Priority Research Area Infections
Mission Projects Funding Techniques Publications Staff
We investigate the molecular principles of the innate immune response to lipids. Bacterial membrane components are highly effective activators of inflammation and antimicrobial effector mechanisms. Dysregulation of these immune responses can lead to severe diseases like pneumonia, acute respiratory distress syndrome, and sepsis. We analyze the mechanisms of initiation and regulation of inflammation with a special focus on the investigation of host defense peptides, proteins and lipids involved in anti-inflammatory immune regulation. The aim of these studies it to evaluate natural immune-response modifiers as candidates for therapeutic applications.