Programmbereich Infektionen

Bioanalytische Chemie

Mission    Projekte    Drittmittel    Methoden  Publikationen    Mitarbeiter/innen



Al Machot, F, R Elkobaisi, M & Kyamakya, K 2020, 'Zero-Shot Human Activity Recognition Using Non-Visual Sensors', Sensors, Jg. 20, Nr. 3.

Bleuzé, M, Auger, J-P, Lavagna, A, Gisch, N, Gottschalk, M & Segura, M 2020, 'In vitro characterization of granulocyte-colony stimulating factor (G-CSF) production by dendritic cells and macrophages during Streptococcus suis infection', Immunobiology, 225:151979. doi: 10.1016/j.imbio.2020.151979

Cairns, CM, van Faassen, H, St Michael, F, Aubry, A, Henry, KA, Rossotti, MA, Logan, SM, Hussack, G, Gisch, N, Hogendorf, WFJ, Pedersen, CM & Cox, AD 2020, 'Development and Characterization of Mouse Monoclonal Antibodies Specific for Clostridiodes (Clostridium) difficile Lipoteichoic Acid', ACS Chemical Biology, Jg. 15, Nr. 4, S. 1050-1058.

Lange, C, Aarnoutse, R, Chesov, D, van Crevel, R., Gillespie, SH, Grobbel, H-P, Kalsdorf, B, Kontsevaya, I, van Laarhoven, A, Nishiguchi, T, Mandalakas, A, Merker, M, Niemann, S, Köhler, N, Heyckendorf, J, Reimann, M, Ruhwald, M, Sanchez-Carballo, P, Schwudke, D, Waldow, F & DiNardo, AR 2020, 'Perspective for Precision Medicine for Tuberculosis', Front. Immunol., 11:566608. doi: 10.3389/fimmu.2020.566608

Lavagna, A, Auger, J-P, Girardin, SE, Gisch, N, Segura, M & Gottschalk, M 2020, 'Recognition of Lipoproteins by Toll-like Receptor 2 and DNA by the AIM2 Inflammasome Is Responsible for Production of Interleukin-1β by Virulent Suilysin-negative Streptococcus suis Serotype 2', Pathogens, Jg. 9, Nr. 2.

Peng, B, Kopczynski, D, Pratt, BS, Ejsing, CS, Burla, B, Hermansson, M, Benke, PI, Tan, SH, Chan, MY, Torta, F, Schwudke, D, Meckelmann, SW, Coman, C, Schmitz, OJ, MacLean, B, Manke, M-C, Borst, O, Wenk, MR, Hoffmann, N & Ahrends, R 2020, 'LipidCreator workbench to probe the lipidomic landscape', Nature communications, Jg. 11, Nr. 1, S. 2057.

Voß, F, van Beek, LF, Schwudke, D, Ederveen, THA, van Opzeeland, FJ, Thalheim, D, Werner, S, de Jonge, MI & Hammerschmidt, S 2020, 'Lipidation of Pneumococcal Antigens Leads to Improved Immunogenicity and Protection', Vaccines, Jg. 8, Nr. 2.



Al Machot F, Elmachot A, Ali M, Al Machot E, Kyamakya K 2019 'A Deep-Learning Model for Subject-Independent Human Emotion Recognition Using Electrodermal Activity Sensors' Sensors, 19: E1659. doi: 10.3390/s19071659.

Azzouz D, Omarbekova A, Heguy A, Schwudke D, Gisch N, Rovin BH, Caricchio R, Buyon JP, Alekseyenko AV, Silverman GJ 2019 'Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal' Ann Rheum Dis. 78:947-956. doi: 10.1136/annrheumdis-2018-214856.

Correa W, Brandenburg J, Behrends J, Heinbockel L, Reiling N, Paulowski L, Schwudke D, Stephan K, Martinez-de-Tejada G, Brandenburg K, Gutsmann T 2019 'Inactivation of bacteria by γ-irradiation to investigate the interaction with antimicrobial peptides.' Biophys. J., pii: S0006-3495(19)30859-8. doi: 10.1016/j.bpj.2019.10.012. [Epub ahead of print]

Komazin G, Maybin M, Woodard RW, Scior T, Schwudke D, Schombel U, Gisch N, Mamat U, Meredith TC 2019 'Substrate structure-activity relationship reveals a limited lipopolysaccharide chemotype range for intestinal alkaline phosphatase' J Biol Chem 294:19405-19423. doi: 10.1074/jbc.RA119.010836.

Kutschera A, Dawid C, Gisch N, Schmid C, Raasch L, Gerster T, Schäffer M, Smakowska-Luzan E, Belkhadir Y, Vlot AC, Chandler CE, Schellenberger R, Schwudke D, Ernst RK, Dorey S, Hückelhoven R, Hofmann T, Ranf S. 2019 'Bacterial medium-chain 3-hydroxy fatty acid metabolites trigger immunity in Arabidopsis plants.' Science. Jg. 364, Nr. 6436, S. 178-181. doi: 10.1126/science.aau1279

Kutschera A, Schombel U, Wröbel M, Gisch N, Ranf S 2019 'Loss of wbpL disrupts O-polysaccharide synthesis and impairs virulence of plant-associated Pseudomonas strains.' Mol Plant Pathol., 20:1535-1549. doi: 10.1111/mpp.12864.

Lavagna A, Auger J.-P., Dumesnil A., Roy D, Girardin SE, Gisch N, Segura M, Gottschalk M 2019 'Interleukin‑1 signaling induced by Streptococcus suis serotype 2 is strain‑dependent and contributes to bacterial clearance and inflammation during systemic disease in a mouse model of infection' Vet. Res. 50:52. doi: 10.1186/s13567-019-0670-y.

Lipinski S, Pfeuffer S, Arnold P, Treitz C, Aden K, Ebsen H, Falk-Paulsen M, Gisch N, Fazio A, Kuiper J, Luzius A, Billmann-Born S, Schreiber S, Nuñez G, Beer HD, Strowig T, Lamkanfi M, Tholey A, Rosenstiel P 2019 'Prdx4 limits caspase-1 activation and restricts inflammasome-mediated signaling by extracellular vesicles.' EMBO J., 38:e101266. doi: 10.15252/embj.2018101266.

Ring S, Eggers L, Behrends J, Wutkowski A, Schwudke D, Kröger A, Hierweger AM, Hölscher C, Gabriel G, Schneider B. 2019 'Blocking IL-10 receptor signaling ameliorates Mycobacterium tuberculosis infection during influenza-induced exacerbation.' JCI Insight. Apr 18;5. pii: 126533. doi: 10.1172/jci.insight.126533

Pfalzgraff A, Correa W, Heinbockel L, Schromm AB, Lübow C, Gisch N, Martinez-de-Tejada G, Brandenburg K, Weindl G 2019 'LPS-neutralizing peptides reduce outer membrane vesicle-induced inflammatory responses' Biochim Biophys Acta Mol Cell Biol Lipids. Jun 1. pii: S1388-1981(19)30092-7. doi: 10.1016/j.bbalip.2019.05.018.



Waldow, F, Kohler, TP, Heß, N, Schwudke, D, Hammerschmidt, S & Gisch, N 2018, 'Attachment of phosphorylcholine residues to pneumococcal teichoic acids and modification of substitution patterns by the phosphorylcholine esterase' The Journal of biological chemistry. DOI: 10.1074/jbc.RA118.003360

Bonzón-Kulichenko, E, Moltó, E, Pintado, C, Fernández, A, Arribas, C, Schwudke, D, Gallardo, N, Shevchenko, A & Andrés, A 2018, 'Changes in visceral adipose tissue plasma membrane lipid composition in old rats are associated with adipocyte hypertrophy with aging' The journals of gerontology. Series A, Biological sciences and medical sciences, Jg. 73, Nr. 9, S. 1139-1146. DOI: 10.1093/gerona/gly081

Hölzl, G, Sohlenkamp, C, Vences-Guzmán, MA & Gisch, N 2018, 'Headgroup hydroxylation by OlsE occurs at the C4 position of ornithine lipid and is widespread in proteobacteria and bacteroidetes' CHEMISTRY AND PHYSICS OF LIPIDS , Jg. 213, S. 32-38. DOI: 10.1016/j.chemphyslip.2018.03.002

Müller, C, Hardt, M, Schwudke, D, Neuman, BW, Pleschka, S & Ziebuhr, J 2018, 'Inhibition of Cytosolic Phospholipase A2α Impairs an Early Step of Coronavirus Replication in Cell Culture' JOURNAL OF VIROLOGY, Jg. 92, Nr. 4. DOI: 10.1128/JVI.01463-17

Eggers, LF & Schwudke, D 2018, 'Shotgun Lipidomics Approach for Clinical Samples' Methods in Molecular Biology, Jg. 1730, S. 163-174. DOI: 10.1007/978-1-4939-7592-1_12

Wutkowski, A, Krajewski, M, Bagwan, N, Schäfer, M, Paudyal, BR, Schaible, UE & Schwudke, D 2018, 'Software-aided quality control of parallel reaction monitoring based quantitation of lipid mediators' ANALYTICA CHIMICA ACTA, Jg. 1037, S. 168-176. DOI: 10.1016/j.aca.2018.01.044.

Gisch, N, Auger, J-P, Thomsen, S, Roy, D, Xu, J, Schwudke, D & Gottschalk, M 2018, 'Structural analysis and immunostimulatory potency of lipoteichoic acids isolated from three Streptococcus suis serotype 2 strains' The Journal of biological chemistry, Jg. 293, Nr. 31, S. 12011-12025. DOI: 10.1074/jbc.RA118.002174

Bülow, S, Zeller, L, Werner, M, Toelge, M, Holzinger, J, Entzian, C, Schubert, T, Waldow, F, Gisch, N, Hammerschmidt, S, Gessner, A 2018 'Bactericidal/Permeability-Increasing Protein Is an Enhancer of Bacterial Lipoprotein Recognition' FRONT. IMMUNOL., Jg. 9, Art. 2768. DOI: 10.3389/fimmu.2018.02768.

Gonzalez, AC, Stroobants, S, Reisdorf, P, Gavin, AL, Nemazee, D, Schwudke, D, D'Hooge, R, Saftig, P, Damme, M 2018 'PLD3 and spinocerebellar ataxia' BRAIN, Jg. 141, e78. doi: 10.1093/brain/awy258.

Casillo, A, Ziaco, M, Lindner, B, Parrilli, E, Schwudke, D, Holgado, A, Beyaert, R, Lanzetta, R, Tutino, ML, Corsaro, MM 'Lipid A structural characterization from the LPS of the Siberian psychro-tolerant Psychrobacter arcticus 273-4 grown at low temperature' EXTREMOPHILES, Jg. 22, S. 955-963. doi: 10.1007/s00792-018-1051-6.

Kos, O, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Heumann, D, Khatri, I, Mach, JP, Rietschel, ET, Terskikh, A, Ulmer, AJ, Waelli, T, Yu, K, Zähringer, U, Gorczynski, RM 2018 'Regulation of fetal hemoglobin expression during hematopoietic stem cell development and its importance in bone metabolism and osteoporosis' INT IMMUNOPHARMACOL, Jg. 57, S. 112-120. doi: 10.1016/j.intimp.2018.02.010.

Khatri, I, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Heumann, D, Mach, JP, Mazzoli, V, Rietschel, E, Terskikh, A, Ulmer, A, Yu, K, Zähringer, U, Gorczynski, R 2018 'Analysis of cytokine immune response profile in response to inflammatory stimuli in mice with genetic defects in fetal and adult hemoglobin chain expression' PHARMACOGENOMICS J., Jg. 18, S. 546-555. doi: 10.1038/s41397-017-0008-y.

Michael, J, Steinberger, C, Shekhovtsov, V, Al Machot, F, Ranasinghe, S, Morak, G 2018 'The HBMS Story, Past and Future of an Active Assistance Approach' EMISAJ, Jg. 13, S. 345-370. doi: 10.18417/

Lunardi, GM, Al Machot, F, Shekhovtsov, VA, Maran, V, Medeiros Machado, G, Machado, A, Mayr, HC, Palazzo M. de Oliveira, J 2018 'IoT-based Human Action Prediction' INTERNET OF THINGS, Elsevier, Jg. 3/4, S. 52-68. doi: 10.1016/j.iot.2018.09.007.

Ali, M, Al Machot, F, Mosa, AH, Jdeed, M, Al Machot, E, Kyamakya, K 2018 'A Globally Generalized Emotion Recognition System Involving Different Physiological Signals Sensors' MDPI, Jg. 18, pii: E1905. doi: 10.3390/s18061905.

Lunardi, GM, Medeiros  Machado, G, Al  Machot, F, Maran, V,  Machado, A, Mayr, HC, Shekhovtsov, VA, Palazzo M. de Oliveira, J 2018 'Probabilistic Ontology Reasoning in Ambient Assistance, Predicting Human   Actions' Proceedings of 32nd International Conference on Advanced Information Networking and Applications (AINA), S. 593-600. doi: 10.1109/AINA.2018.00092.

Al  Machot, F, Ali, M,  Ranasinghe, S, Mosa, AH, Kyamakya, K 2018 'Improving Subject-independent Human Emotion Recognition Using Electrodermal Activity Sensors for Active and Assisted Living' Proceedings of 11th ACM International Conference on PErvasive Technologies Related to Assistive Environments (PETRA), S. 222-228. doi: 10.1145/3197768.3201523.

Al Machot, F, Ranasinghe, S, Plattner, J, Jnoub, N 2018 'Human Activity  Recognition  based  on  Real  Life Scenarios' CoMoRea 2018, IEEE International Conference on Pervasive Computing and Communications (PERCOM), S. 3-8. doi: 10.1109/PERCOMW.2018.8480138.



Recent Advances in Nonlinear Dynamics and Synchronization (Springer, 2018)

Ali, M,  Mosa, AH, Al  Machot, F, Kyamakya, K 'Emotion Recognition Involving Physiological and Speech Signals:  A Comprehensive Review' S. 287-302. doi: 10.1007/978-3-319-58996-1_13.

Al Machot, F, Mayr, HC, Ranasinghe, S 'A Hybrid Reasoning Approach for Activity Recognition based on Answer Set Programming and Dempster-Shafer Theory', S. 303-318. doi: 10.1007/978-3-319-58996-1_14.



Al Machot, F, Haj Mosa, A, Ali, M & Kyamakya, K 2017, 'Activity Recognition in Sensor Data Streams for Active and Assisted Living Environments' IEEE Transactions on Circuits and Systems for Video Technology, Bd PP, Nr. 99. DOI: 10.1109/tcsvT.2017.2764

Ausgezeichnet als "Paper of the month" der DGHM (01/2018)
Heß N, Waldow F, Kohler TP, Rohde M, Kreikemeyer B, Gómez-Mejia A, Hain T, Schwudke D, Vollmer W, Hammerschmidt S, Gisch N. Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae. Nat Commun. 2017 Dec 12; 8: 2093. doi:10.1038/s41467-017-01720-z.

Hebbar S, Khandelwal A, R J, Hindle SJ, Chiang YN, Yew JY, Sweeney ST, Schwudke D. Lipid metabolic perturbation is an early-onset phenotype in adult spin mutants: a Drosophila model for lysosomal storage disorders. Mol Biol Cell. 2017 Oct 18. pii: mbc.E16-09-0674. doi: 10.1091/mbc.E16-09-0674. [Epub ahead of print]

Schwudke D, Shevchenko A, Hoffmann N, Ahrends R. Lipidomics informatics for life-science. J Biotechnol. 2017 Aug 16. pii: S0168-1656(17)31596-1. doi: 10.1016/j.jbiotec.2017.08.010. [Epub ahead of print]

Eggers LF, Müller J, Marella C, Scholz V, Watz H, Kugler C, Rabe KF, Goldmann T, Schwudke D. Lipidomes of lung cancer and tumour-free lung tissues reveal distinct molecular signatures for cancer differentiation, age, inflammation, and pulmonary emphysema. Sci Rep. 2017 Sep 11;7(1):11087. doi: 10.1038/s41598-017-11339-1.

Di Guilmi AM, Bonnet J, Peiβert S, Durmort C, Gallet B, Vernet T, Gisch N, Wong YS. Specific and spatial labeling of choline-containing teichoic acids in Streptococcus pneumoniae by click chemistry. Chem Commun (Camb). 2017 Sep 21;53(76):10572-10575. doi: 10.1039/c7cc05646j.

Corsaro, MM, Casillo, A, Ziaco, M, Lindner, B, Parrilli, E, Schwudke, D, Holgado, A, Verstrepen, L, Sannino, F, Beyaert, R, Lanzetta, R, Tutino, ML. Unusual Lipid A from a cold adapted bacterium: detailed structural characterization. Chembiochem. 2017 Jun 26. doi: 10.1002/cbic.201700287. [Epub ahead of print]

Mehlitz, A, Eylert, E, Huber, C, Lindner, B, Vollmuth, N, Karunakaran, K, Goebel, W, Eisenreich, W, Rudel, T. Metabolic adaptation of Chlamydia trachomatis to mammalian host cells. Mol Microbiol. 2017 Mar;103(6):1004-1019. doi: 10.1111/mmi.13603. Epub 2017 Jan 31.

Gorczynski, RM, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Neumann, D, Mach, JP, Rietschel, ET, Tersikh, A, Ulmer, AJ, Yu, K, Zähringer, U, Khatri, I. An altered REDOX environment, assisted by over-expression of fetal hemoglobins, protects from inflammatory colitis and reduces inflammatory cytokine expression. Int Immunopharmacol. 2017 Jun 19;50:69-76. doi: 10.1016/j.intimp.2017.06.003. [Epub ahead of print]

Steffens, T, Duda, K, Lindner, B, Vorhölter, F-J, Bednarz, H, Niehaus, K & Holst, O 2017, 'The lipopolysaccharide of the crop pathogen Xanthomonas translucens pv. translucens: chemical characterization and determination of signaling events in plant cells' GLYCOBIOLOGY, Bd 27, Nr. 3, S. 264-274. DOI: 10.1093/glycob/cww093

Hindle, SJ, Hebbar, S, Schwudke, D, Elliott, CJ & Sweeney, ST 2017, 'A saposin deficiency model in Drosophila: Lysosomal storage, progressive neurodegeneration and sensory physiological decline' Neurobiology of disease, Nr. 98, S. 77-87. DOI: 10.1016/j.nbd.2016.11.012

Sezin, T, Krajewski, M, Wutkowski, A, Mousavi, S, Chakievska, L, Bieber, K, Ludwig, RJ, Dahlke, M, Rades, D, Schulze, FS, Schmidt, E, Kalies, K, Gupta, Y, Schilf, P, Ibrahim, SM, König, P, Schwudke, D, Zillikens, D & Sadik, CD 2017, 'The Leukotriene B4 and Its Receptor BLT1 Act as Critical Drivers of Neutrophil Recruitment in Murine Bullous Pemphigoid-Like Epidermolysis Bullosa Acquisita' Journal of Investigative Dermatology. DOI: 10.1016/j.jid.2016.12.021

Jeschke, A, Zehethofer, N, Schwudke, D & Haas, A 2017, 'Quantification of Phosphatidylinositol Phosphate Species in Purified Membranes' Methods in Enzymology, Bd 587, S. 271-291. DOI: 10.1016/bs.mie.2016.10.037

Casillo, A, Ziaco, M, Lindner, B, Merino, S, Mendoza-Barberá, E, Tomás, JM & Corsaro, MM 2017, 'Structural Characterization of Core Region in Erwinia amylovora Lipopolysaccharide' INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , Bd 18, Nr. 3. DOI: 10.3390/ijms18030559



Wohnig S, Spork AP, Koppermann S, Mieskes G, Gisch N, Jahn R, Ducho C. Total Synthesis of Dansylated Park's Nucleotide for High-Throughput MraY Assays. Chemistry. 2016 Dec 5;22(49):17813-17819. doi: 10.1002/chem.201604279. Epub 2016 Oct 28.

Carillo S, Pieretti G, Casillo A, Lindner B, Romano I, Nicolaus B, Parrilli M, Giuliano M, Cammarota M, Lanzetta R, Corsaro MM. Structural characterization of the lipid A from the LPS of the haloalkaliphilic bacterium Halomonas pantelleriensis. Extremophiles. 2016 Sep;20(5):687-94.

Klein G, Stupak A, Biernacka D, Wojtkiewicz P, Lindner B, Raina S. Multiple transcriptional factors regulate transcription of the rpoE gene in Escherichia coli under different growth conditions and when the lipopolysaccharide biosynthesis is defective. J Biol Chem. 2016 Sep 14. pii: jbc.M116.748954. [Epub ahead of print]

Palusińska-Szysz, A. Zdybicka-Barabas, E. Reszczyńska, R. Luchowski, M. Kania, N. Gisch, F. Waldow, P. Mak, W. Danikiewicz, W. I. Gruszecki, M. Cytryńska. The lipid composition of Legionella dumoffii membrane modulates the interaction with Galleria mellonella apolipophorin III. Biochim Biophys Acta. 2016 Jul;1861(7):617-29. doi: 10.1016/j.bbalip.2016.04.011. Epub 2016 Apr 17.

Brandenburg, K, Heinbockel, L, Correa-Vargas, W, Fukuoka, S, Gutsmann, T, Zähringer, U & Koch, MHJ 2016, 'Supramolecular structure of enterobacterial wild-type lipopolysaccharides (LPS), fractions thereof, and their neutralization by Pep19-2.5' Journal of Structural Biology., 10.1016/j.jsb.2016.01.014



Encyclopedia of Lipidomics (Springer, 2016)
Lars F. Eggers, Dominik Schwudke; Liquid Extraction: Folch

Annika Sündermann, Lars F. Eggers, Dominik Schwudke; Liquid Extraction: Bligh and Dyer

Lars F. Eggers, Dominik Schwudke; Lipid Extraction: Basics of the Methyl-tert-Butyl Ether Extraction



F. Renzi, U. Zähringer, C. E. Chandler, R. K. Ernst, G. R. Cornelis, S. J. Ittig. Modification of the 1-Phosphate Group during Biosynthesis of Capnocytophaga canimorsus Lipid A. Infect Immun. 2015 Dec 7;84(2):550-61. doi: 10.1128/IAI.01006-15. PMID: 26644381

Hebbar, S, Sahoo, I, Matysik, A, Argudo Garcia, I, Osborne, KA, Papan, C, Torta, F, Narayanaswamy, P, Fun, XH, Wenk, MR, Shevchenko, A, Schwudke, D, Kraut, R. Ceramides And Stress Signalling Intersect With Autophagic Defects In Neurodegenerative Drosophila blue cheese (bchs) Mutants. Sci Rep. 2015 Dec 7;5:15926. doi: 10.1038/srep15926.

Gisch, N, Schwudke, D, Thomsen, S, Heß, N, Hakenbeck, R, Denapaite, D. Lipoteichoic acid of Streptococcus oralis Uo5: a novel biochemical structure comprising an unusual phosphorylcholine substitution pattern compared to Streptococcus pneumoniae. Sci Rep. 2015 Nov 18;5:16718. doi: 10.1038/srep16718.

Marella, C, Torda, AE, Schwudke, D. The LUX Score: A Metric for Lipidome Homology. PLoS Comput Biol 2015, 11(9): e1004511. doi: 10.1371/journal.pcbi.1004511

de Tejada, GM, Heinbockel, L, Ferrer-Espada, R, Heine, H, Alexander, C, Bárcena-Varela, S, Goldmann, T, Correa, W,  Wiesmüller, K-H, Gisch, N, Sánchez-Gómez, S, Fukuoka, S, Schürholz, T, Gutsmann, T, Brandenburg, K. Lipoproteins/peptides are sepsis-inducing toxins from bacteria that can be neutralized by synthetic anti-endotoxin peptides. Scientific Reports 5, Article number: 14292 (2015). doi:10.1038/srep14292

Leidinger P, Treptow J, Hagens K, Eich J, Zehethofer N, Schwudke D, Oehlmann W, Lünsdorf H, Goldmann O, Schaible UE, Dittmar KE, Feldmann C. Isoniazid@Fe2O3 Nanocontainers and Their Antibacterial Effect on Tuberculosis Mycobacteria. Angew Chem Int Ed Engl. 2015 Aug 31. doi: 10.1002/anie.201505493. [Epub ahead of print]

Casillo A, Parrilli E, Filomena S, Lindner B, Lanzetta R, Parrilli M, Tutino ML, Corsaro MM. Structural Investigation of the Oligosaccharide Portion Isolated from the Lipooligosaccharide of the Permafrost Psychrophile Psychrobacter arcticus 273-4. Mar Drugs. 2015 Jul 22;13(7):4539-55.

Petersen A, Kull S, Rennert S, Becker WM, Krause S, Ernst M, Gutsmann T, Bauer J, Lindner B, Jappe U. Peanut defensins: Novel allergens isolated from lipophilic peanut extract. J Allergy Clin Immunol. 2015 May 30. pii: S0091-6749(15)00570-9. [Epub ahead of print]

Jeschke, A, Zehethofer, N, Lindner, B, Krupp, J, Schwudke, D, Haneburger, I, Jovic, M, Backer, JM, Balla, T, Hilbi, H & Haas, A 2015, 'Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis' PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Bd 112, Nr. 15, S. 4636-41.

Zehethofer, N, Bermbach, S, Hagner, S, Garn, H, Müller, J, Goldmann, T, Lindner, B, Schwudke, D & König, P 2015, 'Lipid Analysis of Airway Epithelial Cells for Studying Respiratory Diseases' Chromatographia, Bd 78, Nr. 5-6, S. 403-413., 10.1007/s10337-014-2787-5

Ranf, S, Gisch, N, Schäffer, M, Illig, T, Westphal, L, Knirel, YA, Sánchez-Carballo, PM, Zähringer, U, Hückelhoven, R, Lee, J & Scheel, D 2015, 'A lectin S-domain receptor kinase mediates lipopolysaccharide sensing in Arabidopsis thaliana' NATURE IMMUNOLOGY , Bd 16, Nr. 4, S. 426-33.

Diercks, H, Semeniuk, A, Gisch, N, Hermann, M, Duda, KA & Hölzl, G 2015, 'Accumulation of novel Glycolipids and Ornithine Lipids in Mesorhizobium loti under Phosphate Deprivation' JOURNAL OF BACTERIOLOGY, Bd 197, Nr. 3, S. 497-509.

Johnston, C, Bootsma, HJ, Aldridge, C, Manuse, S, Gisch, N, Schwudke, D, Hermans, PWM, Grangeasse, C, Polard, P, Vollmer, W & Claverys, J-P 2015, 'Co-Inactivation of GlnR and CodY Regulators Impacts Pneumococcal Cell Wall Physiology' PLOS ONE, Bd 10, Nr. 4, S. e0123702.

Mamat, U, Wilke, K, Bramhill, D, Schromm, AB, Lindner, B, Kohl, TA, Corchero, JL, Villaverde, A, Schaffer, L, Head, SR, Souvignier, C, Meredith, TC & Woodard, RW 2015, 'Detoxifying Escherichia coli for endotoxin-free production of recombinant proteins' Microbial Cell Factories, Bd 14, S. 57.

Kallsen, K, Zehethofer, N, Abdelsadik, A, Lindner, B, Kabesch, M, Heine, H & Roeder, T 2015, 'ORMDL deregulation increases stress responses and modulates repair pathways in Drosophila airways' The Journal of allergy and clinical immunology 2015 May 12, pii: S0091-6749(15)00549-7. doi: 10.1016/j.jaci.2015.04.009.



Gisch, N., Peters, K., Zähringer, U. & Vollmer, W. The pneumococcal cell wall. In: Streptococcus pneumoniae: Molecular mechanisms of host-pathogen interactions (eds J. S. Brown, S. Hammerschmidt, & C. J. Orihuela) Chapter 8, 145-167 (Elsevier, 2015).



Gronbach, K, Flade, I, Holst, O, Lindner, B, Ruscheweyh, HJ, Wittmann, A, Menz, S, Schwiertz, A, Adam, P, Stecher, B, Josenhans, C, Suerbaum, S, Gruber, AD, Kulik, A, Huson, D, Autenrieth, IB & Frick, J-S. Endotoxicity of lipopolysaccharide as a determinant of T-cell-mediated colitis induction in mice. Gastroenterology 2014, 146 (3), 765-775.

Correa, W, Manrique-Moreno, M, Behrends, J, Patiño, E, Chakravarty, M, Peláez-Jaramillo, C, Garidel, P, Gutsmann, T, Brandenburg, K & Heinbockel, L.  Galleria mellonella native and analogue peptides Gm1 and ΔGm1. II) anti-bacterial and anti-endotoxic effects. Biochimica et Biophysica Acta 2014, 1838 (10), 2739-2744.

Hilmi D, Parcina M, Stollewerk D, Ostrop J, Josten M, Meilaender A, Zaehringer U, Wichelhaus TA, Bierbaum G, Heeg K, Wolz C, Bekeredjian-Ding I. Heterogeneity of host TLR2 stimulation by Staphylocoocus aureus isolates. PLoS One. 2014 May 8;9(5):e96416. doi: 10.1371/journal.pone.0096416. eCollection 2014.

Claes AK, Steck N, Schultz D, Zähringer U, Lipinski S, Rosenstiel P, Geddes K, Philpott DJ, Heine H, Grassl GA. Salmonella enterica serovar Typhimurium ΔmsbB Triggers Exacerbated Inflammation in Nod2 Deficient Mice. PLoS One. 2014 Nov 25;9(11):e113645. doi: 10.1371/journal.pone.0113645.

Silipo A, Vitiello G, Gully D, Sturiale L, Chaintreuil C, Fardoux J, Gargani D, Lee HI, Kulkarni G, Busset N, Marchetti R, Palmigiano A, Moll H, Engel R, Lanzetta R, Paduano L, Parrilli M, Chang WS, Holst O, Newman DK, Garozzo D, D'Errico G, Giraud E, Molinaro A. Covalently linked hopanoid-lipid A improves outer-membrane resistance of a Bradyrhizobium symbiont of legumes. Nat Commun. 2014 Oct 30;5:5106. doi: 10.1038/ncomms6106.

Komaniecka I, Choma A, Mazur A, Duda KA, Lindner B, Schwudke D, Holst O. Occurrence of an unusual hopanoid-containing lipid A among lipopolysaccharides from Bradyrhizobium species. J Biol Chem. 2014 Dec 19;289(51):35644-55. doi:10.1074/jbc.M114.614529. Epub 2014 Nov 3.

Vassal-Stermann E, Lacroix M, Gout E, Laffly E, Pedersen CM, Martin L, Amoroso A, Schmidt RR, Zähringer U, Gaboriaud C, Di Guilmi AM, Thielens NM. Human L-Ficolin Recognizes Phosphocholine Moieties of Pneumococcal Teichoic Acid. J Immunol. 2014 Dec 1; 193(11):5699-708. doi:10.4049/jimmunol.14001127. Epub Oct 2014.

Hogendorf WFJ, Gisch N, Schwudke D, Heine H, Bols M, Pedersen CM, Total Synthesis of Five Lipoteichoic acids of Clostridium difficile, Chemistry - A European Journal. 2014 20(42): 13511-13516.

Böcking C, Harb H, Ege MJ, Zehethofer N, Fischer K, Krauß J, Holst O, Nüsing RM, Lindner B, von Mutius E, Renz H, Garn H, Pfefferle PI. Bioavailability and allergoprotective capacity of milk-associated conjugated linoleic acid in a murine model of allergic airway inflammation. Int Arch Allergy Immunol. 2014;163(3):234-42. doi: 10.1159/000358523.

Zähringer U, Ittig S, Lindner B, Moll H, Schombel U, Gisch N, Cornelis GR. NMR Based Structural Analysis of the Complete Rough-type LPS Isolated From Capnocytophaga canimorsus. J Biol Chem. 2014 289(34): 23963-23976.

Abdullah MR, Gutiérrez-Fernández J, Pribyl T, Gisch N, Saleh M, Rohde M, Petruschka L, Burchhardt G, Schwudke D, Hermoso JA, Hammerschmidt S. Structure of the pneumococcal l,d-carboxypeptidase DacB and pathophysiological effects of disabled cell wall hydrolases DacA and DacB. Mol Microbiol. 2014 93(6): 1183–1206.

Hanuszkiewicz A, Pittock P, Humphries F, Moll H, Roa Rosales A, Molinaro A, Moynagh PN, Lajoie G, Valvano MA. Identification of the flagellin glycosylation system in Burkholderia cenocepacia and the contribution of glycosylated flagellin to evasion of human innate immune response. J Biol Chem. 2014 Jul 4;289(27):19231-44. doi: 10.1074/jbc.M114.562603. Epub 2014 May 19.

Hebbar S, Schulz WD, Sauer U, Schwudke D. Laser Capture Microdissection coupled with on-column extraction LC-MS(n) enables lipidomics of fluorescently labeled Drosophila neurons. Anal  Chem 2014 Junn 3; 86(11):5345-52. doi:10.1021/ac500276r. PMID:24820458

Turska-Szewczuk A, Duda KA, Schwudke D, Pekala A, Kozinska A, Holst O. Structural studies of the lipopolysaccharide from the fish pathogen Aeromonas veronii strain Bs19, serotype O16. Mar Drugs. 2014 Mar 7;12(3):1298-316. doi: 10.3390/md12031298.

Kohler T, Gisch N, Binsker U, Schlag M, Darm K, Völker U, Zähringer U & Hammerschmidt S. Repeating structures of the major staphylococcal autolysin are essential for the interaction with human thrombospondin-1 and vitronectin.
J Biol Chem 2014 Feb 14; 289(7):4070-82.



Zähringer U, Kawahara K, & Kosma P. 2013. ‘Isolation and structural characterization of a (Kdo-isosteric) D-glycero-alpha-D-talo-oct-2-ulopyranosidic acid (Ko) interlinking the lipid A and core oligosaccharide in the lipopolysaccharide of Acinetobacter calcoaceticus NCTC 10305’. Carbohydr Res. Bd. 378: S. 63-70.
Scior T, Lozano-Aponte J, Figueroa-Vazquez V, Yunes-Rojas JA, Zähringer U & Alexander C. 2013. ‘Three-dimensional mapping of differential amino acids of human, murine, canine and equine TLR4/MD-2 receptor complexes conferring endotoxic activation by lipid A,  Antagonism by eritoran and species-dependent activities of lipid IVA in the mammalian LPS sensor system’. Comp Struct Biotechnol  J. 7 (9), p. 1-11 (online article).

Scior, T, Alexander, C & Zähringer, U. 2013. 'Reviewing and identifying amino acids of human, murine, canine and equine TLR4 / MD-2 receptor complexes conferring endotoxic innate immunity activation by LPS/lipid A, or antagonistic effects by Eritoran'. Comp Struct Biotechnol  J. 5 (6), p. 1-13 (online article).

Gronbach, K, Flade, I, Holst, O, Lindner, B, Ruscheweyh, HJ, Wittmann, A, Menz, S, Schwiertz, A, Adam, P, Stecher, B, Josenhans, C, Suerbaum, S, Gruber, A, Kulik, A, Huson, D, Autenrieth, I & Frick, J-S 2013, 'Endotoxicity of Lipopolysaccharide as a determinant of T-cell mediated colitis induction in mice' Gastroenterology, Nr. doi: 10.1053/j.gastro. 2013.11.033 [Epub ahead of print].

Popovic, M, Andjelkovic, U, Burazer, L, Lindner, B, Petersen, A & Gavrovic-Jankulovic, M 2013, 'Biochemical and immunological characterization of a recombinantly-produced antifungal cysteine proteinase inhibitor from green kiwifruit (Actinidia deliciosa)' Phytochemistry. Bd. 94. S. 53-59. doi:10.1016/j.phytochem.2013.06.006. Epub 2013 Jul 3.

Posch, G, Andrukhov, O, Vinogradov, E, Lindner, B, Messner, P, Holst, O & Schäffer, C 2013, 'Structure and immunogenicity of the rough-type lipopolysaccharide from the periodontal pathogen Tannerella forsythia' Clinical and Vaccine Immunology : CVI, Bd 20, Nr. 6, S. 945-53.,

Turska-Szewczuk, A, Lindner, B, Komaniecka, I, Kozinska, A, Pekala, A, Choma, A & Holst, O 2013, 'Structural and immunochemical studies of the lipopolysaccharide from the fish pathogen, Aeromonas bestiarum strain K296, serotype O18'. Marine drugs, Bd 11, Nr. 4, S. 1235-55.,

Carillo, S, Pieretti, G, Lindner, B, Romano, I, Nicolaus, B, Lanzetta, R, Parrilli, M & Corsaro, MM 2013, 'Structural characterization of the core oligosaccharide isolated from the lipopolysaccharide of the haloalkaliphilic bacterium Salinivibrio sharmensis strain BAG(T)' Carbohydrate Research, Bd 368, S. 61-7.,

Sydor, T, von Bargen, K, Hsu, F-F, Huth, G, Holst, O, Wohlmann, J, Becken, U, Dykstra, T, Söhl, K, Lindner, B, Prescott, JF, Schaible, UE, Utermöhlen, O & Haas, A 2013, 'Diversion of phagosome trafficking by pathogenic Rhodococcus equi depends on mycolic acid chain length' Cellular Microbiology, Bd 15, Nr. 3, S. 458-473.,

Pupo, E, Lindner, B, Brade, H & Schromm, AB 2013, 'Intact rough- and smooth-form lipopolysaccharides from Escherichia coli separated by preparative gel electrophoresis exhibit differential biological activity in human macrophages' FEBS Journal, Bd 280, Nr. 4, S. 1095-1111.,

Carillo, S, Pieretti, G, Lindner, B, Romano, I, Nicolaus, B, Lanzetta, R, Parrilli, M & Corsaro, MM 2013, 'The lipid A from the haloalkaliphilic bacterium Salinivibrio sharmensis strain BAG(T)' Marine drugs, Bd 11, Nr. 1, S. 184-93.,

Klein, G, Müller-Loennies, S, Lindner, B, Kobylak, N, Brade, H & Raina, S. 2013, 'Molecular and structural basis of inner core lipopolysaccharide alterations in Escherichia coli: incorporation of glucuronic acid and phosphoethanolamine in the heptose region' The Journal of Biological Chemistry, Bd 288, S. 8111-8127.,

Herzog R, Schwudke D, Shevchenko A. LipidXplorer: Software for Quantitative Shotgun Lipidomics Compatible with Multiple Mass Spectrometry Platforms. CURRENT PROTOCOLS in BIOINFORMATICS 2013 14.12.1–14.12.30.

Sanderson JP, Brennan PJ, Mansour S, Matulis G, Patel O, Lissin N, Kawahara K, Zähringer U, Rossjohn J, Brenner MB, Gadola SD. CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant NKT cells. EUROPEAN JOURNAL of  IMMUNOLOGY 2013; 43:815-825.
Gisch N, Kohler T, Ulmer AJ, Müthing J, Pribyl T, Fischer K, Lindner G, Hammerschmidt S, Zähringer U. Structural reevaluation of Streptococcus pneumoniae lipoteichoic acid and new insights into its immunostimulatory potency. JOURNAL BIOLOGICAL CHEMISTRY 2013; 288: 15654-1567.               

Gasulla F, Vom Dorp K, Dombrink I, Zähringer U, Gisch N, Bartels D. The role of lipid metabolism in the acquisition of desiccation-tolerance in Craterostigma plantagineum: a comparative approach. PLANT JOURNAL 2013 May 15. doi:10.1111/tpj.12241 [Epub ahead of print]

Subramanian M, Metya SK, Sadaf S, Kumar S, Schwudke D, Hasan G. Altered lipid homeostasis in Drosophila InsP3 receptor mutants leads to obesity and hyperphagia. DISEASE MODEL & MECHANISMS 2013 May;6(3):734-44.