Programmbereich Asthma und Allergie

Experimentelle Pneumologie

Mission    Projekte    Drittmittel    Methoden    Publikationen    Mitarbeiter/innen



Igetei, JE, El-Faham, M, Liddell, S, Schramm, G & Doenhoff, MJ 2018, 'Antigenic cross-reactivity between Schistosoma mansoni and pollen allergens from the birch tree (Betula verrucosa) and Timothy grass (Phleum pratense): involvement of shared glycan epitopes and implications for the hygiene hypothesis' INTERNATIONAL JOURNAL FOR PARASITOLOGY, Bd 48, Nr. 5, S. 345-357. DOI: 10.1016/j.ijpara.2017.12.005

Kaisar, MMM, Ritter, M, Del Fresno, C, Jónasdóttir, HS, van der Ham, AJ, Pelgrom, LR, Schramm, G, Layland, LE, Sancho, D, Prazeres da Costa, C, Giera, M, Yazdanbakhsh, M & Everts, B 2018, 'Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses' PLOS BIOLOGY , Bd 16, Nr. 4, S. e2005504. DOI: 10.1371/journal.pbio.2005504

Lindner, K, Webering, S, Stroebele, M, Bockhorn, H, Hansen, T, König, P & Fehrenbach, H 2018, 'Low Dose Carbon Black Nanoparticle Exposure Does Not Aggravate Allergic Airway Inflammation in Mice Irrespective of the Presence of Surface Polycyclic Aromatic Hydrocarbons' Nanomaterials, Bd 8, Nr. 4. DOI: 10.3390/nano8040213

Spengler, D, Winoto-Morbach, S, Kupsch, S, Vock, C, Blöchle, K, Frank, S, Rintz, N, Diekötter, M, Janga, H, Weckmann, M, Fuchs, S, Schromm, AB, Fehrenbach, H, Schütze, S & Krause, MF 2018, 'Novel therapeutic roles for surfactant-inositols and -phosphatidylglycerols in a neonatal piglet ARDS model. A translational study' AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY , Bd 314, Nr. 1, S. L32-L53. DOI: 10.1152/ajplung.00128.2017



Fehrenbach H, Wagner C, Wegmann M. Airway remodeling in asthma: what really matters. Cell Tissue Res. 2017;367:551-569.

Lindner, K, Ströbele, M, Schlick, S, Webering, S, Jenckel, A, Kopf, J, Danov, O, Sewald, K, Buj, C, Creutzenberg, O, Tillmann, T, Pohlmann, G, Ernst, H, Ziemann, C, Hüttmann, G, Heine, H, Bockhorn, H, Hansen, T, König, P & Fehrenbach, H 2017, 'Biological effects of carbon black nanoparticles are changed by surface coating with polycyclic aromatic hydrocarbons' Particle and Fibre Toxicology, Bd 14, Nr. 1, S. 8. DOI: 10.1186/s12989-017-0189-1

Abla, N, Keiser, J, Vargas, M, Reimers, N, Haas, H & Spangenberg, T 2017, 'Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the Schistosoma mansoni mouse model' PLoS Neglected Tropical Diseases, Bd 11, Nr. 9, S. e0005942. DOI: 10.1371/journal.pntd.0005942

Homann, A, Schramm, G & Jappe, U 2017, 'Glycans and Glycan-specific IgE in Clinical and Molecular Allergology - Sensitization, Diagnosis and Clinical Symptoms.' JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Bd 140, Nr. 2, S. 356-368.

Spengler, D, Winoto-Morbach, S, Kupsch, S, Vock, C, Blöchle, K, Frank, S, Rintz, N, Diekötter, M, Janga, H, Weckmann, M, Fuchs, S, Schromm, AB, Fehrenbach, H, Schütze, S & Krause, MF 2017, 'Novel therapeutic roles for surfactant-inositols and -phosphatidylglycerols in a neonatal piglet ARDS model. A translational study' AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY , S. ajplung.00128.2017. DOI: 10.1152/ajplung.00128.2017

Wilbers, RHP, Westerhof, LB, van Noort, K, Obieglo, K, Driessen, NN, Everts, B, Gringhuis, SI, Schramm, G, Goverse, A, Smant, G, Bakker, J, Smits, HH, Yazdanbakhsh, M, Schots, A & Hokke, CH 2017, 'Production and glyco-engineering of immunomodulatory helminth glycoproteins in plants' Scientific Reports, Bd 7, S. 45910. DOI: 10.1038/srep45910

Haeberlein, S, Obieglo, K, Ozir-Fazalalikhan, A, Chayé, MAM, Veninga, H, van der Vlugt, LEPM, Voskamp, A, Boon, L, den Haan, JMM, Westerhof, LB, Wilbers, RHP, Schots, A, Schramm, G, Hokke, CH & Smits, HH 2017, 'Schistosome egg antigens, including the glycoprotein IPSE/alpha-1, trigger the development of regulatory B cells' PLOS PATHOGENS, Bd 13, Nr. 7, S. e1006539. DOI: 10.1371/journal.ppat.1006539



Zimmer, J, Weitnauer, M, Boutin, S, Küblbeck, G, Thiele, S, Walker, P, Lasitschka, F, Lunding, L, Orinska, Z, Vock, C, Arnold, B, Wegmann, M & Dalpke, A 2016, 'Nuclear Localization of Suppressor of Cytokine Signaling-1 Regulates Local Immunity in the Lung' Frontiers in Immunology, Bd 7, S. 514. DOI: 10.3389/fimmu.2016.00514

Diesner, SC, Bergmayr, C, Pfitzner, B, Assmann, V, Krishnamurthy, D, Starkl, P, Endesfelder, D, Rothballer, M, Welzl, G, Rattei, T, Eiwegger, T, Szépfalusi, Z, Fehrenbach, H, Jensen-Jarolim, E, Hartmann, A, Pali-Schöll, I & Untersmayr, E 2016, 'A distinct microbiota composition is associated with protection from food allergy in an oral mouse immunization model' CLINICAL IMMUNOLOGY , Bd 173, S. 10-18. DOI: 10.1016/j.clim.2016.10.009

Doenhoff, MJ, El-Faham, M, Liddell, S, Fuller, HR, Stanley, RG, Schramm, G & Igetei, JE 2016, 'Cross-Reactivity between Schistosoma mansoni Antigens and the Latex Allergen Hev b 7: Putative Implication of Cross-Reactive Carbohydrate Determinants (CCDs)' PLOS ONE, Bd 11, Nr. 7, S. e0159542. DOI: 10.1371/journal.pone.0159542

Lunding, L, Webering, S, Vock, C, Schröder, A, Raedler, D, Schaub, B, Fehrenbach, H & Wegmann, M 2016, 'Effect of IL-37 on Allergic Airway Inflammation' Annals of the American Thoracic Society, Bd 13 , Nr. Suppl 1, S. S95-6., 10.1513/AnnalsATS.201506-380MG

Boyle, EC, Dombrowsky, H, Sarau, J, Braun, J, Aepfelbacher, M, Lautenschläger, I & Grassl, GA 2016, 'Ex vivo perfusion of the isolated rat small intestine as a novel model of Salmonella enteritis' AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, Bd 310, Nr. 2, S. G55-63., 10.1152/ajpgi.00444.2014

Polansky, JK, Bahri, R, Divivier, M, Duitman, EH, Vock, C, Goyeneche-Patino, DA, Orinska, Z & Bulfone-Paus, S 2016, 'High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner' Scientific Reports, Bd 6, S. 19699., 10.1038/srep19699

Wegmann M, Fehrenbach H, Krauss-Etschmann S. Asthma Update 2015 - What Cell Biology in Basic Pulmonary Research Can Offer to the Pneumologist. Pneumologie. 2016;70:103-9.



Ferguson BJ, Newland SA, Gibbs SE, Tourlomousis P, Fernandes Dos Santos P, Patel MN, Hall SW, Walczak H, Schramm G, Haas H, Dunne DW, Cooke A, Zaccone P. The Schistosoma mansoni T2 ribonuclease omega-1 modulates inflammasome-dependent IL-1β secretion in macrophages. Int J Parasitol. 2015 Nov;45(13):809-13. doi:10.1016/j.ijpara.2015.08.005. Epub 2015 Sep 16.

Smit CH, Homann A, van Hensbergen VP, Schramm G, Haas H, van Diepen A, Hokke CH. Surface expression patterns of defined glycan antigens change during Schistosoma mansoni cercarial transformation and development of schistosomula. Glycobiology. 2015 Dec;25(12):1465-79. doi: 10.1093/glycob/cwv066. Epub 2015 Sep.

Madurga, A, Golec, A, Pozarska, A, Ishii, I, Mižíková, I, Nardiello, C, Vadász, I, Herold, S, Mayer, K, Reichenberger, F, Fehrenbach, H, Seeger, W & Morty, RE 2015, The H2S-generating enzymes cystathionine β-synthase and cystathionine γ-lyase play a role in vascular development during normal lung alveolarization. Am J Physiol Lung Cell Mol Physiol. 2015 Oct 1;309(7):L710-24.  doi: 10.1152/ajplung.00134.2015. Epub 2015 Jul 31.

Meyer, NH, Mayerhofer, H, Tripsianes, K, Blindow, S, Barths, D, Mewes, A, Weimar, T, Köhli, T, Bade, S, Madl, T, Frey, A, Haas, H, Mueller-Dieckmann, J, Sattler, M & Schramm, G 2015, 'A crystallin fold in the interleukin-4-inducing principle of Schistosoma mansoni eggs (IPSE/alpha-1) mediates IgE binding for antigen-independent basophil activation' The Journal of biological chemistry., 10.1074/jbc.M115.675066

Lunding, LP, Webering, S, Vock, C, Behrends, J, Wagner, C, Hölscher, C, Fehrenbach, H & Wegmann, M 2015, Poly(inosinic-cytidylic) Acid-Triggered Exacerbation of Experimental Asthma Depends on IL-17A Produced by NK Cells. JOURNAL OF IMMUNOLOGY, Bd 194, Nr. 12, S. 5615-25.

Vock, C, Yildirim, AÖ, Wagner, C, Schlick, S, Lunding, LP, Lee, CG, Elias, JA, Fehrenbach, H & Wegmann, M 2015, Distal airways are protected from goblet cell metaplasia by diminished expression of IL-13 signaling components. Clin Exp Allergy. 2015 Sep;45(9):1447-58. doi: 10.1111/cea.12526.

Reimers, N, Homann, A, Höschler, B, Langhans, K, Wilson, RA, Pierrot, C, Khalife, J, Grevelding, CG, Chalmers, IW, Yazdanbakhsh, M, Hoffmann, KF, Hokke, CH, Haas, H & Schramm, G 2015, 'Drug-induced exposure of Schistosoma mansoni antigens SmCD59a and SmKK7' PLoS Neglected Tropical Diseases, Bd 9, Nr. 3, S. e0003593.

Fairfax, KC, Everts, B, Amiel, E, Smith, AM, Schramm, G, Haas, H, Randolph, GJ, Taylor, JJ & Pearce, EJ 2015, 'IL-4-Secreting Secondary T Follicular Helper (Tfh) Cells Arise from Memory T Cells, Not Persisting Tfh Cells, through a B Cell-Dependent Mechanism' JOURNAL OF IMMUNOLOGY, Bd 194, Nr. 7, S. 2999-3010.

Lunding, L, Webering, S, Vock, C, Schröder, A, Raedler, D, Schaub, B, Fehrenbach, H & Wegmann, M 2015, 'IL-37 requires IL-18Rα and SIGIRR/IL-1R8 to diminish allergic airway inflammation in mice' ALLERGY, Bd 70(4), S. 366-373.

Heylen, M, Ruyssers, NE, Nullens, S, Schramm, G, Pelckmans, PA, Moreels, TG, De Man, JG & De Winter, BY 2015, 'Treatment with Egg Antigens of Schistosoma mansoni Ameliorates Experimental Colitis in Mice Through a Colonic T-cell-dependent Mechanism' INFLAMMATORY BOWEL DISEASES , Bd 21, Nr. 1, S. 48-59.



Biethahn, K, Orinska, Z, Vigorito, E, Goyeneche-Patino, DA, Mirghomizadeh, F, Föger, N & Bulfone-Paus, S 2014, 'miRNA-155 controls mast cell activation by regulating the PI3Kγ pathway and anaphylaxis in a mouse model' Allergy, Bd 69, Nr. 6, S. 752-62.

Bratu, VA, Erpenbeck, VJ, Fehrenbach, A, Rausch, T, Rittinghausen, S, Krug, N, Hohlfeld, JM & Fehrenbach, H 2014, 'Cell Counting in Human Endobronchial Biopsies - Disagreement of 2D versus 3D Morphometry' PLOS ONE, Bd 9, Nr. 3, S. e92510.

Ghosh, D, Mueller, GA, Schramm, G, Edwards, LL, Petersen, A, London, RE, Haas, H & Gupta-Bhattacharya, S 2014, 'Primary identification, biochemical characterization, and immunologic properties of the allergenic pollen cyclophilin Cat r 1. J Biol Chem. 2014 Aug 1;289(31):21374-85.

Jordakieva, G, Wallmann, J, Schmutz, R, Lemell, P, Wegmann, M, Klein, J, Nittke, T, Mittlböck, M, Epstein, MM, Fehrenbach, H, Godnic-Cvar, J, Zieglmayer, R & Jensen-Jarolim, E 2014, 'Peripheral erythrocytes decrease upon specific respiratory challenge with grass pollen allergen in sensitized mice and in human subjects' PLOS ONE, Bd 9, Nr. 3, S. e86701.

Madurga, A, Mižíková, I, Ruiz-Camp, J, Vadász, I, Herold, S, Mayer, K, Fehrenbach, H, Seeger, W & Morty, R 2014, 'Systemic hydrogen sulfide administration partially restores normal alveolarization in an experimental animal model of bronchopulmonary dysplasia' American journal of physiology. Lung cellular and molecular physiology, Nr. 306(7), S. L684-97.



Sandig H, Jobbings CE, Roldan NG, Whittingham-Dowd JK, Orinska Z, Takeuchi O, Akira S, Bulfone-Paus S. IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation. Eur J Immunol. 2013 Apr;43(4):979-88.

Hussaarts L, Smits HH, Schramm G, van der Ham AJ, van der Zon GC, Haas H, Guigas B, Yazdanbakhsh M.Rapamycin and omega-1: mTOR-dependent and -independent Th2 skewing by human dendritic cells. IMMUNOLOGY AND CELL BIOLOGY 2013 Aug;91(7):486-9.



Bahri R, Bollinger A, Bollinger T, Orinska Z, Bulfone-Paus S. Ectonucleotidase CD38 Demarcates Regulatory, Memory-Like CD8(+) T Cells with IFN-γ-Mediated Suppressor Activities. PLoS ONE 2012;7(9):e45234. Open Access

Everts B, Hussaarts L, Driessen NN, Meevissen MHJ, Schramm G, Van der Ham AJ, Van der Hoeven B, Scholzen T, Burgdorf S, Mohrs M, Pearce EJ, Hokke CH, Haas H, Smits HH, Yazdanbakhsh M. Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor. JOURNAL OF EXPERIMENTAL MEDICINE 2012 Sep;209(10):1753–1767.

Raith M, Schaal K, Koslowski R, Fehrenbach H, Poets CF, Schleicher E, Bernhard W. Effects of recombinant human keratinocyte growth factor on surfactant, plasma, and liver phospholipid homeostasis in hyperoxic neonatal rats. JOURNAL OF APPLIED PHYSIOLOGY 2012 Feb;112(8):1317–1328.

McClellan MJ, Khasnis S, Wood CD, Palermo RD, Schlick SN, Kanhere AS, Jenner RG, West MJ. Downregulation of Integrin Receptor-Signaling Genes by Epstein-Barr Virus EBNA 3C via Promoter-Proximal and -Distal Binding Elements. JOURNAL OF VIROLOGY 2012 May;86(9):5165–5178. Open Access

Fehrenbach H. Alveolar epithelial type II cells from embryonic stem cells: knights in shining armour? EUROPEAN RESPIRATORY JOURNAL 2012 Feb;39(2):240-241.

Abdullah M, Kähler D, Vock C, Reiling N, Kugler C, Dromann D, Rupp J, Hauber HP, Fehrenbach H, Zabel P, Vollmer E, Dalhoff K, Goldmann T. Pulmonary haptoglobin and CD163 are functional immunoregulatory elements in the human lung. RESPIRATION 2012;83(1):61-73.

Wegmann M, Lunding L, Orinska Z, Wong DM, Manz RA, Fehrenbach H. Long-Term Bortezomib Treatment Reduces Allergen-Specific IgE but Fails to Ameliorate Chronic Asthma in Mice. International Archives of Allergy and Immunology 2012;158(1):43-53.



Föger N, Jenckel A, Orinska Z, Lee K-H, Chan AC, Bulfone-Paus S. Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b. JOURNAL OF EXPERIMENTAL MEDICINE 2011 Aug;208(9):1777-87.

Duitman EH, Orinska Z, Bulfone-Paus S. Mechanisms of cytokine secretion: A portfolio of distinct pathways allows flexibility in cytokine activity. EUROPEAN JOURNAL OF CELL BIOLOGY 2011 Jun;90(6-7):476-83.

Meevissen MHJ, Driessen NN, Smits HH, Versteegh R, van Vliet SJ, van Kooyk Y, Schramm G, Deelder AM, Haas H, Yazdanbakhsh M, Hokke CH. Specific Glycan Elements Determine Differential Binding of Individual Egg Glycoproteins of the Human Parasite Schistosoma mansoni by Host C-type Lectin Receptors. INTERNATIONAL JOURNAL OF PARASITOLOGY 2012 February 16;42(3):269-77.

Meyer NH, Schramm G, Sattler M. 1H, 13C and 15N chemical shift assignments of IPSEΔNLS. BIOMOL NMR ASSIGN. 2011 Oct;5(2):225-7. Epub 2011 Apr 24.

Zaccone P, Burton OT, Gibbs SE, Miller N, Jones FM, Schramm G, Haas H, Doenhoff MJ, Dunne DW, Cooke A. The S. mansoni glycoprotein ω-1 induces Foxp3 expression in NOD mouse CD4+ T cells. EUROPEAN JOURNAL OF IMMUNOLOGY 2011 Sep;41(9):2709-2718.

Meevissen MHJ, Balog CIA, Koeleman CAM, Doenhoff MJ, Schramm G, Haas H, Deelder AM, Wuhrer M, Hokke CH. Targeted glycoproteomic analysis reveals that kappa-5 is a major, uniquely glycosylated component of Schistosoma mansoni egg antigens. MOLECULAR & CELLULAR PROTEOMICS: MCP 2011 May;10(5):M110.005710.

Kaur I, Schramm G, Everts B, Scholzen T, Kindle KB, Beetz C, Montiel-Duarte C, Blindow S, Jones AT, Haas H, Stolnik S, Heery DM, Falcone FH. Interleukin-4 Inducing Principle from Schistosoma mansoni Eggs (IPSE/alpha-1) contains a functional C-terminal nuclear localization signal necessary for nuclear translocation in mammalian cells but not for its uptake. INFECTION AND IMMUNITY 2011 Jan;79(4):1779-88.

Schlick SN, Wood CD, Gunnell A, Webb HM, Khasnis S, Schepers A, West MJ. Upregulation of the Cell-Cycle Regulator RGC-32 in Epstein-Barr Virus-Immortalized Cells. PLoS ONE 2011 Dec;6(12):e28638. Open Access

Kılıç A, Sonar SS, Yildirim AO, Fehrenbach H, Nockher WA, Renz H. Nerve growth factor induces type III collagen production in chronic allergic airway inflammation. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2011 Nov;128(5):1058-U510.

Gesche J, Fehrenbach H, Koslowski R, Ohler FM, Pynn CJ, Griese M, Poets CF, Bernhard W. rhKGF stimulates lung surfactant production in neonatal rats in vivo. Pediatric Pulmonology 2011 Sep;46(9):882-95. Epub 2011 Apr 1.

Seifart C, Muyal JP, Plagens A, Yildirim AÖ, Kohse K, Grau V, Sandu S, Reinke C, Tschernig T, Vogelmeier C, Fehrenbach H. ATRA results in irregular repair of septa and fails to inhibit proinflammatory macrophages. EUROPEAN RESPIRATORY JOURNAL 2011 Aug;38(2):425-39.

Marwitz S, Abdullah M, Vock C, Fine JS, Visvanathan S, Gaede K, Hauber HP, Zabel P, Goldmann T. HOPE-BAL: Improved Molecular Diagnostics by Application of a Novel Technique for Fixation and Paraffin-Embedding. JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY 2011 Jun;59(6):601-14. Epub 2011 Mar 23.

Knudsen L, Waizy H, Fehrenbach H, Richter J, Wahlers T, Wittwer T, Ochs M. Ultrastructural changes of the intracellular surfactant pool in a rat model of lung transplantation-related events. RESPIRATORY RESEARCH 2011 Jun;12(1):79.

Kerzel S, Rogosch T, Wagner J, Preisser K, Yildirim A-Ö, Fehrenbach H, Garn H, Maier RF, Schroeder HW Jr, Zemlin M. A Single D(H) Gene Segment Is Sufficient for the Establishment of an Asthma Phenotype in a Murine Model of Allergic Airway Inflammation. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 2011 Jun;156(3):247-258.

Clauss M, Voswinckel R, Rajashekhar G, Sigua NL, Fehrenbach H, Rush NI, Schweitzer KS, Yildirim AÖ, Kamocki K, Fisher AJ, Gu Y, Safadi B, Nikam S, Hubbard WC, Tuder RM, Twigg HL 3rd, Presson RG, Sethi S, Petrache I. Lung endothelial monocyte-activating protein 2 is a mediator of cigarette smoke-induced emphysema in mice. JOURNAL OF CLINICAL INVESTIGATION 2011 May;121(6): 2470-9.

Wegmann M. Targeting Eosinophil’s Biology in Asthma Therapy. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 2011 Apr;45(4):667-74.

Farwick M, Gauglitz G, Pavicic T, Köhler T, Wegmann M, Schwach-Abdellaoui K, Malle B, Tarabin V, Schmitz G, Korting HC. Fifty-kDa hyaluronic acid upregulates some epidermal genes without changing TNF-α expression in reconstituted epidermis. SKIN PHARMACOLOGY AND PHYSIOLOGY 2011 Mar;24(4):210-217.



Orinska Z, Föger N, Huber M, Marschall J, Mirghomizadeh F, Du X, Scheller M, Rosenstiel P, Goldmann T, Bollinger A, Beutler BA, Bulfone-Paus S. I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development. BLOOD 2010 Oct;116(15):2665-2675.Schramm G, Haas H. Th2 immune response against Schistosoma mansoni infection. MICROBES AND INFECTION 2010 Nov; 12(12-13):881-8.

Schramm G, Haas H. Th2 immune response against Schistosoma mansoni infection. MICROBES AND INFECTION 2010 Nov; 12(12-13):881-8.

Bligh J, Schramm G, Chiodini PL, Doenhoff MJ. Serological analysis of the outcome of treatment of Schistosoma mansoni infections with praziquantel. ANNALS OF TROPICAL MEDICINE & PARASITOLOGY 2010; 104(6):511-520.

Meevissen MH, Wuhrer M, Doenhoff MJ, Schramm G, Haas H, Deelder AM, Hokke CH. Structural characterization of glycans on omega-1, a major Schistosoma mansoni egg glycoprotein that drives Th2 responses. JOURNAL OF PROTEOME RESEARCH 2010 May; 9(5):2630-2642.Waknine-Grinberg J, Gold D, Ohayon A, Flescher E, Heyfets A, Doenhoff M, Schramm G, Haas H, Golenser J. Schistosoma mansoni infection reduces the incidence of murine cerebral malaria. MALARIA JOURNAL 2010 Jan;9(5). Open Access

Bleyl JU, Heller AR, Fehrenbach A, Heintz M, Fehrenbach H, Klenz G, Gama de Abreu M, Hübler M, Spieth PM, Koch T. Pretreatment with perfluorohexane vapor attenuates fMLP-induced lung injury in isolated perfused rabbit lungs. EXPERIMENTAL LUNG RESEARCH 2010 Aug;36(6):342-351.

Baru AM, Hartl A, Lahl K, Krishnaswamy JK, Fehrenbach H, Yildirim AÖ, Garn H, Renz H, Behrens GMN, Sparwasser T. Selective depletion of Foxp3(+) regulatory T cells during sensitization phase aggravates experimental allergic airway inflammation. EUROPEAN JOURNAL OF IMMUNOLOGY 2010 Aug;40(8):2259-66.

Vock C, Hauber H, Wegmann M. The Other T Helper Cells in Asthma Pathogenesis. JOURNAL OF ALLERGY 2010 Jun;Vol 2010(Article ID 519298). Open Access

Vock C, Biedasek K, Boomgaarden I, Heins A, Nitz I, Döring F. ACBP knockdown leads to down-regulation of genes encoding rate-limiting enzymes in cholesterol and fatty acid metabolism. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY: INTERNATIONAL JOURNAL OF EXPERIMENTAL CELLULAR PHYSIOLOGY, BIOCHEMISTRY, AND PHARMACOLOGY 2010 May;25(6):675-686.

Yildirim A, Muyal V, John G, Muller B, Seifart C, Kasper M, Fehrenbach H. Palifermin Induces Alveolar Mayntenance Programs in Emphysematous Mice. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2010 Apr;181(7):705-717.

Luger EO, Wegmann M, Achatz G, Worm M, Renz H, Radbruch A. Allergy for a lifetime? ALLERGOLOGY INTERNATIONAL 2010 Mar;59(1):1-8. Open Access

Vock C, Nitz I, Döring F. Transcriptom-based identification of a putative role for the human Acyl-CoA-Binding-Protein (ACBP) in vesicular trafficking. CELLULAR AND MOLECULAR BIOLOGY 2010 Feb;56 Suppl:OL1261-1265.

Singer T, Brand V, Moehrlen U, Fehrenbach H, Purkabiri K, Ott S, Stammberger U, Ochs M, Hamacher J. Left-sided mouse intubation: description and evaluation. EXPERIMENTAL LUNG RESEARCH 2010 Feb;36(1):25-30.

Wegmann M, Hauber HP. Experimental approaches towards allergic asthma therapy-murine asthma models. RECENT PATENTS ON INFLAMMATION & ALLERGY DRUG DISCOVERY 2010;4(1):37-53.

Hsia CC, Hyde DM, Ochs M, Weibel ER, Albertine KH, Burri PH, Crapo JD, Fehrenbach H, Grenier PA, Gundersen HJ, Hoffman EA, Hogg JC, Jeffery PK, Mcloughlin P, Mayhew TM, Mitzner W, Plopper CG, Schuster DP, Woodruff P. An official research policy statement of the American Thoracic Society/European Respiratory Society: standards for quantitative assessment of lung structure. AMERICAN JOURNAL OF RESPIRATORY CRITICAL CARE MEDICINE. 2010 Feb 15;181(4):394-418.



Stelekati E, Bahri R, D'Orlando O, Orinska Z, Mittrucker H, Langenhaun R, Glatzel M, Bollinger A, Paus R, Bulfone-Paus S. Mast Cell-Mediated Antigen Presentation Regulates CD8(+) T Cell Effector Functions. IMMUNITY 2009 Oct;31(4):665-676.

Mirghomizadeh F, Winoto-Morbach S, Orinska Z, Lee K, Schutze S, Bulfone-Paus S. Intracellular IL-15 controls mast cell survival. EXPERIMENTAL CELL RESEARCH 2009 Oct;315(17):3064-3075.

Scutera S, Fraone T, Musso T, Cappello P, Rossi S, Pierobon D, Orinska Z, Paus R, Bulfone-Paus S, Giovarelli M. Survival and Migration of Human Dendritic Cells Are Regulated by an IFN-alpha-Inducible Axl/Gas6 Pathway. JOURNAL OF IMMUNOLOGY 2009 Sep;183(5):3004-3013.

Mirghomizadeh F, Bullwinkel J, Orinska Z, Janssen O, Petersen A, Singh P, Bulfone-Paus S. Transcriptional Regulation of Mouse Mast Cell Protease-2 by Interleukin-15. JOURNAL OF BIOLOGICAL CHEMISTRY 2009 Nov;284(47):32635-32641.

Everts B, Perona-Wright G, Smits H, Hokke C, van der Ham A, Fitzsimmons C, Doenhoff M, van der Bosch J, Mohrs K, Haas H, Mohrs M, Yazdanbakhsh M, Schramm G. Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses. JOURNAL OF EXPERIMENTAL MEDICINE 2009 Aug;206(8):1673-1680.

Schramm G, Hamilton J, Balog C, Wuhrer M, Gronow A, Beckmann S, Wippersteg V, Grevelding C, Goldmann T, Weber E, Brattig N, Deelder A, Dunne D, Hokke C, Haas H, Doenhoff M. Molecular characterisation of kappa-5, a major antigenic glycoprotein from Schistosoma mansoni eggs. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 2009 Jul;166(1):4-14.

Mayerhofer H, Schramm G, Hatzopoulos G, Mueller-Dieckmann C, Haas H, Mueller-Dieckmann J. Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of interleukin-4-inducing principle from Schistosoma mansoni eggs (IPSE/alpha-1). ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION 2009 Jun;65:594-596.

Hauber H, Wegmann M. Obesity and Asthma. RECENT PATENTS ON ENDOCRINE,  IMMUNE DRUG DISCOVERY 2009 Nov;3(3):162-172.

Luger E, Fokuhl V, Wegmann M, Abram M, Tillack K, Achatz G, Manz R, Worm M, Radbruch A, Renz H. Induction of long-lived allergen-specific plasma cells by mucosal allergen challenge. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2009 Oct;124(4):819-826.

Abram M, Wegmann M, Fokuhl V, Sonar S, Luger E, Kerzel S, Radbruch A, Renz H, Zemlin M. Nerve Growth Factor and Neurotrophin-3 Mediate Survival of Pulmonary Plasma Cells during the Allergic Airway Inflammation. JOURNAL OF IMMUNOLOGY 2009 Apr;182(8):4705-4712.

Kerzel S, Wagner J, Rogosch T, Yildirim A, Sikula L, Fehrenbach H, Garn H, Mayer R, Schroeder H, Zemlin M. Composition of the immunoglobulin classic antigen-binding site regulates allergic airway inflammation in a murine model of experimental asthma. CLINICAL AND EXPERIMENTAL ALLERGY 2009 Apr;39(4):591-601.

Muyal J, Muyal V, Kaistha B, Seifart C, Fehrenbach H. Systematic comparison of RNA extraction techniques from frozen and fresh lung tissues: checkpoint towards gene expression studies. DIAGNOSTIC PATHOLOGY 2009 Mar;4:9. Open Access

Wegmann M. Th2 cells as targets for therapeutic intervention in allergic bronchial asthma. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS 2009 Jan;9(1):85-100.

Hirschburger M, Obert M, Traupe H, Kuchenbuch T, Padberg W, Fehrenbach H, Grau V. Treatment with keratinocyte growth factor does not improve lung allograft survival in the rat. LANGENBECK'S ARCHIVES OF SURGERY / DEUTSCHE GESELLSCHAFT FÜR CHIRURGIE 2009 Jan;394(1):133-141.


Brandenburg S, Takahashi T, de la Rosa M, Janke M, Karsten G, Muzzulini T, Orinska Z, Bulfone-Paus S, Scheffold A. IL-2 induces in vivo suppression by CD4(+)CD25(+)Foxp3(+) regulatory T cells. EUROPEAN JOURNAL OF IMMUNOLOGY 2008 Jun;38(6):1643-1653.

Lichtenbergova L, Kolbekova P, Kourilova P, Kasny M, Mikes L, Haas H, Schramm G, Horak P, Kolarova L, Mountford A. Antibody responses induced by Trichobilharzia regenti antigens in murine and human hosts exhibiting cercarial dermatitis. PARASITE IMMUNOLOGY 2008 Dec;30(11-12):585-595.

Schiemann Y, Wegmann M, Lersch R, Heisler E, Farwick M. Polar emollients in cosmetic formulations enhance the penetration and biological effects of Phytosphingosine on skin. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 2008 Dec;331(1-2):103-107.

Presser K, Schwinge D, Wegmann M, Huber S, Schmitt S, Quaas A, Maxeiner J, Finotto S, Lohse A, Blessing M, Schramm C. Coexpression of TGF-beta 1 and IL-10 Enables Regulatory T Cells to Completely Suppress Airway Hyperreactivity. JOURNAL OF IMMUNOLOGY 2008 Dec;181(11):7751-7758.

Paragh G, Schling P, Ugocsai P, Kel A, Liebisch G, Heimerl S, Moehle C, Schiemann Y, Wegmann M, Farwick M, Wikonkal N, Mandl J, Langmann T, Schmitz G. Novel sphingolipid derivatives promote keratinocyte differentiation. EXPERIMENTAL DERMATOLOGY 2008 Dec;17(12):1004-1016.

Fehrenbach H. Commentaries on viewpoint: use of mean airspace chord length to assess emphysema. What does Lm tell us about lung pathology? JOURNAL OF APPLIED PHYSIOLOGY 2008 Dec;105(6):1984-1985; author reply 1986-1987.

Yildirim A, Veith M, Rausch T, Muller B, Kilb P, Van Winkle L, Fehrenbach H. Keratinocyte growth factor protects against Clara cell injury induced by naphthalene. EUROPEAN RESPIRATORY JOURNAL 2008 Sep;32(3):694-704.

Sel S, Rost B, Yildirim A, Sel B, Kalwa H, Fehrenbach H, Renz H, Gudermann T, Dietrich A. Loss of classical transient receptor potential 6 channel reduces allergic airway response. CLINICAL AND EXPERIMENTAL ALLERGY 2008 Sep;38(9):1548-1558.

Pali-Scholl I, Yildirim A, Ackermann U, Knauer T, Becker C, Garn H, Renz H, Jensen-Jarolim E, Fehrenbach H. Anti-acids lead to immunological and morphological changes in the intestine of BALB/c mice similar to human food allergy. EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY 2008 Aug;60(4-5):337-345.

Schmiedl A, Lempa T, Hoymann H, Rittinghausen S, Popa D, Tschernig T, Fehrenbach H, Pabst R, Hoeper M, Hohlfeld J. Elastase-induced lung emphysema in rats is not reduced by hematopoietic growth factors when applied preventionally. VIRCHOWS ARCHIV 2008 Jun;452(6):675-688.

Schaefer M, Reiling N, Fessler C, Stephani J, Taniuchi I, Hatam F, Yildirim A, Fehrenbach H, Walter K, Ruland J, Wagner H, Ehlers S, Sparwasser T. Decreased pathology and prolonged survival of human DC-SIGN transgenic mice during mycobacterial infection. JOURNAL OF IMMUNOLOGY 2008 May;180(10):6836-6845.

Sel S, Wegmann M, Dicke T, Sel S, Henke W, Yildirim A, Renz H, Garn H. Effective prevention and therapy of experimental allergic asthma using a GATA-3-specific DNAzyme. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2008 Apr;121(4):910-916.

Fehrenbach H, Voswinickel R, Michl V, Mehling T, Fehrenbach A, Seeger W, Nyengaard J. Neoalveolarisation contributes to compensatory lung growth following pneumonectomy in mice. EUROPEAN RESPIRATORY JOURNAL 2008 Mar;31(3):515-522.

Wegmann M. Animal models of chronic experimental asthma - strategies for the identification of new therapeutic targets. JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY 2008 Feb;3 Suppl 1:S4.

Gabriel G, Garn H, Wegmann M, Renz H, Herwig A, Klenk H, Stech J. The potential of a protease activation mutant of a highly pathogenic avian influenza virus for a pandemic live vaccine. VACCINE 2008 Feb;26(7):956-965.

Sadovski J, Kuchenbuch T, Ruppert C, Fehrenbach A, Hirschburger M, Padberg W, Gunther A, Hohlfeld J, Fehrenbach H, Grau V. Keratinocyte growth factor prevents intra-alveolar oedema in experimental lung isografts. EUROPEAN RESPIRATORY JOURNAL 2008 Jan;31(1):21-28.

Wagner C, Isermann K, Fehrenbach H, Roeder T. Molecular architecture of the fruit fly's airway epithelial immune system. BMC GENOMICS 2008;9:446. Open Access

Muyal J, Singh S, Fehrenbach H. DNA-Microarray Technology: Comparison of Methodological Factors of Recent Technique Towards Gene Expression Profiling. CRITICAL REVIEWS IN BIOTECHNOLOGY 2008;28(4):239-251.


Orinska Z, Maurer M, Mirghomizadeh F, Bulanova E, Metz M, Nashkevich N, Schiemann F, Schulmistrat J, Budagian V, Giron-Michel J, Brandt E, Paus R, Bulfone-Paus S. IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities. NATURE MEDICINE 2007 Aug;13(8):927-934.

Stelekati E, Orinska Z, Bulfone-Paus S. Mast cells in allergy: Innate instructors of adaptive responses. IMMUNOBIOLOGY 2007 Jun;212(6):505-519.

Lin J, Renault N, Haas H, Schramm G, Vieths S, Vogel L, Falcone F, Alcocer M. A novel tool for the detection of allergic sensitization combining protein microarrays with human basophils. CLINICAL AND EXPERIMENTAL ALLERGY 2007 Dec;37(12):1854-1862.

Schramm G, Mohrs K, Wodrich M, Doenhoff M, Pearce E, Haas H, Mohrs M. Cutting edge: IPSE/alpha-1, a glycoprotein from Scbistosoma mansoni eggs, induces IgE-dependent antigen-indenendent IL-4 production by murine basophils in vivo. JOURNAL OF IMMUNOLOGY 2007 May;178(10):6023-6027.

Ozdemir C, Sel S, Scholl I, Yildirim A, Bluemer N, Garn H, Ackermann U, Wegmann M, Barlan I, Renz H, Selw S. CD4(+) T cells from mice with intestinal immediate-type hypersensitivity induce airway hyperreactivity. CLINICAL AND EXPERIMENTAL ALLERGY 2007 Oct;37(10):1419-1426.

Fehrenbach H, Fehrenbach A, Dietzel E, Tschernig T, Krug N, Grau V, Hohlfeld J. Effects of keratinocyte growth factor on intra-alveolar surfactant fixed in situ: Quantitative ultrastructural and immunoelectron microscopic analysis. ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY 2007 Aug;290(8):974-980.

Reinhold P, Fehrenbach H, Schulz H. Die sich entwickelnde Lunge im Spezies-Vergleich / [Species-specific aspects of the developing lung]. PNEUMOLOGIE 2007 Jul;61(7):478-489.

Sel S, Wegmann M, Sel S, Bauer S, Garn H, Alber G, Renz H. Immunomodulatory effects of viral TLR ligands on experimental asthma depend on the additive effects of IL-12 and IL-10. JOURNAL OF IMMUNOLOGY 2007 Jun;178(12):7805-7813.

Hausding M, Karwot R, Scholtes P, Lehr H, Wegmann M, Renz H, Galle P, Birkenbachl M, Neurath M, Blumberg R, Finotto S. Lung CD11c(+) cells from mice deficient in Epstein-Barr virus-induced gene 3 (EBI-3) prevent airway hyper-responsiveness in experimental asthma. EUROPEAN JOURNAL OF IMMUNOLOGY 2007 Jun;37(6):1663-1677.

Grau V, Wilker S, Hartmann P, Lips K, Grando S, Padberg W, Fehrenbach H, Kummer W. Administration of keratinocyte growth factor (KGF) modulates the pulmonary expression of nicotinic acetylcholine receptor subunits alpha 7, alpha 9 and alpha 10. LIFE SCIENCES 2007 May;80(24-25):2290-2293.

Scholl I, Ackermann U, Ozdemir C, Blumer N, Dicke T, Sel S, Sel S, Wegmann M, Szalai K, Knittelfelder R, Untersmayr E, Scheiner O, Garn H, Jensen-Jarolim E, Renz H. Anti-ulcer treatment during pregnancy induces food allergy in mouse mothers and a Th2-bias in their offspring. FASEB JOURNAL 2007 Apr;21(4):1264-1270.

Wegmann M, Goggel R, Sel S, Sel S, Erb K, Kalkbrenner F, Renz H, Garn H. Effects of a low-molecular-weight CCR-3 antagonist on chronic experimental asthma. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 2007 Jan;36(1):61-67.

Grau V, Wilker S, Lips K, Hartmann P, Rose F, Padberg W, Fehrenbach H, Wessler I, Kummer W. Administration of keratinocyte growth factor down-regulates the pulmonary capacity of acetylcholine production. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 2007;39(10):1955-1963.

Fehrenbach H. Die Entwicklung des pulmonalen Surfactantsystems. PNEUMOLOGIE 2007;61(7):488-489.


1996-2006 (Selection)

Wuhrer M, Balog CIA, Catalina MI, Jones FM, Schramm G, Haas H, Doenhoff MJ, Dunne DW, Deelder AM, Hokke CH. IPSE/alpha-1, a major secretory glycoprotein antigen from schistosome eggs, expresses the Lewis X motif on core-difucosylated N-glycans. FEBS JOURNAL 2006 May;273(10):2276-2292.

Schramm G, Gronow A, Knobloch J, Wippersteg V, Grevelding CG, Galle J, Fuller H, Stanley RG, Chiodini PL, Haas H, Doenhoff MJ. IPSE/alpha-1: a major immunogenic component secreted from Schistosoma mansoni eggs. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 2006 May;147(1):9-19.

Fitzsimmons CM, Schramm G, Jones FM, Chalmers IW, Hoffmann KF, Grevelding CG, Wuhrer M, Hokke CH, Haas H, Doenhoff MJ, Dunne DW. Molecular characterization of omega-1: a hepatotoxic ribonuclease from Schistosoma mansoni eggs. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 2005 Nov;144(1):123-127.

Aumüller E, Schramm G, Gronow A, Brehm K, Gibbs BF, Doenhoff MJ, Haas H. Echinococcus multilocularis metacestode extract triggers human basophils to release interleukin-4. PARASITE IMMUNOLOGY 2004 Oct;26(10):387-395.

Schramm G, Falcone FH, Gronow A, Haisch K, Mamat U, Doenhoff MJ, Oliveira G, Galle J, Dahinden CA, Haas H. Molecular characterization of an interleukin-4-inducing factor from Schistosoma mansoni eggs. JOURNAL OF BIOLOGICAL CHEMISTRY 2003 May;278(20):18384-18392.

Book Chapters

Fehrenbach H. Die Reize der Lungenentwicklung.  In: Riedl-Seifert, Roland J (Hrsg.): Lungenkarrieren in Wort und Bild.  München: Agileum-Verl.-Ges.; 2007 p. 17-18.