Mission Projects Funding Techniques Publications Staff
Within the Core Unit, we carry out histological work on animal models generated in FZB projects. In addition to consulting on pre-analysis, we process tissue for embedding in paraffin, preparation of sections, histological staining, immunohistochemistry and archiving of block material. Frozen sections are also part of our tasks. In the field of archieving, we work closely with BMB Nord. We consult the various research groups on the planning and execution of histological analyzes as well as further investigations such as transcriptomics, multispectral IHC, nanostring and spatial transcriptomics.
As part of the German Center for Lung Research (DZL) at the North site (ARCN), we are involved in third-party funded projects in the disease areas lung cancer, COPD, asthma/allergy and biobanking. Our particular research focus is the TGF-beta signaling pathway in NSCLC. Moreover, embryological processes and the tumor microenvironment are gaining increasing relevance. After years of basic research, we are now intensively engaged in translating the results obtained in this field into clinical practice. In the area of infection, we are particularly interested in the multispectral immunohistochemical analysis of pathophysiological events in tuberculosis granulomas and transcriptome studies within various model systems and cohorts, with the aim of developing host directed therapies.