M & Jappe, U 2018, 'Persistent cow's milk anaphylaxis from early childhood monitored by IgE and BAT to cow's and human milk under therapy', Pediatric Allergy and Immunology, Jg. 29, Nr. 2, S. 210-214. https://doi.org/10.1111/pai.12843

 

Head

Prof. Dr. Uta Jappe
Prof. Dr. Uta Jappe
Leiterin der Forschungsgruppe, Oberärztin und Leiterin der Interdisziplinären Allergie-Ambulanz, Medizinische Klinik III (Pneumologie), UK-SH Lübeck, Sprecherin des Comprehensive Allergy Centers "Kompetenzzentrum Lübeck für Interdisziplinäre und Molekulare Allergologie (KLIMA)".
(Anmeldung für Patienten: Tel.: 0451-500-44165; -44195; -44196 sowie unter der E-Mailadresse ambulanz.innere.luebeck@uksh.de)
+49 4537 / 188-7406
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Scientific staff

Dr. Marua Abu Risha
Dr. Marua Abu Risha
+49 4537 / 188-5870
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Dr. Sara Knape
+49 4537 / 188-4901
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Nathalie Martin
Masterstudentin
+49 4537 / 188-5870
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Dr. Melanie Plum
+49 4537 / 188-4590
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Dr. Eva-Maria Rick
+49 4537 / 188-4970
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Technical staff

 
Marisa Böttger
+49 4537 / 188-4951
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Maren Hohn
+49 4537 / 188-4961
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Cameron Kolberg
Auszubildender
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Daniel Rosero
+49 4537 / 188-4621
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Alumni

  • MSC Elisabeth Albert
  • Isabell Behrens
  • MSC Blessing Asuquo Esu
  • Dr. med. Askin Gülsen
  • MSC Saskia Hellmig
  • Dr. Arne Homann
  • MSc Arabella Karstedt
  • Dr. med. Tamina Kolaly
  • MSC Miriam Kosakowski
  • Dr. Skadi Kull
  • MSC Vivian Lelleck
  • Dr. Sandra Minge
  • MSC Muriel Mrose
  • Carolin Murawski
  • Dr. med. Annika Opitz
  • Laura Paulsen
  • Prof. Dr. Arnd Petersen
  • Dr. Sandra Rennert
  • MSC Celina Sachs
  • MSC Alexandra Scharf
  • Dr. Frauke Schocker
  • Dr. Christian Schwager
  • Dr. Mareike de Vries
  • Theresa Walsemann
  • Dr. Lizzy Wanka

 

 

 

Last Update: 04.02.20126