Programmbereich Infektionen

Molekulare und Experimentelle Mykobakteriologie

Mission    Projekte    Drittmittel    Methoden    Publikationen    Mitarbeiter/innen

Publikationen von 2011 bis 2006

2011

Feuerriegel S, Köser CU, Baù D, Rüsch-Gerdes S, Summers DK, Archer JAC, Marti-Renom MA, Niemann S. Impact of fgd1 and ddn diversity in Mycobacterium tuberculosis complex on in vitro susceptibility to PA-824. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2011 Dec;55(12):5718-22.

Roetzer A, Schuback S, Diel R, Gasau F, Ubben T, di Nauta A, Richter E, Rüsch-Gerdes S, Niemann S. Evaluation of Mycobacterium tuberculosis typing methods in a four-year study in Schleswig-Holstein, Northern Germany. JOURNAL OF CLINICAL MICROBIOLOGY 2011 Dec;49(12):4173-8.

Bonnet M, Pardini M, Meacci F, Orrù G, Yesilkaya H, Jarosz T, Andrew PW, Barer M, Checchi F, Rinder H, Orefici G, Rüsch-Gerdes S, Fattorini L, Oggioni MR, Melzer J, Niemann S, Varaine F. Treatment of Tuberculosis in a Region with High Drug Resistance: Outcomes, Drug Resistance Amplification and Re-Infection. PLoS ONE 2011 Aug;6:e23081. Open Access

Reddington K, O’Grady J, Dorai-Raj S, Niemann S, van Soolingen D, Barry T. A novel multiplex real-time PCR for the identification of mycobacteria associated with zoonotic tuberculosis. PloS One 2011;6(8):e23481. Open Access

Smith NH, Berg S, Dale J, Allen A, Rodriguez S, Romero B, Matos F, Ghebremichael S, Karoui C, Donati C, Machado A da C, Mucavele C, Kazwala RR, Hilty M, Cadmus S, Ngandolo BNR, Habtamu M, Oloya J, Muller A, Milian-Suazo F, Andrievskaia O, Projahn M, Barandiarán S, Macías A, Müller B, Zanini MS, Ikuta CY, Rodriguez CAR, Pinheiro SR, Figueroa A, Cho S-N, Mosavari N, Chuang P-C, Jou R, Zinsstag J, van Soolingen D, Costello E, Aseffa A, Proaño-Perez F, Portaels F, Rigouts L, Cataldi AA, Collins DM, Boschiroli ML, Hewinson RG, Neto JSF, Surujballi O, Tadyon K, Botelho A, Zárraga AM, Buller N, Skuce R, Michel A, Aranaz A, Gordon SV, Jeon B-Y, Källenius G, Niemann S, Boniotti MB, van Helden PD, Harris B, Zumárraga MJ, Kremer K. European 1: A globally important clonal complex of Mycobacterium bovis. INFECTION, GENETICS AND EVOLUTION 2011 Aug;11(6):1340-1351.

Supply P, Niemann S, Wirth T. On the mutation rates of spoligotypes and variable numbers of tandem repeat loci of Mycobacterium tuberculosis. Infect. Genet. Evol. 2011 Mar;11(2):251-252. [Comment on Reyes JF, Tanaka MM. Mutation rates of spoligotypes and variable numbers of tandem repeat loci in Mycobacterium tuberculosis. INFECTION, GENETICS AND EVOLUTION 2010 Oct;10(7):1046-1051.]

Thye T, Niemann S, Walter K, Homolka S, Intemann CD, Chinbuah MA, Enimil A, Gyapong J, Osei I, Owusu-Dabo E, Rüsch-Gerdes S, Horstmann RD, Ehlers S, Meyer CG. Variant G57E of mannose binding lectin associated with protection against tuberculosis caused by Mycobacterium africanum but not by M. tuberculosis. PLoS ONE 2011 Jun;6(6):e20908. Open Access

Plinke C, Walter K, Aly S, Ehlers S, Niemann S. Mycobacterium tuberculosis embB306 mutations confer moderately increased resistance to Ethambutol in vitro and in vivo. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2011 Jun;55(6):2891-6.

Projahn M, Köser CU, Homolka S, Summers DK, Archer JAC, Niemann S. Polymorphisms in isoniazid and prothionamide resistance genes of the Mycobacterium tuberculosis complex. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2011 Jun;55(9):4408-11.

Diel R, Loddenkemper R, Niemann S, Meywald-Walter K, Nienhaus A. Negative and Positive Predictive Value of a Whole-Blood Interferon-{gamma} Release Assay for Developing Active Tuberculosis: An Update. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2011 Jan;183(1):88-95.

 

2010

Homolka S, Meyer CG, Hillemann D, Owusu-Dabo E, Adjei O, Horstmann RD, Browne ENL, Chinbuah A, Osei I, Gyapong J, Kubica T, Ruesch-Gerdes S, Niemann S. Unequal distribution of resistance-conferring mutations among Mycobacterium tuberculosis and Mycobacterium africanum strains from Ghana. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY 2010 Nov;300(7):489-95.

Feuerriegel S, Köser C, Trübe L, Archer J, Gerdes SR, Richter E, Niemann S. Thr202Ala in thyA is a marker for the Latin American Mediterranean lineage of the Mycobacterium tuberculosis complex rather than para-aminosalicylic acid resistance. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2010 Nov;54(11):4794-8.

Niemann S, Diel R, Khechinashvili G, Gegia M, Mdivani N, Tang Y. Mycobacterium tuberculosis Beijing Lineage favours the spread of multidrug resistant tuberculosis in the Republic of Georgia. JOURNAL OF CLINICAL MICROBIOLOGY 2010 Oct;48(10):3544-50.

Russell DG, VanderVen BC, Lee W, Abramovitch RB, Kim M, Homolka S, Niemann S, Rohde KH. Mycobacterium tuberculosis Wears What It Eats. CELL HOST & MICROBE 2010 Jul;8(1):68-76.

Homolka S, Niemann S, Russell DG, Rohde KH. Functional genetic diversity among Mycobacterium tuberculosis complex clinical isolates: delineation of conserved core and lineage-specific transcriptomes during intracellular survival. PLOS PATHOGENS 2010 Jul;6(7):e1000988 Open Access

Plinke C, Cox HS, Zarkua N, Karimovich HA, Braker K, Diel R, Rüsch-Gerdes S, Feuerriegel S, Niemann S. embCAB sequence variation among ethambutol-resistant Mycobacterium tuberculosis isolates without embB306 mutation. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 2010 Jul;65(7):1359-67.

Weniger T, Krawczyk J, Supply P, Niemann S, Harmsen D. MIRU-VNTRplus: a web tool for polyphasic genotyping of Mycobacterium tuberculosis complex bacteria. NUCLEIC ACIDS RESEARCH 2010 May;38(Suppl. 2):W326-W331.

Honisch C, Mosko M, Arnold C, Gharbia S, Diel R, Niemann S. Replacing Reverse Line Blot Hybridization Spoligotyping of the Mycobacterium tuberculosis Complex. JOURNAL OF CLINICAL MICROBIOLOGY 2010 May;48(5):1520-1526.

Comas I, Chakravartti J, Small PM, Galagan J, Niemann S, Kremer K, Ernst JD, Gagneux S. Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved. NATURE GENETICS 2010 May;42(6):498-503.

Devaux I, Manissero D, Fernandez de la Hoz K, Kremer K, van Soolingen D. Surveillance of extensively drug-resistant tuberculosis in Europe, 2003-2007. EUROSURVEILLANCE 2010 März;15(11): pii: 19518.

Vasconcellos S, Huard R, Niemann S, Kremer K, Santos A, Suffys P, Ho J. Distinct genotypic profiles of the two major clades of Mycobacterium africanum. BMC INFECTIOUS DISEASES 2010 Mar;10(80). Open Access

 

2009

Barniol J, Niemann S, Louis V, Brodhun B, Dreweck C, Richter E, Becher H, Haas W, Junghanss T. Transmission dynamics of pulmonary tuberculosis between autochthonous and immigrant sub-populations. BMC INFECTIOUS DISEASES 2009 Dec;9(197). Open Access

Comas I, Homolka S, Niemann S, Gagneux S. Genotyping of Genetically Monomorphic Bacteria: DNA Sequencing in Mycobacterium tuberculosis Highlights the Limitations of Current Methodologies. PLOS ONE 2009 Nov;4(11):e7815. Open Access

Plinke C, Cox H, Kalon S, Doshetov D, Rusch-Gerdes S, Niemann S. Tuberculosis ethambutol resistance: Concordance between phenotypic and genotypic test results. TUBERCULOSIS 2009 Nov;89(6):448-452.

Niemann S, Koser C, Gagneux S, Plinke C, Homolka S, Bignell H, Carter R, Cheetham R, Cox A, Gormley N, Kokko-Gonzales P, Murray L, Rigatti R, Smith V, Arends F, Cox H, Smith G, Archer J. Genomic Diversity among Drug Sensitive and Multidrug Resistant Isolates of Mycobacterium tuberculosis with Identical DNA Fingerprints. PLOS ONE 2009 Oct;4(10):e7407. Open Access

Intemann C, Thye T, Niemann S, Browne E, Chinbuah M, Enimil A, Gyapong J, Osei I, Owusu-Dabo E, Helm S, Rusch-Gerdes S, Horstmann R, Meyer C. Autophagy Gene Variant IRGM-261T Contributes to Protection from Tuberculosis Caused by Mycobacterium tuberculosis but Not by M. africanum Strains. PLOS PATHOGENS 2009 Sep;5(9):e1000577. Open Access

Feuerriegel S, Cox H, Zarkua N, Karimovich H, Braker K, Rusch-Gerdes S, Niemann S. Sequence Analyses of Just Four Genes To Detect Extensively Drug-Resistant Mycobacterium tuberculosis Strains in Multidrug-Resistant Tuberculosis Patients Undergoing Treatment. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2009 Aug;53(8):3353-3356.

Thye T, Scarisbrick G, Browne E, Chinbuah M, Gyapong J, Osei I, Owusu-Dabo E, Niemann S, Rusch-Gerdes S, Meyer C, Horstmann R. CTLA4 Autoimmunity-Associated Genotype Contributes to Severe Pulmonary Tuberculosis in an African Population. PLOS ONE 2009 Jul;4(7):e6307. Open Access

Pardini M, Niemann S, Varaine F, Iona E, Meacci F, Orru G, Yesilkaya H, Jarosz T, Andrew P, Barer M, Checchi F, Rinder H, Orefici G, Rusch-Gerdes S, Fattorini L, Oggioni M, Bonnet M. Characteristics of drug-resistant tuberculosis in Abkhazia (Georgia), a high-prevalence area in Eastern Europe. TUBERCULOSIS 2009 Jul;89(4):317-324.

Thye T, Browne E, Chinbuah M, Gyapong J, Osei I, Owusu-Dabo E, Brattig N, Niemann S, Rusch-Gerdes S, Horstmann R, Meyer C. IL 10 Haplotype Associated with Tuberculin Skin Test Response but Not with Pulmonary TB. PLOS ONE 2009 May;4(5):e5420. Open Access

Homolka S, Koser C, Archer J, Rusch-Gerdes S, Niemann S. Single-Nucleotide Polymorphisms in Rv2629 Are Specific for Mycobacterium tuberculosis Genotypes Beijing and Ghana but Not Associated with Rifampin Resistance. JOURNAL OF CLINICAL MICROBIOLOGY 2009 Jan;47(1):223-226.

 

2008

Hershberg R, Lipatov M, Small P, Sheffer H, Niemann S, Homolka S, Roach J, Kremer K, Petrov D, Feldman M, Gagneux S. High Functional Diversity in Mycobacterium tuberculosis Driven by Genetic Drift and Human Demography. PLOS BIOLOGY 2008 Dec;6(12):2658-2671. Open Access

Cox H, Sibilia K, Feuerriegel S, Kalon S, Polonsky J, Khamraev A, Rusch-Gerdes S, Mills C, Niemann S. Emergence of Extensive Drug Resistance during Treatment for Multidrug-Resistant Tuberculosis. NEW ENGLAND JOURNAL OF MEDICINE 2008 Nov;359(22):2398-2400.

Wirth T, Hildebrand F, Allix-Beguec C, Wolbeling F, Kubica T, Kremer K, van Soolingen D, Rusch-Gerdes S, Locht C, Brisse S, Meyer A, Supply P, Niemann S. Origin, spread and demography of the Mycobacterium tuberculosis complex. PLOS PATHOGENS 2008 Sep;4(9). Open Access

Meyer C, Scarisbrick G, Niemann S, Browne E, Chinbuah M, Gyapong J, Osei I, Owusu-Dabo E, Kubica T, Rusch-Gerdes S, Thye T, Horstmann R. Pulmonary tuberculosis: Virulence of Mycobacterium africanum and relevance in HIV co-infection. TUBERCULOSIS 2008 Sep;88(5):482-489.

Allix-Beguec C, Harmsen D, Weniger T, Supply P, Niemann S. Evaluation and strategy for use of MIRU-VNTRplus, a multifunctional database for online analysis of genotyping data and phylogenetic identification of Mycobacterium tuberculosis complex isolates. JOURNAL OF CLINICAL MICROBIOLOGY 2008 Aug;46(8):2692-2699.

Homolka S, Post E, Oberhauser B, George A, Westman L, Dafae F, Rusch-Gerdes S, Niemann S. High genetic diversity among Mycobacterium tuberculosis complex strains from Sierra Leone. BMC MICROBIOLOGY 2008 Jun:8(103). Open Access

Diel R, Loddenkemper R, Meywald-Walter K, Niemann S, Nienhaus A. Predictive value of a whole blood IFN-gamma assay for the development of active tuberculosis disease after recent infection with Mycobacterium tuberculosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2008 May;177(10):1164-1170.

Herb F, Thye T, Niemann S, Browne E, Chinbuah M, Gyapong J, Osei I, Owusu-Dabo E, Werz O, Rusch-Gerdes S, Horstmann R, Meyer C. ALOX5 variants associated with susceptibility to human pulmonary tuberculosis. HUMAN MOLECULAR GENETICS 2008 Apr;17(7):1052-1060.

 

2007

Kodmon C, Niemann S, Gutierrez M, Sola C, Rastogi N, Lukacs J, Somoskovi A. Molecular clues of a microepidemy among homeless tuberculosis patients in Budapest due to a new and local Mycobacterium tuberculosis clade. INFECTION GENETICS AND EVOLUTION 2007 Sep;7(5):632-635.

Cox H, Niemann S, Ismailov G, Doshetov D, Orozco J, Blok L, Rusch-Gerdes S, Kebede Y. Risk of acquired drug resistance during short-course directly observed treatment of tuberculosis in an area with high levels of drug resistance. CLINICAL INFECTIOUS DISEASES 2007 Jun;44(11):1421-1427.

Oelemann M, Diel R, Vatin V, Haas W, Rusch-Gerdes S, Locht C, Niemann S, Supply P. Assessment of an optimized mycobacterial interspersed repetitive-unit-variable-number tandem-repeat typing system combined with spoligotyping for population-based molecular epidemiology studies of tuberculosis. JOURNAL OF CLINICAL MICROBIOLOGY 2007 Marz;45(3):691-697.

 

2005 -2006 (Selection)

Supply P, Allix C, Lesjean S, Cardoso-Oelemann M, Rusch-Gerdes S, Willery E, Savine E, de Haas P, van Deutekom H, Roring S, Bifani P, Kurepina N, Kreiswirth B, Sola C, Rastogi N, Vatin V, Gutierrez M, Fauville M, Niemann S, Skuce R, Kremer K, Locht C, van Soolingen D. Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosis. JOURNAL OF CLINICAL MICROBIOLOGY 2006 Dec;44(12):4498-4510.

Kodmon C, Niemann S, Lukacs J, Sor E, David S, Somoskovi A. Molecular epidemiology of drug-resistant tuberculosis in Hungary. JOURNAL OF CLINICAL MICROBIOLOGY 2006 Nov;44(11):4258-4261.

Yesilkaya H, Meacci F, Niemann S, Hillemann D, Rusch-Gerdes S, Barer M, Andrew P, Oggioni M. Evaluation of molecular-beacon, TaqMan, and fluorescence resonance energy transfer probes for detection of antibiotic resistance-conferring single nucleotide Polymorphisms in mixed Mycobacterium tuberculosis DNA extracts. JOURNAL OF CLINICAL MICROBIOLOGY 2006 Oct;44(10):3826-3829.

Cox H, Kebede Y, Allamuratova S, Ismailov G, Davletmuratova Z, Byrnes G, Stone C, Niemann S, Rusch-Gerdes S, Blok L, Doshetov D. Tuberculosis recurrence and mortality after successful treatment: Impact of drug resistance. PLOS MEDICINE 2006 Oct;3(10):1836-1843. Open Access

Thye T, Browne E, Chinbuah M, Gyapong J, Osei I, Owusu-Dabo E, Niemann S, Rusch-Gerdes S, Horstmann R, Meyer C. No associations of human pulmonary tuberculosis with Sp110 variants. JOURNAL OF MEDICAL GENETICS 2006 Jul;43(7).
 
Owusu-Dabo E, Adjei O, Meyer C, Horstmann R, Enimil A, Kruppa T, Bonsu F, Browne E, Chinbuah M, Osei I, Gyapong J, Berberich C, Kubica T, Niemann S, Ruesch-Gerdes S. Mycobacterium tuberculosis drug resistance, Ghana. EMERGING INFECTIOUS DISEASES 2006 Jul;12(7):1170-1172.

Diel R, Ernst M, Doscher G, Visuri-Karbe L, Greinert U, Niemann S, Nienhaus A, Lange C. Avoiding the effect of BCG vaccination in detecting Mycobacterium tuberculosis infection with a blood test. EUROPEAN RESPIRATORY JOURNAL 2006 Jul;28(1):16-23.

Plinke C, Rusch-Gerdes S, Niemann S. Significance of mutations in embB codon 306 for prediction of ethambutol resistance in clinical Mycobactetium tuberculosis isolates. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2006 May;50(5):1900-1902.

Kubica T, Agzamova R, Wright A, Rakishev G, Rusch-Gerdes S, Niemann S. Mycobacterium bovis isolates with M. tuberculosis specific characteristics. EMERGING INFECTIOUS DISEASES 2006 May;12(5):763-765.

Brudey K, Driscoll J, Rigouts L, Prodinger W, Gori A, Al-Hajoj S, Allix C, Aristimuno L, Arora J, Baumanis V, Binder L, Cafrune P, Cataldi A, Cheong S, Diel R, Ellermeier C, Evans J, Fauville-Dufaux M, Ferdinand S, Garcia de Viedma D, Garzelli C, Gazzola L, Gomes H, Guttierez M, Hawkey P, van Helden P, Kadival G, Kreiswirth B, Kremer K, Kubin M, Kulkarni S, Liens B, Lillebaek T, Ly H, Martin C, Martin C, Mokrousov I, Narvskaia O, Ngeow Y, Naumann L, Niemann S, Parwati I, Rahim Z, Rasolofo-Razanamparany V, Rasolonavalona T, Rossetti M, Rusch-Gerdes S, Sajduda A, Samper S, Shemyakin I, Singh U, Somoskovi A, Skuce R, van Soolingen D, Streicher E, Suffys P, Tortoli E, Tracevska T, Vincent V, Victor T, Warren R, Yap S, Zaman K, Portaels F, Rastogi N, Sola C. Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpoIDB4) for classification, population genetics and epidemiology. BMC MICROBIOLOGY 2006 Marz;6(23). Open Access

Gagneux S, DeRiemer K, Van T, Kato-Maeda M, de Jong B, Narayanan S, Nicol M, Niemann S, Kremer K, Gutierrez M, Hilty M, Hopewell P, Small P. Variable host-pathogen compatibility in Mycobacterium tuberculosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF 2006 Feb;103(8):2869-2873.

Cox H, Kubica T, Doshetov D, Kebede Y, Rusch-Gerdess S, Niemann S. The Beijing genotype and drug resistant tuberculosis in the Aral Sea region of Central Asia. RESPIRATORY RESEARCH 2005 Nov;6(134). Open Access

Kubica T, Agzamova R, Wright A, Aziz M, Rakishev G, Bismilda V, Richter E, Rusch-Gerdes S, Niemann S. The Beijing genotype is a major cause of drug-resistant tuberculosis in Kazakhstan. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 2005 Jun;9(6):646-653.