Priority Research Area Infections

Cellular Microbiology

Mission   Projects   Funding   Techniques   Publications    Staff

2021

Boom, WH, Schaible, UE & Achkar, JM 2021, 'The knowns and unknowns of latent Mycobacterium tuberculosis infection', Journal of Clinical Investigation, Jg. 131, Nr. 3, S. e136222. https://doi.org/10.1172/JCI136222

Gradtke, A-C, Mentrup, T, Lehmann, CHK, Cabrera-Cabrera, F, Desel, C, Okakpu, D, Assmann, M, Dalpke, A, Schaible, UE, Dudziak, D & Schröder, B 2021, 'Deficiency of the Intramembrane Protease SPPL2a Alters Antimycobacterial Cytokine Responses of Dendritic Cells', JOURNAL OF IMMUNOLOGY, Jg. 206, Nr. 1, S. 164-180. https://doi.org/10.4049/jimmunol.2000151

Klionsky, DJ, Abdel-Aziz, AK, Abdelfatah, S, Abdellatif, M, Abdoli, A, Abel, S, Abeliovich, H, Abildgaard, MH, Abudu, YP, Acevedo-Arozena, A, Adamopoulos, IE, Adeli, K, Adolph, TE, Adornetto, A, Aflaki, E, Agam, G, Agarwal, A, Aggarwal, BB, Agnello, M, Agostinis, P, Agrewala, JN, Agrotis, A, Aguilar, PV, Ahmad, ST, Ahmed, ZM, Ahumada-Castro, U, Aits, S, Aizawa, S, Akkoc, Y, Akoumianaki, T, Akpinar, HA, Al-Abd, AM, Al-Akra, L, Al-Gharaibeh, A, Alaoui-Jamali, MA, Alberti, S, Alcocer-Gómez, E, Alessandri, C, Ali, M, Alim Al-Bari, MA, Aliwaini, S, Alizadeh, J, Almacellas, E, Almasan, A, Alonso, A, Dallenga, T, Leschczyk, C, Schaible, UE, Schneider, BE & Sonawane, A 2021, 'Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1', Autophagy, Jg. 17, Nr. 1, S. 1-382. https://doi.org/10.1080/15548627.2020.1797280

Kontsevaya, I, Lange, C, Comella-Del-Barrio, P, Coarfa, C, DiNardo, AR, Gillespie, SH, Hauptmann, M, Leschczyk, C, Mandalakas, AM, Martinecz, A, Merker, M, Niemann, S, Reimann, M, Rzhepishevska, O, Schaible, UE, Scheu, KM, Schurr, E, Abel Zur Wiesch, P & Heyckendorf, J 2021, 'Perspectives for systems biology in the management of tuberculosis', European Respiratory Review, Jg. 30, Nr. 160. https://doi.org/10.1183/16000617.0377-2020

Tizzano, B, Dallenga, T, Utpatel, C, Behrends, J, Homolka, S, Kohl, T & Niemann, S 2021, 'Survival of hypoxia-induced dormancy is not a common feature of all strains of the Mycobacterium tuberculosis complex', Scientific Reports, Jg. 11, Nr. 1, S. 2628. https://doi.org/10.1038/s41598-021-81223-6

 

2020

Alio, I, Gudzuhn, M, Pérez García, P, Danso, D, Schoelmerich, M, Mamat, U, Schaible, UE, Steinmann, J, Yero, D, Gibert, I, Kohl, TA, Niemann, S, Gröschel, MI, Haerdter, J, Hackl, T, Vollstedt, C, Bömeke, M, Egelkamp, R, Daniel, R, Poehlein, A & Streit, WR 2020, 'Phenotypic and Transcriptomic Analyses of Seven Clinical Stenotrophomonas maltophilia Isolates Identify a Small Set of Shared and Commonly Regulated Genes Involved in the Biofilm Lifestyle', APPLIED AND ENVIRONMENTAL MICROBIOLOGY , Jg. 86, Nr. 24. https://doi.org/10.1128/AEM.02038-20

Dorhoi, A, Kotzé, LA, Berzofsky, JA, Sui, Y, Gabrilovich, DI, Garg, A, Hafner, R, Khader, SA, Schaible, UE, Kaufmann, SH, Walzl, G, Lutz, MB, Mahon, RN, Ostrand-Rosenberg, S, Bishai, W & du Plessis, N 2020, 'Therapies for tuberculosis and AIDS: myeloid-derived suppressor cells in focus', Journal of Clinical Investigation, Jg. 130, Nr. 6, S. 2789-2799. https://doi.org/10.1172/JCI136288

Gröschel, MI, Meehan, CJ, Barilar, I, Diricks, M, Gonzaga, A, Steglich, M, Conchillo-Solé, O, Scherer, I-C, Mamat, U, Luz, CF, De Bruyne, K, Utpatel, C, Yero, D, Gibert, I, Daura, X, Kampmeier, S, Rahman, NA, Kresken, M, van der Werf, TS, Alio, I, Streit, WR, Zhou, K, Schwartz, T, Rossen, JWA, Farhat, MR, Schaible, UE, Nübel, U, Rupp, J, Steinmann, J, Niemann, S & Kohl, TA 2020, 'The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia', Nature communications, Jg. 11, Nr. 1, S. 2044. https://doi.org/10.1038/s41467-020-15123-0

Lozano-Aponte, J, Scior, T, Ambrosio, FNM, González-Melchor, M & Alexander, C 2020, 'Exploring electrostatic patterns of human, murine, equine and canine TLR4/MD-2 receptors', INNATE IMMUNITY, Jg. 26, Nr. 5, S. 364-380. https://doi.org/10.1177/1753425919894628

Mackiewicz, M, Seitzer, U, Ahmed, JS & Reiling, N 2020, 'Theileria annulata surface protein (TaSP) is a target of cyclin‐dependent kinase 1 phosphorylation in Theileria annulata‐infected cells', Transboundary and Emerging Diseases, Jg. 67, Nr. S1, S. 40-55. https://doi.org/10.1111/tbed.13458

Naik, SK, Pattanaik, K, Eich, J, Sparr, V, Hauptmann, M, Kalsdorf, B, Reiling, N, Liedtke, W, Kuebler, WM, Schaible, UE & Sonawane, A 2020, 'Differential Roles of the Calcium Ion Channel TRPV4 in Host Responses to Mycobacterium tuberculosis Early and Late in Infection', iScience, Jg. 23, Nr. 6, S. 101206. https://doi.org/10.1016/j.isci.2020.101206

Patel, A, Redinger, N, Richter, A, Woods, A, Neumann, PR, Keegan, G, Childerhouse, N, Imming, P, Schaible, UE, Forbes, B & Dailey, LA 2020, 'In vitro and in vivo antitubercular activity of benzothiazinone-loaded human serum albumin nanocarriers designed for inhalation', JOURNAL OF CONTROLLED RELEASE , Jg. 328, S. 339-349. https://doi.org/10.1016/j.jconrel.2020.08.022

Pfrommer, E, Dreier, C, Gabriel, G, Dallenga, T, Reimer, R, Schepanski, K, Scherließ, R, Schaible, UE & Gutsmann, T 2020, 'Enhanced tenacity of mycobacterial aerosols from necrotic neutrophils', Scientific Reports, Jg. 10, Nr. 1, S. 9159. https://doi.org/10.1038/s41598-020-65781-9

Schick, J, Schäfer, J, Alexander, C, Dichtl, S, Murray, PJ, Christensen, D, Sorg, U, Pfeffer, K, Schleicher, U & Lang, R 2020, 'Cutting Edge: TNF Is Essential for Mycobacteria-Induced MINCLE Expression, Macrophage Activation, and Th17 Adjuvanticity', JOURNAL OF IMMUNOLOGY, Jg. 205, Nr. 2, S. 323-328. https://doi.org/10.4049/jimmunol.2000420

Shuaib, YA, Khalil, EAG, Wieler, LH, Schaible, UE, Bakheit, MA, Mohamed-Noor, SE, Abdalla, MA, Kerubo, G, Andres, S, Hillemann, D, Richter, E, Kranzer, K, Niemann, S & Merker, M 2020, 'Mycobacterium tuberculosis Complex Lineage 3 as Causative Agent of Pulmonary Tuberculosis, Eastern Sudan', EMERGING INFECTIOUS DISEASES, Jg. 26, Nr. 3, S. 427-436. https://doi.org/10.3201/eid2603.191145

Stachnik, K, Warmer, M, Mohacsi, I, Hennicke, V, Fischer, P, Meyer, J, Spitzbart, T, Barthelmess, M, Eich, J, David, C, Feldmann, C, Busse, B, Jähn, K, Schaible, UE & Meents, A 2020, 'Multimodal X-ray imaging of nanocontainer-treated macrophages and calcium distribution in the perilacunar bone matrix', Scientific Reports, Jg. 10, Nr. 1, S. 1784. https://doi.org/10.1038/s41598-020-58318-7

Yero, D, Huedo, P, Conchillo-Solé, O, Martínez-Servat, S, Mamat, U, Coves, X, Llanas, F, Roca, I, Vila, J, Schaible, UE, Daura, X & Gibert, I 2020, 'Genetic Variants of the DSF Quorum Sensing System in Stenotrophomonas maltophilia Influence Virulence and Resistance Phenotypes Among Genotypically Diverse Clinical Isolates', Frontiers in Microbiology, Jg. 11, S. 1160. https://doi.org/10.3389/fmicb.2020.01160


 

2019

Lozano-Aponte, J, Scior, T, Ambrosio, FNM, González-Melchor, M & Alexander, C 2019, 'Exploring electrostatic patterns of human, murine, equine and canine TLR4/MD-2 receptors', INNATE IMMUNITY, S. 1753425919894628. https://doi.org/10.1177/1753425919894628

Komazin, G, Maybin, M, Woodard, RW, Scior, T, Schwudke, D, Schombel, U, Gisch, N, Mamat, U & Meredith, TC 2019, 'Substrate structure-activity relationship reveals a limited lipopolysaccharide chemotype range for intestinal alkaline phosphatase', The Journal of biological chemistry, Jg. 294, Nr. 50, S. 19405-19423. https://doi.org/10.1074/jbc.RA119.010836

Paschke, A, Schaible, UE & Hein, W 2019, 'Legionella transmission through cooling towers: towards better control and research of a neglected pathogen', Lancet Respiratory Medicine, Jg. 7, Nr. 5, S. 378-380. https://doi.org/10.1016/S2213-2600(19)30041-4

Rein, V, Meschkov, A, Hagens, K, Redinger, N, Schepers, U, Mehlhorn, H, Schaible, UE & Feldmann, C 2019, 'Zirconyl Hydrogenphosphate Nanocontainers for Flexible Transport and Release of Lipophilic Cytostatics, Insecticides, and Antibiotics', Advanced Functional Materials, Jg. 2019, Nr. 29, 10.1002/adfm.201900543. https://doi.org/10.1002/adfm.201900543


 

2018

Binsker, U, Palankar, R, Wesche, J, Kohler, TP, Prucha, J, Burchhardt, G, Rohde, M, Schmidt, F, Bröker, BM, Mamat, U, Pané-Farré, J, Graf, A, Ebner, P, Greinacher, A & Hammerschmidt, S 2018, 'Secreted Immunomodulatory Proteins of Staphylococcus aureus Activate Platelets and Induce Platelet Aggregation' Thrombosis and Haemostasis, Jg. 118, Nr. 4, S. 745-757. DOI: 10.1055/s-0038-1637735

Dallenga, T, Linnemann, L, Paudyal, B, Repnik, U, Griffiths, G & Schaible, UE 2018, 'Targeting neutrophils for host-directed therapy to treat tuberculosis' INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, Jg. 308, Nr. 1, S. 142-147. DOI: 10.1016/j.ijmm.2017.10.001

Herzmann, C, Dallenga, T & Kalinke, U 2018, 'Pulmonale Immunität bei Tuberkulose' PNEUMOLOGIE, Jg. 72, S. 1-10. DOI: 10.1055/s-0043-122961 

Khatri, I, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Heumann, D, Mach, J-P, Mazzoli, V, Rietschel, E, Terskikh, A, Ulmer, A, Yu, K, Zähringer, U & Gorczynski, R 2018, 'Analysis of cytokine immune response profile in response to inflammatory stimuli in mice with genetic defects in fetal and adult hemoglobin chain expression' Pharmacogenomics J., Jg. 18, Nr. 4, S. 546-555. DOI: 10.1038/s41397-017-0008-y

Kos, O, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Heumann, D, Khatri, I, Mach, JP, Rietschel, ET, Tersikh, A, Ulmer, AJ, Waelli, T, Yu, K, Zähringer, U & Gorczynski, RM 2018, 'Regulation of fetal hemoglobin expression during hematopoietic stem cell development and its importance in bone metabolism and osteoporosis' INTERNATIONAL IMMUNOPHARMACOLOGY , Jg. 57, S. 112-120. DOI: 10.1016/j.intimp.2018.02.010

Lange, C, Alghamdi, WA, Al-Shaer, MH, Brighenti, S, Diacon, AH, DiNardo, AR, Grobbel, HP, Gröschel, MI, von Groote-Bidlingmaier, F, Hauptmann, M, Heyckendorf, J, Köhler, N, Kohl, TA, Merker, M, Niemann, S, Peloquin, CA, Reimann, M, Schaible, UE, Schaub, D, Schleusener, V, Thye, T & Schön, T 2018, 'Perspectives for personalized therapy for patients with multidrug-resistant tuberculosis' JOURNAL OF INTERNAL MEDICINE . DOI: 10.1111/joim.12780

Malm, S, Maaß, S, Schaible, UE, Ehlers, S & Niemann, S 2018, 'In vivo virulence of Mycobacterium tuberculosis depends on a single homologue of the LytR-CpsA-Psr proteins' Scientific Reports, Jg. 8, Nr. 1, S. 3936. DOI: 10.1038/s41598-018-22012-6

Shuaib YA, Khalil EAG, Schaible UE, Wieler LH, Bakheit MAM, Mohamed-Noor SE, Abdalla MA, Homolka S, Andres S, Hillemann D, Lonnroth K, Richter E, Niemann S, Kranzer K. Smear Microscopy for Diagnosis of Pulmonary Tuberculosis in Eastern Sudan. Tuberc Res Treat. 2018 Jun 14;2018:8038137. doi: 10.1155/2018/8038137. eCollection 2018.

Steinmann, J, Mamat, U, Abda, EM, Kirchhoff, L, Streit, WR, Schaible, UE, Niemann, S & Kohl, TA 2018, 'Analysis of Phylogenetic Variation of Reveals Human-Specific Branches' Frontiers in Microbiology, Jg. 9, S. 806. DOI: 10.3389/fmicb.2018.00806

Surmann K, Depke M, Dhople VM, Pané-Farré J, Hildebrandt P, Gumz J, Schaible UE, Völker U, Schmidt F. Analysis of Staphylococcus aureus proteins secreted inside infected human epithelial cells. Int J Med Microbiol. 2018 Aug;308(6):664-674. doi: 10.1016/j.ijmm.2018.06.002. Epub 2018

Wutkowski A, Krajewski M, Bagwan N, Schäfer M, Paudyal BR, Schaible UE, Schwudke D. Software-aided quality control of parallel reaction monitoring based quantitation of lipid mediators. Anal Chim Acta. 2018 Dec 11;1037:168-176. doi: 10.1016/j.aca.2018.01.044. Epub 2018


 

2017

Gorczynski, RM, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Heumann, D, Mach, J-P, Rietschel, ET, Ulmer, AJ, Zähringer, U, Yu, K & Khatri, I 2017, 'An altered REDOX environment, assisted by over-expression of fetal hemoglobins, protects from inflammatory colitis and reduces inflammatory cytokine expression' INTERNATIONAL IMMUNOPHARMACOLOGY , Bd 50, Nr. (2017), S. 69-76.

Groeger, S, Jarzina, F, Mamat, U & Meyle, J 2017, 'Induction of B7-H1 receptor by bacterial cells fractions of Porphyromonas gingivalis on human oral epithelial cells: B7-H1 induction by Porphyromonas gingivalis fractions' IMMUNOBIOLOGY, Bd 222, Nr. 2, S. 137-147. DOI: 10.1016/j.imbio.2016.10.011

Dallenga, T, Repnik, U, Corleis, B, Eich, J, Reimer, R, Griffiths, GW & Schaible, UE 2017, 'M. tuberculosis-Induced Necrosis of Infected Neutrophils Promotes Bacterial Growth Following Phagocytosis by Macrophages' Cell Host & Microbe, Bd 22, Nr. 4, S. 519-530.e3. DOI: 10.1016/j.chom.2017.09.003

Dallenga, T, Linnemann, L, Paudyal, B, Repnik, U, Griffiths, G & Schaible, UE 2017, 'Targeting neutrophils for host-directed therapy to treat tuberculosis' INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY. DOI: 10.1016/j.ijmm.2017.10.001

Haas, A, Hensel, M, Lührmann, A, Rudel, T, Saftig, P & Schaible, UE 2017, 'Intracellular compartments of pathogens: Highways to hell or stairways to heaven?' INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY. DOI: 10.1016/j.ijmm.2017.10.009

Patin, EC, Orr, SJ & Schaible, UE 2017, 'Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity' Frontiers in Immunology, Bd 8, S. 861. DOI: 10.3389/fimmu.2017.00861

Jeschke, A, Zehethofer, N, Schwudke, D & Haas, A 2017, 'Quantification of Phosphatidylinositol Phosphate Species in Purified Membranes' Methods in Enzymology, Bd 587, S. 271-291. DOI: 10.1016/bs.mie.2016.10.037

Singh, S, Dallenga, T, Winkler, A, Roemer, S, Maruschak, B, Siebert, H, Brück, W & Stadelmann, C 2017, 'Relationship of acute axonal damage, Wallerian degeneration, and clinical disability in multiple sclerosis' Journal of Neuroinflammation, Bd 14, Nr. 1, S. 57. DOI: 10.1186/s12974-017-0831-8

Schaible, UE, Linnemann, L, Redinger, N, Patin, E & Dallenga, T 2017, 'Strategies to improve vaccine efficacy againts tuberculosis by targeting innate immunity' Frontiers in Immunology, Bd 8, Nr. 1755, 1755. DOI: 10.3389/fimmu.2017.01755

Patin, EC, Geffken, AC, Willcocks, S, Leschczyk, C, Haas, A, Nimmerjahn, F, Lang, R, Ward, TH & Schaible, UE 2017, 'Trehalose dimycolate interferes with FcγR-mediated phagosome maturation through Mincle, SHP-1 and FcγRIIB signalling' PLOS ONE, Bd 12, Nr. 4, S. e0174973. DOI: 10.1371/journal.pone.0174973, 10.1371/journal.pone.0174973