Wirtsdeterminanten bei Lungeninfektionen
Schwerpunkt
Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) is one of the most deadly infectious diseases worldwide. The rate of progression to disease is driven by a complex interplay of pathogen and host-related factors. The current poor understanding of protective versus non-protective host responses hampers the development of new treatments, particularly those based on immunomodulatory strategies. The overall goal of our research is to understand how host-related factors regulate anti-tuberculosis defenses, focusing on two major aspects, which are likely to play a crucial role in the pathogenesis of TB: the biological sex and viral coinfections.
Vaccines:
- Molecular basis of sex-dependency in vaccine efficacy
B cells
- Elucidate the sex-specific role of B cells in TB
- B cell development in the bone-marrow during chronic infection
Myeloid cells
- Sex-specific regulation and function of monocytes and macrophages in TB
- Sex-specific regulation of immunoproteasome function in lung infection (Meiners/Schneider)
Coinfection
- Viral triggers of TB disease: Impact of influenza or MCMV on TB disease and Mtb-specific immunity
Deutsche Forschungsgemeinschaft:
- DFG SCHN 1150/6-1 Wirtsdeterminanten der Suszeptibilität gegenüber Mycobacterium tuberculosis: die Rolle des biologischen Geschlechts (2020- )
- DFG SCHN 1150/4-1 Untersuchungen zur Wirksamkeit von Bestrahlungs-attenuierten Plasmodium Sporozoiten als Malariaimpfstoff während einer Infektion mit Mycobacterium tuberculosis (2015-2018)
- COVSH-NET (experimentelle Studien zu COVID-19)
Leibniz-Graduiertenschule "Modellsysteme für Infektionskrankheiten"
- Hormonal effects on Mycobacterium tuberculosis-infected human macrophages (Schneider / Sellau; 2021-2024)
- Viral triggers of tuberculosis disease: a case for cytomegalovirus? Schneider / Brune; (2020-2023)
- Der Einfluss einer Influenzavirus Infektion auf den Verlauf einer experimentellen Tuberkulose in der Maus; Schneider / Gabriel; (2015-2018)
- Malaria – Tuberculosis Co‐Infection: Dissecting the immunological interactions during concurrent Plasmodium and Mycobacterium infection; Schneider / Jacobs; (2012-2015)
Life Science-Stiftung München:
- The role of B cell/Plasma cell-derived IL-10 in tuberculosis
2024
Harikumar Parvathy G, Bhandiwad D, Eggers L, von Borstel L, Behrends J, Hein M, Hertz D, Marschner J, Orinska Z, Kaufmann SHE, Flores-Valdez MA, Lotter H, Schneider BE. Sex differences in vaccine induced immunity and protection against Mycobacterium tuberculosis. bioRxiv 2024.04.20.590403; doi: https://doi.org/10.1101/2024.04.20.590403
Hertz D, Marwitz S, Eggers L, von Borstel L, Harikumar Parvathy G, Behrends J, Jonigk DD, Manz RA, Goldmann T, Schneider BE. Ablation of B cell-derived IL-10 increases tuberculosis resistance. bioRxiv 2024.07.17.603865
doi: https://doi.org/10.1101/2024.07.17.603865
2021
Henning J, Walendy-Gnirß K, Tekin-Bubenheim N, Kouassi NM, Ben-Batalla I, Berenbrok N, Wolff M, dos Reis VP, Zickler M, Scholl L, Gries A, Jania H, Kloetgen A, Düsedau A, Pilnitz-Stolze G, Jeridi A, Yildirim AÖ, Fuchs H, Gailus-Durner V, Stoeger C, de Angelis MH, Manuylova T, Klingel K, Culley FJ, Behrends J, Loges S, Schneider B, Krauss-Etschmann S, Openshaw P, Gabriel G. Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life. /Nat Commun/ *12, *4957 (2021). https://doi.org/10.1038/s41467-021-25220-3.
Klionsky, DJ, Abdel-Aziz, AK, Abdelfatah, S, Abdellatif, M, Abdoli, A, Abel, S, Abeliovich, H, Abildgaard, MH, Abudu, YP, Acevedo-Arozena, A, Adamopoulos, IE, Adeli, K, Adolph, TE, Adornetto, A, Aflaki, E, Agam, G, Agarwal, A, Aggarwal, BB, Agnello, M, Agostinis, P, Agrewala, JN, Agrotis, A, Aguilar, PV, Ahmad, ST, Ahmed, ZM, Ahumada-Castro, U, Aits, S, Aizawa, S, Akkoc, Y, Akoumianaki, T, Akpinar, HA, Al-Abd, AM, Al-Akra, L, Al-Gharaibeh, A, Alaoui-Jamali, MA, Alberti, S, Alcocer-Gómez, E, Alessandri, C, Ali, M, Alim Al-Bari, MA, Aliwaini, S, Alizadeh, J, Almacellas, E, Almasan, A, Alonso, A, Dallenga, T, Leschczyk, C, Schaible, UE, Schneider, BE & Sonawane, A 2021, 'Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1, Autophagy, Jg. 17, Nr. 1, S. 1-382. https://doi.org/10.1080/15548627.2020.1797280
2020
Beer, AJ, Hertz, D, Seemann, E, Beretta, M, Westermann, M, Bauer, R, Bauer, M, Kessels, MM & Qualmann, B 2020, 'Reduced Mrp2 surface availability as PI3Kγ-mediated hepatocytic dysfunction reflecting a hallmark of cholestasis in sepsis', Scientific Reports, Jg. 10, Nr. 1, 13110. https://doi.org/10.1038/s41598-020-69901-3
Dutta, NK & Schneider, B 2020, 'Are There Sex-Specific Differences in Response to Adjunctive Host-Directed Therapies for Tuberculosis?', FRONTIERS IN IMMUNOLOGY, Jg. 11, S. 1465. https://doi.org/10.3389/fimmu.2020.01465
Hertz D, Dibbern J, Eggers L, von Borstel L, Schneider BE. Increased male susceptibility to Mycobacterium tuberculosis infection is associated with smaller B cell follicles in the lungs. Scientific Reports 2020; 10: 5142
Witschkowski J, Behrends J, Frank R, Eggers L, von Borstel L, Hertz D, Mueller A.-K, Schneider BE. BCG Provides Short-Term Protection from Experimental Cerebral Malaria in Mice. Vaccines 2020, 8, 745.
Leitung der Forschungsgruppe
Wissenschaftliche Mitarbeiter:innen
Technische Mitarbeiter:innen
Alumni
- Maja Grote
- Laura Knüppel