Programmbereich Asthma und Allergie

Mukosale Immunologie und Diagnostik

Mission    Projekte    Drittmittel    Methoden    Publikationen    Mitarbeiter/innen



Frey, A., Lars P. Lunding, L.P., Johanna C. Ehlers, J.C.,  Markus Weckmann, M., Ulrich M. Zissler & Wegmann, M. „More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis“ FrontImmunol 11:761.  doi: 10.3389/fimmu.2020.00761 


Fujimoto, N.,  Bade, S., Röckendorf, N., Ramaker, K., & Frey, A. „Polyethylene glycol-conjugated alkylamines - A novel class of surfactants for the saturation of immunoassay solid phase surfaces“ Talanta 211:120741. doi: 10.1016/j.talanta.2020.120741


Krause, T, Röckendorf, N, Frey, B, Sinnecker, H, Schwager, C, Möckel, S, Jappe, U & Frey, A 2020, 'IgE Epitope Profiling for Allergy Diagnosis and Therapy – Parallel Analysis of a Multitude of Potential Linear Epitopes Using a High Throughput Screening Platform', FRONTIERS IN IMMUNOLOGY, Jg. 2020, Nr. 11, 565243, S. 652-666.e11.,

Röckendorf, N, Zarrin, PS & Wenger, C 2020, 'In-Vitro Classification of Saliva Samples of COPD Patients and Healthy Controls Using Machine Learning Tools', IEEE Access The Multidisciplinary Open Access Journal, Jg. 8, S. 168053.



Frey, A., Ramaker, K., Röckendorf, N., Wollenberg, B., Lautenschläger, I., Gébel, G., Giemsa, A., Heine, M., Bargheer, D., & Nielsen, P. „Fate and Translocation of (Nano)Particulate Matter in the Gastrointestinal Tract“ In: Biological Responses to Nanoscale Particles, P. Gehr & R. Zellner, eds., Springer nature Switzerland, pp. 281-327. doi: 10.1007/978-3-030-12461-8_12



Krause, T, Röckendorf, N, El-Sourani, N, Ramaker, K, Henkel, M, Hauke, S, Borschbach, M & Frey A 2018, 'Breeding cell penetrating peptides: optimization of cellular uptake by a function-driven evolutionary process' Bioconjugate Chemistry DOI: 10.1021/acs.biocojchem.8b00583

Ramaker, K, Henkel, M, Krause, T, Röckendorf, N & Frey, A 2018, 'Cell penetrating peptides: a comparative transport analysis for 474 sequence motifs' Drug Delivery, Bd 25, Nr. 1, S. 928-937.



Homann, A, Röckendorf, N, Kromminga, A, Frey, A, Platts-Mills, TA & Jappe, U 2017, 'Glycan and Peptide IgE Epitopes of the TNF-alpha Blockers Infliximab and Adalimumab - Precision Diagnostics by Cross-Reactivity Immune Profiling of Patient Sera.' Theranostics, Bd 7, Nr. 19, S. 4699-4709.

Röckendorf, N, Meckelein, B, Scherf, KA, Schalk, K, Köhler, P & Frey, A 2017, 'Identification of novel antibody-reactive detection sites for comprehensive gluten monitoring' PLOS ONE, Bd 10, Nr. 7, S. e0181566. DOI: 10.1371/journal.pone.0181566

Schwager, C, Kull, S, Behrends, J, Röckendorf, N, Schocker, F, Frey, A, Homann, A, Becker, W-M & Jappe, U 2017, 'Peanut oleosins associated with severe peanut allergy - Importance of lipophilic allergens for comprehensive allergy diagnostics' JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Bd 140, Nr. 5, 10.1016/j.jaci.2017.02.020, S. 1331-1338. DOI: 10.1016/j.jaci.2017.02.020

Lautenschläger, I, Wong, YL, Sarau, J, Goldmann, T, Zitta, K, Albrecht, M, Frerichs, I, Weiler, N & Uhlig, S 2017, 'Signalling mechanisms in PAF-induced intestinal failure' Scientific Reports, Bd 7, Nr. 1, S. 13382. DOI: 10.1038/s41598-017-13850-x



Frey, A, Röckendorf, N & Henkel, M 2016, 'Selective and efficient cysteine conjugation by maleimides in the presence of phosphine reductants' BIOCONJUGATE CHEMISTRY , Bd 27, Nr. 10, S. 2260-2265. DOI: 10.1021-acs.bioconjchem.6b00371



Homann A, Röckendorf N, Kromminga A, Frey A, Jappe U. B cell epitopes on infliximab identified by oligopeptide microarray with unprocessed patient sera. J Transl Med. 2015 Oct 29;13:339. doi: 10.1186/s12967-015-0706-7. PubMed PMID: 26511203

Meyer, NH, Mayerhofer, H, Tripsianes, K, Blindow, S, Barths, D, Mewes, A, Weimar, T, Köhli, T, Bade, S, Madl, T, Frey, A, Haas, H, Mueller-Dieckmann, J, Sattler, M & Schramm, G 2015, A crystallin fold in the interleukin-4-inducing principle of Schistosoma mansoni eggs (IPSE/alpha-1) mediates IgE binding for antigen-independent basophil activation.  J Biol Chem. 2015 Sep 4;290(36):22111-26. doi:10.1074/jbc.M115.675066. Epub 2015 Jul 10.

Wong, YL, Lautenschläger, I, Dombrowsky, H, Zitta, K, Bein, B, Krause, T, Goldmann, T, Frerichs, I, Steinfath, M, Weiler, N & Albrecht, M 2015, 'Hydroxyethyl Starch (HES 130/0.4) Impairs Intestinal Barrier Integrity and Metabolic Function: Findings from a Mouse Model of the Isolated Perfused Small Intestine' PLOS ONE, Bd 10, Nr. 3, S. e0121497.



Sinnecker, H, Krause, T, Koelling, S, Lautenschläger, I & Frey, A 2014, 'The gut wall provides an effective barrier against nanoparticle uptake' Beilstein Journal of Nanotechnology, Bd 5, S. 2092-2101., 10.3762/bjnano.5.218

Sinnecker, H, Ramaker, K & Frey, A 2014, 'Coating with luminal gut-constituents alters adherence of nanoparticles to intestinal epithelial cells' Beilstein Journal of Nanotechnology, Bd 5, S. 2308-2315., 10.3762/bjnano.5.239



Henkel, M, Reuter, F, Röckendorf, N & Frey, A 2013, 'Peptidomimetics as mucosal immunogens' in 36th Symposium of the north german Immunologists: Understanding Infections & Allergy - still a lung way to go .



Röckendorf N, Borschbach M, Frey A. Molecular Evolution of Peptide Ligands with Custom-Tailored Characteristics for Targeting of Glycostructures. PLoS COMPUTATIONAL BIOLOGY 2012 Dec;8(12):e1002800. Open Access

Schrader C, Ernst IMA, Sinnecker H, Soukup ST, Kulling SE, Rimbach G. Genistein as a potential inducer of the anti-atherogenic enzyme paraoxonase-1: studies in cultured hepatocytes in vitro and in rat liver in vivo. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2012 Oct;16(10):2331–2341.

Gorris HH, Bade S, Röckendorf N, Fránek M, Frey A. Pushing Antibody-Based Labeling Systems to Higher Sensitivity by Linker-Assisted Affinity Enhancement. BIOCONJUGATE CHEMISTRY 2011 Aug;22(8):1619-1624.

Bade S, Gorris HH, Koelling S, Olivier V, Reuter F, Zabel P, Frey A. Quantitation of major protein constituents of murine intestinal fluid. ANALYTICAL BIOCHEMISTRY 2010 Nov;406(2):157-165.

Lautenschlager I, Dombrowsky H, Frerichs I, Kuchenbecker S, Bade S, Schultz H, Zabel P, Scholz J, Weiler N, Uhlig S. A model of the isolated perfused rat small intestine. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 2010 Feb;298(2):G304-G313.

Bade S, Rockendorf N, Franek M, Gorris H, Lindner B, Olivier V, Schaper K, Frey A. Biolabeling with 2,4-Dichlorophenoxyacetic Acid Derivatives: The 2,4-D Tag. ANALYTICAL CHEMISTRY 2009 Dec;81(23):9695-9702.

Reuter F, Bade S, Hirst T, Frey A. Bystander protein protects potential vaccine-targeting ligands against intestinal proteolysis. JOURNAL OF CONTROLLED RELEASE 2009 Jul;137(2):98-103.

Gorris H, Bade S, Rockendorf N, Albers E, Schmidt M, Franek M, Frey A. Rapid Profiling of Peptide Stability in Proteolytic Environments. ANALYTICAL CHEMISTRY 2009 Feb;81(4):1580-1586.

Bade S, Frey A. Vaccines against transmissible spongiform encephalopathies - An urgent need? HUMAN VACCINES 2008 Feb;4(1):79-81.

Rockendorf N, Helfmann J, Fujimoto N, Wehry K, Burger M, Frey A. Peptide-based optical contrast agents for targeting of intestinal malignancies.  In: Popp J, von Bally G, (Ed) Biophotonics 2007: Optics in Life Science.  Munich, Germany: SPIE; 2007 p. 66332A-9.

Rockendorf N, Bade S, Hirst T, Gorris H, Frey A. Synthesis of a fluorescent ganglioside G(M1) derivative and screening of a synthetic peptide library for G(M1) binding sequence motifs. BIOCONJUGATE CHEMISTRY 2007 Apr;18(2):573-578.

Bade S, Frey A. Potential of active and passive immunizations for the prevention and therapy of transmissible spongiform encephalopathies. EXPERT REVIEW OF VACCINES 2007 Apr;6(2):153-168.

Boetel T, Bade S, Schmidt M, Frey A. Prion protein 90-231 contains a streptavidin-binding motif. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2006 Oct;349(1):296-302.

Bade S, Baier M, Boetel T, Frey A. Intranasal immunization of Balb/c mice against prion protein attenuates orally acquired transmissible spongiform encephalopathy. VACCINE 2006 Feb;24(9):1242-1253.

Book Chapters

Ramaker K, Röckendorf N, Frey A. Engineering contrast agents for gastrointestinal magnetic particle imaging: the biological perspective. In: Buzug & J. Borgert, (eds.): Magnetic particle imaging : a novel SPIO nanoparticle imaging technique. Heidelberg [u.a.]: Springer; 2012 p. 205–210.

Bade S, Röckendorf N, Frey A, Petersen A. Western Blotting. In: Jansohn, M.; Rothämel, S.(Hrsg.): Gentechnische Methoden : eine Sammlung von Arbeitsanleitungen für das molekularbiologische Labor. Heidelberg: Spektrum Akad. Verl.; 2012 p. 279-308.

Röckendorf N, Bade S, Gorris H, Frey A. 18 Peptid-Arrays auf Cellulosemembranen. In: Jansohn, M.; Rothämel, S.(Hrsg.): Gentechnische Methoden : eine Sammlung von Arbeitsanleitungen für das molekularbiologische Labor. Heidelberg: Spektrum Akad. Verl.; 2012 p. 501-528.

Gorris H, Bade S, Frey A. Peptidarrays auf Cellulosemembranen.  In: Jansohn M, Aigner A, (Ed.). Gentechnische Methoden : eine Sammlung von Arbeitsanleitungen für das molekularbiologische Labor. 2007 p. 419-544.

Frey A, Bade S, Petersen A. Western Blotting.  In: Jansohn M, Aigner A, (Ed.). Gentechnische Methoden : eine Sammlung von Arbeitsanleitungen für das molekularbiologische Labor. 2007 S. 395-422.

Helfmann J, Bindig U, Meckelein B, Wehry K, Röckendorf N, Schädel D, Schmidt M, Bürger M, Frey A. Early Diagnosis of Cancer.  In: Popp, Jürgen; Strehle, Marion: Biophotonics : visions for better health care.  Weinheim: Wiley-VCH; 2006 p. 231-300.