Priority Research Area Chronic Lung Diseases

2023

Bieber, K, Hundt, JE, Yu, X, Ehlers, M, Petersen, F, Karsten, CM, Köhl, J, Kridin, K, Kalies, K, Kasprick, A, Goletz, S, Humrich, JY, Manz, RA, Künstner, A, Hammers, CM, Akbarzadeh, R, Busch, H, Sadik, CD, Lange, T, Grasshoff, H, Hackel, AM, Erdmann, J, König, I, Raasch, W, Becker, M, Kerstein-Stähle, A, Lamprecht, P, Riemekasten, G, Schmidt, E & Ludwig, RJ 2023, 'Autoimmune pre-disease', AUTOIMMUNITY REVIEWS , Jg. 22, Nr. 2, S. 103236. https://doi.org/10.1016/j.autrev.2022.103236

Cabral-Marques, O, Moll, G, Catar, R, Preuß, B, Bankamp, L, Pecher, A-C, Henes, J, Klein, R, Kamalanathan, AS, Akbarzadeh, R, van Oostveen, W, Hohberger, B, Endres, M, Koolmoes, B, Levarht, N, Postma, R, van Duinen, V, van Zonneveld, AJ, de Vries-Bouwstra, J, Fehres, C, Tran, F, do Vale, FYN, da Silva Souza, KB, Filgueiras, IS, Schimke, LF, Baiocchi, GC, de Miranda, GC, da Fonseca, DLM, Freire, PP, Hackel, AM, Grasshoff, H, Stähle, A, Müller, A, Dechend, R, Yu, X, Petersen, F, Sotzny, F, Sakmar, TP, Ochs, HD, Schulze-Forster, K, Heidecke, H, Scheibenbogen, C, Shoenfeld, Y & Riemekasten, G 2023, 'Autoantibodies targeting G protein-coupled receptors: An evolving history in autoimmunity. Report of the 4th international symposium', AUTOIMMUNITY REVIEWS , Jg. 22, Nr. 5, S. 103310. https://doi.org/10.1016/j.autrev.2023.103310

 

2022

Kasper, B, Yue, X, Goldmann, T, Gülsen, A, Kugler, C, Yu, X & Petersen, F 2022, 'Air exposure and cell differentiation are essential for investigation of SARS-CoV-2 entry genes in human primary airway epithelial cells in vitro', Frontiers in Medicine, Jg. 9, S. 897695. https://doi.org/10.3389/fmed.2022.897695

Philippe, A, Kleinau, G, Gruner, JJ, Wu, S, Postpieszala, D, Speck, D, Heidecke, H, Dowell, SJ, Riemekasten, G, Hildebrand, PW, Kamhieh-Milz, J, Catar, R, Szczepek, M, Dragun, D & Scheerer, P 2022, 'Molecular Effects of Auto-Antibodies on Angiotensin II Type 1 Receptor Signaling and Cell Proliferation', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , Jg. 23, Nr. 7. https://doi.org/10.3390/ijms23073984

Shan, L, Zhang, L, Zhu, X, Wang, Z, Fang, S, Lin, J, Wang, J, Li, N, Liu, H, Zhang, X, Feng, Y, Liu, J, Pan, J, Ye, G, Yu, X, Tufman, A, Katalinic, A, Goldmann, T, Petersen, F, Jiang, J, Geng, G & Yu, X 2022, 'Chinese never smokers with adenocarcinoma of the lung are younger and have fewer lymph node metastases than smokers', RESPIRATORY RESEARCH , Jg. 23, Nr. 1, S. 293. https://doi.org/10.1186/s12931-022-02199-z

Shu, Y, Ma, X, Chen, C, Wang, Y, Sun, X, Zhang, L, Lu, Z, Petersen, F, Qiu, W & Yu, X 2022, 'Myelin oligodendrocyte glycoprotein-associated disease is associated with BANK1, RNASET2 and TNIP1 polymorphisms', Journal of neuroimmunology, Jg. 372, S. 577937. https://doi.org/10.1016/j.jneuroim.2022.577937

Shu, Y, Yue, X, Wax, J, Kasper, B, Yin, J, Wang, X, Zhang, L, Ahmadi, M, Heidecke, H, Müller, A, Lamprecht, P, Yu, X, Riemekasten, G & Petersen, F 2022, 'Both T and B cells are indispensable for the development of a PBMC transfer-induced humanized mouse model for SSc',  ARTHRITIS RESEARCH & THERAPY , Jg. 24, Nr. 1, S. 209. https://doi.org/10.1186/s13075-022-02896-6

Tran, F, Harris, DMM, Scharmacher, A, Graßhoff, H, Sterner, K, Schinke, S, Käding, N, Humrich, JY, Cabral-Marques, O, Bernardes, JP, Mishra, N, Bahmer, T, Franzenburg, J, Hoyer, BF, Glück, A, Guggeis, M, Ossysek, A, Küller, A, Frank, D, Lange, C, Rupp, J, Heyckendorf, J, Gaede, KI, Amital, H, Rosenstiel, P, Shoenfeld, Y, Halpert, G, Rosenberg, AZ, Schulze-Forster, K, Heidecke, H, Riemekasten, G & Schreiber, S 2022, 'Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19', ERJ Open Research, Jg. 8, Nr. 4. https://doi.org/10.1183/23120541.00379-2022

Wang, G, Ma, A, Zhang, L, Guo, J, Liu, Q, Petersen, F, Wang, Z & Yu, X 2022, 'Acute exacerbations of chronic obstructive pulmonary disease in a cohort of Chinese never smokers goes along with decreased risks of recurrent acute exacerbation, emphysema and comorbidity of lung cancer as well as decreased levels of circulating eosinophils and basophils', Frontiers in Medicine, Jg. 9, S. 907893. https://doi.org/10.3389/fmed.2022.907893

Yue, X, Yin, J, Wang, X, Heidecke, H, Hackel, AM, Dong, X, Kasper, B, Wen, L, Zhang, L, Schulze-Forster, K, Junker, J, Grasshoff, H, Müller, A, Wallukat, G, Schimke, I, Zeiner, J, Deckstein, LM, Mertens, N, Kerstein-Staehle, A, Hundt, JE, Kostenis, E, Yu, X, Riemekasten, G & Petersen, F 2022, 'Induced antibodies directed to the angiotensin receptor type 1 provoke skin and lung inflammation, dermal fibrosis and act species overarching', ANNALS OF THE RHEUMATIC DISEASES , Jg. 81, Nr. 9, annrheumdis-2021-222088, S. 1281-9. https://doi.org/10.1136/annrheumdis-2021-222088

Zhang, L, Wax, J, Huang, R, Petersen, F & Yu, X 2022, 'Meta-Analysis and Systematic Review of the Association between a Hypoactive NCF1 Variant and Various Autoimmune Diseases', Antioxidants (Basel, Switzerland), Jg. 11, Nr. 8, 1589. https://doi.org/10.3390/antiox11081589

 

2021

Hiroyasu, S, Zeglinski, MR, Zhao, H, Pawluk, MA, Turner, CT, Kasprick, A, Tateishi, C, Nishie, W, Burleigh, A, Lennox, PA, Van Laeken, N, Carr, NJ, Petersen, F, Crawford, RI, Shimizu, H, Tsuruta, D, Ludwig, RJ & Granville, DJ 2021, 'Granzyme B inhibition reduces disease severity in autoimmune blistering diseases', Nature communications, Jg. 12, Nr. 1, S. 302. https://doi.org/10.1038/s41467-020-20604-3

Ma, A, Zhang, L, Ye, X, Chen, J, Yu, J, Zhuang, L, Weng, C, Petersen, F, Wang, Z & Yu, X 2021, 'High Levels of Circulating IL-8 and Soluble IL-2R Are Associated With Prolonged Illness in Patients With Severe COVID-19', FRONTIERS IN IMMUNOLOGY, Jg. 12, S. 626235. https://doi.org/10.3389/fimmu.2021.626235

Shang, Y, Chen, F, Li, S, Song, L, Gao, Y, Yu, X & Zheng, J 2021, 'Investigation of Interaction between the Spike Protein of SARS-CoV-2 and ACE2-Expressing Cells Using an In Vitro Cell Capturing System', Biological procedures online, Jg. 23, Nr. 1, S. 16. https://doi.org/10.1186/s12575-021-00153-9

Shu, Y, Guo, J, Ma, X, Yan, Y, Wang, Y, Chen, C, Sun, X, Wang, H, Yin, J, Long, Y, Yan, X, Lu, Z, Petersen, F, Yu, X & Qiu, W 2021, 'Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is associated with IRF7, BANK1 and TBX21 polymorphisms in two populations', European journal of neurology, Jg. 28, Nr. 2, S. 595-601. https://doi.org/10.1111/ene.14596

Shu, Y, He, D, Ma, X, Li, J, Wu, H, Chen, C, Lu, Z, Petersen, F, Qiu, W & Yu, X 2021, 'Infiltration of plasma cells in colorectal adenocarcinoma associated with autoimmune encephalitis', Annals of clinical and translational neurology, Jg. 8, Nr. 2, S. 498-503. https://doi.org/10.1002/acn3.51283

Wen, L, Dong, X, Li, Q, Schramm, G, Zhang, B, Zillikens, D, Ludwig, RJ, Petersen, F & Yu, X 2021, 'Preventive but Not Therapeutic Topical Application of Local Anesthetics Can Inhibit Experimental Epidermolysis Bullosa Acquisita in Mice', FRONTIERS IN IMMUNOLOGY, Jg. 12, S. 750160. https://doi.org/10.3389/fimmu.2021.750160

Yin, J, Ibrahim, S, Petersen, F & Yu, X 2021, 'Autoimmunomic Signatures of Aging and Age-Related Neurodegenerative Diseases Are Associated With Brain Function and Ribosomal Proteins', Frontiers in Aging Neuroscience, Jg. 13, S. 679688. https://doi.org/10.3389/fnagi.2021.679688

Yue, X, Deng, F, Chen, J, Yin, J, Zheng, J, Chen, Y, Huang, Q, Gao, X, Liu, Z, Luo, J, Müller, A, Heidecke, H, Riemekasten, G, Petersen, F & Yu, X 2021, 'Autoantibodies against C5aR1, C3aR1, CXCR3, and CXCR4 are decreased in primary Sjogren's syndrome',  MOLECULAR IMMUNOLOGY, Jg. 131, S. 112-120. https://doi.org/10.1016/j.molimm.2020.12.027

Yue, X, Petersen, F, Shu, Y, Kasper, B, Magatsin, JDT, Ahmadi, M, Yin, J, Wax, J, Wang, X, Heidecke, H, Lamprecht, P, Müller, A, Yu, X & Riemekasten, G 2021, 'Transfer of PBMC From SSc Patients Induces Autoantibodies and Systemic Inflammation in Rag2-/-/IL2rg-/- Mice', FRONTIERS IN IMMUNOLOGY, Jg. 12, S. 677970. https://doi.org/10.3389/fimmu.2021.677970

Zillikens, H, Kasprick, A, Osterloh, C, Gross, N, Radziewitz, M, Hass, C, Hartmann, V, Behnen-Härer, M, Ernst, N, Boch, K, Vidarsson, G, Visser, R, Laskay, T, Yu, X, Petersen, F, Ludwig, RJ & Bieber, K 2021, 'Topical Application of the PI3Kβ-Selective Small Molecule Inhibitor TGX-221 Is an Effective Treatment Option for Experimental Epidermolysis Bullosa Acquisita', Frontiers in Medicine, Jg. 8, S. 713312. https://doi.org/10.3389/fmed.2021.713312

 

2020

Chen, Y, Li, S, Huang, R, Zhang, Z, Petersen, F, Zheng, J & Yu, X 2020, 'Comprehensive meta-analysis reveals an association of the HLA-DRB1*1602 allele with autoimmune diseases mediated predominantly by autoantibodies', AUTOIMMUNITY REVIEWS  Jg. 19, Nr. 6, S. 102532. https://doi.org/10.1016/j.autrev.2020.102532

Gao, Y, Chen, Y, Zhang, Z, Yu, X & Zheng, J 2020, 'Recent Advances in Mouse Models of Sjögren's Syndrome', FRONTIERS IN IMMUNOLOGY, Jg. 11, S. 1158. https://doi.org/10.3389/fimmu.2020.01158

Geng, G, Yu, X, Jiang, J & Yu, X 2020, 'Aetiology and pathogenesis of paraneoplastic autoimmune disorders', AUTOIMMUNITY REVIEWS, Jg. 19, Nr. 1, S. 102422. https://doi.org/10.1016/j.autrev.2019.102422

Ma, A, Wen, L, Yin, J, Hu, Y, Yue, X, Li, J, Dong, X, Gupta, Y, Ludwig, RJ, Krauss-Etschmann, S, Riemekasten, G, Petersen, F & Yu, X 2020, 'Serum Levels of Autoantibodies Against Extracellular Antigens and Neutrophil Granule Proteins Increase in Patients with COPD Compared to Non-COPD Smokers', International journal of chronic obstructive pulmonary disease, Jg. 15, S. 189-200. https://doi.org/10.2147/COPD.S235903

Stüssel, P, Schulze Dieckhoff, K, Künzel, S, Hartmann, V, Gupta, Y, Kaiser, G, Veldkamp, W, Vidarsson, G, Visser, R, Ghorbanalipoor, S, Matsumoto, K, Krause, M, Petersen, F, Kalies, K, Ludwig, RJ & Bieber, K 2020, 'Propranolol Is an Effective Topical and Systemic Treatment Option for Experimental Epidermolysis Bullosa Acquisita', JOURNAL OF INVESTIGATIVE DERMATOLOGY. https://doi.org/10.1016/j.jid.2020.04.025


2019

Gao, X, Yin, J, Wang, X, Petersen, F & Yu, X 2019, 'A comprehensive comparison of hematological parameters among 39 common diseases', Scandinavian journal of clinical and laboratory investigation, Jg. 79, Nr. 4, S. 251-259. https://doi.org/10.1080/00365513.2019.1591636

Shu, Y, Qiu, W, Zheng, J, Sun, X, Yin, J, Yang, X, Yue, X, Chen, C, Deng, Z, Li, S, Yang, Y, Peng, F, Lu, Z, Hu, X, Petersen, F & Yu, X 2019, 'HLA class II allele DRB1*16:02 is associated with anti-NMDAR encephalitis', Journal of neurology neurosurgery and psychiatry, Jg. 90, Nr. 6, S. 652-658. https://doi.org/10.1136/jnnp-2018-319714

Shu, Y, Long, Y, Wang, S, Hu, W, Zhou, J, Xu, H, Chen, C, Ou, Y, Lu, Z, Lau, AY, Yu, X, Kermode, AG & Qiu, W 2019, 'Brain histopathological study and prognosis in MOG antibody-associated demyelinating pseudotumor', Annals of clinical and translational neurology, Jg. 6, Nr. 2, S. 392-396. https://doi.org/10.1002/acn3.712


2018

Epp, A, Hobusch, J, Bartsch, YC, Petry, J, Lilienthal, G-M, Koeleman, CAM, Eschweiler, S, Möbs, C, Hall, A, Morris, SC, Braumann, D, Engellenner, C, Bitterling, J, Rahmöller, J, Leliavski, A, Thurmann, R, Collin, M, Moremen, KW, Strait, RT, Blanchard, V, Petersen, A, Gemoll, T, Habermann, JK, Petersen, F, Nandy, A, Kahlert, H, Hertl, M, Wuhrer, M, Pfützner, W, Jappe, U, Finkelman, FD & Ehlers, M 2018, 'Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions', The Journal of allergy and clinical immunology, Jg. 141, Nr. 1, S. 399-402.e8. https://doi.org/10.1016/j.jaci.2017.06.021

Gao, Y, Li, S, Zhang, Z, Yu, X & Zheng, J 2018, 'The Role of Long Non-coding RNAs in the Pathogenesis of RA, SLE, and SS', Frontiers in Medicine, Jg. 5, S. 193. https://doi.org/10.3389/fmed.2018.00193

Kasprick, A, Holtsche, MM, Rose, EL, Hussain, S, Schmidt, E, Petersen, F, Panicker, S & Ludwig, RJ 2018, 'The anti-C1s antibody TNT003 prevents complement activation in the skin induced by bullous pemphigoid autoantibodies', JOURNAL OF INVESTIGATIVE DERMATOLOGY, Jg. 138, Nr. 2, S. 458-461. https://doi.org/10.1016/j.jid.2017.08030

Krauss-Etschmann, S, Yu, X, Petersen, F & Wen, L 2018, 'Autoantibodies in Chronic Obstructive Pulmonary Disease', FRONTIERS IN IMMUNOLOGY, Jg. 9, Nr. 66, S. 66. https://doi.org/10.3389/fimmu.2018.00066

Lamprecht, P, Kerstein, A, Klapa, S, Schinke, S, Karsten, CM, Yu, X, Ehlers, M, Epplen, JT, Holl-Ulrich, K, Wiech, T, Kalies, K, Lange, T, Laudien, M, Laskay, T, Gemoll, T, Schumacher, U, Ullrich, S, Busch, H, Ibrahim, S, Fischer, N, Hasselbacher, K, Pries, R, Petersen, F, Weppner, G, Manz, R, Humrich, JY, Nieberding, R, Riemekasten, G & Müller, A 2018, 'Pathogenetic and Clinical Aspects of Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitides', FRONTIERS IN IMMUNOLOGY, Jg. 9, S. 680. https://doi.org/10.3389/fimmu.2018.00680

Shu, Y, Chang, Y, Wu, H, Li, J, Cao, B, Sun, X, Wang, J, Peng, L, Hu, X, Yu, X & Qiu, W 2018, 'Serum cystatin C and anti-N-methyl-D-aspartate receptor encephalitis', Acta neurologica Scandinavica, Jg. 137, Nr. 5, S. 515-522. https://doi.org/10.1111/ane.12894

Shu, Y, Xu, Y, Chen, C, Li, J, Li, R, Wu, H, Hu, X, Lu, Z, Yu, X & Qiu, W 2018, 'Serum Bilirubin and Albumin in Anti-N-Methyl-D-Aspartate Receptor Encephalitis', Neuroimmunomodulation, Jg. 25, Nr. 4, S. 206-214. https://doi.org/10.1159/000494801

Weigold, F, Günther, J, Pfeiffenberger, M, Cabral-Marques, O, Siegert, E, Dragun, D, Philippe, A, Regensburger, A-K, Recke, A, Yu, X, Petersen, F, Catar, R, Biesen, R, Hiepe, F, Burmester, GR, Heidecke, H & Riemekasten, G 2018, 'Antibodies against chemokine receptors CXCR3 and CXCR4 predict progressive deterioration of lung function in patients with systemic sclerosis',  ARTHRITIS RESEARCH & THERAPY , Jg. 20, Nr. 1, S. 52. https://doi.org/10.1186/s13075-018-1545-8

Yin, J, Zheng, J, Deng, F, Zhao, W, Chen, Y, Huang, Q, Huang, R, Wen, L, Yue, X, Petersen, F & Yu, X 2018, 'Gene Expression Profiling of Lacrimal Glands Identifies the Ectopic Expression of MHC II on Glandular Cells as a Presymptomatic Feature in a Mouse Model of Primary Sjögren's Syndrome', FRONTIERS IN IMMUNOLOGY, Jg. 9, S. 2362. https://doi.org/10.3389/fimmu.2018.02362

Yu, X, Riemekasten, G & Petersen, F 2018, 'Autoantibodies against muscarinic acetylcholine receptor M in Sjogren's syndrome and corresponding mouse models', Frontiers in bioscience (Landmark edition), Jg. 23, S. 2053-2064.

Yu, X & Petersen, F 2018, 'A methodological review of induced animal models of autoimmune diseases', AUTOIMMUNITY REVIEWS , Jg. 17, Nr. 5, S. 473-479. https://doi.org/10.1016/j.autrev.2018.03.001

Yu, X, Kasprick, A, Hartmann, K & Petersen, F 2018, 'The Role of Mast Cells in Autoimmune Bullous Dermatoses', FRONTIERS IN IMMUNOLOGY, Jg. 9, S. 386. https://doi.org/10.3389/fimmu.2018.00386

Yu, X, Akbarzadeh, R, Pieper, M, Scholzen, T, Gehrig, S, Schultz, C, Zillikens, D, König, P & Petersen, F 2018, 'Neutrophil Adhesion Is a Prerequisite for Antibody-Mediated Proteolytic Tissue Damage in Experimental Models of Epidermolysis Bullosa Acquisita', JOURNAL OF INVESTIGATIVE DERMATOLOGY, Jg. 138, Nr. 9, S. 1990-1998. https://doi.org/10.1016/j.jid.2018.03.1499

Yue, X, Yu, X, Petersen, F & Riemekasten, G 2018, 'Recent advances in mouse models for systemic sclerosis', AUTOIMMUNITY REVIEWS , Jg. 17, Nr. 12, S. 1225-1234. https://doi.org/10.1016/j.autrev.2018.06.013


2017

Deng, F, Chen, Y, Zheng, J, Huang, Q, Cao, X, Zillikens, D, Petersen, F & Yu, X 2017, 'CD11b-deficient mice exhibit an increased severity in the late phase of antibody transfer-induced experimental epidermolysis bullosa acquisita', EXPERIMENTAL DERMATOLOGY , Jg. 26, Nr. 12, 12, S. 1175-1178. https://doi.org/10.1111/exd.13434

Michelfelder, M, Becker, W-M, Riedlinger, A, Siegert, E, Drömann, D, Yu, X, Petersen, F & Riemekasten, G 2017, 'Interstitial lung disease increases mortality in systemic sclerosis patients with pulmonary arterial hypertension without affecting hemodynamics and exercise capacity', Clinical Rheumatology, Jg. 36, Nr. 2, S. 381-390. https://doi.org/10.1007/s10067-016-3504-6

Petersen, F, Yue, X, Riemekasten, G & Yu, X 2017, 'Dysregulated homeostasis of target tissues or autoantigens - A novel principle in autoimmunity', AUTOIMMUNITY REVIEWS , Jg. 16, Nr. 6, S. 602-611. https://doi.org/10.1016/j.autrev.2017.04.006

Zhao, W, Yue, X, Liu, K, Zheng, J, Huang, R, Zou, J, Riemekasten, G, Petersen, F & Yu, X 2017, 'The status of pulmonary fibrosis in systemic sclerosis is associated with IRF5, STAT4, IRAK1, and CTGF polymorphisms', RHEUMATOLOGY INTERNATIONAL, Jg. 37, Nr. 8, S. 1303-1310. https://doi.org/10.1007/s00296-017-3722-5

Zheng, J, Huang, Q, Huang, R, Deng, F, Yue, X, Yin, J, Zhao, W, Chen, Y, Wen, L, Zhou, J, Huang, R, Riemekasten, G, Liu, Z, Petersen, F & Yu, X 2017, 'B Cells Are Indispensable for a Novel Mouse Model of Primary Sjögren's Syndrome', FRONTIERS IN IMMUNOLOGY, Jg. 8, S. 1384. https://doi.org/10.3389/fimmu.2017.01384