Medizin

Biobank

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Publikationen

Folgende Publikationen sind unter Verwendung von Proben und Daten aus der BioMaterialBank Nord und/oder aktiven Mitgliedern entstanden:

2018

Fuchs O, Bahmer T, Weckmann M, Dittrich AM, Schaub B, Rosler B, Happle C, Brinkmann F, Ricklefs I, Konig IR, Watz H, Rabe KF, Kopp MV, Hansen G, von Mutius E (2018) The all age asthma cohort (ALLIANCE) - from early beginnings to chronic disease: a longitudinal cohort study. BMC Pulm Med 18: 140 (ARCN, BREATH, CPC-M)

Heinbockel L, Marwitz S, Schromm AB, Watz H, Kugler C, Ammerpohl O, Schnepf K, Rabe KF, Droemann D, Goldmann T (2018) Identification of novel target genes in human lung tissue involved in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 13: 2255-2259 (ARCN)

Marwitz S, Heinbockel L, Scheufele S, Kugler C, Reck M, Rabe KF, Perner S, Goldmann T, Ammerpohl O (2018) Fountain of youth for squamous cell carcinomas? On the epigenetic age of NSCLC and corresponding tumor-free lung tissues. Int J Cancer (ARCN)

Schupp JC, Freitag-Wolf S, Bargagli E, Mihailović-Vučinić V, Rottoli P, Grubanovic A, Müller A, Jochens A, Tittmann L, Schnerch J, Olivieri C, Fischer A, Jovanovic D, Filipovic S, Videnovic-Ivanovic J, Bresser P, Jonkers R, O'Reilly K, Ho LP, Gaede KI, Zabel P, Dubaniewicz A, Marshall B, Kieszko R, Milanowski J, Günther A, Weihrich A, Petrek M, Kolek V, Keane MP, O'Beirne S, Donnelly S, Haraldsdottir SO, Jorundsdottir KB, Costabel U, Bonella F, Wallaert B, Grah C, Peroš-Golubičić T, Luisetti M, Kadija Z, Pabst S, Grohé C, Strausz J, Vašáková M, Sterclova M, Millar A, Homolka J, Slováková A, Kendrick Y, Crawshaw A, Wuyts W, Spencer L, Pfeifer M, Valeyre D, Poletti V, Wirtz H, Prasse A, Schreiber S, Krawczak M, Müller-Quernheim J. Phenotypes of organ involvement in sarcoidosis. Eur Respir J. 2018 Jan 25;51(1). pii: 1700991. doi: 10.1183/13993003.00991-2017.  Print 2018 Jan. PubMed PMID: 29371378.
 

2017

Bahmer, T., Waschki, B., Schatz, F., Herzmann, C., Zabel, P., Kirsten, A-M., Rabe, K. F., Watz, H. & ERA-Study Group (Gaede, KI Member of ERA-Study Group) Physical activity, airway resistance and small airway dysfunction in severe asthma . 04.01.2017 in : EUROPEAN RESPIRATORY JOURNAL. 49

Eggers LF, Julia Müller, Chakravarthy Marella, Verena Scholz, Henrik Watz, Christian Kugler, Klaus F. Rabe, Torsten Goldmann, and Dominik Schwudke. Lipidomes of lung cancer and tumour-free lung tissues reveal distinct molecular signatures for cancer differentiation, age, inflammation, and pulmonary emphysema. Sci Rep. 2017 Sep 11;7(1):11087.

Gaber R, Watermann I, Kugler C, Vollmer E, Perner S, Reck M, Goldmann T (2017) Preselection of EGFR mutations in non-small-cell lung cancer patients by immunohistochemistry: comparison with DNA-sequencing, EGFR wild-type expression, gene copy number gain and clinicopathological data. Rom J Morphol Embryol 58: 1175-1184 (ARCN)

Hoppe J, Can Murat Ünal, Stefanie Thiem, Louisa Grimpe, Torsten Goldmann, Nikolaus Gaßler, Matthias Richter, Olga Shevchuk, Michael Steinert PilY1 promotes Legionella pneumophila infection of human lung tissue explants and contributes to bacterial adhesion, host cell invasion and twitching motility. Frontiers in Cellular and Infection Microbiology Front Cell Infect Microbiol. 2017 Mar 7;7:63.

Kaufhold I, Sünja Osbahr, Kensuke Shima, Sebastian Marwitz, Kristina Rohmann, Daniel Drömann, Torsten Goldmann, Klaus Dalhoff, Jan Rupp. Nontypeable Haemophilus influenzae (NTHi) directly interfere with the regulation of E-cadherin in lung epithelial cells. Microbes Infect. 2017 Nov;19(11):560-566.

Krause T, Rockendorf N, Gaede KI, Ramaker K, Sinnecker H, Frey A (2017) Validation of antibody reagents for mucin analysis in chronic inflammatory airway diseases. MAbs 9: 333-341 (ARCN)

Marwitz S, Heinbockel L, Scheufele S, Nitschkowski D, Kugler C, Perner S, Reck M, Ammerpohl O, Goldmann T (2017) Epigenetic modifications of the VGF gene in human non-small cell lung cancer tissues pave the way towards enhanced expression. Clin Epigenetics 9: 123 (ARCN)

Marwitz S, Scheufele S, Perner S, Reck M, Ammerpohl O, Goldmann T (2017) Epigenetic modifications of the immune-checkpoint genes CTLA4 and PDCD1 in non-small cell lung cancer results in increased expression. Clin Epigenetics 9: 51 (ARCN)

Müller-Quernheim, J., Fischer, A., Krawczak, M., Freitag-Wolf, S., Bargagli, E., Schupp, J. C., Mihailovic-Vucinic , V., Rottoli, P., Grubanovic, A., Müller, A., Jochens, A., Tittmann, L., Schnerch, J., Olivieri, C., Prasse, A., Schreiber, S., GenPhenReSa consortium & Gaede, K. I. Morbidity and phenotypes of organ involvements in sarcoidosis. The European respiratory journal.  2017 (Accepted/In press)

Watz H, Uddin M, Pedersen F, Kirsten A, Goldmann T, Stellmacher F, Groth E, Larsson B, Böttcher G, Malmgren A, Kraan M, Rabe KF. Effects of the CXCR2 antagonist AZD5069 on lung neutrophil recruitment in asthma. Pulm Pharmacol Ther. 2017 Aug;45:121-123.

Zimmermann A, Knecht H, Hasler R, Zissel G, Gaede KI, Hofmann S, Nebel A, Muller-Quernheim J, Schreiber S, Fischer A (2017) Atopobium and Fusobacterium as novel candidates for sarcoidosis-associated microbiota. Eur Respir J 50 (ARCN)

 

2016

Ganbat D, Seehase S, Richter E, Vollmer E, Reiling N, Fellenberg K, Gaede KI, Kugler C, Goldmann T (2016) Mycobacteria infect different cell types in the human lung and cause species dependent cellular changes in infected cells. BMC Pulm Med 16: 19 (ARCN)

Goldmann T, Kugler C, Reinmuth N, Vollmer E, Reck M (2016) PD-L1 copy number gain in nonsmall-cell lung cancer defines a new subset of patients for anti PD-L1 therapy. Ann Oncol 27: 206-207 (ARCN)

Herrtwich L, Nanda I, Evangelou K, Nikolova T, Horn V, Sagar, Erny D, Stefanowski J, Rogell L, Klein C, Gharun K, Follo M, Seidl M, Kremer B, Münke N, Senges J, Fliegauf M, Aschman T, Pfeifer D, Sarrazin S, Sieweke MH, Wagner D, Dierks Ch, Haaf T, Ness T, Zaiss MM, Voll RE, Deshmukh SD, Prinz M, Goldmann T, Hölscher Ch, Hauser AE, Lopez-Contreras AJ, Grün D, Gorgoulis V, Diefenbach A, Henneke Ph, Triantafyllopoulo A. DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas. Cell 167, 1–17, November 17, 2016. IF 28.710

Marwitz S, Depner S, Dvornikov D, Merkle R, Szczygiel M, Muller-Decker K, Lucarelli P, Wasch M, Mairbaurl H, Rabe KF, Kugler C, Vollmer E, Reck M, Scheufele S, Kroger M, Ammerpohl O, Siebert R, Goldmann T, Klingmuller U (2016) Downregulation of the TGFbeta Pseudoreceptor BAMBI in Non-Small Cell Lung Cancer Enhances TGFbeta Signaling and Invasion. Cancer Res 76: 3785-3801 (ARCN, TLRC)

Schnerch J, Prasse A, Vlachakis D, Schuchardt KL, Pechkovsky DV, Goldmann T, Gaede KI, Muller-Quernheim J, Zissel G (2016) Functional Toll-Like Receptor 9 Expression and CXCR3 Ligand Release in Pulmonary Sarcoidosis. Am J Respir Cell Mol Biol 55: 749-757 (ARCN)

 

2015

Fischer A, Ellinghaus D, Nutsua M, Hofmann S, Montgomery CG, Iannuzzi MC, Rybicki BA, Petrek M, Mrazek F, Pabst S, Grohé C, Grunewald J, Ronninger M, Eklund A, Padyukov L, Mihailovic-Vucinic V, Jovanovic D, Sterclova M, Homolka J, Nöthen MM, Herms S, Gieger C, Strauch K, Winkelmann J, Boehm BO, Brand S, Büning C, Schürmann M, Ellinghaus E, Baurecht H, Lieb W, Nebel A, Müller-Quernheim J, Franke A, Schreiber S; GenPhenReSa Consortium (Gaede KI, Member of GenPhenReSa Consortium). Identification of Immune-Relevant Factors Conferring Sarcoidosis Genetic Risk. Am J Respir Crit Care Med. 2015 Sep 15;192(6):727-36. doi: 10.1164/rccm.201503-0418OC. PMID: 26051272

Pedersen F, Holz O, Lauer G, Quintini G, Kiwull-Schöne H, Kirsten AM, Magnussen H, Rabe KF, Goldmann T, Watz H. Multi-analyte profiling of inflammatory mediators in COPD sputum - the effects of processing. Cytokine. 2015 Feb;71(2):401-4.

Pedersen F, Sebastian Marwitz3, Olaf Holz4, Anne Kirsten1, Thomas Bahmer2, Benjamin Waschki2, Helgo Magnussen1, Klaus F. Rabe2, Torsten Goldmann3, Mohib Uddin5†, Henrik Watz1. Neutrophil extracellular trap formation and extracellular DNA in sputum of stable COPD patients. Respir Med. 2015 Oct;109(10):1360-2.

Wagner C, T. Goldmann, K. Rohmann, D. Wilpsbäumer, J. Rupp, S. Marwitz2 J. Rotta detto Loria, P. Zabel, K. Dalhoff, D. Drömann. Budesonide inhibits intracellular infection with non-typeable Haemophilus influenzae  despite anti-inflammatory effects in respiratory cells and human lung tissue: a role for p38 MAP kinase. Respiration. 2015;90(5):416-25.

Watermann I, Schmitt B, Stellmacher F, Muller J, Gaber R, Kugler C, Reinmuth N, Huber RM, Thomas M, Zabel P, Rabe KF, Jonigk D, Warth A, Vollmer E, Reck M, Goldmann T (2015) Improved diagnostics targeting c-MET in non-small cell lung cancer: expression, amplification and activation? Diagn Pathol 10: 130 (ARCN, BREATH, CPC-M, TLRC)

Zehethofer N, Bermbach S, Hagner S, Garn H, Muller J, Goldmann T, Lindner B, Schwudke D, Konig P (2015) Lipid Analysis of Airway Epithelial Cells for Studying Respiratory Diseases. Chromatographia 78: 403-413 (ARCN, UGMLC)

 

 

2014

Bermbach S, Weinhold K, Roeder T, Petersen F, Kugler C, Goldmann T, Rupp J, Konig P (2014) Mechanisms of cilia-driven transport in the airways in the absence of mucus. Am J Respir Cell Mol Biol 51: 56-67 (ARCN)

Jäger J, Marwitz S, Tiefenau J, Rasch J, Shevchuk O, Kugler C, Goldmann T, Steinert M. Human lung tissue explants reveal novel interactions during Legionella pneumophila infections. Infect Immun. 2014 Jan;82(1):275-85.

Lang DS, Marwitz S, Heilenkötter U, Schumm W, Behrens O, Simon R, Reck M, Vollmer E, Goldmann T. Transforming Growth Factor-Beta signaling leads to uPA/PAI-1 activation and metastasis: A study on human breast cancer tissues. Pathol Oncol Res. 2014 Mar 9. [Epub ahead of print]

Lang DS, S. Marwitz, Ch. Kugler, N. Reinmuth, E. Vollmer, P. Zabel, M. Reck, T. Goldmann. Double homeobox protein DUX 4 in the human lung: expression under normal and pathological conditions. Global Journal of Pathology and Microbiology 2014, 2, 1-9.

Marwitz S, Kolarova J, Reck M, Reinmuth N, Kugler C, Schadlich I, Haake A, Zabel P, Vollmer E, Siebert R, Goldmann T, Ammerpohl O (2014) The tissue is the issue: improved methylome analysis from paraffin-embedded tissues by application of the HOPE technique. Lab Invest 94: 927-933 (ARCN)

Petersen A, Rennert S, Kull S, Becker W, Notbohm H, Goldmann T, Jappe U. Roasting and lipid binding provide allergenic and proteolytic stability to the peanut allergen Ara h 8. Biol Chem. 2014 Feb;395(2):239-50.

Shevchuk, Olga; Abidi, Nada; Klawonn, Frank; Wissing, Josef; Nimtz, Manfred; Kugler, Christian; Steinert, Michael; Goldmann, Torsten; Jänsch, Lothar. HOPE-fixation of lung tissue allows retrospective proteome and phosphoproteome studies. Journal of Proteome Research 2014 7;13(11):5230-9. IF 5.056

 

 

2013

Euler U, Dahmann D, Follmann M, Gaede KI, Gäßler A, Groneberg D, Heger M, Krutz K, Latza U, Lelgemann M, Letzel S, Merget R, Müller-Quernheim J, Nauert T, Seidler A; Deutsche Gesellschaft für Arbeitsmedizin und Umweltmedizin e. V. [Health surveillance for workers exposed to beryllium and diagnostic procedures in beryllium-associated diseases]. Dtsch Med Wochenschr. 2013 Mar;138(10):488-92. doi: 10.1055/s-0032-1332900. Epub 2013 Feb 26. German. PubMed PMID: 23444026.

Flesch BK, Wesche J, Berthold T, Goldmann T, Hundt M, Greinacher A, Bux J. Expression of the CTL2 Transcript Variants in Human Peripheral Blood Cells and Human Tissues. Transfusion. 2013 Dec;53(12):3217-23.

Goldmann T, Pedersen F, Seehase S, Marwitz M, Lang DS, Kirsten AM, Zabel P, Vollmer E, Magnussen H, Rabe KF, Watz H. The effect of dithiothreitol on the transcriptome of induced sputum cells. Respiration 2013;86(3):262-3.

Hofmann S, Fischer A, Nothnagel M, Jacobs G, Schmid B, Wittig M, Franke A, Gaede KI, Schürmann M, Petrek M, Mrazek F, Pabst S, Grohé C, Grunewald J, Ronninger M, Eklund A, Rosenstiel P, Höhne K, Zissel G, Müller-Quernheim J, Schreiber S. Genome-wide association analysis reveals 12q13.3-q14.1 as new risk locus for sarcoidosis. Eur Respir J. 2013 Apr;41(4):888-900. doi: 10.1183/09031936.00033812. Epub 2012 Aug 30. PubMed PMID: 22936702.

Rotta detto Loria J, Rohmann K, Droemann D, Kujath P, Rupp J, Goldmann T, Dalhoff K. Nontypeable Haemophilus influenzae activates the NLRP3 inflammasome and leads to caspase-1-dependent secretion of Interleukin-1 - a possible pathway of exacerbations in COPD. 2013 PlosOne 8(6): e66818.

van Bremen T, Daniel Drömann, Karin Luitjens, Christoph Dodt, Klaus Dalhoff, Torsten Goldmann and Bernhard Schaaf. Triggering receptor expressed on myeloid cells -1 (Trem-1) on blood neutrophils is associated with endotoxin tolerance in human E.coli sepsis. 2013 Diagnostic Pathology 15;8(1):24. IF 2.41
 

2012

Abdullah M, D. Kähler, C. Vock, C. Kugler, D. Drömann, J. Rupp, H.-P. Hauber,  N. Reiling5, K. Dalhoff, P. Zabel, E. Vollmer, T. Goldmann. Pulmonary haptoglobin and CD163 are first line immunoregulatory elements in the human lung. Respiration. 2012;83(1):6 Abgelegt in 2011 da in press IF 2.651

Abdullah M, Goldmann T. Pulmonary haptoglobin (pHp) is part of the surfactant system in the human lung. Diagnostic Pathology 2012, 7:158. DOI: 10.1186/1746-1596-7-158 IF 2.41

Fischer A, Schmid B, Ellinghaus D, Nothnagel M, Gaede KI, Schürmann M, Lipinski S, Rosenstiel P, Zissel G, Höhne K, Petrek M, Kolek V, Pabst S, Grohé C, Grunewald J, Ronninger M, Eklund A, Padyukov L, Gieger C, Wichmann HE, Nebel A, Franke A, Müller-Quernheim J, Hofmann S, Schreiber S. A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1. Am J Respir Crit Care Med. 2012 Nov 1;186(9):877-85. doi: 10.1164/rccm.201204-0708OC. Epub 2012 Jul 26. PubMed PMID: 22837380.

Hattar K, Savai R, Subtil FSB, Wilhelm J, Schmall A, Lang DS , Goldmann T, Eul B, Dahlem G, Fink L, Schermuly RT, Banat GA, Sibelius U, Grimminger F, Vollmer E, Seeger W, Ulrich Grandel* Endotoxin induces proliferation of NSCLC in vitro and in vivo – role of COX-2 and EGFR activation. Cancer Immunology Immunotherapy 2012 Aug 26.IF 3.94 [Epub ahead of print] IF 4.846

Pedersen F, Marwitz S, Seehase S, Kirsten AM, Zabel P, Vollmer E, Rabe KF, Magnussen H, Watz H, Goldmann T. HOPE-preservation of paraffin-embedded sputum samples – a new way of bioprofiling in COPD. 2012 Resp Med 107(4):587-95. IF 3.036

Seidler A, Euler U, Müller-Quernheim J, Gaede KI, Latza U, Groneberg D, Letzel S. Systematic review: Progression of beryllium sensitization to chronic beryllium disease. Occup Med (Lond). 2012 Oct;62(7):506-13. doi: 10.1093/occmed/kqs069. Epub 2012 Jun 15. Review. PubMed PMID: 22705916.