Diagnostische Mykobakteriologie (NRZ)
As part of the worldwide laboratory network of the WHO, the German National Reference Laboratory for mycobacteria (NRL) acts as a Supranational Reference Laboratory since 1995. Since 2008, the NRL coordinates and provides samples for external quality assurance in the field of mycobacterial diagnostics, organized by INSTAND e-V. Düsseldorf. On a daily basis consultancy is provided for laboratories and clinics concerning diagnostics and therapy of mycobacterial diseases. The research of the NRL focusses on the topics “evaluation of new techniques for the improvement of diagnostics”, “resistance of tuberculosis”, and “variability of clinical mycobacterial isolates”.
Diagnostische Verfahren:
- Resistenztestung von „Second Line"-Antibiotika
- Evaluierung und Etablierung von Streifentests zur Mykobakterien-Diagnostik
- Evaluierung und Etablierung eines immunchromatographischen Tests zur Identifizierung von Tuberkulosebakterien
- Evaluierung und Etablierung eines Direkttests zum Nachweis von Tuberkulosebakterien und Resistenz-assoziierten Genmutationen
- Effektivität des MGIT 960-Systems zum Nachweis von Tuberkulose und zur Resistenzbestimmung in MDR-‚high burden’-Ländern
- Untersuchungen zu neuen EMB-Resistenzmechanismen
Epidemiologische Studien:
- aller Antibiotika-resistenten M. tuberculosis-Stämmen aus Deutschland
- aller kulturell bestätigter Tuberkulosefälle der Regionen Hamburg, Hannover, Frankfurt, Schleswig-Holstein und Baden-Württemberg
Surveillance in ‚high-incidence’ Ländern
- Studie zu Entstehung von Resistenzen und Verbreitung von MDR-Stämmen in Usbekistan
- Surveillance der Tuberkulose in Aserbaidschan und Armenien
Weitere Projekte:
- Etablierung eines externen Qualitätskontrollnetzwerkes für „Second Line"-Antibiotika (Baltic Nordic TB-Laboratory Network; EU)
- Testung der Wirksamkeit von Desinfektionsmitteln gegen Mykobakterien
- Austestung neuer Substanzen auf ihre Wirksamkeit gegen Tuberkulosebakterien
- Forschungsnetzwerk zu Empfänglichkeit und Resistenz gegenüber Infektionen mit nicht-tuberkulösen Mykobakterien
Bundesministerium für Gesundheit
- Nationales Referenzzentrum für Mykobakterien
- MetaCorDia: Metagenomik Labor für den Nachweis von Coronaviren in respiratorischen Patientenmaterialien & Strukturierte medizinische Ersteinschätzung (SmE), schnelle Diagnostik im Rahmen eines Corona Virus Ausbruchs und neue antivirale Stoffe am FZB
- CoroDia: Auswertung der Corona-Testungskapazität im südlichen Schleswig-Holstein
- PHIMS-TB: Public Health Beitrag einer bundesweiten integrierten molekularen Surveillance am Beispiel der Tuberkulose, 2020 - 2022
Robert-Koch-Institut
- MIRU-VNTR Re-Typisierung der Stämme aus der longitudinalen Modellstudie zur Epidemiologie der Tuberkulose in Hamburg und der Durchführung einer Modellstudie zur effektiven Linkung von molekularepidemiologischen Daten mit SurvNet-Daten des RKI
Bundesministerium für Bildung und Forschung
- MDxTB: Molekulare Tuberkulosediagnostik am Point-of-Care, 2019-2022
Europäische Union
- Pan-European network for the study and clinical management of drug resistant tuberculosis
- ETBRA: European tubercolosis regimen accelerator, 2020-
Foundation for Innovative New Diagnostics (FIND)
- Effectiveness of Mycobacteria Growth Indicator Tube (MGIT) for Detection of Pulmonary Tuberculosis and Drug Susceptibility Testing (DST) in High PDR/MDR TB Burden Countries
- Precision study of an assay for direct detection of MTB and RMP resistance
- Preparation of slides for evaluation of a new technique for microscopy
Stiftungen
- Schleswig-Holsteinische Gesellschaft zur Verhütung und Bekämpfung der Tuberkulose und Lungenkrankheiten: Populationsstruktur und Diversität von M. tuberculosis-Stämmen aus Schleswig-Holstein
- Mukoviszidose e.V.: CronoClone: Clinical relevance of nontuberculous mycobacteria recovered from cystic fibrosis patients and genome changes in highly virulent clones, 2020-2023
- Mikroskopie:
Nachweis säurefester Stäbchen mit Ziehl-Neelsen-, Kinyoun und Auramin-Färbung. - Primärisolierung:
Kultureller Nachweis von Mykobakterien aus allen biologischen Untersuchungsmaterialien. Anzucht in flüssigen Medien (MGIT 960, BACTEC 9050, BACTEC 460) und auf festen Nährböden (Löwenstein-Jensen, Stonebrink, Middlebrook). - Differenzierung:
Identifizierung von Mykobakterienisolaten mit molekularbiologischen Techniken (Streifenhybridisierungstests, Sequenzierung relevanter Gene (16S rDNA, ITS, hsp65), Spoligotyping). - Resistenzbestimmung von „First“- und „Second Line“-Antibiotika:
Modifizierte Proportionsmethode im flüssigen (MGIT 960) und auf festem Löwenstein-Jensen-Medium.
Molekularbiologischer Nachweis von Resistenz-assoziierten Mutationen für INH und RMP. - Epidemiologische Methoden:
Fingerprintmethoden von Tuberkulose-Stämmen zum Nachweis von Übertragungen oder bei Verdacht auf Laborkontaminationen (IS6110-Fingerprint-Technik, Spoligotyping und MIRU-VNTR-Analyse).
2024
Blankson, HNA, Kamara, RF, Barilar, I, Andres, S, Conteh, OS, Dallenga, T, Foray, L, Maurer, F, Kranzer, K & Utpatel, C et al. 2024, 'Molecular determinants of multidrug-resistant tuberculosis in Sierra Leone', Microbiology spectrum, Jg. 12, Nr. 3, S. e0240523. https://doi.org/10.1128/spectrum.02405-23
de Vos, M, David, A, Duraisamy, K, Nadarajan, D, Noroc, E, Penn-Nicholson, A, Crudu, V, Giri, S, Maurer, FP & Pati, S et al. 2024, 'Accuracy of cobas MTB and MTB-RIF/INH for Detection of Mycobacterium tuberculosis and Drug Resistance', Journal of Molecular Diagnostics, Jg. 26, Nr. 8, S. 708-718. https://doi.org/10.1016/j.jmoldx.2024.05.004
Friesen, I, Dreyer, V, Klingmüller, A, Zuber, S, Hoffmann, AM, Suárez, I, Schütz, B, Preßel, T, Andres, S & Niemann, S et al. 2024, 'First detection of a Mycobacterium tuberculosis XDR clinical isolate harbouring an RpoB I491F mutation in a Ukrainian patient treated in Germany, October 2023', Eurosurveillance, Jg. 29, Nr. 28. https://doi.org/10.2807/1560-7917.ES.2024.29.28.2400420
Friesen, I, Saluzzo, F, Groenheit, R, Aubry, A, Anthony, R, Niemann, S, Mathys, V, Cirillo, DM & TB European Reference Laboratory Network (ERLTB-Net-3) 2024, 'Re: 'Availability of drugs and resistance testing for BPaLM regimen for rifampicin-resistant tuberculosis in Europe' by Lange et al', CLINICAL MICROBIOLOGY AND INFECTION , Jg. 30, Nr. 9, S. 1204-1206. https://doi.org/10.1016/j.cmi.2024.06.001
Froböse, NJ, Theiler, T, Horn, D, Sußiek, J, Böing, C, Kuhns, M, Schuler, F, Raschke, M, Schaumburg, F & Roßlenbroich, SB 2024, 'Fracture-associated infection with Mycobacterium smegmatis in a 16-year old patient', Diagnostic microbiology and infectious disease, Jg. 110, Nr. 1, S. 116379. https://doi.org/10.1016/j.diagmicrobio.2024.116379
Gröschel, MI, Pérez-Llanos, FJ, Diel, R, Vargas, R, Escuyer, V, Musser, K, Trieu, L, Meissner, JS, Knorr, J & Klinkenberg, D et al. 2024, 'Differential rates of Mycobacterium tuberculosis transmission associate with host-pathogen sympatry', Nature Microbiology, Jg. 9, Nr. 8, S. 2113-2127. https://doi.org/10.1038/s41564-024-01758-y
Meiwes, L, Kontsevaya, I, Chesov, D, Kulciţkaia, S, Dreyer, V, Hillemann, D, Dlamini, Q, Williams, C, Barer, M & Brinkmann, F et al. 2024, 'Whispers in the wind: Face mask sampling for Mycobacterium tuberculosis detection in children with pulmonary tuberculosis', JOURNAL OF INFECTIOUS DISEASES. https://doi.org/10.1093/infdis/jiae282
Otto-Knapp, R, Bauer, T, Brinkmann, F, Feiterna-Sperling, C, Friesen, I, Geerdes-Fenge, H, Hartmann, P, Häcker, B, Heyckendorf, J & Kuhns, M et al. 2024, 'Treatment of MDR, Pre-XDR, XDR, and Rifampicin-Resistant Tuberculosis or in Case of Intolerance to at Least Rifampicin in Austria, Germany, and Switzerland', RESPIRATION, Jg. 103, Nr. 9, S. 593-600. https://doi.org/10.1159/000539410
Paulowski, L, Filip, R, Jankovic Makek, M, Guglielmetti, L, Goletti, D, van Ingen, J, Kranzer, K, Maurer, FP & ESGMYC 2024, 'Impact of the COVID-19 pandemic on the real-world diagnostic infrastructure for tuberculosis-An ESGMYC collaborative study', PLOS ONE, Jg. 19, Nr. 4, S. e0291404. https://doi.org/10.1371/journal.pone.0291404
Svensson, E, Ketelsen, H, Andres, S, Folkvardsen, DB, Hillemann, D, Conteh, O, Norman, A, Niemann, S, Lillebaek, T & Kuhns, M 2024, 'Dual-centre evaluation of the FluoroType MTBDR version 2 assay for detection of Mycobacterium tuberculosis complex and resistance-conferring mutations in pulmonary and extrapulmonary samples from Denmark, Germany and Sierra Leone', CLINICAL MICROBIOLOGY AND INFECTION , Jg. 30, Nr. 8, S. 1055-1060. https://doi.org/10.1016/j.cmi.2024.04.006
Trauth, J, Kantelhardt, V, Usenko, B, Knipper, M, Kuhns, M, Friesen, I & Herold, S 2024, 'Bedaquiline, pretomanid and linezolid in multidrug-resistant and pre-extensively drug-resistant tuberculosis in refugees from Ukraine and Somalia in Germany', The European respiratory journal, Jg. 63, Nr. 5. https://doi.org/10.1183/13993003.00303-2024
Wetzstein, N, Diricks, M, Andres, S, Kuhns, M, Marschall, L, Biciusca, T, Smaczny, C, Friesen, I, Niemann, S & Wichelhaus, TA 2024, 'Genomic diversity and clinical relevance of Mycobacterium simiae', ERJ Open Research, Jg. 10, Nr. 2, 00773-2023. https://doi.org/10.1183/23120541.00773-2023
Wetzstein, N, Diricks, M, Anton, TB, Andres, S, Kuhns, M, Kohl, TA, Schwarz, C, Lewin, A, Kehrmann, J & Kahl, BC et al. 2024, 'Clinical and genomic features of Mycobacterium avium complex: a multi-national European study', Genome medicine, Jg. 16, Nr. 1, S. 86. https://doi.org/10.1186/s13073-024-01359-8
2023
Brehm, TT, Köhler, N, Schmiedel, S, Terhalle, E, Martensen, J, Kalsdorf, B, Kandulla, J, Heyckendorf, J, Kuhns, M, Friesen, I & Lange, C 2023, 'Therapie der Tuberkulose: Was gibt es Neues?', Innere Medizin (Heidelberg, Germany), Jg. 64, Nr. 7, S. 701-707. https://doi.org/10.1007/s00108-023-01523-z
EUCAST AMST and ESCMYC study groups, Fröberg, G, Maurer, FP, Chryssanthou, E, Fernström, L, Benmansour, H, Boarbi, S, Mengshoel, AT, Keller, PM, Viveiros, M, Machado, D, Fitzgibbon, MM, Mok, S, Werngren, J, Cirillo, DM, Alcaide, F, Hyyryläinen, H-L, Aubry, A, Andres, S, Nadarajan, D, Svensson, E, Turnidge, J, Giske, CG, Kahlmeter, G, Cambau, E, van Ingen, J & Schön, T 2023, 'Towards clinical breakpoints for non-tuberculous mycobacteria - Determination of epidemiological cut off values for the Mycobacterium avium complex and Mycobacterium abscessus using broth microdilution', CLINICAL MICROBIOLOGY AND INFECTION , Jg. 29, Nr. 6, S. 758-764. https://doi.org/10.1016/j.cmi.2023.02.007
Koehler, N, Andres, S, Merker, M, Dreyer, V, John, A, Kuhns, M, Krieger, D, Choong, E, Verougstraete, N, Zur Wiesch, PA, Wicha, SG, König, C, Kalsdorf, B, Sanchez Carballo, PM, Schaub, D, Werngren, J, Schön, T, Peloquin, CA, Schönfeld, N, Verstraete, AG, Decosterd, LA, Aarnoutse, R, Niemann, S, Maurer, FP & Lange, C 2023, 'Pretomanid-Resistant Tuberculosis', Journal of infection, Jg. 86, Nr. 5, S. 520-524. https://doi.org/10.1016/j.jinf.2023.01.039
Maier, C, Chesov, D, Schaub, D, Kalsdorf, B, Andres, S, Friesen, I, Reimann, M & Lange, C 2023, 'Long-term treatment outcomes in patients with multidrug-resistant tuberculosis', CLINICAL MICROBIOLOGY AND INFECTION , Jg. 29, Nr. 6, S. 751-757. https://doi.org/10.1016/j.cmi.2023.02.013
Pérez-Llanos, FJ, Dreyer, V, Barilar, I, Utpatel, C, Kohl, TA, Murcia, MI, Homolka, S, Merker, M & Niemann, S 2023, 'Transmission Dynamics of a Mycobacterium tuberculosis Complex Outbreak in an Indigenous Population in the Colombian Amazon Region', Microbiology spectrum, S. e0501322. https://doi.org/10.1128/spectrum.05013-22
Rollo, RF, Mori, G, Hill, TA, Hillemann, D, Niemann, S, Homolka, S, Fairlie, DP & Blumenthal, A 2023, 'Wollamide Cyclic Hexapeptides Synergize with Established and New Tuberculosis Antibiotics in Targeting Mycobacterium tuberculosis', Microbiology spectrum, Jg. 11, Nr. 4, S. e0046523. https://doi.org/10.1128/spectrum.00465-23
TBNET and RESIST-TB networks, Domínguez, J, Boeree, MJ, Cambau, E, Chesov, D, Conradie, F, Cox, V, Dheda, K, Dudnyk, A, Farhat, MR, Gagneux, S, Grobusch, MP, Gröschel, MI, Guglielmetti, L, Kontsevaya, I, Lange, B, van Leth, F, Lienhardt, C, Mandalakas, AM, Maurer, FP, Merker, M, Miotto, P, Molina-Moya, B, Morel, F, Niemann, S, Veziris, N, Whitelaw, A, Horsburgh, CR & Lange, C 2023, 'Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: a 2023 TBnet/RESIST-TB consensus statement', Lancet Infectious Diseases, Jg. 23, Nr. 4, S. e122-e137. https://doi.org/10.1016/S1473-3099(22)00875-1
Van, N, Degefu, YN, Leus, PA, Larkins-Ford, J, Klickstein, J, Maurer, FP, Stone, D, Poonawala, H, Thorpe, CM, Smith, TC & Aldridge, BB 2023, 'Novel Synergies and Isolate Specificities in the Drug Interaction Landscape of Mycobacterium abscessus', ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Jg. 67, Nr. 7, S. e0009023. https://doi.org/10.1128/aac.00090-23
2022
Akwani, WC, van Vliet, AHM, Joel, JO, Andres, S, Diricks, M, Maurer, FP, Chambers, MA & Hingley-Wilson, SM 2022, 'The Use of Comparative Genomic Analysis for the Development of Subspecies-Specific PCR Assays for Mycobacterium abscessus', Frontiers in Cellular and Infection Microbiology, Jg. 12, S. 816615. https://doi.org/10.3389/fcimb.2022.816615
Antimycobacterial Susceptibility Testing Group 2022, 'Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment', The European respiratory journal, Jg. 59, Nr. 4, 2200166. https://doi.org/10.1183/13993003.00166-2022
Bateson, A, Ortiz Canseco, J, McHugh, TD, Witney, AA, Feuerriegel, S, Merker, M, Kohl, TA, Utpatel, C, Niemann, S, Andres, S, Kranzer, K, Maurer, FP, Ghodousi, A, Borroni, E, Cirillo, DM, Wijkander, M, Toro, JC, Groenheit, R, Werngren, J, Machado, D, Viveiros, M, Warren, RM, Sirgel, F, Dippenaar, A, Köser, CU, Sun, E & Timm, J 2022, 'Ancient and recent differences in the intrinsic susceptibility of Mycobacterium tuberculosis complex to pretomanid', JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Jg. 77, Nr. 6, S. 1685-1693. https://doi.org/10.1093/jac/dkac070
Brandenburg, J, Heyckendorf, J, Marwitz, F, Zehethofer, N, Linnemann, L, Gisch, N, Karaköse, H, Reimann, M, Kranzer, K, Kalsdorf, B, Sanchez-Carballo, P, Weinkauf, M, Scholz, V, Malm, S, Homolka, S, Gaede, KI, Herzmann, C, Schaible, UE, Hölscher, C, Reiling, N & Schwudke, D 2022, 'Tuberculostearic Acid-Containing Phosphatidylinositols as Markers of Bacterial Burden in Tuberculosis', ACS infectious diseases, Jg. 8, Nr. 7, S. 1303-1315. https://doi.org/10.1021/acsinfecdis.2c00075
Chesov, E, Chesov, D, Maurer, FP, Andres, S, Utpatel, C, Barilar, I, Donica, A, Reimann, M, Niemann, S, Lange, C, Crudu, V, Heyckendorf, J & Merker, M 2022, 'Emergence of bedaquiline resistance in a high tuberculosis burden country', The European respiratory journal, Jg. 59, Nr. 3, 2100621. https://doi.org/10.1183/13993003.00621-2021
Diricks, M, Merker, M, Wetzstein, N, Kohl, TA, Niemann, S & Maurer, FP 2022, 'Delineating Mycobacterium abscessus population structure and transmission employing high-resolution core genome multilocus sequence typing', Nature communications, Jg. 13, Nr. 1, S. 4936. https://doi.org/10.1038/s41467-022-32122-5
European Laboratory Initiative on TB, HIV and viral hepatitis core group members 2022, 'Integrated use of laboratory services for multiple infectious diseases in the WHO European Region during the COVID-19 pandemic and beyond', Eurosurveillance, Jg. 27, Nr. 29, 2100930. https://doi.org/10.2807/1560-7917.ES.2022.27.29.2100930
European Laboratory Initiative on TB, HIV and Viral Hepatitis(3) & Niemann, S 2022, 'Diagnostic Capacities for Multidrug-Resistant Tuberculosis in the World Health Organization European Region: Action is Needed by all Member States', Journal of Molecular Diagnostics, Jg. 24, Nr. 11, S. 1189-1194. https://doi.org/10.1016/j.jmoldx.2022.07.005
Finci, I, Albertini, A, Merker, M, Andres, S, Bablishvili, N, Barilar, I, Cáceres, T, Crudu, V, Gotuzzo, E, Hapeela, N, Hoffmann, H, Hoogland, C, Kohl, TA, Kranzer, K, Mantsoki, A, Maurer, FP, Nicol, MP, Noroc, E, Plesnik, S, Rodwell, T, Ruhwald, M, Savidge, T, Salfinger, M, Streicher, E, Tukvadze, N, Warren, R, Zemanay, W, Zurek, A, Niemann, S & Denkinger, CM 2022, 'Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multicentre observational study', The Lancet. Microbe, Jg. 3, Nr. 9, S. e672-e682. https://doi.org/10.1016/S2666-5247(22)00116-1
Gisch, N, Utpatel, C, Gronbach, LM, Kohl, TA, Schombel, U, Malm, S, Dobos, KM, Hesser, DC, Diel, R, Götsch, U, Gerdes, S, Shuaib, YA, Ntinginya, NE, Khosa, C, Viegas, S, Kerubo, G, Ali, S, Al-Hajoj, SA, Ndung’u, PW, Rachow, A, Hoelscher, M, Maurer, FP, Schwudke, D, Niemann, S, Reiling, N & Homolka, S 2022, 'Sub-Lineage Specific Phenolic Glycolipid Patterns in the Mycobacterium tuberculosis Complex Lineage 1', Frontiers in Microbiology, Jg. 13, S. 832054. https://www.frontiersin.org/article/10.3389/fmicb.2022.832054
Hansen, J, Kolbe, K, König, IR, Scherließ, R, Hellfritzsch, M, Malm, S, Müller-Loennies, S, Zallet, J, Hillemann, D, Wiesmüller, K-H, Herzmann, C, Brandenburg, J & Reiling, N 2022, 'Lipobiotin-capture magnetic bead assay for isolation, enrichment and detection of Mycobacterium tuberculosis from saliva', PLOS ONE, Jg. 17, Nr. 7, S. e0265554. https://doi.org/10.1371/journal.pone.0265554
Kanyala, E, Shuaib, YA, Schwarz, NG, Andres, S, Richter, E, Sawadogo, B, Sawadogo, M, Germaine, M, Lassina, O, Poppert, S & Frickmann, H 2022, 'Prevalence and Molecular Characterization of Mycobacterium bovis in Slaughtered Cattle Carcasses in Burkina Faso; West Africa', Microorganisms, Jg. 10, Nr. 7, 1378. https://doi.org/10.3390/microorganisms10071378
Klein, C, Borsche, M, Balck, A, Föh, B, Rahmöller, J, Peters, E, Knickmann, J, Lane, M, Vollstedt, E-J, Elsner, SA, Käding, N, Hauswaldt, S, Lange, T, Hundt, JE, Lehrian, S, Giese, J, Mischnik, A, Niemann, S, Maurer, F, Homolka, S, Paulowski, L, Kramer, J, Twesten, C, Sina, C, Gillessen-Kaesbach, G, Busch, H, Ehlers, M, Taube, S, Rupp, J & Katalinic, A 2022, 'One-year surveillance of SARS-CoV-2 transmission of the ELISA cohort: A model for population-based monitoring of infection risk', Science advances, Jg. 8, Nr. 15, S. eabm5016. https://doi.org/10.1126/sciadv.abm5016
Lagune, M, Le Moigne, V, Johansen, MD, Vásquez Sotomayor, F, Daher, W, Petit, C, Cosentino, G, Paulowski, L, Gutsmann, T, Wilmanns, M, Maurer, FP, Herrmann, J-L, Girard-Misguich, F & Kremer, L 2022, 'The ESX-4 substrates, EsxU and EsxT, modulate Mycobacterium abscessus fitness', PLOS PATHOGENS, Jg. 18, Nr. 8, S. e1010771. https://doi.org/10.1371/journal.ppat.1010771
Merker, M, Rasigade, J-P, Barbier, M, Cox, H, Feuerriegel, S, Kohl, TA, Shitikov, E, Klaos, K, Gaudin, C, Antoine, R, Diel, R, Borrell, S, Gagneux, S, Nikolayevskyy, V, Andres, S, Crudu, V, Supply, P, Niemann, S & Wirth, T 2022, 'Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis', Nature communications, Jg. 13, Nr. 1, S. 5105. https://doi.org/10.1038/s41467-022-32455-1
Paulowski, L, Beckham, KSH, Johansen, MD, Berneking, L, Van, N, Degefu, Y, Staack, S, Sotomayor, FV, Asar, L, Rohde, H, Aldridge, BB, Aepfelbacher, M, Parret, A, Wilmanns, M, Kremer, L, Combrink, K & Maurer, FP 2022, 'C25-modified rifamycin derivatives with improved activity against Mycobacterium abscessus', PNAS nexus, Jg. 1, Nr. 4, S. pgac130. https://doi.org/10.1093/pnasnexus/pgac130
Schaberg, T, Brinkmann, F, Feiterna-Sperling, C, Geerdes-Fenge, H, Hartmann, P, Häcker, B, Hauer, B, Haas, W, Heyckendorf, J, Lange, C, Maurer, FP, Nienhaus, A, Otto-Knapp, R, Priwitzer, M, Richter, E, Salzer, HJF, Schoch, O, Schönfeld, N, Stahlmann, R & Bauer, T 2022, 'Tuberkulose im Erwachsenenalter', Pneumologie (Stuttgart, Germany), Jg. 76, Nr. 11, S. 727-819. https://doi.org/10.1055/a-1934-8303
Shuaib, YA, Utpatel, C, Kohl, TA, Barilar, I, Diricks, M, Ashraf, N, Wieler, LH, Kerubo, G, Mesfin, EA, Diallo, AB, Al-Hajoj, S, Ndung'u, P, Fitzgibbon, MM, Vaziri, F, Sintchenko, V, Martinez, E, Viegas, SO, Zhou, Y, Azmy, A, Al-Amry, K, Godreuil, S, Varma-Basil, M, Narang, A, Ali, S, Beckert, P, Dreyer, V, Kabwe, M, Bates, M, Hoelscher, M, Rachow, A, Gori, A, Tekwu, EM, Sidze, LK, Jean-Paul, AA, Beng, VP, Ntoumi, F, Frank, M, Diallo, AG, Mboup, S, Tessema, B, Beyene, D, Khan, SN, Diel, R, Supply, P, Maurer, FP, Hoffmann, H, Niemann, S & Merker, M 2022, 'Origin and Global Expansion of Mycobacterium tuberculosis Complex Lineage 3', Genes, Jg. 13, Nr. 6, 990. https://doi.org/10.3390/genes13060990
Sibandze, DB, Kay, A, Dreyer, V, Sikhondze, W, Dlamini, Q, DiNardo, A, Mtetwa, G, Lukhele, B, Vambe, D, Lange, C, Glenn Dlamini, M, Ness, T, Mejia, R, Kalsdorf, B, Heyckendorf, J, Kuhns, M, Maurer, FP, Dlamini, S, Maphalala, G, Niemann, S & Mandalakas, A 2022, 'Rapid molecular diagnostics of tuberculosis resistance by targeted stool sequencing', Genome medicine, Jg. 14, Nr. 1, S. 52. https://doi.org/10.1186/s13073-022-01054-6
Study Group on Mycobacteria of the European Society of Microbiology and Infectious Diseases (ESGMYC), European Society of Mycobacteriology (ESM), European Respiratory Society (ERS) and 2022, 'Rifapentine access in Europe: growing concerns over key tuberculosis treatment component', The European respiratory journal, Jg. 59, Nr. 5, S. 2200388. https://doi.org/10.1183/13993003.00388-2022
Walter, K, Kokesch-Himmelreich, J, Treu, A, Waldow, F, Hillemann, D, Jakobs, N, Lemm, A-K, Schwudke, D, Römpp, A & Hölscher, C 2022, 'Interleukin-13 overexpressing mice represent an advanced pre-clinical model for detecting the distribution of anti-mycobacterial drugs within centrally necrotizing granulomas', ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Jg. 66, Nr. 6, S. e0158821. https://doi.org/10.1128/AAC.01588-21
Welte, T, Dinkel, J, Maurer, F, Richter, E, Rohde, G, Schwarz, C, Taube, C & Diel, R 2022, 'Versorgung von Patienten/innen mit einer durch nichttuberkulöse Mykobakterien verursachten Lungenerkrankung in Deutschland – ein transsektorales patientenorientiertes Versorgungskonzept', Pneumologie (Stuttgart, Germany), Jg. 76, Nr. 8, S. 534-546. https://doi.org/10.1055/a-1855-0858
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