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Prof. Dr. rer. nat. Silke Meiners

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Prof. Dr. rer. nat. Silke Meiners
Forschungszentrum Borstel, Leibniz Lungenzentrum
Research Center Borstel, Leibniz Lung Center
Parkallee 1-40
23845 Borstel
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+49 4537 / 188-5846

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Biosketch Silke Meiners

Silke Meiners was trained as a biochemist and molecular biologist at the universities of Bonn (Germany), Norwich (GB), and Berlin, where she obtained her PhD degree. She worked as a Postdoc and assistant professor at the Charité in Berlin and habilitated there on the application of proteasome inhibitors in cardiovascular disease in 2008. In 2010, Silke Meiners joined the Comprehensive Pneumology Center at the Helmholtz Center Munich (Germany) as a research group leader and started to work on the proteasome in lung health and disease. Since September 2021, Silke Meiners is heading a research group dedicated to immunoproteasome research at the Research Center Borstel/Leibniz Lung Center. She also holds a Leibniz Chair for Immunoproteasome Research at the University of Kiel (Germany).

Silke Meiners is fellow of the European Respiratory Society (FERS) where she served as the ERS Research Seminar and Conference Director organizing the annual Lung Science Conferences and Research Seminars from 2022-2025. For the European Respiratory Journal and European Respiratory Reviews, she serves as an associate editor. Since 2012, Silke Meiners is PI of the German Center for Lung Research (DZL) and co-chairs the DZL-Academy that trains, mentors and supports early career scientists within the DZL. She is also a PI and steering committee member of the excellence cluster Precision Medicine in Inflammation (PMI) in Kiel.

Download Curriculum Vitae and Publication Record

 

 

Additional Publications of Silke Meiners not affiliated with the Research Center Borstel

 

2021

Laveneziana P, Straus C, Meiners S. How and to What Extent Immunological Responses to SARS-CoV-2 Shape Pulmonary Function in COVID-19 Patients. Front Physiol. 2021 Jun 29;12:628288.

Yazgili AS, Meul T, Welk V, Semren N, Kammerl IE, Meiners S. In-gel proteasome assay to determine the activity, amount, and composition of proteasome complexes from mammalian cells or tissues. STAR Protoc. 2021 May 4;2(2):100526.

 

2020

Korfei M, MacKenzie B, Meiners S. The ageing lung under stress. Eur Respir Rev. 2020 Jul 7;29(156):200126. Review

Hu C, Meiners S, Lukas C, Stathopoulos GT, Chen J. Role of exosomal microRNAs in lung cancer biology and clinical applications. Cell Prolif. 2020 May 11:e12828. Review
Coux O, Zieba BA, Meiners S. The Proteasome System in Health and Disease. Adv Exp Med Biol. 2020;1233:55-100. Book chapter
Wang X, Meul T, Meiners S. Exploring the proteasome system: A novel concept of proteasome inhibition and regulation. Pharmacol Ther. 2020 Mar 13:107526. Review
Ubags ND, Baker J, Boots A, Costa R, El-Merhie N, Fabre A, Faiz A, Heijink IH, Hiemstra PS, Lehmann M, Meiners S, Rolandsson Enes S, Bartel S. ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly. ERJ Open Res. 2020 Mar 2;6(1). pii: 00350-2019. Report

Coux O, Zieba BA, Meiners S. The Proteasome System in Health and Disease. Adv Exp Med Biol. 2020;1233:55-100. Book chapter

Wang X, Meul T, Meiners S. Exploring the proteasome system: A novel concept of proteasome inhibition and regulation. Pharmacol Ther. 2020 Mar 13:107526. Review

Ubags ND, Baker J, Boots A, Costa R, El-Merhie N, Fabre A, Faiz A, Heijink IH, Hiemstra PS, Lehmann M, Meiners S, Rolandsson Enes S, Bartel S. ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly. ERJ Open Res. 2020 Mar 2;6(1). pii: 00350-2019. Report

Meul T, Berschneider K, Schmitt S, Mayr CH, Mattner LF, Schiller H, Yazgili A, Wang W, Lukas C, Prehn C, Adamski J, Graf E, Schwarzmayr T, Perocchi F, Kukat A, Trifunovic A, Kremer L, Prokisch H, Popper B; von Toerne C, Hauck SM, Zischka H, Meiners S. Mitochondrial regulation of the 26S proteasome. Cell Reports 2020, Aug 25;32(8):108059.

Bölükbas DA, Datz S, Meyer-Schwickerath C, Morrone C, Doryab A, Gössl D, Vreka M, Yang L, Argyo C. van Rijt SH, Lindner M, Eickelberg O, Stoeger T, Schmid O, Lindstedt S, Stathopoulos GT, Bein T, Wagner DE, Meiners S. Organ-restricted vascular delivery of nanoparticles for lung cancer therapy. Advanced Therapeutics. 2020, 3: 2070016

Heitmeier T, Sydykov A, Lukas C, Vroom C, Korfei M, Petrovic A, Klingel K, Günther A, Eickelberg O, Weissmann N, Ghofrani HA, Seeger W, Grimminger F, Schermuly RT, Meiners S‡, Kosanovic D‡. Altered proteasome function in right ventricular hypertrophy. Cardiovasc Res. 2020 Feb 1;116(2):406-415. ‡ equal contribution

 

2019

Welk V, Meul T, Lukas C, Kammerl IE, Mulay SR, Schamberger AC, Semren N, Fernandez IE, Anders HJ, Günther A, Behr J, Eickelberg O, Korfei M, Meiners S. Proteasome activator PA200 regulates myofibroblast differentiation. Scientific Rep. 2019 Oct 23;9(1):15224.

Kesireddy VS, Chillappagari S, Ahuja S, Knudsen L, Henneke I, Graumann J, Meiners S, Ochs M, Ruppert C, Korfei M, Seeger W, Mahavadi P. Susceptibility of microtubule-associated protein 1 light chain 3β (MAP1LC3B/ LC3B) knockout mice to lung injury and fibrosis. FASEB J. 2019 Nov;33(11):12392-12408.

Kammerl IE, Caniard A, Merl-Pham J, Ben-Nissan G, Mayr CH, Mossina A, Geerlof A, Eickelberg O, Hauck SM, Sharon M, Meiners S. Dissecting the molecular effects of cigarette smoke on proteasome function. J Proteomics. 2019 Feb 20;193:1-9.

 

2018

Meiners S, Lloyd C, Chambers RC. Cell-matrix interactions in lung disease and regeneration: ERS Lung Science Conference 2018 report. Eur Respir Rev. 2018 Jun 27;27(148). pii: 180040. Report

Amatngalim GD, Vieira RP, Meiners S, Bartel S. Novel insights into the effects of cigarette smoke on the airway epithelial surface-lessons learned at the European Respiratory Society International Congress 2018 in Paris. J Thorac Dis. 2018 Sep;10(Suppl 25):S2977-S2982. Report

Meiners S, Evankovich J, Mallampalli RK. The ubiquitin proteasome system as a potential therapeutic target for systemic sclerosis. Transl Res. 2018 Aug;198:17-28. Review

Houssaini A, Breau M, Kebe K, Abid S, Marcos E, Lipskaia L, Rideau D, Parpaleix A, Huang J, Amsellem V, Vienney N, Validire P, Maitre B, Attwe A, Lukas C, Vindrieux D, Boczkowski J, Derumeaux G, Pende M, Bernard D, Meiners S, Adnot S. mTOR pathway activation drives lung cell senescence and emphysema. JCI Insight. 2018 Feb 8;3(3). pii: 93203.