Priority Research Area Asthma and Allergy

Mucosal Immunology and Diagnostic

Mission   Projects   Funding   Techniques   Publications    Staff



Krause, T, Röckendorf, N, El-Sourani, N, Ramaker, K, Henkel, M, Hauke, S, Borschbach, M & Frey A 2018, 'Breeding cell penetrating peptides: optimization of cellular uptake by a function-driven evolutionary process' Bioconjugate Chemistry DOI: 10.1021/acs.biocojchem.8b00583

Ramaker, K, Henkel, M, Krause, T, Röckendorf, N & Frey, A 2018, 'Cell penetrating peptides: a comparative transport analysis for 474 sequence motifs' Drug Delivery, Bd 25, Nr. 1, S. 928-937.



Homann, A, Röckendorf, N, Kromminga, A, Frey, A, Platts-Mills, TA & Jappe, U 2017, 'Glycan and Peptide IgE Epitopes of the TNF-alpha Blockers Infliximab and Adalimumab - Precision Diagnostics by Cross-Reactivity Immune Profiling of Patient Sera.' Theranostics, Bd 7, Nr. 19, S. 4699-4709.

Röckendorf, N, Meckelein, B, Scherf, KA, Schalk, K, Köhler, P & Frey, A 2017, 'Identification of novel antibody-reactive detection sites for comprehensive gluten monitoring' PLOS ONE, Bd 10, Nr. 7, S. e0181566. DOI: 10.1371/journal.pone.0181566

Schwager, C, Kull, S, Behrends, J, Röckendorf, N, Schocker, F, Frey, A, Homann, A, Becker, W-M & Jappe, U 2017, 'Peanut oleosins associated with severe peanut allergy - Importance of lipophilic allergens for comprehensive allergy diagnostics' JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Bd 140, Nr. 5, 10.1016/j.jaci.2017.02.020, S. 1331-1338. DOI: 10.1016/j.jaci.2017.02.020

Lautenschläger, I, Wong, YL, Sarau, J, Goldmann, T, Zitta, K, Albrecht, M, Frerichs, I, Weiler, N & Uhlig, S 2017, 'Signalling mechanisms in PAF-induced intestinal failure' Scientific Reports, Bd 7, Nr. 1, S. 13382. DOI: 10.1038/s41598-017-13850-x



Frey, A, Röckendorf, N & Henkel, M 2016, 'Selective and efficient cysteine conjugation by maleimides in the presence of phosphine reductants' BIOCONJUGATE CHEMISTRY , Bd 27, Nr. 10, S. 2260-2265. DOI: 10.1021-acs.bioconjchem.6b00371



Homann A, Röckendorf N, Kromminga A, Frey A, Jappe U. B cell epitopes on infliximab identified by oligopeptide microarray with unprocessed patient sera. J Transl Med. 2015 Oct 29;13:339. doi: 10.1186/s12967-015-0706-7. PubMed PMID: 26511203

Meyer, NH, Mayerhofer, H, Tripsianes, K, Blindow, S, Barths, D, Mewes, A, Weimar, T, Köhli, T, Bade, S, Madl, T, Frey, A, Haas, H, Mueller-Dieckmann, J, Sattler, M & Schramm, G 2015, A crystallin fold in the interleukin-4-inducing principle of Schistosoma mansoni eggs (IPSE/alpha-1) mediates IgE binding for antigen-independent basophil activation.  J Biol Chem. 2015 Sep 4;290(36):22111-26. doi:10.1074/jbc.M115.675066. Epub 2015 Jul 10.

Wong, YL, Lautenschläger, I, Dombrowsky, H, Zitta, K, Bein, B, Krause, T, Goldmann, T, Frerichs, I, Steinfath, M, Weiler, N & Albrecht, M 2015, 'Hydroxyethyl Starch (HES 130/0.4) Impairs Intestinal Barrier Integrity and Metabolic Function: Findings from a Mouse Model of the Isolated Perfused Small Intestine' PLOS ONE, Bd 10, Nr. 3, S. e0121497.



Sinnecker, H, Krause, T, Koelling, S, Lautenschläger, I & Frey, A 2014, 'The gut wall provides an effective barrier against nanoparticle uptake' Beilstein Journal of Nanotechnology, Bd 5, S. 2092-2101., 10.3762/bjnano.5.218

Sinnecker, H, Ramaker, K & Frey, A 2014, 'Coating with luminal gut-constituents alters adherence of nanoparticles to intestinal epithelial cells' Beilstein Journal of Nanotechnology, Bd 5, S. 2308-2315., 10.3762/bjnano.5.239



Henkel, M, Reuter, F, Röckendorf, N & Frey, A 2013, 'Peptidomimetics as mucosal immunogens' in 36th Symposium of the north german Immunologists: Understanding Infections & Allergy - still a lung way to go .



Röckendorf N, Borschbach M, Frey A. Molecular Evolution of Peptide Ligands with Custom-Tailored Characteristics for Targeting of Glycostructures. PLoS COMPUTATIONAL BIOLOGY 2012 Dec;8(12):e1002800. Open Access

Schrader C, Ernst IMA, Sinnecker H, Soukup ST, Kulling SE, Rimbach G. Genistein as a potential inducer of the anti-atherogenic enzyme paraoxonase-1: studies in cultured hepatocytes in vitro and in rat liver in vivo. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2012 Oct;16(10):2331–2341.

Gorris HH, Bade S, Röckendorf N, Fránek M, Frey A. Pushing Antibody-Based Labeling Systems to Higher Sensitivity by Linker-Assisted Affinity Enhancement. BIOCONJUGATE CHEMISTRY 2011 Aug;22(8):1619-1624.

Bade S, Gorris HH, Koelling S, Olivier V, Reuter F, Zabel P, Frey A. Quantitation of major protein constituents of murine intestinal fluid. ANALYTICAL BIOCHEMISTRY 2010 Nov;406(2):157-165.

Lautenschlager I, Dombrowsky H, Frerichs I, Kuchenbecker S, Bade S, Schultz H, Zabel P, Scholz J, Weiler N, Uhlig S. A model of the isolated perfused rat small intestine. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 2010 Feb;298(2):G304-G313.

Bade S, Rockendorf N, Franek M, Gorris H, Lindner B, Olivier V, Schaper K, Frey A. Biolabeling with 2,4-Dichlorophenoxyacetic Acid Derivatives: The 2,4-D Tag. ANALYTICAL CHEMISTRY 2009 Dec;81(23):9695-9702.

Reuter F, Bade S, Hirst T, Frey A. Bystander protein protects potential vaccine-targeting ligands against intestinal proteolysis. JOURNAL OF CONTROLLED RELEASE 2009 Jul;137(2):98-103.

Gorris H, Bade S, Rockendorf N, Albers E, Schmidt M, Franek M, Frey A. Rapid Profiling of Peptide Stability in Proteolytic Environments. ANALYTICAL CHEMISTRY 2009 Feb;81(4):1580-1586.

Bade S, Frey A. Vaccines against transmissible spongiform encephalopathies - An urgent need? HUMAN VACCINES 2008 Feb;4(1):79-81.

Rockendorf N, Helfmann J, Fujimoto N, Wehry K, Burger M, Frey A. Peptide-based optical contrast agents for targeting of intestinal malignancies.  In: Popp J, von Bally G, (Ed) Biophotonics 2007: Optics in Life Science.  Munich, Germany: SPIE; 2007 p. 66332A-9.

Rockendorf N, Bade S, Hirst T, Gorris H, Frey A. Synthesis of a fluorescent ganglioside G(M1) derivative and screening of a synthetic peptide library for G(M1) binding sequence motifs. BIOCONJUGATE CHEMISTRY 2007 Apr;18(2):573-578.

Bade S, Frey A. Potential of active and passive immunizations for the prevention and therapy of transmissible spongiform encephalopathies. EXPERT REVIEW OF VACCINES 2007 Apr;6(2):153-168.

Boetel T, Bade S, Schmidt M, Frey A. Prion protein 90-231 contains a streptavidin-binding motif. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2006 Oct;349(1):296-302.

Bade S, Baier M, Boetel T, Frey A. Intranasal immunization of Balb/c mice against prion protein attenuates orally acquired transmissible spongiform encephalopathy. VACCINE 2006 Feb;24(9):1242-1253.

Book Chapters

Ramaker K, Röckendorf N, Frey A. Engineering contrast agents for gastrointestinal magnetic particle imaging: the biological perspective. In: Buzug & J. Borgert, (eds.): Magnetic particle imaging : a novel SPIO nanoparticle imaging technique. Heidelberg [u.a.]: Springer; 2012 p. 205–210.

Bade S, Röckendorf N, Frey A, Petersen A. Western Blotting. In: Jansohn, M.; Rothämel, S.(Hrsg.): Gentechnische Methoden : eine Sammlung von Arbeitsanleitungen für das molekularbiologische Labor. Heidelberg: Spektrum Akad. Verl.; 2012 p. 279-308.

Röckendorf N, Bade S, Gorris H, Frey A. 18 Peptid-Arrays auf Cellulosemembranen. In: Jansohn, M.; Rothämel, S.(Hrsg.): Gentechnische Methoden : eine Sammlung von Arbeitsanleitungen für das molekularbiologische Labor. Heidelberg: Spektrum Akad. Verl.; 2012 p. 501-528.

Gorris H, Bade S, Frey A. Peptidarrays auf Cellulosemembranen.  In: Jansohn M, Aigner A, (Ed.). Gentechnische Methoden : eine Sammlung von Arbeitsanleitungen für das molekularbiologische Labor. 2007 p. 419-544.

Frey A, Bade S, Petersen A. Western Blotting.  In: Jansohn M, Aigner A, (Ed.). Gentechnische Methoden : eine Sammlung von Arbeitsanleitungen für das molekularbiologische Labor. 2007 S. 395-422.

Helfmann J, Bindig U, Meckelein B, Wehry K, Röckendorf N, Schädel D, Schmidt M, Bürger M, Frey A. Early Diagnosis of Cancer.  In: Popp, Jürgen; Strehle, Marion: Biophotonics : visions for better health care.  Weinheim: Wiley-VCH; 2006 p. 231-300.